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1. Candidate molecules as diagnostic biomarker for human uterine mesenchymal tumors

Author

Yaish P, Sano K, Takuma Hayashi, Ichimura T, Tonegawa S, Yaegashi N, Zharhary D, Kanai Y, Gur G, and Konishi I

Subjects
Leiomyosarcoma, Oncology, medicine.medical_specialty, Poor prognosis, business.industry, Uterine leiomyosarcoma, Mesenchymal stem cell, Cancer, medicine.disease, body regions, Internal medicine, medicine, Overall survival, General Earth and Planetary Sciences, Diagnostic biomarker, Stage iv, business, General Environmental Science
Abstract

Unfortunately, uterine leiomyosarcoma still has a poor prognosis. The National Cancer Institute reported that the median overall survival (mOS) at stage I to stage IV of leiomyosarcoma was 31 months.

Published
2020

2. Surface detectors of the TAx4 experiment

Author

Telescope Array Collaboration, Abbasi, R. U., Abe, M., Abu-Zayyad, T., Allen, M., Arai, Y., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Cady, R., Cheon, B. G., Chiba, J., Chikawa, M., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Fukushima, R., Furlich, G., Hanlon, W., Hayashi, M., Hayashida, N., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inadomi, T., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwakura, H., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawai, H., Kawakami, S., Kawana, S., Kawata, K., Kido, E., Kim, H. B., Kim, J. H., Kim, M. H., Kim, S. W., Kimura, Y., Kishigami, S., Kuzmin, V., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., Lundquist, J. P., Machida, K., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Minamino, M., Mukai, K., Myers, I., Nagataki, S., Nakai, K., Nakamura, R., Nakamura, T., Nakamura, Y., Nonaka, T., Oda, H., Ogio, S., Ohnishi, M., Ohoka, H., Oku, Y., Okuda, T., Omura, Y., Ono, M., Onogi, R., Oshima, A., Ozawa, S., Park, I. H., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rubtsov, G. I., Ryu, D., Sagawa, H., Sahara, R., Saito, Y., Sakaki, N., Sako, T., Sakurai, N., Sano, K., Sato, K., Seki, T., Sekino, K., Shah, P. D., Shibata, F., Shibata, N., Shibata, T., Shimodaira, H., Shin, B. K., Shin, H. S., Shinto, D., Smith, J. D., Sokolsky, P., Sone, N., Stokes, B. T., Stroman, T. A., Suzawa, T., Takagi, Y., Takahashi, Y., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, H., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsuda, R., Tsunesada, Y., Uchihori, Y., Udo, S., Uehama, T., Urban, F., Wong, T., Yada, K., Yamamoto, M., Yamazaki, K., Yang, J., Yashiro, K., Yoshida, F., Zhezher, Y., and Zundel, Z.

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, 0103 physical sciences, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 010306 general physics, Astrophysics - Instrumentation and Methods for Astrophysics, 010303 astronomy & astrophysics, 01 natural sciences, 7. Clean energy, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

Telescope Array (TA) is the largest ultrahigh energy cosmic-ray (UHECR) observatory in the Northern Hemisphere. It explores the origin of UHECRs by measuring their energy spectrum, arrival-direction distribution, and mass composition using a surface detector (SD) array covering approximately 700 km$^2$ and fluorescence detector (FD) stations. TA has found evidence for a cluster of cosmic rays with energies greater than 57 EeV. In order to confirm this evidence with more data, it is necessary to increase the data collection rate.We have begun building an expansion of TA that we call TAx4. In this paper, we explain the motivation, design, technical features, and expected performance of the TAx4 SD. We also present TAx4's current status and examples of the data that have already been collected., Comment: 26 pages, 17 figures, submitted to Nuclear Inst. and Methods in Physics Research, A

Published
2021
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3. Evidence for a Supergalactic Structure of Magnetic Deflection Multiplets of Ultra-High Energy Cosmic Rays

Author

Telescope Array Collaboration, Abbasi, R. U., Abe, M., Abu-Zayyad, T., Allen, M., Azuma, R., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Cady, R., Cheon, B. G., Chiba, J., Chikawa, M., di Matteo, A., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Furlich, G., Hanlon, W., Hayashi, M., Hayashida, N., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inadomi, T., Inoue, N., Ishii, T., Ishimori, R., Ito, H., Ivanov, D., Iwakura, H., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawai, H., Kawakami, S., Kawana, S., Kawata, K., Kido, E., Kim, H. B., Kim, J. H., Kim, M. H., Kim, S. W., Kishigami, S., Kuzmin, V., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., Lundquist, J. P., Machida, K., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Minamino, M., Mukai, K., Myers, I., Nagataki, S., Nakai, K., Nakamura, R., Nakamura, T., Nakamura, Y., Nonaka, T., Oda, H., Ogio, S., Ohnishi, M., Ohoka, H., Oku, Y., Okuda, T., Omura, Y., Ono, M., Onogi, R., Oshima, A., Ozawa, S., Park, I. H., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rubtsov, G., Ryu, D., Sagawa, H., Sahara, R., Saito, Y., Sakaki, N., Sako, T., Sakurai, N., Sano, K., Seki, T., Sekino, K., Shah, P. D., Shibata, F., Shibata, T., Shimodaira, H., Shin, B. K., Shin, H. S., Smith, J. D., Sokolsky, P., Sone, N., Stokes, B. T., Stroman, T. A., Suzawa, T., Takagi, Y., Takahashi, Y., Takamura, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, H., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsunesada, Y., Uchihori, Y., Udo, S., Uehama, T., Urban, F., Wong, T., Yada, K., Yamamoto, M., Yamazaki, K., Yang, J., Yashiro, K., Yosei, M., Zhezher, Y., and Zundel, Z.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Evidence for a large-scale supergalactic cosmic ray multiplet (arrival directions correlated with energy) structure is reported for ultra-high energy cosmic ray (UHECR) energies above 10$^{19}$ eV using seven years of data from the Telescope Array (TA) surface detector and updated to 10 years. Previous energy-position correlation studies have made assumptions regarding magnetic field shapes and strength, and UHECR composition. Here the assumption tested is that, since the supergalactic plane is a fit to the average matter density of the local Large Scale Structure (LSS), UHECR sources and intervening extragalactic magnetic fields are correlated with this plane. This supergalactic deflection hypothesis is tested by the entire field-of-view (FOV) behavior of the strength of intermediate-scale energy-angle correlations. These multiplets are measured in spherical cap section bins (wedges) of the FOV to account for coherent and random magnetic fields. The structure found is consistent with supergalactic deflection, the previously published energy spectrum anisotropy results of TA (the hotspot and coldspot), and toy-model simulations of a supergalactic magnetic sheet. The seven year data post-trial significance of this supergalactic structure of multiplets appearing by chance, on an isotropic sky, is found by Monte Carlo simulation to be 4.2$\sigma$. The ten years of data post-trial significance is 4.1$\sigma$. Furthermore, the starburst galaxy M82 is shown to be a possible source of the TA Hotspot, and an estimate of the supergalactic magnetic field using UHECR measurements is presented.

