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2. Association between Basiliximab inductions with adult patient survival after liver retransplantation procedure: analysis of a single center experience

Author

Alessandro Tropea, D. Pagano, Giovanna Panarello, Mazzolai Barbara, F. di Francesco, S. Li Petri, Salvatore Gruttadauria, and Davide Cintorino

Subjects
medicine.medical_specialty, Hepatology, Basiliximab, business.industry, Internal medicine, Gastroenterology, medicine, Patient survival, Single Center, business, medicine.drug
Published
2018
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4. Evolution of Surgical Technique in Conventional Open Hepatectomy for Living Liver Donation Over a 12-Year Period in a Single Center

Author

Marco Spada, Pasquale Bonsignore, Salvatore Gruttadauria, S. Li Petri, Calogero Ricotta, Settimo Caruso, Giovanni Vizzini, Davide Cintorino, Luigi Maruzzelli, and Duilio Pagano

Subjects
medicine.medical_specialty, Intra operative, medicine.medical_treatment, Liver transplantation, Single Center, Intraoperative ultrasound, Living Donors, Hepatectomy, Humans, Medicine, Laparoscopy, Ultrasonography, Transplantation, Intraoperative Care, medicine.diagnostic_test, business.industry, Liver Transplantation, Surgery, Italy, Liver, Donation, business
Abstract

We report details of the experience from the largest Italian program with hepatic living donation, focusing particularly on the use of intraoperative ultrasound in liver transplantation and living donation. During a 12-year period we changed our surgical technique in the conventional open procedures thanks to the experience gained into the laparoscopic setting. Intraoperative ultrasound has been implemented during these delicate procedures for ensuring a fast and safer detection of the accessory veins and final severing of the vascular stumps during liver transection.

Published
2014
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5. Prucalopride for the treatment of delayed gastric emptying after pancreaticoduodenectomy: a pilot study

Author

Sergio Calamia, Davide Cintorino, Calogero Ricotta, B. Pasquale, S. Li Petri, G. Checchini, D. Pagano, Alessandro Tropea, F. di Francesco, and Salvatore Gruttadauria

Subjects
medicine.medical_specialty, Prucalopride, Hepatology, Gastric emptying, business.industry, Internal medicine, medicine.medical_treatment, Gastroenterology, medicine, business, Pancreaticoduodenectomy, medicine.drug
Published
2018
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6. Poster presentation

