332 results on '"Sang Jae, Park"'
Search Results
2. Refining Classification of Cholangiocarcinoma Subtypes via Proteogenomic Integration Reveals New Therapeutic Prospects
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Soo Young Cho, Heeyoun Hwang, Yun-Hee Kim, Byong Chul Yoo, Nayoung Han, Sun-Young Kong, Min-Jeong Baek, Kyung-Hee Kim, Mi Rim Lee, Jae Gwang Park, Sung-Sik Han, Woo Jin Lee, Charny Park, Jong Bae Park, Jin Young Kim, Sang-Jae Park, and Sang Myung Woo
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Hepatology ,Gastroenterology - Published
- 2023
3. Postoperative Poor Oral Intake After Distal Pancreatectomy
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Hyeong Min PARK, Sang-Jae PARK, Mee Joo KANG, Sung-Sik HAN, and Sun-Whe KIM
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Endocrinology ,Hepatology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Materials Science - Published
- 2022
4. Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea‐Japan collaborative study
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Hyung Sun Kim, Woojin Kim, Itaru Endo, Jin‐Young Jang, Hongbeom Kim, Ki Byung Song, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Sang‐Jae Park, Sung‐Sik Han, Yoo‐Seok Yoon, Jae Do Yang, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Yanagimoto, Tetsuo Ajiki, Masayuki Ohtsuka, Daisuke Suzuki, Dong‐Shik Lee, Yuji Kitahata, Koji Amaya, Jun Sakata, Hyung Il Seo, Junichiro Yamauchi, Yasuhiro Yabushita, Takayuki Tanaka, Naoki Sakurai, Teijiro Hirashita, Akihiko Horiguchi, Michiaki Unno, Dong Do You, Yo‐ichi Yamashita, Shogo Kobayashi, Yusuke Kyoden, Takao Ide, Hiroaki Nagano, Masafumi Nakamura, Hiroki Yamaue, Masakazu Yamamoto, and Joon Seong Park
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Hepatology ,Surgery - Abstract
In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence-free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study.A total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5-year OS and 3-year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell's concordance index (C-index) and calibration curves using bootstrapping.A total of 2007 and 1873 patients were collected for nomogram construction to predict 5-year OS and 3-year RFS. We developed four types of nomograms, including models for 5-year OS and 3-year RFS in patients who did not receive postoperative adjuvant therapy, and 5-year OS and 3-year RFS in patients who received postoperative adjuvant therapy. The C-indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766-0.823), 0.712 (95% CI: 0.674-0.750), 0.804 (95% CI: 0.7778-0.829), and 0.703 (95% CI: 0.669-0.737), respectively.This predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients.
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- 2022
5. Do jejunal veins matter during pancreaticoduodenectomy?
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Mee Joo Kang, Sung-Sik Han, Sang-Jae Park, Hyeong Min Park, and Sun-Whe Kim
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Transplantation ,Hepatology ,Gastroenterology ,Surgery - Abstract
When planning pancreaticoduodenectomy for pancreatic head cancer, the prevalence of anatomical variation of the proximal jejunal vein (PJV), the associated short-term surgical outcomes, and the level of PJV convergence to the superior mesenteric vein must be carefully analyzed from both technical and oncological points of view. The prevalence of the first jejunal trunk (FJT) and PJV located ventral to the superior mesenteric artery is 58%-88% and 13%-37%, respectively. Patients with the FJT had a larger amount of intraoperative bleeding and a higher proportion of patients requiring transfusions compared to those without a common trunk. The risk of transfusion was higher in patients with ventral PJV compared to those with dorsal PJV. Although less frequent, sacrificing the FJT can result in fatal venous congestion of the jejunum. Therefore, a well-planned approach for pancreaticoduodenectomy, based on preoperative evaluation of anatomical variation in the PJV, may help reduce intraoperative bleeding and postoperative morbidity. Additionally, the importance of invasion into the PJVs should be revisited in terms of resectability and oncological clearance.
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- 2022
6. Randomized controlled study comparing the analgesic effects of intravenous patient-controlled analgesia and patient-controlled epidural analgesia after open major surgery for pancreatobiliary cancer
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Jangho Park, Eun Young Park, Sung-Sik Han, Hyeong Min Park, Meeyoung Lee, Soon-ae Lee, Sun-Whe Kim, Dae-hyun Kim, and Sang-Jae Park
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Analgesia, Epidural ,Analgesics, Opioid ,Pain, Postoperative ,Hepatology ,Neoplasms ,Troponin I ,Gastroenterology ,Humans ,Analgesia, Patient-Controlled - Abstract
This randomized clinical trial was performed to compare pain scales between intravenous patient-controlled analgesia (IV-PCA) and patient-controlled epidural analgesia (PCEA) in patients undergoing open surgical resection of major pancreatobiliary malignancies.One hundred ten patients were randomly assigned to the PCEA or IV-PCA group. We compared the numeric rating scale pain score during ambulation on postoperative day (PD) 2 and at rest (at 06:00, 12:00, and 18:00) from PD 1 to 7, the serum level of troponin I on PD 1, and the incidence of postoperative complications between the two groups.There were no significant differences in the pain scores during ambulation on PD 2, at rest up to PD 7, serum troponin I level, and postoperative complication rates. The incidences of nausea (20.4% vs. 6.3%; p = 0.039) and drowsiness (20.4% vs. 0%; p = 0.001) were higher in the IV-PCA group and the rate of dysuria (0% vs. 14.6%; p = 0.004) was higher in the PCEA group.PCEA showed no superiority over IV-PCA in terms of postoperative pain relief or morbidity after major open surgery for pancreatobiliary malignancies. The method of analgesia should be considered based the characteristics of the patient, surgeon, anesthesiologist, and institute.
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- 2022
7. Functional Separator Decorated with Polydopamine and Halloysite Nanotubes to Boost Li+ Transfer in Lithium Metal Batteries
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Yong Min Kim, Sang Jae Park, Le Thi Thao, Jeong Hyeon Yoo, Yoon Bo Sim, Hami Lee, Junyoung Mun, and Ki Jae Kim
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Biomaterials ,Renewable Energy, Sustainability and the Environment ,Materials Chemistry ,Energy Engineering and Power Technology - Published
- 2023
8. Effect of perioperative fluid volume restriction on the incidence of complications following pancreaticoduodenectomy
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Jangho Park, Sung‐Sik Han, Sang‐Jae Park, Mee Joo Kang, Hyeong Min Park, Jihye Yu, and Sun‐Whe Kim
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Pancreatic Fistula ,Postoperative Complications ,Risk Factors ,Incidence ,Humans ,Surgery ,General Medicine ,Acute Kidney Injury ,Pancreaticoduodenectomy ,Retrospective Studies - Abstract
Perioperative fluid restriction has been suggested to reduce morbidity and length of stay. The purpose of this study was to compare the morbidity following pancreaticoduodenectomy (PD) between fluid restriction group and conventional management group.Seventy-two patients were enrolled for perioperative fluid restriction of PD. During the operation, main fluid was infused at a rate of less than 8 mL/kg/hr. Until POD#3, 10% dextrose and Hartmann's solution were administered at rates of 40 mL/h and {(1.5*body weight) - 42} mL/h, respectively. The historical control group consisted of 139 patients. We compared the rates of major complication (Clavien-Dindo grade III to V) and clinically relevant postoperative pancreatic fistula (CR-POPF), length of hospital stays (LOS), amount of urine output, and the rate of acute kidney injury (AKI).The rates of major complication (19.0% versus 18.7%; p 0.999), CR-POPF (15.5% versus 15.1%; p 0.999), and LOS (19 days [range: 10-52] versus 19 days [range: 11-75]; p = 0.514) were comparable in the study and the control group, respectively. Amount of urine output during the operation and from POD#1 to POD#3 was more than minimal amount (0.5 mL/kg/hr) in the both groups. Incidence rate of AKI in the study group was not higher than the control group (Stage I: 1.7% versus 2.9%, p 0.999; stage II: 0% versus 1.4%, p 0.999).There was no decrease in incidence of morbidity including POPF following PD with perioperative fluid restriction. Fluid restriction was feasible because it did not reduce urine output and did not increase incidence of AKI.
