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1. Wendelstein 7-X on the path to long-pulse high-performance operation

Author

W7-X Team, Endler, M., Baldzuhn, J., Beidler, C. D., Bosch, H.-S., Bozhenkov, S., Buttenschön, B., Dinklage, A., Fellinger, J., Feng, Y., Fuchert, G., Gao, Y., Geiger, J., Grulke, O., Hartmann, D., Jakubowski, M., König, R., Laqua, H. P., Lazerson, S., McNeely, P., Naujoks, D., Neuner, U., Otte, M., Pasch, E., Sunn Pedersen, T., Perseo, V., Puig Sitjes, A., Rahbarnia, K., Rust, N., Schmitz, O., Spring, A., Stange, T., Stechow, A. von, Turkin, Y., Wang, E., Wolf, R. C., Gantenbein, Gerd, Huber, Martina, Illy, Stefan, Jelonnek, John, Kobarg, Thorsten, Lang, Rouven, Leonhardt, Wolfgang, Mellein, Daniel, Papenfuß, Daniel, Scherer, Theo, Thumm, Manfred, Wadle, Simone, Weggen, Jörg, and W7-X Team, Max Planck Institute for Plasma Physics, Max Planck Society

Subjects
Technology, Optimisation, Steady-state, Stellarator, Wendelstein 7-X, Nuclear engineering, 01 natural sciences, 7. Clean energy, 010305 fluids & plasmas, law.invention, Data acquisition, law, Range (aeronautics), 0103 physical sciences, Water cooling, General Materials Science, 010306 general physics, Civil and Structural Engineering, Steady state, Mechanical Engineering, Fusion power, Nuclear Energy and Engineering, Path (graph theory), ddc:600
Abstract

The Wendelstein 7-X project is aimed at demonstrating that an optimised stellarator is an attractive candidate for a fusion reactor. This requires the achievement of a number of technical and physics goals. Several of these goals have already been achieved in the first three experimental campaigns. We shall exemplify this by a number of results. One important goal is the demonstration of quasi-steady-state operation at high plasma density and temperature for half an hour, which encompasses the physical and technical requirements of stable operation with density and impurity control, cw heating, water-cooled targets, particle exhaust, and an appropriate control and data acquisition system for long-pulse operation. In the previous experimental campaigns, with uncooled targets, stationary discharges for up to 25 s with 5 MW heating power and up to 100 s with 2 MW heating power were achieved. For the next operational phase, to start in 2022, water-cooled targets are being installed, water cooling will be provided for all first-wall components, and a number of further upgrades to plasma heating, vacuum and fuelling systems as well as diagnostics will become available. With this equipment, the further goals of the project will be tackled, including the stepwise extension of discharge intervals to the multi-minute range. The experimental results so far have confirmed the neoclassical theory underlying several of the optimisation goals. At the same time, they showed that an optimisation is also required with respect to anomalous transport. In the future operational phases we aim at building a solid theoretical, experimental and technical foundation for the design of a next-step stellarator device.

