1. Carbazole Derivatives as STAT Inhibitors: An Overview
- Author
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Anna Caruso, Giovanni Salzano, Maria Stefania Sinicropi, Alessia Carocci, Carmela Saturnino, and Alexia Barbarossa
- Subjects
Technology ,Murraya ,QH301-705.5 ,QC1-999 ,03 medical and health sciences ,chemistry.chemical_compound ,tumoral cells ,0302 clinical medicine ,Clausena ,General Materials Science ,Biology (General) ,Structural motif ,QD1-999 ,Instrumentation ,Glycosmis ,030304 developmental biology ,Fluid Flow and Transfer Processes ,heterocycles ,0303 health sciences ,biology ,Carbazole ,Kinase ,Physics ,Process Chemistry and Technology ,General Engineering ,Biological activity ,target STATs ,STAT inhibitors ,Engineering (General). Civil engineering (General) ,biology.organism_classification ,Computer Science Applications ,carbazoles ,STAT proteins ,Chemistry ,chemistry ,Biochemistry ,030220 oncology & carcinogenesis ,STAT protein ,TA1-2040 - Abstract
The carbazole class is made up of heterocyclically structured compounds first isolated from coal tar. Their structural motif is preponderant in different synthetic materials and naturally occurring alkaloids extracted from the taxonomically related higher plants of the genus Murraya, Glycosmis, and Clausena from the Rutaceae family. Concerning the biological activity of these compounds, many research groups have assessed their antiproliferative action of carbazoles on different types of tumoral cells, such as breast, cervical, ovarian, hepatic, oral cavity, and small-cell lung cancer, and underlined their potential effects against psoriasis. One of the principal mechanisms likely involved in these effects is the ability of carbazoles to target the JAK/STATs pathway, considered essential for cell differentiation, proliferation, development, apoptosis, and inflammation. In this review, we report the studies carried out, over the years, useful to synthesize compounds with carbazole moiety designed to target these kinds of kinases.
- Published
- 2021