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- 2022
9. Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma
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Kum Hei Ryu, Sunhwa Park, Jung Won Chun, Eunhae Cho, Jongmun Choi, Dong-Eun Lee, Hyoeun Shim, Yun-Hee Kim, Sung-Sik Han, Sang-Jae Park, Sang Myung Woo, and Sun-Young Kong
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Cancer Research ,Oncology - Published
- 2023
10. Features of <scp>T1</scp> pancreatic cancer and validation of the eighth edition <scp>AJCC</scp> staging system definition using a <scp>Korean–Japanese</scp> joint cohort and the <scp>SEER</scp> database
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Wooil Kwon, Jin Seok Heo, In Woong Han, Chang Moo Kang, Ho Kyoung Hwang, Song Cheol Kim, Sang‐Jae Park, Yoo‐Seok Yoon, Yong Hoon Kim, Chang‐Sup Lim, Seung Yeoun Lee, Taesung Park, Hideki Takami, Nobuyuki Watanabe, Yasuhiro Shimizu, Masataka Okuno, Hiroki Yamaue, Manabu Kawai, Hirono Seiko, Yuichi Nagakawa, Hiroaki Osakabe, Teiichi Sugiura, Hirochika Toyama, Masayuki Ohtsuka, Michiaki Unno, Itaru Endo, Minoru Kitago, and Jin‐Young Jang
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Hepatology ,Surgery - Published
- 2023
11. Selective Conversion of Malononitrile and Unprotected Carbohydrates to Bicyclic Polyhydroxyalkyl Dihydrofurans Using Magnesium Oxide as a Recyclable Catalyst
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Nima Ronaghi, Elizabeth V. Jones, Hyun June Moon, Sang Jae Park, Christopher W. Jones, and Stefan France
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Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2022
12. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis
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Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, and Hyo-Jin An
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Male ,Plant Extracts ,Prostate ,Prostatic Hyperplasia ,Apoptosis ,Dihydrotestosterone ,General Chemistry ,Zea mays ,Rats ,Testosterone Propionate ,Anthocyanins ,Rats, Sprague-Dawley ,Phosphatidylinositol 3-Kinases ,Animals ,Humans ,Testosterone ,General Agricultural and Biological Sciences ,Cell Proliferation - Abstract
Purple corn (
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- 2022
13. CO2 methanation reaction pathways over unpromoted and NaNO3-promoted Ru/Al2O3 catalysts
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Sang Jae Park, Xiang Wang, Madelyn R. Ball, Laura Proano, Zili Wu, and Christopher W. Jones
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Catalysis - Abstract
Catalytic CO2 sorbents, materials that adsorb and pre-concentrate CO2 on the catalyst surface prior to subsequent conversion, are becoming important materials in CO2 capture and utilization.
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- 2022
14. Extended Cholecystectomy (Including Segment IVb and V Resection)
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Sang-Jae Park
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- 2023
15. Heukharang Lettuce (Lactuca Sativa L.) Extract Displays Sleep-Promoting Effects Through GABA A Receptor
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Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, and Kyungae Jo
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- 2023
16. Perioperative Management of Morbidly Obese Patients during Major Abdominal Surgery
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Byeong-Gon Na and Sang-Jae Park
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- 2021
17. Establishment of Patient-derived Preclinical Models for Invasive Papillary Cholangiocarcinoma
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Benjamin, Mwesige, Mi Rim, Lee, Yu-Sun, Lee, Na Young, Han, Ji Eun, Im, Joon-Ki, Kim, Sun Il, Choi, En Kyung, Hong, A-Ra, Jeon, Sang-Jae, Park, Sang Myung, Woo, and Yun-Hee, Kim
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Keratin-19 ,Cancer Research ,Mucin-1 ,Antineoplastic Agents ,General Medicine ,Mucin 5AC ,Xenograft Model Antitumor Assays ,Carcinoma, Papillary ,Cholangiocarcinoma ,Gene Expression Regulation, Neoplastic ,Disease Models, Animal ,Mice ,Oncology ,Cell Line, Tumor ,Animals ,Humans ,Female ,Transcriptome ,Aged ,Cell Proliferation - Abstract
Invasive papillary cholangio-carcinoma (IPC) is a minor subtype of extrahepatic cholangiocarcinoma. However, its etiology and characteristics remain unknown because of the unavailability of in vitro and in vivo models. We aimed to establish a novel preclinical model for translational research of IPC.A patient-derived xenograft (PDX) was engrafted in NOG mice and the cell line National Cancer Center human IPC (NCChIPC) was subsequently established from the PDX tumors. Immunohistochemistry and RNA-sequencing were used to determine the retention of original characteristics of patient tissues.PDX tumors showed successful amplification, and the NCChIPC-derived xenograft largely retained the histopathological features of the original tumor with CK19, MUC1 and MUC5AC expression. Transcriptome analysis showed a high correlation between patient and preclinical models. Additionally, anticancer drugs response was analyzed in the NCChIPC PDX.These novel preclinical models here will help elucidate IPC etiology and facilitate translational research.
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- 2021
18. Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer
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Zahra Nouri, Sung Weon Choi, Il Ju Choi, Keun Won Ryu, Sang Myung Woo, Sang-Jae Park, Woo Jin Lee, Wonyoung Choi, Yuh-Seog Jung, Seung-Kwon Myung, Jong-Ho Lee, Joo-Yong Park, Zeba Praveen, Yun Jung Woo, Jin Hee Park, and Mi Kyung Kim
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Cancer Research ,Oncology ,oral microbiota ,machine learning ,SCFAs ,FFAR2 ,TNFAIP8 ,IL-6/STAT3 ,cancer onset - Abstract
The association between oral microbiota and cancer development has been a topic of intense research in recent years, with compelling evidence suggesting that the oral microbiome may play a significant role in cancer initiation and progression. However, the causal connections between the two remain a subject of debate, and the underlying mechanisms are not fully understood. In this case–control study, we aimed to identify common oral microbiota associated with several cancer types and investigate the potential mechanisms that may trigger immune responses and initiate cancer upon cytokine secretion. Saliva and blood samples were collected from 309 adult cancer patients and 745 healthy controls to analyze the oral microbiome and the mechanisms involved in cancer initiation. Machine learning techniques revealed that six bacterial genera were associated with cancer. The abundance of Leuconostoc, Streptococcus, Abiotrophia, and Prevotella was reduced in the cancer group, while abundance of Haemophilus and Neisseria enhanced. G protein-coupled receptor kinase, H+-transporting ATPase, and futalosine hydrolase were found significantly enriched in the cancer group. Total short-chain fatty acid (SCFAs) concentrations and free fatty acid receptor 2 (FFAR2) expression levels were greater in the control group when compared with the cancer group, while serum tumor necrosis factor alpha induced protein 8 (TNFAIP8), interleukin-6 (IL6), and signal transducer and activator of transcription 3 (STAT3) levels were higher in the cancer group when compared with the control group. These results suggested that the alterations in the composition of oral microbiota can contribute to a reduction in SCFAs and FFAR2 expression that may initiate an inflammatory response through the upregulation of TNFAIP8 and the IL-6/STAT3 pathway, which could ultimately increase the risk of cancer onset.