Published
2020
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4. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

Author

Sands, B. E., Sandborn, W. J., Panaccione, R., O'Brien, C. D., Zhang, H., Johanns, J., Adedokun, O. J., Li, K., Peyrin-Biroulet, L., Van Assche, G., Danese, S., Targan, S., Abreu, M. T., Hisamatsu, T., Szapary, P., Brown S, Marano C., Connor, S, De Cruz, P, Ding, Nj, Florin, T, Hendy, P, Leong, R, Moore, G, Pavli, P, Sparrow, M, Gassner, S, Vogelsang, H, Baert, F, Colard, A, De Vos, M, D'Heygere, F, Ferrante, M, Louis, E, Staessen, D, Berova, T, Churchev, J, Draganova, R, Gancheva, D, Ivanova, N, Marinova, I, Markov, M, Nikolov, R, Tsonev, N, Vassileva, G, Afif, W, Berstein, C, Bressler, B, Jairath, V, Lachance, Jr, Singh, R, Tilbe, K, Komarek, V, Kozeluhova, J, Lukas, M, Volfova, M, Dahlerup, J, Altwegg, R, Beorchia, S, Bouguen, G, Cadiot, G, Dupas, Jl, Desreumaux, P, Flourie, B, Grimaud, Jc, Guillaud, O, Moreau, J, Roblin, X, Zerbib, F, Baumgart, D, Beckebaum, S, Bokemeyer, B, Ebert, M, Hasselblatt, P, Lügering, A, Maaser, C, Schiefke, I, Schreiber, S, Seidler, U, Altorjay, I, Kiss, Gg, Literati-Nagy, B, Patai, A, Pecsi, G, Salamon, A, Schnabel, R, Székely, A, Tulassay, Z, Varga, M, Fich, A, Fishman, S, Konikoff, F, Lichtenstein, L, Rainis, T, Sbeit, W, Schwartz, D, Annese, V, Biancone, L, Bossa, F, Costintino, R, Danese, S, Fries, W, Gasbarrini, A, Guidi, L, Kohn, A, Maconi, G, Rocca, R, Rogai, F, Villa, E, Zoli, G, Akiho, H, Aoyama, N, Arisawa, T, Hidaka, H, Hisamatsu, T, Horiki, N, Inaba, T, Inoue, S, Ishida, T, Ishida, H, Ishiguro, Y, Ishihara, S, Iwabuchi, M, Kato, J, Katsushima, S, Kobayashi, T, Kojima, Y, Kurihara, H, Masuo, T, Matsui, T, Matsumoto, T, Matsuoka, K, Mitsuyama, K, Motoya, S, Nakagawa, T, Nakai, K, Nakamura, S, Niihara, T, Ohnishi, Y, Ohta, A, Osada, T, Ryuichi, I, Sakai, Y, Sakata, Y, Sameshima, Y, Sano, K, Shibatoge, M, Shibuya, T, Suzuki, Y, Takeshima, F, Tanaka, S, Taruishi, M, Tokito, S, Ueo, T, Watanabe, K, Yamagami, H, Cheon, Jh, Cho, Kb, Knowles, Kim, Kim, Hj, Kim, Y, Lee, Km, Yang, Sk, D'Haens, G, Pierik, M, Gearry, R, Inns, S, Rowbotham, D, Schultz, M, Bochenek, A, Gawdis-Wojnarska, B, Kleczkowski, D, Leszczyszyn, J, Malecka-Panas, E, Mamos, A, Petryka, R, Regula, J, Rozciecha, J, Stefanuik, P, Wozniak-Stolarska, B, Cimpoeru, N, Craciun, E, Ovidiu, Cf, Goldis, E, Ionita-Radu, F, Lazar, D, Suciu, I, Abdulkhakov, R, Alikhanov, B, Apartsin, K, Bakulin, I, Belousova, E, Gofman, A, Grinevich, V, Kulyapin, A, Nizov, A, Osipenko, M, Simanenkov, V, Tkachev, A, Uspenskiy, Y, Valuyskikh, E, Jovanovic, I, Nagorni, A, Svorcan, P, Zdravkovic, N, Bunganic, I, Abrahamovych, O, Bilianskyi, L, Datsenko, O, Golovchenko, O, Kharchenko, N, Klymenko, V, Levchenko, O, Lozynskyy, Y, Murenets, N, Oliinyk, O, Prystupa, L, Pyrogovskyi, V, Reznikova, V, Rishko, I, Stanislavchuk, M, Vizir, V, Yatsyshyn, R, Arasaradnam, R, Bloom, S, Cummings, F, Iqbal, T, Irving, P, Kaser, A, Shonde, A, Subramanian, S, Aberra, F, Aguilar, H, Araya, V, Bakken, A, Beaulieu, D, Cappa, Ja, Chiorean, M, Cohen, N, Dryden, G, Duvall, G, Ehrlich, A, Eisner, M, Ertan, A, Fogel, R, Friedenberg, K, Gatof, D, Glover, S, Grosman, I, Gunaratnam, N, Gupta, N, Haynes, P, Hemaidan, A, Higgins, P, Hou, J, Hudesman, D, Iskandar, H, Jazrawi, S, Jones, M, Karnam, U, Khurana, S, Killpack, M, Kreines, M, Lawlor, G, Lee, S, Loftus, E, Lukin, Dj, Marcet, J, Mattar, M, Melmed, G, Minor, T, Mirkin, K, Mutlu, E, Nichols, M, Nudell, J, Rai, R, Ramos, C, Mcleod, Randall, Rausher, D, Ritter, T, Singh Saini, S, Salzberg, B, Saubermann, L, Scherl, E, Sedghi, S, Sellin, J, Shafran, I, Sorrentino, D, Suiter, D, Swaminath, A, Tiongco, F, Vrabie, R, Walp, K, Warner, N, Winstead, N, Wolf, Dc, Woods, J, Yen, E, Younes, Z., Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Maag Darm Lever (9), Interne Geneeskunde, Sands, Be, Sandborn, Wj, Panaccione, R, O'Brien, Cd, Zhang, H, Johanns, J, Adedokun, Oj, Li, K, Peyrin-Biroulet, L, Van Assche, G, Danese, S, Targan, S, Abreu, Mt, Hisamatsu, T, Szapary, P, and Marano, C