Author

F. Duparc, M. Noyon, J. Ozeel, A. Gerometta, C. Michot, M. Tadjalli, H. Moslemy, S. Safaei, A. Heiman, S. Wish-Baratz, T. Melnikov, E. Smoliar, A. Y. Hakan, F. Yucel, D. K. Kachlík, M. P. Pešl, V. B. Báča, J. S. Stingl, K. D. Kachlík, Č. P. Čech, B. V. Báča, B. Mompeó, A. Marrero-Rodriguez, A. Zeybek, B. Sağlam, E. Çikler, Ş. Çetinel, F. Ercan, G. Şener, Y. Kawawa, E. Kohda, T. Tatsuya, M. Moroi, T. Kunimasa, M. Nagamoto, H. Terada, B. C. J. Labuschagne, T. J. van der Krieke, P. V. Hoogland, C. J. F. Muller, R. Lyners, W. Vorster, P. Matusz, D. E. Zaboi, S. C. Xu, L. L. Tu, Q. Wang, M. Zhang, H. Han, W. Tao, Y. Jiao, G. Pang, M. E. Aydin, C. Kopuz, M. T. Demir, M. Yildirim, A. Kale, Y. Ince, K. Khamanarong, P. Jeeravipoolvarn, W. Chaijaroonkhanarak, W. Gawgleun, T. Fujino, A. Uz, N. Apaydin, M. Bozkurt, A. Elhan, M. T. Sheibani, M. Adibmoradi, N. Jahovic, I. Alican, G. Erkanli, S. Arbak, S. Karakaş, F. Taşer, H. Güneş, Y. Yildiz, Y. Yazici, R. C. Aland, V. Kippers, W. C. Song, S. H. Park, C. Shin, K. S. Koh, G. Russo, F. Pomara, M. Veca, F. Cacciola, U. Martorana, G. Gravante, A. C. Tobenas-Dujardin, A. Laquerrière, J. M. Muller, P. Fréger, N. López-Serna, E. Álvarez-González, V. Torres-Gonzàlez, G. Laredo-López, G. V. Esparza-González, R. Álvarez-Cantú, C. E. Garza-González, S. Guzmán-López, M. M. Aldur, H. H. Çelik, S. Sürücü, C. Denk, H. J. Yang, Y. C. Gil, T. J. Kim, H. Y. Lee, W. J. Lee, H. Lee, K. S. Hu, K. Akita, H. J. Kim, H. S. Jung, H. Gurbuz, S. Balik, G. Wavreille, C. Chantelot, X. Demondion, C. Fontaine, S. Çavdar, A. Yalin, E. Saka, Ö. Özdoǧmuş, Ö. Çakmak, L. Elevli, B. Saǧlam, D. Coquerel-Beghin, P. Y. Milliez, G. Lemierre, G. Oktem, S. Vatansever, S. Ayla, A. Uysal, S. Aktas, B. Karabulut, A. Bilir, S. Uslu, H. Aktug, M. E. Yurtseven, H. H. Celik, I. Tatar, S. Surucu, A. Karaduman, S. Tunali, S. Neuhüttler, A. Kröll, B. Moriggl, E. Brenner, M. Loukas, S. Arora, R. G. Louis, Q. A. Fogg, T. Wagner, R. A. Tedman, H. Y. Ching, N. Eze, I. D. Bottrill, P. Blyth, R. L. M. Faull, J. Vuletic, R. E. Elizondo-Omaña, M. A. García Rodríguez, S. Guzmán López, O. Tijerina de la Garza, Y. H. Liu, K. L. Zhang, D. H. Lu, H. H. Kwak, H. D. Park, K. H. Youn, H. J. Kang, H. C. Kang, S. H. Han, Z. A. Aktan Ikiz, H. Ucerler, M. Uygur, T. Kutoglu, C. Dina, D. Iliescu, E. Şapte, P. Bordei, I. Lekšan, M. Marcikić, R. Radić, V. Nikolić, S. Kurbel, R. Selthofer, V. Báča, A. Doubková, D. Kachlík, J. Stingl, V. Džupa, R. Grill, Y. S. Nam, D. J. Paik, C. S. Shin, S. J. Kim, D. G. Kim, C. S. Jin, D. I. Kim, U. Y. Lee, D. S. Kwak, J. H. Lee, C. H. Han, A. Carpino, V. Rago, F. Romeo, C. Carani, S. Andò, R. Y. Arican, N. Coskun, L. Sarikcioglu, M. Sindel, Y. R. Arican, U. Altun, U. Ozsoy, N. Oguz, F. B. Yildirim, K. Nakajima, E. Duygulu, H. Aydin, E. Inanc Gurer, O. Ozkan, S. Tuzuner, U. Özsoy, S. Çubukçu, B. M. Demirel, S. M. Akkin, T. Marur, A. H. Weiglein, T. T. Maghiar, C. Borza, A. Bumbu, G. Bumbu, G. Polle, I. Auquit-Auckbur, F. Dujardin, N. Biga, E. Olivier, T. Defives, S. Ghazali, G. Anastasi, G. Rizzo, A. Favaloro, D. Miliardi, O. Giacobbe, G. Santoro, F. Trimarchi, G. Cutroneo, F. Govsa, O. Bilge, M. A. Ozer, S. Erdogmus, F. Grizzi, F. Pelillo, M. Mori, B. Franceschini, N. Portinaro, G. Godlewski, M. Viala, J. P. Rouanet, D. Prat, Z. S. Rahmé, M. Prudhomme, E. Eken, M. Kwiatkowska, J. Liegmann, R. Chmielewski, J. Grimmond, M. Kwiatkowski, M. V. Schintler, G. Windisch, G. Wittgruber, E. C. Prandl, P. Prodinger, F. Anderhuber, E. Scharnagl, A. Gerbino, M. Buscemi, A. Leone, R. Mandracchia, G. Peri, D. Lipari, E. Farina-Lipari, B. Valentino, S. D’Arpa, A. Cordova, F. Bucchieri, A. Ribbene, S. David, A. Palma, D. E. Davies, H. M. Haitchi, S. T. Holgate, G. La Rocca, R. Anzalone, C. Campanella, F. Rappa, T. Bartolotta, F. Cappello, M. Bellafiore, G. Sivverini, D. Palumbo, F. Macaluso, F. Farina, V. Di Felice, A. Montalbano, N. Ardizzone, V. Marcianò, G. Zummo, E. Tanyeli, M. Üzel, F. Carini, G. A. Scardina, P. Varia, V. Valenza, P. Messina, J. H. Meiring, C. Schumann, I. Whitmore, L. M. Greyling, O. Hamel, A. Hamel, R. Robert, M. Garçon, S. Lagier, Y. Blin, O. Armstrong, J. M. Rogez, J. Le Borgne, C. Feng Ifrim, A. Maghiar, M. Botea, M. Ifrim, O. Pop, M. Sandor, Z. Behdadipour, M. Saberi, E. Esfandiary, C. Gentile, A. Marconi, M. A. Livrea, G. Uzan, P. D’Alessio, C. G. Ridola, N. Grassi, G. Pantuso, A. Bottino, E. Cacace, S. Li Petri, F. Di Gaudio, G. Guercio, M. A. Latteri, D. Nobile, C. Cipolla, G. Caruso, G. Salvaggio, A. Lo Cascio, G. Fatta, R. Lagalla, A. Campisi, F. Verderame, A. Martegani, A. E. Cardinale, and M. V. Luedinghausen