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- 2023
19. Incidence, mortality and survival of gallbladder, extrahepatic bile duct, and pancreatic cancer using Korea central cancer registry database: 1999-2019
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Mee Joo Kang, E Hwa Yun, Kyu-Won Jung, and Sang-Jae Park
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Transplantation ,Hepatology ,Gastroenterology ,Surgery - Abstract
In Korea, pancreatic cancer and "gallbladder and extrahepatic bile duct cancer" were ranked the 8th and 9th most frequent cancers in 2019 and the 4th and 6th most common causes of cancer deaths in 2020, respectively.This review provides national cancer statistics and secular trends of 207,521 patients with gallbladder (n = 44,178), extrahepatic bile duct (n = 61,856), and pancreatic cancer (n = 101,487) between 1999 and 2019 in Korea.The crude incidence rate in both sexes increased in the gallbladder (2.8 to 5.4 per 100,000), extrahepatic bile duct (3.6 to 9.0), and pancreatic cancer (5.5 to 15.8). The age-standardized incidence rate in both sexes significantly increased in the extrahepatic bile duct (3.7 to 4.1) and pancreatic (5.6 to 7.6) cancers but decreased in gallbladder cancer (2.9 to 2.4). The overall 5-year relative survival rate increased in the gallbladder (21.8% to 30.6%), extrahepatic bile duct (23.1% to 27.5%), and pancreatic (8.5% to 13.3%) cancers. Between 2006 and 2019, the proportion of localized or regional stages remained stable. The proportion of surgical treatment within the first 4 months after diagnosis was relatively higher in the gallbladder (42.2%) and extrahepatic bile duct (45.9%) cancers than in pancreatic cancer (22.2%).The crude incidence and mortality rates of the gallbladder, extrahepatic bile duct, and pancreatic cancer are steadily increasing in Korea, and the prognosis remains poor. Early detection, active application of surgical treatment, and minimization of the proportion of untreated patients are required to improve the survival rates of these cancers.
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- 2022
20. Oxidative Dehydrogenation of Propane to Propylene with Soft Oxidants via Heterogeneous Catalysis
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Jonas Baltrusaitis, Bobby G. Sumpter, Zili Wu, Christopher W. Jones, Lohit Sharma, Sang Jae Park, Xiao Jiang, and Victor Fung
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010405 organic chemistry ,General Chemistry ,Oxidative phosphorylation ,Nitrous oxide ,010402 general chemistry ,Heterogeneous catalysis ,Photochemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Propane ,Carbon dioxide ,Dehydrogenation - Abstract
Oxidative dehydrogenation of propane to propylene can be achieved using conventional, oxygen-assisted dehydrogenation of propane (O2–ODHP) or via the use of soft oxidants, such as CO2, N2O, S-conta...
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- 2021
21. Synergistic effects of concurrent photodynamic therapy with indocyanine green and chemotherapy in hepatocellular carcinoma cell lines and mouse models
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Jae Sun Park, Sohyun Park, Sang-Jae Park, and Seok-Ki Kim
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Radiation ,Radiological and Ultrasound Technology ,Biophysics ,Radiology, Nuclear Medicine and imaging - Published
- 2023
22. Concentric aesthetics unraveled through play -Hyundeok Fairytale Theory
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Sang-jae Park
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Aesthetics ,media_common.quotation_subject ,Art ,Concentric ,media_common - Published
- 2020
23. Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience
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Sathathone Douangprachanh, Hyun Jin Joo, Hyeong Min Park, Nayoung Han, Hye Young Jang, Young Hwan Koh, Tae Hyun Kim, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee, Sang Myung Woo, and Jung Won Chun
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Pancreatic Neoplasms ,Neuroendocrine Tumors ,Treatment Outcome ,Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Temozolomide ,Humans ,Capecitabine ,Retrospective Studies - Abstract
Background/Aims: The combination of capecitabine and temozolomide (CAPTEM) is one of the treatment options for metastatic pancreatic neuroendocrine neoplasms (pNENs). This study aims to evaluate the efficacy of CAPTEM in patients with metastatic intermediate to high-grade pancreatic neuroendocrine tumor (pNET) or carcinoma (pNEC).Methods: This study was conducted retrospectively in a single center. Patients were treated for intermediate to high-grade tumor with 750 mg/m² of capecitabine twice daily from day 1 to 14 and 200 mg/m² of temozolomide once daily from day 10 to 14, repeating twice in a cycle of 28 days. The primary outcomes were durations of overall survival (OS) and progression-free survival (PFS). The secondary outcomes consisted of objective response rate and disease control rate.Results: A total of 12 patients (grade 2 NET in six, grade 3 NET in three, NEC in three patients) who received CAPTEM were included in this study. Patients received a median of five cycles (range, 2 to 46) of CAPTEM. The median dose combined 1,150 mg of capecitabine and 300 mg of temozolomide. The median OS and PFS were 41.2 months (range, 3.2 to 167) and 39.7 months (range, 2.1 to 100), respectively. Patients with NET had longer OS and PFS compared to those of patients with NEC (p = 0.002 and p = 0.028). High Ki-67 proliferative index (> 50%) was significantly associated with poor survival outcomes.Conclusions: CAPTEM showed favorable survival outcomes in patients with metastatic intermediate to high-grade pNENs. Our study supports that CAPTEM may be an effective treatment option for metastatic pNENs.
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- 2022
24. Gastroepiploic arteriovenous shunt as a salvage treatment for hepatic artery occlusion after living donor liver transplantation
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Sang-Jae Park and Seong Hoon Kim
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medicine.medical_specialty ,Text mining ,business.industry ,Salvage treatment ,Medicine ,Artery occlusion ,business ,Living donor liver transplantation ,Letter to the Editor ,Shunt (medical) ,Surgery - Published
- 2021
25. Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study
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Jin Seok Heo, Hongbeom Kim, Heejeong Lee, Jung Hoon Kim, Yoo Seok Yoon, Ho-Seong Han, Sang Jae Park, Il Young Park, Yang Won Nah, Jung Hee Lee, Haeryoung Kim, Joo Young Kim, Hong Jin Kim, Wan-Joon Kim, Eun Kyung Hong, Seung-Mo Hong, Wooil Kwon, Chang Ho Cho, Jae Ri Kim, Hee Sung Kim, Hyung Il Seo, Kyu Yeoun Won, Hye-Jeong Choi, In Woong Han, Young Hun Roh, Kyung-Hee Kim, Jeong Mo Bae, Hyeon Kook Lee, Joon Hyuk Choi, Yu Na Kang, Wonae Lee, Chong Woo Chu, Woo Sung Moon, Kee Taek Jang, In Sang Song, Kyungbun Lee, Young Dong Yu, Sungho Jo, Shin Hwang, Seung Eun Lee, Ho Gak Kim, Hee Chul Yu, Jin Sook Jeong, Jong Sil Lee, Chang-Sup Lim, Sun Whe Kim, Min Sun Cho, Hyung Woo Park, Koo Jeong Kang, Sun Hyung Joo, Do Youn Park, Dong-Sik Kim, Kang Min Han, Jin-Young Jang, Chi Young Jeong, and Dong Wook Choi
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medicine.medical_specialty ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Survival analysis ,Intraductal Papillary Neoplasm ,Hepatology ,Bile duct ,business.industry ,Incidence (epidemiology) ,medicine.disease ,Bile Ducts, Intrahepatic ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Dysplasia ,030220 oncology & carcinogenesis ,Cohort ,030211 gastroenterology & hepatology ,Bile Ducts ,business ,Rare disease ,Cohort study - Abstract
Background IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.