Subjects
Adult, Male, Infusions, [SDV]Life Sciences [q-bio], Injections, Subcutaneous, Anti-Inflammatory Agents, Ulcerative, Klinikai orvostudományok, Article, Injections, Maintenance Chemotherapy, Dose-Response Relationship, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, INFLIXIMAB, Colitis, Ulcerative, Dose-Response Relationship, Drug, Female, Humans, Induction Chemotherapy, Infusions, Intravenous, Patient Acuity, Remission Induction, Ustekinumab, ComputingMilieux_MISCELLANEOUS, ACTIVITY INDEXES, Subcutaneous, Orvostudományok, General Medicine, EFFICACY, Colitis, 3. Good health, INFECTIONS, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Drug, Intravenous
Abstract

The efficacy of ustekinumab, an antagonist of the p40 subunit of interleukin-12 and interleukin-23, as induction and maintenance therapy in patients with ulcerative colitis is unknown.We evaluated ustekinumab as 8-week induction therapy and 44-week maintenance therapy in patients with moderate-to-severe ulcerative colitis. A total of 961 patients were randomly assigned to receive an intravenous induction dose of ustekinumab (either 130 mg [320 patients] or a weight-range-based dose that approximated 6 mg per kilogram of body weight [322]) or placebo (319). Patients who had a response to induction therapy 8 weeks after administration of intravenous ustekinumab were randomly assigned again to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 12 weeks [172 patients] or every 8 weeks [176]) or placebo (175). The primary end point in the induction trial (week 8) and the maintenance trial (week 44) was clinical remission (defined as a total score of ≤2 on the Mayo scale [range, 0 to 12, with higher scores indicating more severe disease] and no subscore1 [range, 0 to 3] on any of the four Mayo scale components).The percentage of patients who had clinical remission at week 8 among patients who received intravenous ustekinumab at a dose of 130 mg (15.6%) or 6 mg per kilogram (15.5%) was significantly higher than that among patients who received placebo (5.3%) (P0.001 for both comparisons). Among patients who had a response to induction therapy with ustekinumab and underwent a second randomization, the percentage of patients who had clinical remission at week 44 was significantly higher among patients assigned to 90 mg of subcutaneous ustekinumab every 12 weeks (38.4%) or every 8 weeks (43.8%) than among those assigned to placebo (24.0%) (P = 0.002 and P0.001, respectively). The incidence of serious adverse events with ustekinumab was similar to that with placebo. Through 52 weeks of exposure, there were two deaths (one each from acute respiratory distress syndrome and hemorrhage from esophageal varices) and seven cases of cancer (one each of prostate, colon, renal papillary, and rectal cancer and three nonmelanoma skin cancers) among 825 patients who received ustekinumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received placebo.Ustekinumab was more effective than placebo for inducing and maintaining remission in patients with moderate-to-severe ulcerative colitis. (Funded by Janssen Research and Development; UNIFI ClinicalTrials.gov number, NCT02407236.).

Published
2019

5. The Appearance of In vivo ANA Positivity after a Period of 17 years in a Patient with Lupus Nephritis who had Received both Methylprednisolone and Cyclophosphamide Pulse Therapy

Author

Yan K, Sumiishi A, Matsubara S, Sano K, Kudo A, K Fukuoka, Arimura Y, Nose M, and Nakabayashi K

Subjects
Pathology, medicine.medical_specialty, biology, medicine.diagnostic_test, Cyclophosphamide, business.industry, Lupus nephritis, Autopsy, medicine.disease, Methylprednisolone, In vivo, Biopsy, medicine, biology.protein, Immunohistochemistry, Antibody, business, medicine.drug
Abstract

In vivo anti-nuclear antibody positive phenomenon in the renal tissues except for necropsy/autopsy cases or very severe cases of systemic lupus erythematosus is a controversial issue until today. However, we experienced a case of lupus nephritis that showed in vivo anti-nuclear antibody-positive cells in the renal tissues. Four successive renal biopsies over 17 years were studied with immunofluorescence as well as immunohistochemical and immuneelectron microscopic staining. The first, second and third biopsies did not reveal any in vivo anti-nuclear antibodypositive cells. However, the fourth biopsy in relapse showed positive cells, and the transfer of the patient’s serum into the mice provoked in vivo anti-nuclear antibody-positive cells in the mouse intestines. We present this case in detail and discuss the implications of these observations.