Published
2021

2. Performance of Wendelstein 7-X stellarator plasmas during the first divertor operation phase

Author

Wolf, R. C., Alonso, A., Akaslompolo, S., Baldzuhn, J., Beurskens, M., Beidler, C. D., Biedermann, C., Bosch, H. -S., Bozhenkov, S., Brakel, R., Braune, H., Brezinsek, S., Brunner, K. -J., Damm, H., Dinklage, A., Drewelow, P., Effenberg, F., Feng, Y., Ford, O., Fuchert, G., Gao, Y., Geiger, J., Grulke, O., Harder, N., Hartmann, D., Helander, P., Heinemann, B., Hirsch, M., Hofel, U., Hopf, C., Ida, K., Isobe, M., Jakubowski, M. W., Kazakov, Y. O., Killer, C., Klinger, T., Knauer, J., Konig, R., Krychowiak, M., Langenberg, A., Laqua, H. P., Lazerson, S., Mcneely, P., Marsen, S., Marushchenko, N., Nocentini, R., Ogawa, K., Orozco, G., Osakabe, M., Otte, M., Pablant, N., Pasch, E., Pavone, A., Porkolab, M., Puig Sitjes, A., Rahbarnia, K., Riedl, R., Rust, N., Scott, E., Schilling, J., Schroeder, R., Stange, T., Von Stechow, A., Strumberger, E., Sunn Pedersen, T., Svensson, J., Thomson, H., Turkin, Y., Vano, L., Wauters, T., Wurden, G., Yoshinuma, M., Zanini, M., Zhang, D., Andreeva, T., Brandt, C., Burhenn, R., Buttenschon, B., Geiger, B., Tamura, N., Thomsen, H., Wegner, T., Abramovic, I., Alcuson, J., Aleynikov, P., Aleynikova, K., Ali, A., Anda, G., Ascasibar, E., Bahner, J. P., Baek, S. G., Balden, M., Banduch, M., Barbui, T., Behr, W., Beidler, C., Benndorf, A., Biel, W., Blackwell, B., Blanco, E., Blatzheim, M., Ballinger, S., Bluhm, T., Bockenhoff, D., Boswirth, B., Bottger, L. -G., Borchardt, M., Borsuk, V., Boscary, J., Brand, H., Brauer, T., Bussiahn, R., Bykov, V., Cai, J., Calvo, I., Cannas, B., Cappa, A., Carls, A., Carralero, D., Carraro, L., Carvalho, B., Castejon, F., Charl, A., Chaudhary, N., Chauvin, D., Chernyshev, F., Cianciosa, M., Citarella, R., Claps, G., Coenen, J., Cole, M., Cole, M. J., Cordella, F., Cseh, G., Czarnecka, A., Czerski, K., Czerwinski, M., Czymek, G., Da Molin, A., Da Silva, A., De La Pena, A., Degenkolbe, S., Dhard, C. P., Dibon, M., Dittmar, T., Drevlak, M., Drews, P., Durodie, F., Edlund, E., Van Eeten, P., Ehrke, G., Elgeti, S., Endler, M., Ennis, D., Esteban, H., Estrada, T., Fellinger, J., Flom, E., Fernandes, H., Fietz, W. H., Figacz, W., Fontdecaba, J., Fornal, T., Frerichs, H., Freund, A., Funaba, T., Galkowski, A., Gantenbein, G., Garcia Regana, J., Gates, D., Giannella, V., Gogoleva, A., Goncalves, B., Goriaev, A., Gradic, D., Grahl, M., Green, J., Greuner, H., Grosman, A., Grote, H., Gruca, M., Guerard, C., Hacker, P., Han, X., Harris, J. H., Hathiramani, D., Hein, B., Henneberg, S., Henkel, M., Hernandez Sanchez, J., Hidalgo, C., Hollfeld, K. P., Holting, A., Hoschen, D., Houry, M., Howard, J., Huang, X., Huang, Z., Hubeny, M., Huber, M., Hunger, H., Ilkei, T., Illy, S., Israeli, B., Jablonski, S., Jakubowski, M., Jelonnek, J., Jenzsch, H., Jesche, T., Jia, M., Junghanns, P., Kacmarczyk, J., Kallmeyer, J. -P., Kamionka, U., Kasahara, H., Kasparek, W., Kenmochi, N., Kirschner, A., Kleiber, R., Knaup, M., Knieps, A., Kobarg, T., Kocsis, G., Kochl, F., Kolesnichenko, Y., Konies, A., Kornejew, P., Koschinsky, J. -P., Koster, F., Kramer, M., Krampitz, R., Kramer-Flecken, A., Krawczyk, N., Kremeyer, T., Krom, J., Ksiazek, I., Kubkowska, M., Kuhner, G., Kurki-Suonio, T., Kurz, P. A., Kwak, S., Landreman, M., Lang, P., Lang, R., Langish, S., Laqua, H., Laube, R., Lechte, C., Lennartz, M., Leonhardt, W., Li, C., Li, Y., Liang, Y., Linsmeier, C., Liu, S., Lobsien, J. -F., Loesser, D., Loizu Cisquella, J., Lore, J., Lorenz, A., Losert, M., Lucke, A., Lumsdaine, A., Lutsenko, V., Maassberg, H., Marchuk, O., Matthew, J. H., Marushchenko, M., Masuzaki, S., Maurer, D., Mayer, M., Mccarthy, K., Meier, A., Mellein, D., Mendelevitch, B., Mertens, P., Mikkelsen, D., Mishchenko, A., Missal, B., Mittelstaedt, J., Mizuuchi, T., Mollen, A., Moncada, V., Monnich, T., Morisaki, T., Moseev, D., Murakami, S., Nafradi, G., Nagel, M., Naujoks, D., Neilson, H., Neu, R., Neubauer, O., Neuner, U., Ngo, T., Nicolai, D., Nielsen, S. K., Niemann, H., Nishizawa, T., Nuhrenberg, C., Nuhrenberg, J., Obermayer, S., Offermanns, G., Olmanns, J., Ongena, J., Oosterbeek, J. W., Pacios Rodriguez, L., Panadero, N., Panadero Alvarez, N., Papenfuss, D., Paqay, S., Pawelec, E., Pedersen, T. S., Pelka, G., Perseo, V., Peterson, B., Pilopp, D., Pingel, S., Pisano, F., Plaum, B., Plunk, G., Poloskei, P., Proll, J., Puiatti, M. -E., Purps, F., Rack, M., Recsei, S., Reiman, A., Reimold, F., Reiter, D., Remppel, F., Renard, S., Riemann, J., Risse, K., Rohde, V., Rohlinger, H., Rome, M., Rondeshagen, D., Rong, P., Roth, B., Rudischhauser, L., Rummel, K., Rummel, T., Runov, A., Ryc, L., Ryosuke, S., Sakamoto, R., Salewski, M., Samartsev, A., Sanchez, E., Sano, F., Satake, S., Schacht, J., Satheeswaran, G., Schauer, F., Scherer, T., Schlaich, A., Schlisio, G., Schluck, F., Schluter, K. -H., Schmitt, J., Schmitz, H., Schmitz, O., Schmuck, S., Schneider, M., Schneider, W., Scholz, P., Schrittwieser, R., Schroder, M., Schroder, T., Schumacher, H., Schweer, B., Sereda, S., Shanahan, B., Sibilia, M., Sinha, P., Siplia, S., Slaby, C., Sleczka, M., Smith, H., Spiess, W., Spong, D. A., Spring, A., Stadler, R., Stejner, M., Stephey, L., Stridde, U., Suzuki, C., Szabo, V., Szabolics, T., Szepesi, T., Szokefalvi-Nagy, Z., Tancetti, A., Terry, J., Thomas, J., Thumm, M., Travere, J. M., Traverso, P., Tretter, J., Trimino Mora, H., Tsuchiya, H., Tsujimura, T., Tulipan, S., Unterberg, B., Vakulchyk, I., Valet, S., Van Milligen, B., Van Vuuren, A. J., Vela, L., Velasco, J. -L., Vergote, M., Vervier, M., Vianello, N., Viebke, H., Vilbrandt, R., Vorkoper, A., Wadle, S., Wagner, F., Wang, E., Wang, N., Wang, Z., Warmer, F., Wegener, L., Weggen, J., Wei, Y., Weir, G., Wendorf, J., Wenzel, U., Werner, A., White, A., Wiegel, B., Wilde, F., Windisch, T., Winkler, M., Winter, A., Winters, V., Wolf, S., Wright, A., Xanthopoulos, P., Yamada, H., Yamada, I., Yasuhara, R., Yokoyama, M., Zarnstorff, M., Zeitler, A., Zhang, H., Zhu, J., Zilker, M., Zocco, A., Zoletnik, S., Zuin, M., Science and Technology of Nuclear Fusion, Turbulence in Fusion Plasmas, and W7-X Team, Max Planck Institute for Plasma Physics, Max Planck Society