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- 2020
26. Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: a Japan‐Korea collaborative study
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Hyung Il Seo, Keiichi Kubota, Sang-Jae Park, Yasuo Haruyama, Noriyoshi Fukushima, Dong Wook Choi, Yasuni Nakanuma, Dong Sup Yoon, Yoh Zen, Dong-Sik Kim, Jin Seok Heo, Eun Kyung Hong, Jaeri Kim, Yang Won Nah, Michiaki Unno, Haeryoung Kim, Masaru Miyazaki, Atsushi Nanashima, Tetsuo Ohta, Jin-Young Jang, Kazuo Inui, Takatsugu Matsumoto, Masafumi Nakamura, Takumi Fukumoto, Shinji Uemoto, Yuhki Sakuraoka, Seung-Mo Hong, Kyung Bun Lee, Joo Young Kim, Kee Taek Jang, Itaru Endo, Shin Hwang, Koo Jeong Kang, Toru Furukawa, and Ho-Seong Han
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medicine.medical_specialty ,Intrahepatic bile ducts ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,Republic of Korea ,medicine ,Humans ,In patient ,Intraductal Papillary Neoplasm ,Biliary tract neoplasm ,Invasive carcinoma ,Hepatology ,Intraductal papillary mucinous neoplasm ,Bile duct ,business.industry ,medicine.disease ,Bile Ducts, Intrahepatic ,medicine.anatomical_structure ,Bile Duct Neoplasms ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Bile Ducts ,Pancreas ,business - Abstract
BACKGROUND The prevalent location and incidence of intraductal papillary neoplasm of the bile duct (IPNB) and invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria and tumor location. METHODS IPNBs were classified into two types: Type 1 IPNB, being histologically similar to intraductal papillary mucinous neoplasm of the pancreas, and Type 2 IPNB, having a more complex histological architecture with irregular papillary branching or foci of solid-tubular components. Medical data were evaluated. RESULTS Among 694 IPNB patients, 520 and 174 had Type 1 and Type 2, respectively. The levels of AST, ALT, ALP, T. Bil, and CEA were significantly higher in patients with Type 2 than in those with Type 1. Type 1 IPNB was more frequently located in the intrahepatic bile duct than Type 2, whereas Type 2 was more frequently located in the distal bile duct than Type 1 IPNB (P
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- 2020
27. NaNO 3 ‐Promoted Mesoporous MgO for High‐Capacity CO 2 Capture from Simulated Flue Gas with Isothermal Regeneration
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Christopher W. Jones, Sang Jae Park, and Youngjo Kim
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Flue gas ,Sorbent ,Materials science ,General Chemical Engineering ,Induction period ,Sorption ,02 engineering and technology ,Partial pressure ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Isothermal process ,0104 chemical sciences ,General Energy ,Chemical engineering ,Desorption ,Environmental Chemistry ,General Materials Science ,0210 nano-technology ,Inert gas - Abstract
NaNO3 -promoted MgO composite materials have been prepared and their ability to sorb CO2 at a concentration relevant to CO2 capture from flue gas is explored. The uptake kinetics and capacities of sorbents of different NaNO3 /MgO ratios are measured at intermediate temperatures of 230-300 °C. The sorbent with a NaNO3 /MgO ratio of 0.10 has the highest 12 h sorption capacity among sorbents with different NaNO3 loadings, and the highest sorption capacity of 11.2 mmol CO2 g-1 is observed at 260 °C. Intriguingly, an induction period is observed in the initial stage of CO2 sorption. In situ XRD analysis, in situ FTIR spectroscopy, and a comparison of the CO2 sorption behavior under simulated flue gas conditions in comparison to prior studies employing pure CO2 indicated that the sorption of CO2 occurred through nucleation of MgCO3 crystallites in the material. The data indicate that the concentration of CO2 within the molten medium of NaNO3 , which is affected by both the solubility of CO2 in molten NaNO3 and the partial pressure of CO2 in the surrounding atmosphere, has a critical impact on the length of the induction period. A partially desorbed sample after sorption of CO2 displays much-improved sorption kinetics in the next cycle and was able to sorb and desorb CO2 over multiple cycles at isothermal conditions by simply switching the feed gas from CO2 to inert gas.
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- 2020
28. Effect of preoperative nutritional support in malnourished patients with pancreatobiliary cancer: a quasi-experimental study
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Hyeong Min Park, Young Hwa Kang, Dong Eun Lee, Mee Joo Kang, Sung-Sik Han, and Sang-Jae Park
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) - Abstract
Background In malnourished patients, postoperative morbidity, hospitalization period, and medical expenses are reportedly to be high. We evaluated the clinical impact of a preoperative nutritional support program (PNSP) among malnourished cancer patients. Methods For this quasi-experimental study, we enrolled 90 patients who underwent major pancreatobiliary cancer surgery. Malnutrition was defined as at least one of the following: (1) Patient-Generated Subjective Global Assessment (PG-SGA) grade B or C; (2) > 10% weight loss within 6 months; (3) body mass index 2; and (4) serum albumin level < 3.0 g/dL. Forty-five malnourished patients allocated to the PNSP group received in-hospital PNSP for a median of 6 (4–35) days. In the PNSP group, the nutrition support team calculated the patients’ daily nutritional requirements based on their nutritional status and previous day’s intake. The supplementation targets were as follows: total calorie intake, 30–35 kcal/kg/day; protein intake, 1.2–1.5 g/kg/day; and lipid intake, 1–1.5 g/kg/day. Patients who did not meet the diagnostic criteria for malnutrition were allocated to the well-nourished group and underwent surgery without receiving the PNSP (n = 45). We compared the perioperative nutritional indices (as measured using PG-SGA), postoperative outcome, and quality of life (QOL) according to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire version 3.0. Results In the PNSP group, the proportion of patients with serum prealbumin p = 0.013). Moreover, patients with PG-SGA grade A had a statistically significant increase (2.2% vs. 50%, p < 0.001). The overall and major complication rates were higher in the PNSP group than in the well-nourished group without significance (51.1%, 33.3%; 42.2%, 26.7%, respectively). However, the overall and major complication rates were similar between the subgroup with PG-SGA improvement after PNSP and the well-nourished group (40.9% vs. 42.2%, p = 0.958; 27.3% vs. 26.7%, p = 0.525, respectively). QOL indicators in the PNSP group were comparable with those in the well-nourished group after PNSP. Conclusion PNSP may improve perioperative nutritional status and clinical outcomes among malnourished patients with pancreatobiliary cancer.
- Published
- 2021
29. Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study
- Author
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Mee Joo Kang, Jiwon Lim, Sung-Sik Han, Hyeong Min Park, Sun-Whe Kim, Woo Jin Lee, Sang Myung Woo, Tae Hyun Kim, Young-Joo Won, and Sang-Jae Park
- Subjects
Multidisciplinary ,Biliary Tract Neoplasms ,Humans ,General Materials Science ,Prognosis ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern and prognosis of BTC according to tumor location using the Korea Central Cancer Registry data of 97,676 patients with BTC from 2006 to 2017. The proportion of localized and regional Surveillance, Epidemiology, and End Results (SEER) stage was the highest in ampulla of Vater (AoV, 78.2%) cancer, followed by extrahepatic bile duct (BD, 68.3%), gallbladder (GB, 52.6%), and intrahepatic BD (49.5%) cancers. Overall, the “no active anti-cancer treatment” rate was the highest in intrahepatic BD (52.8%), followed by extrahepatic BD (49.5%), GB (39.6%), and AoV cancers (28.9%). The 5-year relative survival rate was the highest in AoV (48.5%), followed by GB (28.5%), extrahepatic BD (19.9%), and intrahepatic BD (10.8%) cancers, which significantly improved over time, except for intrahepatic BD cancer. In the localized and regional stage, older patients had a higher risk of receiving no active anti-cancer treatment in each tumor location after adjusting for period and sex. BTC statistics should be reported separately according to tumor location due to its distinct SEER stage distribution, treatment pattern, and prognosis. Care should be taken in elderly patients to reduce the rate of no active anti-cancer treatment.
- Published
- 2021
30. Poly(glycidyl amine)-Loaded SBA-15 Sorbents for CO2 Capture from Dilute and Ultradilute Gas Mixtures
- Author
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Bo Hu, Sang Jae Park, Eric W. Ping, Dharam R. Kumar, Christopher W. Jones, Achintya Sujan, and Miles A. Sakwa-Novak
- Subjects
chemistry.chemical_classification ,Flue gas ,Materials science ,Polymers and Plastics ,Chemical engineering ,chemistry ,Process Chemistry and Technology ,Organic Chemistry ,Amine gas treating ,Polymer ,Co2 adsorption ,Ambient air - Abstract
Solid-supported amine-based polymers are known to be effective for CO2 capture from dilute streams, including flue gas and ambient air. In this work, we report the synthesis of well-defined poly(gl...