Published
2018

6. Correlative studies of dynamics and pathology in whip-lash and head injuries

Author

Sano K, Nakamura N, Hirakawa K, and Hashizume

Subjects
Intracranial Pressure, Acceleration, Rehabilitation, Physical Therapy, Sports Therapy and Rehabilitation, Haplorhini, General Medicine, Models, Biological, Brain Injuries, Pressure, Animals, Craniocerebral Trauma, Humans, Mathematics, Whiplash Injuries, Cerebral Hemorrhage, Cerebrospinal Fluid
Abstract

is missing

Published
2015

7. The Expressive Power of Modal Dependence Logic

Author

Hella, L., Luosto, K., Sano, K., and Jonni Virtema

Subjects
FOS: Computer and information sciences, Computer Science - Logic in Computer Science, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, ComputerApplications_MISCELLANEOUS, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, FOS: Mathematics, Mathematics - Logic, Logic (math.LO), Hardware_LOGICDESIGN, Logic in Computer Science (cs.LO)
Abstract

We study the expressive power of various modal logics with team semantics. We show that exactly the properties of teams that are downward closed and closed under team k-bisimulation, for some finite k, are definable in modal logic extended with intuitionistic disjunction. Furthermore, we show that the expressive power of modal logic with intuitionistic disjunction and extended modal dependence logic coincide. Finally we establish that any translation from extended modal dependence logic into modal logic with intuitionistic disjunction increases the size of some formulas exponentially., Comment: 19 pages

Published
2014
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8. A car lane-changing model under bus priority-lane effects

Author

Tu, T. V. and Sano, K.

Subjects
Bus priority-lane, car lane-changing model, gap acceptance model, ComputerApplications_COMPUTERSINOTHERSYSTEMS, ComputerSystemsOrganization_PROCESSORARCHITECTURES
Abstract

Car lane-changing behaviour has been well investigated at merging locations or weaving sections where the lane-changes are usually due to different origin-destination trip purposes. However, the lane-changing behaviour under the effects of bus priority-lanes in urban streets has not been received much attention. This kind of behaviour is found to initially depend on the existence of oncoming buses in priority-lanes in urban streets. In this paper, a car lane-changing model under bus priority-lane effects in urban streets is proposed. This model comprises three steps: looking-back threshold determination, gap acceptance model and execution model. The model’s parameters are estimated jointly by using the Maximum Likelihood Method. The research results show that the car lane-changing behaviour under bus-priority-lane effects in urban streets is considered compulsory behaviour. The behaviour has specific characteristics with smaller critical gaps compared with those at other normal lane cases and can be modelled by the proposed model.

Published
2013

9. Effects of heart rate on coronary circulation and external mechanical efficiency in elderly hypertensive patients with left ventricular hypertrophy

Author

N Oyake, Sano K, H Yoshitomi, S Nosaka, Y Ishibashi, T Umeno, Shigefumi Morioka, S Kobayashi, and Toshio Shimada

Subjects
medicine.medical_specialty, Heart disease, Ischemia, Hemodynamics, Left ventricular hypertrophy, Coronary circulation, Heart Rate, Reference Values, Coronary Circulation, Internal medicine, Heart rate, medicine, Humans, Lactic Acid, Coronary sinus, Aged, Heart Failure, Analysis of Variance, business.industry, General Medicine, medicine.disease, medicine.anatomical_structure, Heart failure, Hypertension, Cardiology, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business
Abstract

Background and hypothesis: Mechanisms of heart failure in elderly hypertensive patients with hypertrophy have not been studied sufficiently. We hypothesized that impaired increment of coronary blood flow in response to increases in heart rate could be responsible for the occurrence or aggravation of heart failure. Methods: To test this hypothesis, we measured coronary hemodynamics and lactate balance during basal conditions and atrial pacing in 21 elderly patients aged ≥ 65 years (mean 74 ± 6 years) without coronary arterial disease: 7 normoten-sive control patients (Group 1), 7 hypertensive hypertrophic patients without a history of congestive heart failure (Group 2), and 7 patients with such history (Group 3). Coronary sinus blood flow (CSBF) was measured in coronary sinus using a thermodilution catheter. Results: During basal conditions, heart rate did not differ among the three groups (67 ± 3 in Group 1,65 ±11 in Group 2, and 63 ± 6 beats/min in Group 3). CSBF was significantly higher in the two hypertrophic groups than in the control group, but CSBF normalized by left ventricular mass was significantly lower in both hypertrophic groups. External mechanical efficiency (EME) obtained as left ventricular work divided by myocardial oxygen consumption did not differ among groups during basal conditions (36 ± 9% in Group 1, 35 ± 8% in Group 2, and 29 ± 9% in Group 3, NS). During atrial pacing to increase heart rate by 25 ± 5% (lower) and 54 ± 6% (higher), the increases in CSBF were markedly limited in both hypertrophic groups, and the response in Group 3 was more depressed than that in Group 2. EME did not change in the control group or in Group 2, but did decrease to 21 ± 5% in Group 3 during the higher pacing rate (p

Published
1996

10. Pulse-density-modulated power control of a 4 kW, 450 kHz voltage-source inverter for induction melting applications

Author

Fujita, Hideaki, Akagi, Hirofumi, Sano, K., and Leonard, R. H.

Subjects
Engineering, melting, Induction heating, business.industry, Electrical engineering, Induction furnace, DC-AC power convertors, pulse modulation, induction heating, power control, Industrial and Manufacturing Engineering, resonant power convertors, Control and Systems Engineering, Modulation, Electronic engineering, Inverter, RLC circuit, Electrical and Electronic Engineering, business, Pulse-density modulation, Pulse-width modulation, Power control
Abstract

This paper presents a 4 kW, 450 kHz voltage-source inverter with a series resonant circuit for induction melting applications, which is characterized by the power control based on pulse density modulation (PDM). The pulse-density-modulated inverter makes an induction melting system simple and compact, thus leading to higher efficiency. A modulation strategy is proposed to realize the induction melting system capable of operation at the frequency and power level of interest. Some interesting experimental results are shown to verify the validity of the concept

Published
1996

11. Electron localization near Mott transition in organic superconductor $��$-(BEDT-TTF)$_{2}$Cu[N(CN)$_{2}]$Br

Author

Sano, K., Sasaki, T., Yoneyama, N., and Kobayashi, N.