Subjects
Physics, Technology, Plasma parameters, Divertor, Nuclear engineering, Plasma, Condensed Matter Physics, 01 natural sciences, 7. Clean energy, Electron cyclotron resonance, 010305 fluids & plasmas, law.invention, Magnetic field, law, 0103 physical sciences, Limiter, Wendelstein 7-X, 010306 general physics, ddc:600, Stellarator
Abstract

Wendelstein 7-X is the first comprehensively optimized stellarator aiming at good confinement with plasma parameters relevant to a future stellarator power plant. Plasma operation started in 2015 using a limiter configuration. After installing an uncooled magnetic island divertor, extending the energy limit from 4 to 80 MJ, operation continued in 2017. For this phase, the electron cyclotron resonance heating (ECRH) capability was extended to 7 MW, and hydrogen pellet injection was implemented. The enhancements resulted in the highest triple product (6.5 × 1019 keV m-3 s) achieved in a stellarator until now. Plasma conditions [Te(0) ≈ Ti(0) ≈ 3.8 keV, τE > 200 ms] already were in the stellarator reactor-relevant ion-root plasma transport regime. Stable operation above the 2nd harmonic ECRH X-mode cutoff was demonstrated, which is instrumental for achieving high plasma densities in Wendelstein 7-X. Further important developments include the confirmation of low intrinsic error fields, the observation of current-drive induced instabilities, and first fast ion heating and confinement experiments. The efficacy of the magnetic island divertor was instrumental in achieving high performance in Wendelstein 7-X. Symmetrization of the heat loads between the ten divertor modules could be achieved by external resonant magnetic fields. Full divertor power detachment facilitated the extension of high power plasmas significantly beyond the energy limit of 80 MJ.