- Published
- 2019
31. CO2 Adsorption and Oxidative Degradation of Silica-Supported Branched and Linear Aminosilanes
- Author
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Christopher W. Jones, Chun-Jae Yoo, and Sang Jae Park
- Subjects
Chemistry ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,Oxidative phosphorylation ,Mesoporous silica ,021001 nanoscience & nanotechnology ,Co2 adsorption ,Industrial and Manufacturing Engineering ,Adsorption ,020401 chemical engineering ,Chemical engineering ,lipids (amino acids, peptides, and proteins) ,0204 chemical engineering ,0210 nano-technology - Abstract
An array of aminosilanes is synthesized and grafted onto a mesoporous silica support to evaluate the effect of aminosilane structure on CO2 adsorption and oxidative stability. Both linear (NH2(CH2)...
- Published
- 2019
32. Effects of Sarcopenia on Prognosis After Resection of Gallbladder Cancer
- Author
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Seung Duk Lee, Eung Chang Lee, Sang-Jae Park, Sung-Sik Han, and Seong Hoon Kim
- Subjects
Sarcopenia ,medicine.medical_specialty ,Multivariate analysis ,Disease ,030230 surgery ,Gastroenterology ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Adjuvant therapy ,Humans ,Stage (cooking) ,Gallbladder cancer ,Retrospective Studies ,business.industry ,Hazard ratio ,Prognosis ,medicine.disease ,Survival Rate ,030220 oncology & carcinogenesis ,Gallbladder Neoplasms ,Surgery ,business - Abstract
This study aimed to determine the prognostic significance of radiographic sarcopenia (RS) in patients with gallbladder cancer (GBC). From March 2001 to December 2013, 158 GBC patients who underwent curative intent surgery were included. The presence of RS was determined by skeletal muscle mass index using abdominal computed tomography. The 1-, 3-, and 5-year overall survival (OS) rates were 63.6%, 41.9%, and 36.4%, respectively, for patients with RS (n = 88), and 84.3%, 62.6%, and 54.3%, respectively, for those without RS (n = 70) (P = 0.006). Multivariate analysis showed that RS (hazard rate [HR] 1.704, P = 0.024) was a significant prognostic factor for patient survival, as well as disease stage (IV: HR 7.181, P
- Published
- 2019
33. CO2 and SO2 Interactions with Methylated Poly(ethylenimine)-Functionalized Capacitive Micromachined Ultrasonic Transducers (CMUTs): Gas Sensing and Degradation Mechanism
- Author
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Sang Jae Park, Christopher W. Jones, Jonas Baltrusaitis, Darius Viržonis, Gailius Vanagas, Dovydas Barauskas, Jason J. Lee, and Donatas Pelenis
- Subjects
Mechanism (engineering) ,Capacitive micromachined ultrasonic transducers ,Materials science ,business.industry ,Acid gas ,Capacitive sensing ,Materials Chemistry ,Electrochemistry ,Optoelectronics ,Degradation (geology) ,Ultrasonic sensor ,business ,Electronic, Optical and Magnetic Materials - Abstract
A capacitive micromachined ultrasonic transducer (CMUT)-based sensor modified with methylated poly(ethylenimine) (mPEI) was designed and tested for the detection of two acidic gases: carbon dioxide...
- Published
- 2019
34. Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?
- Author
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Wooil Kwon, Jin-Young Jang, Joo Seop Kim, Sang-Jae Park, Seungyeon Lee, Joon Seong Park, Jae Seung Kang, Sung-Sik Han, Tae Ho Hong, Chang-Sup Lim, Jae Ri Kim, Youngmin Han, Dong Wook Choi, Sun-Whe Kim, Hongbeom Kim, Dong Sup Yoon, Jin Seok Heo, Taesung Park, Sae-Byeol Choi, Song Cheol Kim, and Seong Ho Choi
- Subjects
medicine.medical_specialty ,Hepatology ,Receiver operating characteristic ,business.industry ,Endocrinology, Diabetes and Metabolism ,Hazard ratio ,Gastroenterology ,External validation ,030230 surgery ,University hospital ,medicine.disease ,Confidence interval ,03 medical and health sciences ,Editorial ,0302 clinical medicine ,Lower body ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Original Article ,Mass index ,business - Abstract
Background: Although several prediction models for the occurrence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD) exist, all were established using Western cohorts. Large-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index (BMI) are scarce. The purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean cohorts. Methods: Nine tertiary university hospitals in the Republic of Korea participated. Patients’ preoperative characteristics, intraoperative factors, and pathologic findings were evaluated. POPF grades were determined according to the 2016 International Study Group on Pancreatic Surgery definition. Three POPF risk models (Callery, Roberts, and Mungroop) were selected for external validation. Results: A total of 1,898 PD patients were enrolled. A non-pancreatic disease diagnosis [hazard ratio (HR), 1.856; 95% confidence interval (CI), 1.223–2.817; P=0.004), higher preoperative BMI (HR, 1.069; 95% CI, 1.019–1.121; P=0.006), and soft pancreatic texture (HR, 1.859; 95% CI, 1.264–2.735; P=0.002) were independent risk factors for clinically relevant POPF (CR-POPF). The area under the receiver operating characteristic curve (AUC) values were 0.61, 0.64, and 0.63 on the Callery, Roberts, and Mungroop models, respectively; all were lower than those published in each external validation study. Conclusions: Western POPF prediction models performed less well when applied to Korean cohorts. Thus, a large-scale Eastern-specific and externally validated POPF prediction model is needed.
- Published
- 2019
35. Impact of ABO-incompatibility on hepatocellular carcinoma recurrence after living donor liver transplantation
- Author
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Byung Gon Na, Sang-Jae Park, Seong Hoon Kim, and Eung Chang Lee
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Kaplan-Meier Estimate ,030230 surgery ,Gastroenterology ,ABO Blood-Group System ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,hemic and lymphatic diseases ,Internal medicine ,ABO blood group system ,Republic of Korea ,parasitic diseases ,Living Donors ,medicine ,ABO incompatibility ,Humans ,Propensity Score ,Retrospective Studies ,business.industry ,Liver Neoplasms ,Patient survival ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,biological factors ,Liver Transplantation ,Survival Rate ,Oncology ,Blood Group Incompatibility ,Hepatocellular carcinoma ,Propensity score matching ,Female ,030211 gastroenterology & hepatology ,Surgery ,Rituximab ,Neoplasm Recurrence, Local ,Living donor liver transplantation ,business ,medicine.drug - Abstract
Background ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) has been reported to have acceptable outcomes in the era of rituximab-based prophylaxis. However, the outcomes of ABO-I LDLT for hepatocellular carcinoma (HCC) remain to be elucidated. This study aimed to clarify the impact of ABO-Incompatibility on oncologic outcomes of LDLT for HCC. Methods Patients with HCC who underwent ABO-I LDLT were randomly matched by 1:2 ratio to those who underwent ABO-compatible (ABO-C) LDLT according to propensity score. HCC recurrence and patient survival were analyzed using the Kaplan-Meier method and log-rank test. Results Between January 2012 and December 2015, a total of 160 patients underwent LDLT for HCC confirmed by pathology analysis of liver explants. Thirty-nine consecutive patients underwent ABO-I LDLT for HCC, and 78 ABO-C LDLT patients were selected by propensity score matching, which made no significant difference between the two groups in baseline, perioperative, and tumor characteristics. The 1-, 3-, and 5-year recurrence-free survival rates in the ABO-I and ABO-C LDLT groups were 76.9%, 68.5%, 63.6% and 74.4%, 70.5%, 70.5%, respectively (p = 0.77). The site distribution of initial recurrence showed no significant difference between the two groups. The overall survival rates over the same period in the ABO-I and ABO-C LDLT groups were 82.1%, 73.5%, 73.5% and 92.2%, 80.3%, 80.3%, respectively (p = 0.34). Conclusions ABO-I LDLT, having no adverse impact on oncological outcomes, can be a feasible transplant option for HCC.