Subjects
Superconductivity (cond-mat.supr-con), Strongly Correlated Electrons (cond-mat.str-el), FOS: Physical sciences, Condensed Matter::Strongly Correlated Electrons, Condensed Matter::Disordered Systems and Neural Networks
Abstract

The effect of disorder on the electronic properties near the Mott transition is studied in an organic superconductor $��$-(BEDT-TTF)$_{2}$Cu[N(CN)$_{2}$]Br, which is systematically irradiated by X-ray. We observe that X-ray irradiation causes Anderson-type electron localization due to molecular disorder. The resistivity at low temperatures demonstrates variable range hopping conduction with Coulomb interaction. The experimental results show clearly that the electron localization by disorder is enhanced by the Coulomb interaction near the Mott transition., 5 pages, 4 figures

Published
2010
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12. Mechanism underlying specificity of proteins targeting inorganic materials

Author

HAYASHI, Tomohiro, Sano, K., Shiba, K., Kumashiro, Y., Iwahori, K., Yamashita, I., and Hara, M.

Subjects
Models, Molecular, binding, Molecular Sequence Data, Static Electricity, Bioengineering, Peptide, Tissue Adhesions, Microscopy, Atomic Force, Sensitivity and Specificity, Protein structure, Pulmonary surfactant, Static electricity, surface, General Materials Science, atomic-force microscopy, Amino Acid Sequence, Peptide sequence, chemistry.chemical_classification, Mechanical Engineering, Substrate (chemistry), Proteins, General Chemistry, Adhesion, Condensed Matter Physics, display, Protein Structure, Tertiary, Crystallography, chemistry, Inorganic Chemicals, Biophysics, peptides, identification, affinity, oxide, Gold, recognition, Macromolecule, ferritin molecules
Abstract

Adhesion force analysis using atomic force microscopy clearly revealed for the first time the mechanism underlying the specific binding between a titanium surface and ferritin possessing the sequence of Ti-binding peptide in its N-terminal domain. Our results proved that the specific binding is due to double electrostatic bonds between charged residue and surface groups of the substrate. Furthermore, it is also demonstrated that the accretion of surfactant reduces nonspecific interactions, dramatically enhancing the selectivity and specificity of Ti-binding peptide.

Published
2006

16. [Primary Sjögren's syndrome with pulmonary hypertension]

Author

Kazuhiro Usui, Anzai C, Sano K, Kumazaki S, and Ishihara T

Subjects
Anemia, Hemolytic, Sjogren's Syndrome, Hypergammaglobulinemia, Hypertension, Pulmonary, Prednisolone, Anti-Inflammatory Agents, Humans, Female, Raynaud Disease, Middle Aged, Cyclophosphamide, Methylprednisolone, Immunosuppressive Agents
Abstract

A 50-year-old woman was admitted to our hospital because of dyspnea on exertion. A chest X-ray film showed cardiomegaly and echocardiography revealed right-heart overload. Right heart catheterization studies revealed pulmonary hypertension and no signs of pulmonary embolism or vasculitis. The patient had complained of Raynaud's phenomenon since 6 years before admission. She did not notice eye or mouth dryness, but examination of a lip-biopsy specimen showed infiltration of lymphocytes into the salivary glands. Laboratory findings showed hypergammaglobulinemia and hemolytic anemia. Primary Sjögren's syndrome with pulmonary hypertension was diagnosed. Her general condition improved with steroid pulse therapy followed by oral administration of corticosteroids and cyclophosphamide.

Published
1998

19. Regenerative signals for heterotopic hepatocyte transplantation

Author

Sano K, Ra, Cusick, Lee H, Jm, Pollok, Pm, Kaufmann, Uyama S, David Mooney, Langer R, and Jp, Vacanti

Subjects
Male, Transplantation, Heterotopic, Epidermal Growth Factor, Islets of Langerhans Transplantation, Cell Separation, Microspheres, Liver Regeneration, Liver Transplantation, Rats, Islets of Langerhans, Transplantation, Isogeneic, Liver, Rats, Inbred Lew, Animals, Cell Division
Published
1996

22. Detection of right ventricular infarction by gadolinium DTPA-enhanced magnetic resonance imaging

Author

Sano K, T. Shimada, K. Ochial, Y Murakami, J. Kitamura, H. Sato, and S. Morioka

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Hemodynamics, Infarction, Magnetic resonance imaging, medicine.disease, medicine.anatomical_structure, Ventricle, Internal medicine, cardiovascular system, Cardiology, Medicine, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business, Pulmonary wedge pressure, Perfusion, Technetium-99m, Emission computed tomography
Abstract

We investigated the usefulness of gadolinium-enhanced magnetic resonance (Gd-MR) imaging for diagnosis of right ventricular (RV) infarction in 14patients with acute inferior infarction. Myocardial perfusion images with thallium 201 and technetium 99m pyrophosphate (dual single-photon emission computed tomography: dual SPECT) and haemodynamic data were obtained on admission. Patients were classified into three groups based on dual SPECT and Gd-MR findings: no accumulation in the right ventricle (negative, Type 1), posterior RV infarction (Type 2) and anterior and posterior RV infarction (Type 3). No patients exhibited the haemodynamic criteria for RV infarction (a mean right atrial pressure above 10 mmHg and a ratio of mean right atrial pressure to pulmonary artery wedge pressure above 0.8). Dual SPECT identified RV infarction in eight patients (three Type 2 and five Type 3, 57% of the total). Gd-MR imaging also identified eight patients (57%) as positive (five Type 2 and three Type 3). Our results showed that Gd-MR imaging was not only useful for diagnosis of RV infarction, but also equal to dual SPECT in sensitivity and specificity, and superior to it as regards acquisition time and assessing the spatial anatomy of heart. In conclusion, Gd-MR imaging is superior to dual SPECT for detection of RV infarction.