Subjects
Radiology, Nuclear Medicine and imaging, Surgery, Anatomy, Pathology and Forensic Medicine
Published
2005
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7. Unusual Presentation of Left Hepatic Vein in Deceased Donor: Case Report

Author

Bruno Gridelli, F. di Francesco, Gaetano Burgio, Luigi Maruzzelli, Duilio Pagano, Roberto Miraglia, Davide Cintorino, S. Li Petri, Salvatore Gruttadauria, and Gabriel J. Echeverri

Subjects
Adult, Male, Reoperation, medicine.medical_specialty, medicine.medical_treatment, Hepatic Veins, Liver transplantation, Inferior vena cava, Right gastric vein, Cadaver, Harmonic scalpel, Humans, Medicine, Vein, Transplantation, business.industry, Anatomy, Middle Aged, Tissue Donors, Liver Transplantation, Surgery, Treatment Outcome, medicine.anatomical_structure, medicine.vein, Cuff, cardiovascular system, Female, Primary Graft Dysfunction, business
Abstract

An anomaly of the left hepatic vein was discovered in a deceased donor for whole liver transplantation. This vein was attached by a thin bridge of tissue to the suprahepatic inferior vena cava cuff, which received the right and middle hepatic vein in a common trunk. The left hepatic vein and the common trunk drained together into the right atrium. The thin bridge of tissue connecting the 2 independent vessels was severed, and ex situ reduction of the left lateral segments was using a harmonic scalpel. Although a graft with reduced size is not ideal, ex situ reduction should be considered a valuable option when viability of the left lateral segments is uncertain in the donor or at the back table.