- Published
- 2019
36. Cytopathological results of initial endoscopic ultrasound‐guided fine needle aspiration for primary mass and prognosis in pancreatic cancer patients
- Author
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Ju Hee Lee, Sang-Jae Park, Sung-Sik Han, Tae Hyun Kim, Woojin Lee, Sang Myung Woo, Jung Hwan Lee, and Eun Kyung Hong
- Subjects
Adult ,Male ,Endoscopic ultrasound ,medicine.medical_specialty ,Histology ,Cytodiagnosis ,030209 endocrinology & metabolism ,Gastroenterology ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Pancreatic cancer ,Internal medicine ,Atypia ,medicine ,Humans ,Stage (cooking) ,skin and connective tissue diseases ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Pancreas ,Aged ,medicine.diagnostic_test ,business.industry ,Proportional hazards model ,Hazard ratio ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Pancreatic Neoplasms ,Fine-needle aspiration ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Objectives Clinical outcomes remain unclear in patients suspected of having pancreatic cancer with indeterminate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) results. This work aimed to investigate the prognosis of pancreatic cancer patients with indeterminate findings at initial EUS-FNA. Methods Findings in all patients who underwent EUS-FNA for suspected pancreatic cancer between 2008 and 2015 at the National Cancer Center, Korea, were retrospectively reviewed. A final diagnosis of pancreatic ductal adenocarcinoma was based on pathology reports. Results Of the 144 patients evaluated, 113 (78%) were diagnosed as being positive/suspicious for malignancy on cytological evaluation and 31 (22%) as having atypia/negative/non-diagnostic findings at initial EUS-FNA but subsequently diagnosed with pancreatic ductal adenocarcinoma. Tumour size, clinical stage and treatment modalities did not differ significantly between these two groups. Median overall survival was significantly shorter in patients diagnosed (11.3 ± 0.74 months; 95% confidence interval [CI], 9.4-12.8 months) than non-diagnosed (16.9 ± 2.34 months; 95% CI, 12.0-17.4 months) on initial EUS-FNA (P = .024). Multivariate Cox regression analysis showed that a non-diagnosis on initial EUS-FNA was independently associated with better overall survival (hazard ratio, 0.58; 95% CI, 0.38-0.88; P = .011). Conclusions Non-diagnostic results on initial EUS-FNA of a primary mass may be associated with better prognosis in patients with pancreatic cancer.
- Published
- 2019
37. Self-powered wearable keyboard with fabric based triboelectric nanogenerator
- Author
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Sang-Jae Park, Joon-Kyu Han, Yang-Kyu Choi, Daewon Kim, Seung-Bae Jeon, Weon-Guk Kim, Ik-Kyeong Jin, and Il-Woong Tcho
- Subjects
Flexibility (engineering) ,Materials science ,Renewable Energy, Sustainability and the Environment ,business.industry ,Interface (computing) ,Process (computing) ,Nanogenerator ,Wearable computer ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Key (cryptography) ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Computer hardware ,Word (computer architecture) ,Triboelectric effect - Abstract
In Internet of Things (IoT) era, electronic textiles (E-textiles), which combine various functional devices on a fabric, have attracted attention. Among various components for E-textiles, the human-machine interface device, for example, a keyboard, is one of the most important parts. The triboelectric nanogenerator (TENG) can be a powerful sensing component for the interface device due to its cost-effectiveness, design flexibility and self-powered operation. Previous studies reported fabric-based sensor devices with TENG, but as yet, no device that harnesses commercial compatibility with the textile industry has been reported. It is timely to explore a low-cost TENG-based keyboard made completely of commercial fabric for early commercialization. This paper proposes a TENG-based wearable keyboard that uses only cheap commercial fabrics. Each cell in the proposed keyboard generates electrical signals according to an external touch without any power supply. After an appropriate filtering process, the proposed keyboard can detect a key stroke without any ambiguity. We verify the keyboard operation by typing a word and playing music. The material dependency of the proposed keyboard is experimentally validated with various material pairs. Finally, the endurance of the proposed keyboard against folding, repeated touches and washing is experimentally confirmed for actual applications in a real environment.
- Published
- 2018
38. Prognostic impact of tumor vascularity on CT in resectable intrahepatic cholangiocarcinoma
- Author
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Sang-Jae Park, Hyeong Min Park, Hye Young Jang, Sun-Whe Kim, Sung-Sik Han, Dong E. Lee, and Mee J. Kang
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Hazard ratio ,Gastroenterology ,Retrospective cohort study ,Hypervascularity ,Prognosis ,Confidence interval ,Resection ,Cholangiocarcinoma ,Vascularity ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Tumor vascularity ,medicine ,Hepatectomy ,Humans ,Radiology ,medicine.symptom ,business ,Tomography, X-Ray Computed ,Intrahepatic Cholangiocarcinoma ,Retrospective Studies - Abstract
We investigated the vascularity of intrahepatic cholangiocarcinoma (ICC) on computed tomography (CT) images and its association with ICC recurrence after surgery and prognosis after recurrence.In this retrospective study, the data of patients who underwent resection with curative intent for ICC between March 2001 and July 2017 were reviewed. Clinicopathologic factors including tumor vascularity (hypovascular, rim-enhancement, and hypervascular) on CT that could affect recurrence-free survival (RFS) were assessed. The association between the vascularity of recurrent ICC and survival after recurrence was also analyzed.Overall, 147 patients were enrolled and followed up for a median of 36.1 months of which, 101 (68.7%) experienced ICC recurrence. Hypervascularity of ICC showed better RFS than other vascularities [rim-enhanced image hazard ratio (HR), 3.893; 95% confidence interval (CI), 1.700-8.915, p = 0.001; hypovascular image HR, 6.241; 95% CI, 2.670-14.586, p 0.001]. The hypervascular recurrent ICC was also significantly associated with better survival after recurrence (log-rank test, p 0.001).Hypervascular ICC was associated with a longer RFS and better prognosis after recurrence. The vascularity of ICC on CT may be a noninvasive, accessible, and useful prognostic index, and should be considered while planning treatment.
- Published
- 2021
39. Impact of changes in the topographic classification of Klatskin tumor on incidence of intra- and extrahepatic bile duct cancer: A population-based national cancer registry study
- Author
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Sun Whe Kim, Sang-Jae Park, Sung Sik Han, Mee Joo Kang, Young-Joo Won, Hyeong Min Park, and Jiwon Lim
- Subjects
medicine.medical_specialty ,Population ,Extrahepatic bile duct cancer ,Bile Duct Neoplasm ,Gastroenterology ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Bile Ducts, Extrahepatic ,Internal medicine ,Epidemiology ,medicine ,Humans ,Registries ,education ,education.field_of_study ,Hepatology ,business.industry ,Incidence (epidemiology) ,Incidence ,medicine.disease ,Cancer registry ,Klatskin tumor ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Standardized rate ,business ,Klatskin Tumor - Abstract
BACKGROUND Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is highly endemic. METHODS The data of incidence, topography and morphology code of BDC from 1999 to 2017 were obtained from the Korea Central Cancer Registry, which covers the entire 51.6 million Korean population. For misclassification analysis, all Klatskin tumors were reclassified as eBDC. RESULTS Klatskin tumors accounted for 13.5% of all 81 414 BDC cases. In the registry, an average of 59.7% of Klatskin tumors were classified as iBDC, gradually decreasing from 95.5% to 16.9%. Misclassification led to a 17.3% overestimation of iBDC cases and a 15.0% underestimation of eBDC cases on average. After reclassification, age standardized rate (ASR) of incidence per 100 000 population decreased in iBDC from 3.4 to 2.9 and increased in eBDC from 2.8 to 3.2. Average annual percentage change of iBDC and eBDC incidences were 2.0% and 1.2%, respectively, but ASR of iBDC significantly decreased since 2012 (P
- Published
- 2021
40. Randomized controlled study comparing the analgesic effects of intravenous patient-controlled analgesia and patient-controlled epidural analgesia after open major surgery for pancreatobiliary cancer