Published
1995

24. [A preliminary study to determine the activity of topoisomerase II in human kidney cancer cells with DNA unknotting method]

Author

Shuuin T, Ikegami I, Shiomi Y, Sano K, and Hosaka M

Subjects
Oncology, medicine.medical_specialty, Urology, Dose dependence, Biology, chemistry.chemical_compound, Internal medicine, medicine, Tumor Cells, Cultured, Humans, Topoisomerase II Inhibitors, Etoposide, Dose-Response Relationship, Drug, Topoisomerase, Human kidney, medicine.disease, Kidney Neoplasms, DNA Topoisomerases, Type II, chemistry, Cancer cell, biology.protein, Cancer research, Drug Screening Assays, Antitumor, Kidney cancer, DNA, medicine.drug
Abstract

For the purpose of examining the Topoisomerase II (Topo II) activity in human kidney cancer cells, we performed experiments with using DNA unknotting method. This method check relative Topo II activity with its conversion of knotted form P4 phage DNA to unknotted form. Our preliminary results demonstrate remarkable activity of Topo II with specific conversion of knotted form P4 DNA to unknotted form in human kidney cancer cells, YCR and ACHN. Moreover, addition of etoposide to the same experiment suppressed Topo II activity in a dose dependent manner. Our results suggest that kidney cancer has a certain amount of Topo II, a target for etoposide. We believe this method is useful to measure Topo II activity in cancer cells and to estimate chemotherapeutic potential of Topo II inhibitors including etoposide in human kidney cancers.

Published
1992

30. [A case of acute spinal epidural hematoma in a patient with antiplatelet therapy]

Author

Mishima K, Aritake K, Akio Morita, Miyagawa N, Segawa H, and Sano K

Subjects
Hematoma, Epidural, Cranial, Male, Ticlopidine, Acute Disease, Humans, Dipyridamole, Platelet Aggregation Inhibitors, Aged
Abstract

The authors report a case of acute spinal epidural hematoma occurring in a patient receiving antiplatelet drugs. A 76-year-old man with a history of cerebral infarction had been taking antiplatelet agents for one year. He suddenly developed severe back pain which woke him from sleep, and numbness of his lower extremities was then noted. He was hospitalized 15 hours later. Neurological examination revealed flaccid paralysis of both lower extremities with negative Babinski's reflex, and sensory disturbance below the level of L1. The bleeding time and prothrombin time were prolonged. Computed tomographic (CT) scan revealed a biconvex, relatively hyperdense mass in the posterior spinal canal at the level of T12. Metrizamide myelography disclosed an incomplete blockage caused by an epidural mass at the level of T11. Post-myelographic CT scan demonstrated a sharply demarcated extradural filling defect at the level of T11. Seventeen hours after the onset of symptoms, an emergency laminectomy was performed extending from T12 to L3, and the epidural clot was totally evacuated. Histological examination of the capsule of the hematoma revealed no vascular anomalies. The patient made a good postoperative recovery. To the authors' knowledge, this is the first reported case of spontaneous intraspinal hemorrhage in a patient taking antiplatelet drugs. Acute onset of persistent pain anywhere along the spinal axis and the development of spinal neurological deficits in a patient on antiplatelet therapy should raise the suspicion of a spinal epidural hematoma. It should be stressed that prompt neuroradiological diagnosis and rapid surgical decompression are essential to allow good recovery. The present case illustrates that neurological emergencies can occur in patients receiving antiplatelet therapy.

33. UHECR arrival directions in the latest data from the original Auger and TA surface detectors and nearby galaxies

Author

Di Matteo, A., Anchordoqui, L., Bister, T., Biteau, J., Caccianiga, L., De Almeida, R., Deligny, O., Giaccari, U., Harari, D., Kim, J., Kuznetsov, M., Maris, I., Rubtsov, G., Tinyakov, P., Troitsky, S., Urban, F., Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Almela, A., Alvarez-Muñiz, J., Alves Batista, R., Anastasi, G. A., Andrada, B., Andringa, S., Aramo, C., Araújo Ferreira, P. R., Arteaga Velázquez, J. C., Asorey, H., Assis, P., Avila, G., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Barreira Luz, R. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Binet, V., Bismark, K., Blazek, J., Bleve, C., Bohácová, M., Boncioli, D., Bonifazi, C., Bonneau Arbeletche, L., Borodai, N., Botti, A. M., Brack, J., Bretz, T., Brichetto Orchera, P. G., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Canfora, F., Caracas, I., Carceller, J. M., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Correia Dos Santos, D., Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., De Almeida, R. M., De Jesús, J., De Jong, S. J., De Mauro, G., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Oliveira Franco, D., De Palma, F., De Souza, V., De Vito, E., Del Río, M., Deval, L., Dobrigkeit, C., D’Olivo, J. C., Domingues Mendes, L. M., Dos Anjos, R. C., Dos Santos, D., Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipcic, A., Fitoussi, T., Fodran, T., Freire, M. M., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Garcia Vegas, A. L., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Karastathis, N., Keilhauer, B., Kemp, J., Khakurdikar, A., Kizakke Covilakam, V. V., Klages, H. O., Kleifges, M., Kleinfeller, J., Köpke, M., Kunka, N., Lago, B. L., Lang, R. G., Langner, N., Leigui De Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., MacHado Payeras, A., Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariazzi, A. G., Maris, I. C., Marsella, G., Martello, D., Martinelli, S., Martínez Bravo, O., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K.-D., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pedreira, F., Pȩkala, J., Pelayo, R., Peña-Rodriguez, J., Pereira Martins, E. E., Perez Armand, J., Pérez Bertolli, C., Perlin, M., Perrone, L., Petrera, S., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Salamida, F., Salazar, H., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schröder, S., Schulte, J., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Šmída, R., Sommers, P., Soriano, J. F., Souchard, J., Squartini, R., Stadelmaier, M., Stanca, D., Stanic, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Todero Peixoto, C. J., Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Valdés Galicia, J. F., Valore, L., Varela, E., Vásquez-Ramírez, A., Veberic, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczynski, H., Wirtz, M., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., Abbasi, R. U., Abu-Zayyad, T., Allen, M., Arai, Y., Arimura, R., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Buckland, I., Cady, R., Cheon, B. G., Chiba, J., Chikawa, M., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Fukushima, R., Furlich, G., Gonzalez, R., Hanlon, W., Hayashi, M., Hayashida, N., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inadomi, T., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwakura, H., Iwasaki, A., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawai, H., Kawakami, S., Kawana, S., Kawata, K., Kharuk, I., Kido, E., Kim, H. B., Kim, J. H., Kim, M. H., Kim, S. W., Kimura, Y., Kishigami, S., Kubota, Y., Kurisu, S., Kuzmin, V., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., MacHida, K., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Minamino, M., Mukai, K., Myers, I., Nagataki, S., Nakai, K., Nakamura, R., Nakamura, T., Nakamura, Y., Nakazawa, A., Nishio, E., Nonaka, T., Oda, H., Ogio, S., Ohnishi, M., Ohoka, H., Oku, Y., Okuda, T., Omura, Y., Ono, M., Onogi, R., Oshima, A., Ozawa, S., Park, I. H., Potts, M., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rubtsov, G. I., Ryu, D., Sagawa, H., Sahara, R., Saito, Y., Sakaki, N., Sako, T., Sakurai, N., Sano, K., Sato, K., Seki, T., Sekino, K., Shah, P. D., Shibasaki, Y., Shibata, F., Shibata, N., Shibata, T., Shimodaira, H., Shin, B. K., Shin, H. S., Shinto, D., Smith, J. D., Sokolsky, P., Sone, N., Stokes, B. T., Stroman, T. A., Takagi, Y., Takahashi, Y., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, H., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tkachev, I., Tokuno, H., Tomida, T., Tsuda, R., Tsunesada, Y., Uchihori, Y., Udo, S., Uehama, T., Wong, T., Yada, K., Yamamoto, M., Yamazaki, K., Yang, J., Yashiro, K., Yoshida, F., Yoshioka, Y., Zhezher, Y., Zundel, Z., Pierre Auger Collaboration, and Telescope Array Collaboration