Published
2010
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8. The Role of Basiliximab Induction Therapy in Adult-to-Adult Living-Related Transplantation and Deceased Donor Liver Transplantation: A Comparative Retrospective Analysis of a Single-Center Series

Author

G. Varotti, Amadeo Marcos, Marta I. Minervini, J. Viganò, Bruno Gridelli, Giovanni Vizzini, Ioannis Petridis, Lucio Mandala, Davide Cintorino, S. Li Petri, Domenico Biondo, Salvatore Gruttadauria, Riccardo Volpes, and Wallis Marsh

Subjects
Adult, Graft Rejection, medicine.medical_specialty, Basiliximab, Recombinant Fusion Proteins, medicine.medical_treatment, Liver transplantation, Single Center, Gastroenterology, Tacrolimus, Internal medicine, Cadaver, Living Donors, medicine, Humans, Family, Survival analysis, Probability, Retrospective Studies, Transplantation, business.industry, Incidence (epidemiology), Graft Survival, Antibodies, Monoclonal, Survival Analysis, Tissue Donors, Liver Transplantation, Surgery, Regimen, Drug Therapy, Combination, business, Immunosuppressive Agents, medicine.drug
Abstract

Aim The aim of this study was to report our single-center experience with the use of basiliximab, in combination with a steroid and tacrolimus–based regimen in adult to adult living-related liver transplantation (ALRLT) and in deceased donor liver transplantation (DDLT). Materials and Methods Seventy-seven consecutive ALRLT recipients (group 1) and 244 DDLT recipients (group 2) were analyzed. All patients received 2 20-mg doses of basiliximab (days 0 and 4 after transplantation) followed by tacrolimus (0.15 mg/kg/d; 10–15 ng/mL target trough levels) and a dose regimen of steroids. Follow-up ranged from 4–1972 days after transplantation in group 1 and from 1–2741 days in group. Results In group 1, 89.32% of the patients remained rejection-free during follow-up, with an actuarial rejection-free probability of 93.51% within 3 months. Actuarial patient survival rate at 3 years was 84.49%. In group 2, 86.07% of the patients remained rejection-free during follow-up, with an actuarial rejection-free probability of 93.04% within 3 months. Actuarial patient survival rate at 3 years was 87.69%. We observed 14 cases of hepatitis C virus (HCV) recurrence in group 1 (prevalence of 26.92%) and 80 cases in group 2 (prevalence of 54.05%). Conclusion Basiliximab in association with tacrolimus and steroids is effective in reducing episodes of acute cellular rejection (ACR) and increasing ACR-free survival after ALRLT and DDLT. No difference in patient and graft survival was found between group 1 and 2, nor was there any difference in the incidence of ACR between the 2 groups. However, less risk of HCV recurrence was present in the LRLT group.

Published
2008
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9. Intra-Operative Contrast Cholangiography in Living Donor Liver Transplantation: The ISMETT Experience

Author

M. C. Saffioti, Pasquale Bonsignore, Alessandro Tropea, Roberto Miraglia, M. Paci, Davide Cintorino, Calogero Ricotta, Duilio Pagano, Marco Spada, Bruno Gridelli, Salvatore Gruttadauria, and S. Li Petri

Subjects
Adult, Male, medicine.medical_specialty, Cholangiopancreatography, Magnetic Resonance, medicine.medical_treatment, Contrast Media, Liver transplantation, End Stage Liver Disease, Liver disease, Cholangiography, ISMETT, Living Donors, medicine, Humans, Retrospective Studies, Transplantation, Magnetic resonance cholangiopancreatography, Intraoperative Care, medicine.diagnostic_test, business.industry, Retrospective cohort study, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Transplant Recipients, Liver Transplantation, Surgery, Etiology, Female, Bile Ducts, business
Abstract

Background We evaluated the clinical impact of donor biliary anatomy discrepancies (DBAD) achieved by comparing pre-operative evaluation obtained with magnetic resonance (MR)/magnetic resonance cholangiopancreatography (MRCP) imaging, with intra-operative cholangiography (IOC) on the living related liver donor (LDLT) and recipient. Methods This single-center, retrospective study included 97 consecutive adult-to-adult (A2A) LDLT performed in our hospital in the last 12 years. Donor sex and age, living donors with biliary and/or vascular anomalies, recipient age, sex, primary etiology, re-transplantation, Model of End-Stage Liver Disease score, co-morbidities, arterial and biliary recipient complications assessed on the basis of clinical follow-up were collected and analyzed for significance through the use of a multivariate linear regression model. Results Biliary complications in the donor (DBC) were detected in 8 (8.2%) cases. Biliary complications in the recipients (RBC) were detected in 38 (39%) cases. DBADs were found in 32 (33%) cases and resulted strictly related to RBC (P = .05). Conclusions After adjusting for co-variables, results of the linear regression analysis confirmed that DBAD is an independent predictor of RBC, but it is not significantly associated with vascular complications or patient survival. We showed that RBCs after LDLT were influenced by DBAD.