Published
2019

3. Modeling of neutral beam heating and current drive in Wendelstein 7-X

Author

Lazerson, S. A., Turkin, Y., Smith, H., Äkäslompolo, S., Drevlak, M., David Pfefferlé, Bozhenkov, S., Ford, O., Rust, N., Mcneely, P., Hartmann, D., Rahbarnia, K., Andreeva, T., Schilling, J., Brandt, C., Neuner, U., Thomsen, H., Wolf, R. C., and W7-X Team, Max Planck Institute for Plasma Physics, Max Planck Society

4. Cutting edge: Rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma

Author

Rod Dunbar, Chen, J. -L, Chao, D., Rust, N., Teisserenc, H., Ogg, G. S., Romero, P., Weynants, P., and Cerundolo, V.

Subjects
Adult, Male, Immunology, Epitopes, T-Lymphocyte, Middle Aged, Immunotherapy, Adoptive, Clone Cells, Neoplasm Proteins, Antigens, Neoplasm, HLA-A2 Antigen, Tumor Cells, Cultured, Immunology and Allergy, Humans, Female, Melanoma, Oligopeptides, Aged, T-Lymphocytes, Cytotoxic
Abstract

Adoptive immunotherapy using CTL has provided some clinical benefit to patients with metastatic melanoma. Use of cloned CTL of known specificity might improve clinical effect, but technical difficulties have limited exploration of this possibility. We have used fluorescence-driven cell sorting to clone tumor-specific CTL after staining with tetrameric MHC class I/peptide complexes. CTL specific for the melanoma Ags melan-A, tyrosinase, and MAGE3 were cloned from the peripheral blood, tumor-infiltrated lymph nodes, and skin metastases of five patients. Clones were isolated and characterized in as little as 6 weeks, much faster than is possible with previous techniques. We show that these CTL clones express markers compatible with immunotherapeutic use in melanoma, including the cutaneous lymphocyte Ag, which is associated with homing to skin.

5. Maximally informative dimensions: Analyzing neural responses to natural signals

Author

Tatyana Sharpee, Rust, N. C., and Bialek, W.

Subjects
Quantitative Biology::Neurons and Cognition, Biological Physics (physics.bio-ph), Physics - Data Analysis, Statistics and Probability, Quantitative Biology - Neurons and Cognition, FOS: Biological sciences, FOS: Physical sciences, Neurons and Cognition (q-bio.NC), Physics - Biological Physics, Data Analysis, Statistics and Probability (physics.data-an)
Abstract

We propose a method that would allow for a rigorous statistical analysis of neural responses to natural stimuli, which are non-Gaussian and exhibit strong correlations. We have in mind a model in which neurons are selective for a small number of stimulus dimensions out of the high dimensional stimulus space, but within this subspace the responses can be arbitrarily nonlinear. Existing analysis methods are based on correlation functions between stimuli and responses, but these methods are guaranteed to work only in the case of Gaussian stimulus ensembles. As an alternative to correlation functions, we maximize the mutual information between the neural responses and projections of the stimulus onto low dimensional subspaces. The procedure can be done iteratively by increasing the dimensionality of this subspace. Those dimensions that allow the recovery of all of the information between spikes and the full unprojected stimuli describe the relevant subspace. If the dimensionality of the relevant subspace indeed is small, it becomes feasible to map out the neuron's input-output function even under fully natural stimulus conditions. These ideas are illustrated in simulations on model visual neurons responding to natural scenes., Comment: 12 pages, 3 figures

6. Experiments close to the beta-limit in W7-AS

Author

Weller, A., Geiger, J., Werner, A., Zarnstorff, M. C., Nührenberg, C., Sallander, E., Baldzuhn, J., Brakel, R., Burhenn, R., Dinklage, A., Fredrickson, E., Gadelmeier, F., Giannone, L., Grigull, P., Hartmann, D., Jaenicke, R., Klose, S., Knauer, J. P., Könies, A., Kolesnichenko, Ya I., Laqua, H. P., Lutsenko, V. V., Mccormick, K., Monticello, D., Osakabe, M., Pasch, E., Reiman, A., Rust, N., Spong, D. A., Wagner, F., and Yurii Yakovenko

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