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Pierre Auger Observatory, Stellar mass, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Order (ring theory), Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Galaxy, Auger, Dipole, Experimental High Energy Physics, High Energy Physics, ddc:620, Astrophysics - High Energy Astrophysical Phenomena, Engineering & allied operations, Astrophysics::Galaxy Astrophysics, Energy (signal processing)
Abstract

The distribution of ultra-high-energy cosmic-ray arrival directions appears to be nearly isotropic except for a dipole moment of order $6 \times (E/10~\mathrm{EeV})$ per cent. Nonetheless, at the highest energies, as the number of possible candidate sources within the propagation horizon and the magnetic deflections both shrink, smaller-scale anisotropies might be expected to emerge. On the other hand, the flux suppression reduces the statistics available for searching for such anisotropies. In this work, we consider two different lists of candidate sources: a sample of nearby starburst galaxies and the 2MRS catalog tracing stellar mass within $250~\mathrm{Mpc}$. We combine surface-detector data collected at the Pierre Auger Observatory until 2020 and the Telescope Array until 2019, and use them to test models in which UHECRs comprise an isotropic background and a foreground originating from the candidate sources and randomly deflected by magnetic fields. The free parameters of these models are the energy threshold, the signal fraction, and the search angular scale. We find a correlation between the arrival directions of $11.8\%_{-3.1\%}^{+5.0\%}$ of cosmic rays detected with $E \ge 38~\mathrm{EeV}$ by Auger or with $E \gtrsim 49~\mathrm{EeV}$ by TA and the position of nearby starburst galaxies on a ${15.5^\circ}_{-3.2^\circ}^{+5.3^\circ}$ angular scale, with a $4.2\sigma$ post-trial significance, as well as a weaker correlation with the overall galaxy distribution., Comment: proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), 12-23 July 2021, Berlin, Germany

35. Living-related liver transplantation for biliary atresia

Author

Fujita S, Tanaka K, Tokunaga Y, Uemoto S, Sano K, Dai Manaka, Shirahase I, Shinohara H, Yamaoka Y, and Ozawa K

Subjects
Male, Reoperation, Tissue and Organ Procurement, Graft Survival, Infant, Portoenterostomy, Hepatic, Tissue Donors, Liver Transplantation, Postoperative Complications, Biliary Atresia, Child, Preschool, Humans, Female, Child, Immunosuppressive Agents
Abstract

We reviewed our initial experience of 29 living-related liver transplantations (LRLT) for children with biliary atresia in terms of postoperative complications and management to analyze the factors that may influence the outcome. All patients underwent an initial portoenterostomy at 17-134 days of age. The age distribution at the time of LRLT ranged from 6 months to 12 years, following revised portoenterostomy 0 to 3 times, and with (n=5) or without enteric stoma (n=24). Living-related donors provided the partial liver grafts weighing 170 to 630 g according to recipient size. Twenty-six of the 29 recipients are alive and well with follow-up between 1 and 27 (mean=14) months. Three patients died of extrahepatic complications including aspiration asphyxia, Candida infection and lymphoproliferative disorder. Four of 5 children with enteric stoma had 9 incidences of postoperative complication, while only 4 incidences occurred in 4 out of 24 children without stoma (p=0.007). Children hospitalized at the time of transplantation seemed to have early postoperative complications more frequently than home-bound children (p=0.06). The present results indicated that LRLT could offer satisfactory outcome for children in whom repeated Kasai's operation could not attain adequate biliary diversion and for those who developed cirrhosis despite good initial bile drainage.(ABSTRACT TRUNCATED AT 250 WORDS)

36. Transplantation of hepatocytes using porous, biodegradable sponges

Author

David Mooney, Pm, Kaufmann, Sano K, Km, Mcnamara, Jp, Vacanti, and Langer R

Subjects
Time Factors, Cell Transplantation, Polymers, Portacaval Shunt, Surgical, Polyesters, Biocompatible Materials, Rats, Transplantation, Isogeneic, Biodegradation, Environmental, Liver, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Inbred Lew, Lactates, Animals, Lactic Acid, Cells, Cultured, Polyglycolic Acid