Published
2015
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10. Two brothers with renal and hepatic polycystic disease treated with combined liver and kidney transplantation: a case report

Author

Salvatore Gruttadauria, Bruno Gridelli, S. Li Petri, Marco Spada, Davide Cintorino, and Duilio Pagano

Subjects
Adult, Male, medicine.medical_specialty, Pathology, medicine.medical_treatment, Urology, Artificial kidney, Organomegaly, medicine, Humans, Transplantation, Polycystic Kidney Diseases, business.industry, Liver and kidney, Liver Diseases, Middle Aged, Kidney Transplantation, Liver Transplantation, Abdominal incision, Polycystic disease, Surgery, Both kidneys, Hemodialysis, medicine.symptom, business
Abstract

We report two brothers with renal and hepatic polycystic disease who developed end-stage renal failure, requiring hemodialysis, and organomegaly syndrome related to the gigantic size of the liver and both kidneys. Although there was no liver failure, combined liver and kidney transplantation was performed owing to worsening of the clinical condition. In both cases, successful transplantation was accomplished with intra-abdominal engraftment of the liver and kidneys through the same abdominal incision.

Published
2013

11. Laparoscopic approach for an intra-abdominal kidney allograft nephrectomy after pediatric transplantation: a case report

Author

J. Argento, S. Li Petri, F. di Francesco, Marco Spada, Duilio Pagano, Davide Cintorino, Silvia Riva, Bruno Gridelli, Tullio Bertani, Gabriel J. Echeverri, and Calogero Ricotta

Subjects
medicine.medical_specialty, Adolescent, medicine.medical_treatment, Abdominal cavity, Medical sciences, Enfermedad de la vejiga, Vesicoureteral reflux, Nephrectomy, Pielonefritis, Ureter, medicine, Humans, Kidney transplantation, Dialysis, Transplantation, Pyelonephritis, business.industry, medicine.disease, Hypochondrium, Kidney Transplantation, Surgery, surgical procedures, operative, medicine.anatomical_structure, Ciencias socio biomédicas, Female, Laparoscopy, Bladder disease, business
Abstract

We report a case of minimally invasive nephrectomy of a kidney transplanted into the abdominal cavity in a child. A 15-year-old girl underwent transplantation with a cadaveric donor kidney due to congenital pyelonephritis, vesicoureteral reflux, and secondary bladder atrophy. The transplant was complicated by hyperacute rejection, cytomegalovirus infection, and anastomotic stenosis of the Bricker neobladder. After recurrent urinary tract infections, the patient was reintroduced to hemodialysis in 2010. After pneumo-peritoneum, we placed 2 10-mm trocars in the hypochondrium and left side and 2 5-mm in the left iliac fossa and right upper quadrant. The transplanted kidney was skeletonized, the artery and vein were cut to the end-to-side anastomoses to the juxta-renal aorta and cava using an automatic 35-mm, stapler, and the ureter was dissected and closed with clips. Via a Pfannestiel minilaparotomy we extracted the allograft. The patient was discharged on the third postoperative day. After 4 months of follow-up, she is alive an on dialysis. Laparoscopic nephrectomy of a kidney transplanted into the abdominal cavity is feasible and safe in centers with skilled minimally invasive techniques.