- Author
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Jangho PARK, Sung-Sik HAN, Hyeong Min PARK, Sun-Whe KIM, and Sang-Jae PARK
- Subjects
General Materials Science - Published
- 2022
41. Relative value of serum amylase after pancreaticoduodenectomy as a novel predictor of clinically relevant pancreatic fistula
- Author
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Sungchun CHO, Sun-Whe KIM, Sang-Jae PARK, Sung-Sik HAN, Mee Joo KANG, and Hyeong Min PARK
- Subjects
General Materials Science - Published
- 2022
42. Impact of postoperative delirium on outcome following major hepatobiliary-pancreas surgery
- Author
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Sungchun CHO, Sang-Jae PARK, Sun-Whe KIM, Sung-sik HAN, Hyeong Min PARK, Seunghoon KIM, Jongheun KIM, and Mee Joo KANG
- Subjects
General Materials Science - Published
- 2022
43. Prevalence of psychological symptoms in patients undergoing pancreatoduodenectomy and results of a distress management system: A clinic-based study
- Author
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Mee Joo Kang, Eun-Seung Yu, Young Hwa Kang, Hyeong Min Park, Sang-Jae Park, Sun-Whe Kim, Jong-Heun Kim, and Sung-Sik Han
- Subjects
Cancer Research ,Oncology ,Depression ,Sleep Initiation and Maintenance Disorders ,Prevalence ,Humans ,General Materials Science ,Stress, Psychological ,Pancreaticoduodenectomy ,Retrospective Studies - Abstract
PurposePatients undergoing pancreatoduodenectomy are a high-risk group that requires psychosocial support. This study retrospectively reviewed the prevalence of psychological symptoms in patients undergoing pancreatoduodenectomy for periampullary neoplasm and the psychosocial referral rate after implementing full screening and triage algorithm for administering a distress management protocol based on the integrated supportive care system established in 2010.Materials and MethodsFrom September 2010 to December 2018, insomnia, anxiety, and depression were screened on the first day of admission (T1) and on the 10th postoperative day (T2). Patients with clinical levels of distress were referred to a mental health clinic for appropriate aftercare. ResultsThe adherence rate to routine screening was 82.7% (364/440). Among the 364 patients, the prevalence of insomnia, anxiety, and depression increased from 22.0% (T1) to 32.6% (T2, p=0.001), 29.1% to 33.6% (p=0.256), and 18.4% to 27.6% (p=0.001), respectively. Less than 45% of those with psychological symptoms expressed their needs for psychological supportive care. Among those with psychological symptoms at T2, clinical insomnia, anxiety, and depression were detected via in-depth evaluations among 77.2%, 38.1%, and 82.5% of patients, respectively. Patients who had two or more symptoms at T2 had a longer postoperative hospital stay, as compared to those with one or no symptoms (a median of 20.5 days vs. 18.0 days, p=0.006). Psychiatric consultation rate was 72.8% among patients with clinical psychological symptoms, and 74% of the consulted patients completed psychiatric intervention before discharge.ConclusionOver one-third of the patients had psychological symptoms before and after pancreatoduodenectomy. Implementing a routine psychological symptoms screening with a systematic psychiatric referral protocol enhanced surgeons’ responsiveness to patients’ psychological symptoms.
- Published
- 2022
44. Near-infrared phototherapy for patient-derived orthotopic xenograft model of hepatocellular carcinoma in combination with indocyanine green
- Author
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Jae Sun Park, Felix Hong, Seungwon Kim, Sang-Jae Park, and Seok-Ki Kim
- Subjects
Indocyanine Green ,Male ,Carcinoma, Hepatocellular ,genetic structures ,Infrared Rays ,medicine.medical_treatment ,030303 biophysics ,Biophysics ,Photodynamic therapy ,02 engineering and technology ,Models, Biological ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,Cell Line, Tumor ,Medicine ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Nir laser ,Cytotoxicity ,0303 health sciences ,Treated group ,Radiation ,High survival rate ,Radiological and Ultrasound Technology ,business.industry ,Liver Neoplasms ,Middle Aged ,Phototherapy ,021001 nanoscience & nanotechnology ,medicine.disease ,eye diseases ,chemistry ,Hepatocellular carcinoma ,Cancer cell ,Cancer research ,Heterografts ,0210 nano-technology ,business ,Indocyanine green - Abstract
Background Hepatocellular carcinoma notably takes up and retains indocyanine green (ICG). Here, we investigated whether patient-derived orthotopic xenograft of hepatocellular carcinoma could accumulate ICG and show full remission via phototherapy. Methods NIR light and ICG were tested for cytotoxicity in cancerous cell lines (Huh-7, Hep3B). Patient-derived orthotopic xenograft (PDoX) mice were subjected to phototherapy comprising of daily NIR exposure (0.5–1.75 W/cm2) and intravenous injection of ICG (5–20 mg/kg2). Moreover, NIR laser was flashed on individual mouse until hepatocellular carcinoma completely loss the fluorescence, as determined by NIR camera. Results Cytotoxicity increased in response to the input energy, but insufficient energy ( Conclusions ICG could potentiate the tumoricidal ability of NIR light in a dose-dependent manner, and vice versa. Regardless of ICG dosage, however, phototherapy treated group showed a relatively high survival rate compared to the non-treated group. Notably, real-time phototherapy could halve the effective ICG dosage for full remission of deep-seated tumor.
- Published
- 2020
45. Propensity score-matched analysis of internal stent vs external stent for pancreatojejunostomy during pancreaticoduodenectomy: Japanese-Korean cooperative project
- Author
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Wataru Izumo, Sun Whe Kim, Hongbeom Kim, Ki Byung Song, Sohei Satoi, Masakazu Yamamoto, Toshio Shimokawa, Sang-Jae Park, Song Cheol Kim, Seiko Hirono, Seong Ho Choi, Jin-Young Jang, Hiroki Yamaue, Joo Seop Kim, Sae Byeol Choi, Michiaki Unno, Joon Seong Park, Hee Chul Yu, Masayuki Sho, Tae Ho Hong, Dong Sup Yoon, Manabu Kawai, Takumi Fukumoto, Young Joon Ahn, Jin Seok Heo, Katsuhiko Uesaka, Tsutomu Fujii, Ryosuke Amano, Masafumi Nakamura, and Ryo Ashida
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Pancreaticoduodenectomy ,Cohort Studies ,03 medical and health sciences ,Pancreatic Fistula ,0302 clinical medicine ,Postoperative Complications ,Japan ,Pancreaticojejunostomy ,Republic of Korea ,medicine ,Clinical endpoint ,Humans ,In patient ,Propensity Score ,Aged ,Aged, 80 and over ,Hepatology ,business.industry ,Incidence (epidemiology) ,Incidence ,Gastroenterology ,Pancreatic Ducts ,Stent ,Middle Aged ,equipment and supplies ,medicine.disease ,Surgery ,Clinical trial ,Treatment Outcome ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Propensity score matching ,030211 gastroenterology & hepatology ,Female ,Stents ,business - Abstract
Several studies comparing internal and external stents have been conducted with the aim of reducing pancreatic fistula after PD. There is still no consensus, however, on the appropriate use of pancreatic stents for prevention of pancreatic fistula. This multicenter large cohort study aims to evaluate whether internal or external pancreatic stents are more effective in reduction of clinically relevant pancreatic fistula after pancreaticoduodenectomy (PD).We reviewed 3149 patients (internal stent n = 1,311, external stent n = 1838) who underwent PD at 20 institutions in Japan and Korea between 2007 and 2013. Propensity score matched analysis was used to minimize bias from nonrandomized treatment assignment. The primary endpoint was the incidence of clinically relevant pancreatic fistula. This study was registered on the UMIN Clinical Trials Registry (UMIN000032402).After propensity score matched analysis, clinically relevant pancreatic fistula occurred in more patients in the external stents group (280 patients, 28.7%) than in patients in the internal stents group (126 patients, 12.9%) (OR 2.713 [95% CI, 2.139-3.455]; P 0.001). In subset analysis of a high-risk group with soft pancreas and no dilatation of the pancreatic duct, clinically relevant pancreatic fistula occurred in 90 patients (18.8%) in internal stents group and 183 patients (35.4%) in external stents group. External stents were significantly associated with increased risk for clinically relevant pancreatic fistula (OR 2.366 [95% CI, 1.753-3.209]; P 0.001).Propensity score matched analysis showed that, regarding clinically relevant pancreatic fistula after PD, internal stents are safer than external stents for pancreaticojejunostomy.