37. [Infantile T cell acute lymphoblastic leukemia complicated by thrombotic microangiopathy and human herpes virus 6 infection after allogeneic peripheral blood stem cell transplantation using CD34-positive cells]

Author

Daiichiro Hasegawa, Sano K, Kosaka Y, Hayakawa A, Kawagoe R, Amo K, Taya K, Hirabayashi N, and Nakamura H

Subjects
Male, Herpesvirus 6, Human, Hematopoietic Stem Cell Transplantation, Humans, Infant, Leukemia-Lymphoma, Adult T-Cell, Antigens, CD34, Thrombosis, Herpesviridae Infections
Abstract

We report on a 19-month-old boy with refractory T-cell acute lymphoblastic leukemia who underwent allogeneic peripheral blood stem cell transplantation using positively selected CD34 cells from his HLA two-loci mismatched mother. The conditioning regimen consisted of busulfan (140 mg/m2/d for 2 days), total body irradiation (12 Gy) and melphalan (210 mg/m2). The patient received cyclosporin A for graft-versus-host disease (GVHD) prophylaxis. The CD34-positive cells were separated using an immunomagnetic cell-separation system (Isolex 50). The number of infused CD34-positive cells was 4.4 x 10(6)/kg. Successful engraftment was confirmed on day 14 by fluorescent in situ hybridization of X chromosomes. The patient experienced severe diarrhea due to thrombotic microangiopathy (TMA) following acute GVHD, and died on day 71 of human herpes virus type 6 pneumonitis. Stem cell transplantation using CD34 positively selected cells from HLA-mismatched related donors may be a useful treatment with low incidence of severe GVHD, but many problems remain to be overcome, including severe viral infections and TMA.

38. Update on the Combined Analysis of Muon Measurements from Nine Air Shower Experiments

Author

Soldin, D., Fomin, Yu A., Kalmykov, N. N., Karpikov, I. S., Kulikov, G. V., Kuznetsov, M. Yu, Rubtsov, G. I., Sulakov, V. P., Troitsky, S. V., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves, A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., Balagopal, A. V., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H, Becker Tjus, J., Bellenghi, C., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., Clercq, C., Delaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S., Desai, A., Desiati, P., Vries, K. D., Wasseige, G., With, M., Deyoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., Duvernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Mcelroy, T., Mcnally, F., Mead, J. V., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez Los Heros, C., Peters, L., Peterson, J., Philippen, S., Pieloth, D., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. 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M., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Garcia Vegas, A. L., Gemmeke, H., Gesualdi, F., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Hebbeker, T., Hojvat, C., Horvath, P., Hrabovský, M., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Karastathis, N., Keilhauer, B., Kemp, J., Khakurdikar, A., Kizakke Covilakam, V. V., Kleifges, M., Kleinfeller, J., Köpke, M., Kunka, N., Lago, B. L., Lang, R. G., Langner, N., Leigui Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., Luce, Q., Lundquist, J. P., Machado Payeras, A., Mancarella, G., Mandat, D., Manning, B. 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V., Ksenofontov, L. T., Lebedev, K. G., Matarkin, S. V., Mokhnachevskaya, V. P., Neustroev, N. I., Petrov, I. S., Proshutinsky, A. S., Sabourov, A. V., Sleptsov, I. Ye, Struchkov, G. G., Timofeev, L. V., and Yakovlev, B. B.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Nuclear physics, Shower, Air shower, Orders of magnitude (time), High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Over the last two decades, various experiments have measured muon densities in extensive air showers over several orders of magnitude in primary energy. While some experiments observed differences in the muon densities between simulated and experimentally measured air showers, others reported no discrepancies. We will present an update of the meta-analysis of muon measurements from nine air shower experiments, covering shower energies between a few PeV and tens of EeV and muon threshold energies from a few 100 MeV to about 10 GeV. In order to compare measurements from different experiments, their energy scale was cross-calibrated and the experimental data has been compared using a universal reference scale based on air shower simulations. Above 10 PeV, we find a muon excess with respect to simulations for all hadronic interaction models, which is increasing with shower energy. For EPOS-LHC and QGSJet-II.04 the significance of the slope of the increase is analyzed in detail under different assumptions of the individual experimental uncertainties., Presented at the 37th International Cosmic Ray Conference (ICRC 2021)

39. [Hereditary hemoglobin H disease in Japanese siblings diagnosed by human parvovirus B19 infection]

Author

Hayakawa A, Sano K, Daiichiro Hasegawa, Kosaka Y, Nakamura H, Ideguchi H, and Harano T

Subjects
Family Health, alpha-Thalassemia, Parvovirus B19, Human, Erythema Infectiosum, Humans, Female, Child
Abstract

Hereditary hemoglobin H (HbH) disease was diagnosed in 2 Japanese sisters who presented with aplastic crisis following acute human parvovirus B19 (HPV B19) infection. The proband, an 8-year-old girl, developed persistent fever and pallor, and samples of her peripheral blood showed hypochromic microcytic anemia. Other laboratory data were consistent with hemolytic anemia. Fever and signs of hypochromic microcytic anemia also developed in her sister 9 days later. Cation exchange HPLC analysis of their hemoglobin revealed abnormal hemoglobin migrating faster than HbF, a finding consistent with HbH. Although they presented neither arthralgia nor skin rash, we concluded that their aplastic crisis was induced by HPV B19, because HPV B19 DNA was detected in samples of their peripheral blood by PCR analysis, and HPV B19 IgM and IgG antibody titers were elevated. A genetic analysis of the alpha-globin gene in both sisters and their parents disclosed that the father was heterozygous for alpha-Thal-2, the mother, heterozygous for alpha-Thal-1, and the proband and her sister, double heterozygous for alpha-Thal-1 and alpha-Thal-2. alpha-Thal-2 is a 3.7 kb-deletion allele.

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