Published
2012

12. Liver Match, a prospective observational cohort study on liver transplantation in Italy: study design and current practice of donor-recipient matching

Author

Mario Angelico 1, Umberto Cillo, Stefano Fagiuoli, Antonio Gasbarrini, Caius Gavrila, Tania Marianelli, Alessandro Nanni Costa, Alessandra Nardi, Mario Strazzabosco, Patrizia Burra, Salvatore Agnes, Umberto Baccarani, Fulvio Calise, Michele Colledan, Oreste Cuomo, Luciano De Carlis, Matteo Donataccio, Giuseppe M Ettorre, Giorgio E Gerunda, Bruno Gridelli, Luigi Lupo, Vincenzo Mazzaferro, Antonio Pinna, Andrea Risaliti, Mauro Salizzoni, Giuseppe Tisone, Umberto Valente, Giorgio Rossi, Massimo Rossi, Fausto Zamboni, S Fagiuoli, A Gasbarrini, M Strazzabosco, D Prati, F Piscaglia, P G Toniutto, L Rizzato, S Venettoni, A Nardi, A Ricci, R Romagnoli, G Bertolotti, D Patrono, J M E Mangoni, L Caccamo, B Antonelli, E Regalia, C Sposito, V Corno, F Tagliabue, S Marin, E Gringeri, D Donataccio, F Bresadola, D Lorenzin, M Gelli, G Rompianesi, A Cucchetti, M G Faraci, D Sforza, S Agnes, M Di Mugno, L Miglioresi, M Rossi, S Ginanni Corradini, A Molinaro, V Scuderi, G Arenga, G Notarnicola, B Gridelli, S Li Petri, G Carbotta, S Dedola, C Gavrila, F Vespasiano, Angelico M, Cillo U, Fagiuoli S, Gasbarrini A, Costa AN, Strazzabosco M, Prati D, Piscaglia F, Toniutto PG, Burra P, Rizzato L, Venettoni S, Marianelli T, Salizzoni M, Romagnoli R, Bertolotti G, Patrono D, De Carolis L, Mangoni JM, Rossi G, Caccamo L, Antonelli B, Mazzaferro V, Regalia E, Sposito C, Colledan M, Corno V, Tagliabue F, Marin S, Gringeri E, Donataccio, Donataccio D, Bresadola F, Lorenzin D, Valente U, Gelli M, Gerunda GE, Rompianesi G, Pinna A, Grazi GL, Cucchetti A, Risaliti A, Faraci MG, Tisone G, Sforza D, Agnes S, Di Mugno M, Ettorre GM, Miglioresi L, Berloco P, Rossi M, Ginanni Corradini S, Molinaro A, Calise F, Scuderi V, Cuomo O, Arenga G, Lupo L, Notarnicola G, Gridelli B, Li Petri S, Zamboni F, Carbotta G, Dedola S, Nardi A, Gavrila C, Ricci A, Vespasiano F, Baccarani U, 1, Mario Angelico, Cillo, Umberto, Fagiuoli, Stefano, Gasbarrini, Antonio, Gavrila, Caiu, Marianelli, Tania, Nanni Costa, Alessandro, Nardi, Alessandra, Strazzabosco, Mario, Burra, Patrizia, Agnes, Salvatore, Baccarani, Umberto, Calise, Fulvio, Colledan, Michele, Cuomo, Oreste, De Carlis, Luciano, Donataccio, Matteo, M Ettorre, Giuseppe, E Gerunda, Giorgio, Gridelli, Bruno, Lupo, Luigi, Mazzaferro, Vincenzo, Pinna, Antonio, Risaliti, Andrea, Salizzoni, Mauro, Tisone, Giuseppe, Valente, Umberto, Rossi, Giorgio, Rossi, Massimo, Zamboni, Fausto, Fagiuoli, S, Gasbarrini, A, Strazzabosco, M, Prati, D, Piscaglia, F, G Toniutto, P, Rizzato, L, Venettoni, S, Nardi, A, Ricci, A, Romagnoli, R, Bertolotti, G, Patrono, D, E Mangoni, J M, Caccamo, L, Antonelli, B, Regalia, E, Sposito, C, Corno, V, Tagliabue, F, Marin, S, Gringeri, E, Donataccio, D, Bresadola, F, Lorenzin, D, Gelli, M, Rompianesi, G, Cucchetti, A, G Faraci, M, Sforza, D, Agnes, S, Di Mugno, M, Miglioresi, L, Rossi, M, Ginanni Corradini, S, Molinaro, A, Scuderi, V, Arenga, G, Notarnicola, G, Gridelli, B, Li Petri, S, Carbotta, G, Dedola, S, Gavrila, C, Vespasiano, F, Angelico, M, Cillo, U, Marianelli, T, Costa, A, Burra, P, Baccarani, U, Calise, F, Colledan, M, Cuomo, O, DE CARLIS, L, Donataccio, M, Ettorre, G, Gerunda, G, Lupo, L, Mazzaferro, V, Pinna, A, Risaliti, A, Salizzoni, M, Tisone, G, Valente, U, Rossi, G, Zamboni, F, and Liver Match, I