- Published
- 2020
46. Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study
- Author
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Joon Seong Park, Sang-Jae Park, Yoo Seok Yoon, Ho-Seong Han, Jin-Young Jang, Dong Sup Yoon, Sung-Sik Han, Sun Whe Kim, Hyung Sun Kim, and Wooil Kwon
- Subjects
Curative resection ,medicine.medical_specialty ,Ampulla of Vater ,medicine.medical_treatment ,Common Bile Duct Neoplasms ,030230 surgery ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Overall survival ,Carcinoma ,Humans ,Neoplasm Staging ,Retrospective Studies ,Hepatology ,business.industry ,Cancer ,Retrospective cohort study ,medicine.disease ,Prognosis ,medicine.anatomical_structure ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,T-stage ,Surgery ,business ,Adjuvant - Abstract
Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curative resection and define the "high-risk" group.Clinical data of patients who underwent curative resection for AoV carcinoma in four hospitals, namely Yonsei Gangnam Severance Hospital, Seoul National University Hospital, Seoul National University Bundang Hospital, and National Cancer Center (n = 651; 2002-2015), were reviewed. Overall survival (OS) and recurrence-free survival (RFS) rates were compared using Kaplan-Meier estimates.Data of 651 patients who had undergone curative resection were retrospectively reviewed. Age, T stage, N stage, and differentiation type remained strong and independent risk factors for RFS and OS. In early-stage AoV carcinoma (T1N0, T2N0), the non-adjuvant group had better prognosis based on the RFS and OS than the adjuvant group (P .001, P = .007). In advanced T stage (T3N0, T4N0), the adjuvant group had better prognosis than the non-adjuvant group, but the difference was not statistically significant (P .05). In node-positive patients (any T, N1/2), adjuvant treatment did not affect RFS and OS (P .05).Adjuvant treatment after curative resection of AoV carcinoma is not associated with improved survival. The high-risk group (node-positive or advanced T stage (T3, T4)) treated with adjuvant treatment was not statistically associated with improved survival; however, our study showed that the adjuvant treatment for the high-risk group might help achieve better patient outcome.
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- 2020
47. NaNO
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Sang Jae, Park, Youngjo, Kim, and Christopher W, Jones
- Abstract
NaNO
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- 2020
48. Learning curve for pancreatoduodenectomy: can it be generalized?
- Author
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Sun-Whe Kim, Sang-Jae Park, Sung-Sik Han, and Hyeong Min Park
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medicine.medical_specialty ,business.industry ,Red Blood Cell Transfusion ,Operative Time ,General Medicine ,Length of Stay ,Surgery ,Pancreaticoduodenectomy ,Postoperative Complications ,Learning curve ,medicine ,Operation time ,Humans ,Clinical Competence ,business ,Learning Curve ,Retrospective Studies - Abstract
BACKGROUND We hypothesized that a learning curve exists for pancreatoduodenectomy (PD) and that the factors that show a learning curve and the degree of improvement over time differ among surgeons. METHODS We analysed the outcomes of PD in 300 patients operated by two surgeons between 2001 and 2014; these comprised the first 150 patients operated by each surgeon. Patients operated by each surgeon were classified into three groups according to the chronological sequence of operation (50 patients per group). RESULTS For surgeon A, the median operation time (496 versus 454 versus 418 min, P
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- 2020
49. Self-powered data erasing of nanoscale flash memory by triboelectricity
- Author
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Ik Kyeong Jin, Weon-Guk Kim, Seung-Wook Lee, Hagyoul Bae, Byung-Hyun Lee, Daewon Kim, Joon-Kyu Han, Yang-Kyu Choi, Seong-Yeon Kim, Jun-Young Park, Sang-Jae Park, Seung-Bae Jeon, and Il-Woong Tcho
- Subjects
Hardware_MEMORYSTRUCTURES ,Materials science ,Renewable Energy, Sustainability and the Environment ,business.industry ,Electrical engineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Chip ,01 natural sciences ,Flash memory ,0104 chemical sciences ,General Materials Science ,Transient (computer programming) ,State (computer science) ,Electronics ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Kill switch ,Mobile device ,Triboelectric effect - Abstract
Irrecoverable data destruction on a mobile device is important to prevent unintentional data disclosure. In this regard, transient electronics, a form of electronics that can be made to disappear or can be destroyed in a controllable manner, has been actively researched. To erase data completely, irreversible reactions such as physical or chemical destruction have been used. However, these techniques either require external voltage or destroy a memory device so that it cannot be reused. Here, we demonstrate a novel self-powered data-erasing method for nanoscale flash memory devices which uses triboelectricity via a kill switch, which consists of a nylon pad connected to a gate electrode of the flash memory. Through a one-time touch of the kill switch by a finger wearing a polytetrafluoroethylene (PTFE) glove, data stored in flash memory is set to the ‘1′ state on the chip scale simultaneously with low-level triboelectricity, allowing the memory to be reused afterward. Moreover, the memory can be permanently destroyed by a single touch of the kill switch with a finger without a glove that generates high-level triboelectricity. These erase methods provide a rapid and convenient means of self-powered irrecoverable data erasing in the era of the Internet of Things (IoT).
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- 2018
50. Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
- Author
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Jun Hwa Lee, Tae Hyun Kim, Woojin Lee, Sang Myung Woo, In-Hye Jeong, Seung Eun Yu, Myung Hyun Yu, Byong Chul Yoo, Eun Kyung Hong, Sang-Jae Park, Sung-Sik Han, Jae Youl Cho, and Kyung-Hee Kim
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Bioinformatics ,Colorectal cancer ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Metabolomics ,Pancreatic cancer ,Internal medicine ,Drug Discovery ,Cancer screening ,medicine ,Screening programs ,Biliary tract cancer ,business.industry ,Research ,Health Policy ,Biochemistry (medical) ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Ovarian cancer ,business ,Predictive preventive personalized medicine ,Biomarkers - Abstract
Background Pancreatic cancer (PC) and biliary tract cancer (BTC) are highly aggressive cancers, characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. Diagnosis of PC and BTC is complex and is made using a combination of appropriate clinical suspicion, imaging and endoscopic techniques, and cytopathological examination. However, the late-stage detection and poor prognosis of this tumor have led to an urgent need for biomarkers for early and/or predictive diagnosis and improved personalized treatments. Working hypothesis There are two hypotheses for focusing on low-mass metabolites in the blood. First, valuable information can be obtained from the masses and relative amounts of such metabolites, which present as low-mass ions (LMIs) in mass spectra. Second, metabolic profiling of individuals may provide important information regarding biological changes in disease states that is useful for the early diagnosis of PC and BTC. Materials and methods To assess whether profiling metabolites in serum can serve as a non-invasive screening tool for PC and BTC, 320 serum samples were obtained from patients with PC (n = 51), BTC (n = 39), colorectal cancer (CRC) (n = 100), and ovarian cancer (OVC) (n = 30), and from healthy control subjects (control) (n = 100). We obtained information on the relative amounts of metabolites, as LMIs, via triple time-of-flight mass spectrometry. All data were analyzed according to the peak area ratios of discriminative LMIs. Results and conclusions The levels of the 14 discriminative LMIs were higher in the PC and BTC groups than in the control, CRC and OVC groups, but only two LMIs discriminated between PC and BTC: lysophosphatidylcholine (LysoPC) (16:0) and LysoPC(20:4). The levels of these two LysoPCs were also slightly lower in the PC/BTC/CRC/OVC groups compared with the control group. Taken together, the data showed that metabolic profiling can precisely denote the status of cancer, and, thus, could be useful for screening. This study not only details efficient methods to identify discriminative LMIs for cancer screening but also provides an example of metabolic profiling for distinguishing PC from BTC. Furthermore, the two metabolites [LysoPC(16:0), LysoPC(20:4)] shown to discriminate these diseases are potentially useful when combined with other, previously identified protein or metabolic biomarkers for predictive, preventive and personalized medical approach. Electronic supplementary material The online version of this article (10.1007/s13167-018-0147-5) contains supplementary material, which is available to authorized users.
- Published
- 2018
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