Subjects
impact of donor/recipient matching on outcomes, Male, Alcoholic liver disease, Cirrhosis, Multicenter Study, Humans, Prospective Study, Liver Transplantation, Donor Risk Index, Hepatocellular Carcinoma, Italy, Donor Liver transplant Recipient, donor match, liver transplantation, donor, recipient, Settore MED/18 - CHIRURGIA GENERALE, medicine.medical_treatment, liver-match, liver transplant, Liver transplantation, Model for End-Stage Liver Disease, MED/12 - GASTROENTEROLOGIA, Prospective Studies, Prospective cohort study, Child, Liver transplant, donor, Aged, 80 and over, Settore MED/12 - Gastroenterologia, education.field_of_study, liver transplantation, Histocompatibility Testing, Graft Survival, Liver Neoplasms, Gastroenterology, Middle Aged, liver transplantations, liver transplant, information on donors and recipients, recipient, Tissue Donors, Treatment Outcome, Donor, Recipient, Hepatocellular carcinoma, Female, Cohort study, Adult, medicine.medical_specialty, Tissue and Organ Procurement, Adolescent, Waiting Lists, Population, NO, Internal medicine, medicine, education, donor match, Aged, Hepatology, business.industry, Patient Selection, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Fibrosis, Surgery, business
Abstract

BACKGROUND: The Liver Match is an observational cohort study that prospectively enrolled liver transplantations performed at 20 out of 21 Italian Transplant Centres between June 2007 and May 2009. Aim of the study is to investigate the impact of donor/recipient matching on outcomes. In this report we describe the study methodology and provide a cross-sectional description of donor and recipient characteristics and of graft allocation. METHODS: Adult primary transplants performed with deceased heart-beating donors were included. Relevant information on donors and recipients, organ procurement and allocation were prospectively entered in an ad hoc database within the National Transplant Centre web-based Network. Data were blindly analysed by an independent Biostatistical Board. RESULTS: The study enrolled 1530 donor/recipient matches. Median donor age was 56 years. Female donors (n = 681, median 58, range 12-92 years) were older than males (n = 849, median 53, range 2-97 years, p < 0.0001). Donors older than 60 years were 42.2%, including 4.2% octogenarians. Brain death was due to non-traumatic causes in 1126 (73.6%) cases. Half of the donor population was overweight, 10.1% was obese and 7.6% diabetic. Hepatitis B core antibody (HBcAb) was present in 245 (16.0%) donors. The median Donor Risk Index (DRI) was 1.57 (>1.7 in 35.8%). The median cold ischaemia time was 7.3h (≥ 10 in 10.6%). Median age of recipients was 54 years, and 77.7% were males. Hepatocellular carcinoma (HCC) was the most frequent indication overall (44.4%), being a coindication in roughly 1/3 of cases, followed by viral cirrhosis without HCC (28.2%) and alcoholic cirrhosis without HCC (10.2%). Hepatitis C virus infection (with or without HCC) was the most frequent etiologic factor (45.9% of the whole population and 71.4% of viral-related cirrhosis), yet hepatitis B virus infection accounted for 28.6% of viral-related cirrhosis, and HBcAb positivity was found in 49.7% of recipients. The median Model for End Stage Liver Disease (MELD) at transplant was 12 in patients with HCC and 18 in those without. Multivariate analysis showed a slight but significant inverse association between DRI and MELD at transplant. CONCLUSIONS: The deceased donor population in Italy has a high-risk profile compared to other countries, mainly due to older donor age. Almost half of the grafts are transplanted in recipients with HCC. Higher risk donors tend to be preferentially allocated to recipients with HCC, who are usually less ill and older. No other relevant allocation strategy is currently adopted at national level.

Published
2010

13. Technical aspects of living-related liver donation: single-center experience

Author

Davide Cintorino, S. Li Petri, T. Dominioni, Bruno Gridelli, Amadeo Marcos, F. di Francesco, Salvatore Gruttadauria, James W. Marsh, D. Lorenzin, and Marco Spada

Subjects
Transplantation, medicine.medical_specialty, business.industry, Live donor, General surgery, medicine.medical_treatment, Perioperative, Liver transplantation, Single Center, Surgery, Liver Transplantation, Donation, Living Donors, Medicine, Humans, Organ donation, Living donor liver transplantation, business
Abstract

Living-related donor liver transplantation is the newest and both technically and ethically most challenging evolution in liver transplantation and has contributed to reduction in donor shortage. We briefly report the technical aspects of surgical procedures performed to achieve a partial graft from a live donor. Eighty-four adult and two pediatric recipients underwent living-related donor liver transplantation at our center. There were no donor deaths, and all patients returned to their normal activities after the perioperative period. This single-center experience may contribute to refinement of the surgical technique required to improve the outcome of these complex operations.

Published
2009

14. Liver abscess and septic shock as an unusual complication after endoscopic ampullectomy

Author

Mario Traina, S. Li Petri, Gabriel J. Echeverri, Ilaria Tarantino, Calogero Ricotta, Salvatore Gruttadauria, and Bruno Gridelli

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Septic shock, business.industry, Ampullectomy, Common Bile Duct Neoplasms, Liver Abscess, Gastroenterology, Middle Aged, medicine.disease, Shock, Septic, Endoscopy, Gastrointestinal, Endoscopy, Surgery, Shock (circulatory), medicine, Humans, Female, medicine.symptom, Complication, business, Liver abscess
Published
2011
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15. Is Intra-Operative Contrast Cholangiography Still Crucial for Planning an Adult-to-Adult Right Lobe Living Donor Liver Transplantation?

Author

Salvatore Gruttadauria, Roberto Miraglia, P. Bonsignore, Davide Cintorino, Marco Spada, M. Paci, B. Gridelli, S. Li Petri, D. Pagano, and Calogero Ricotta

Subjects
Transplantation, medicine.medical_specialty, Intra operative, medicine.diagnostic_test, business.industry, media_common.quotation_subject, Lobe, Surgery, medicine.anatomical_structure, Cholangiography, Medicine, Contrast (vision), Living donor liver transplantation, business, media_common
Published
2014
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17. F-46 Graft survival is worse in HCV positive females transplanted with male donor grafts

Author

Marcos A. Rossi, L. Miglioresi, C. Gavrila, S. Ginanni Corradini, Carlo Sposito, Salvatore Agnes, S. Li Petri, Enrico Gringeri, A. Cucchetti, U. Cillo, A.D. Pinna, Fausto Zamboni, L. Lupo, Damiano Patrono, F. Tagliabue, Alessandra Nardi, Fulvio Calise, L. De Carlis, Daniele Sforza, Gianluca Rompianesi, G. Tisone, Michele Colledan, G.E. Gerunda, M. Donataccio, O. Cuomo, Renato Romagnoli, Mario Angelico, Lino Belli, Marco Spada, Vincenzo Mazzaferro, J. Mangoni, M. Gelli, T. Marianelli, Andrea Risaliti, Giuseppe Maria Ettorre, Umberto Baccarani, and B. Antonelli

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Graft survival, business, HCV Positive
Published
2012
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