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Background: The need to combat and reduce the incidence, virulence, and drug resistance of species belonging to Candida genus, has led to the development of new strategies. Nanotechnology, through the implementation of nanomaterials, has emerged as an infallible tool to treat various diseases caused by pathogens, where its mechanisms of action prevent the development of undesirable pharmacological resistance. Objective: The antifungal activity and adjuvant properties of biogenic silver nanoparticles in different Candida species (C. parapsilosis, C. glabrata, and C. albicans) are evaluated. Method: The biogenic metallic nanoparticles were developed by quercetin-mediated biological synthesis. The physicochemical properties were studied by light scattering, electrophoretic mobility, UV-vis and infrared spectroscopy, and transmission electron microscopy. The elucidation of mechanisms of antifungal action was carried out under stress conditions in Candida species at the cell wall and response to oxidative stress. Results: Small silver nanoparticles (≈ 16.18 nm) with irregular morphology, and negative surface electrical charge (≈ -48.99 mV), were obtained through quercetin-mediated biosynthesis. Infrared spectra showed that the surface of silver nanoparticles is functionalized with the quercetin molecule. The antifungal activity of biogenic nanoparticles had efficacy in the following trend C. glabrata ≥ C. parapsilosis > C. albicans. Biogenic nanoparticles and stressors showed synergistic and potentiated antifungal effects through cell damage, osmotic stress, cell wall damage, and oxidative stress. Conclusion: Silver nanoparticles synthesized by quercetin-mediated biosynthesis could be implemented as a powerful adjuvant agent to enhance the inhibition effects of diverse compounds over different Candida species.

Electric vehicles (EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air pollution. Crucial factors for the widespread of EVs are the electrical charging infrastructure, driving range, and the reduction of the cost of battery packets. For this reason, there is a massive effort from manufacturers, governments, and the scientific community to reduce battery costs and boost sustainable electrical production and distribution. Battery reuse is an alternative to reduce batteries’ costs and environmental impacts. Second-life batteries can be used in a wide variety of secondary applications. Second-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems, vehicle charging stations, forklifts, and frequency control. The present work aims to analyze the main challenges imposed on the reuse of batteries, the leading technologies for their reuse, and the different types of batteries in terms of their feasibility for second-life use. The main novelty of this work is the discussion about the barriers, opportunities, uncertainties, and technologies for the second life market. Here we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility, environmental impacts, and perspectives. The results show five business models that have been proposed in the literature, three types of markets for trading second-life batteries, and the main opportunities and barriers for each actor in the battery supply chain.

Oxadiazoles are heterocyclic compounds that belong azole class which contain two nitrogen atoms and one oxygen, forming a five-membered heterocyclic ring. Four isomers of oxadiazoles are described in the literature. Among these, 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole have several applications biological. Compounds of this type have been used in the treatment of various diseases in both humans and animals.Among the immense class of heterocycle compounds with important biological activities already identified, the 1,2,5-oxadiazoles have stood out for the wide variety of applications in medicinal chemistry, in material, and agricultural chemistry. In this work, the main synthesis methods and advances for obtaining 1,2,5-oxadiazoles and their derivatives reported in the literature over the years are reviewed, as well as the applications of these compounds in several branches of chemistry and their biological activities discovered until the moment.

This review presents the technological evolution of devices based on Ion Sensitive Field Effect Transistors (ISFETs), which try to go along with the Metal Oxide Semiconductor FET (MOSFET) technology. Furthermore, many examples of the applications as chemical or biological sensors with different structures (planar or 3D), conduction channels (Silicon or Graphene), and dielectric gate films (SiNx, TiOx, TaOx, and AlOx) will be discussed.

Objetivo: avaliar a experiência de mães residentes em município paraibano sobre aleitamento materno. Método: nota prévia de um projeto guarda-chuva, de corte transversal, realizado com 252 mães, através de questionário virtual, por meio do Google Forms. Resultados: a principal motivação para continuidade do aleitamento materno exclusivo foi vínculo entre mãe e filho (23,4%) e a principal barreira foi o retorno ao trabalho (16,8%). Os três principais recursos de ingestão que provocaram a percepção do aumento do aleitamento materno foram sucos cítricos (21,2%), água (19,5%) e frutas diversas (7%). A maioria ingeriu até dois litros de água (46,4%), a substância mais eliciada para favorecer o volume de leite foi a tintura de algodoeiro (12,3%) e o método mais referido para aumento da produção foi a ordenha manual (63,6%), sendo problemas emocionais (40,5%) o maior motivo para a redução do leite. Sobre a ingestão de alimentos que porventura poderiam provocar gases, foram chocolate (27,6%), refrigerante (17,6%) e café (15%) os mais eliciados. Conclusão: acredita-se que este estudo traz contribuições a área materno-neonatal, bem como aos profissionais de saúde, pois incita o debate acerca dessa temática, de maneira que possibilita a ampliação do conhecimento e permita uma reflexão sobre as ações de promoção e apoio a amamentação, em busca da intersetorialidade e interdisciplinaridade, visando a redução nas taxas de desmame precoce.

Objetivo: Determinar la prevalencia de P. humanus var. capitis en escolares de primaria de una Institución Educativa Pública de Comas (Lima Metropolitana). Material y método: La investigación se realizó auscultando a 61 escolares entre niños y niñas del nivel primaria de una Institución Educativa, para ello cada escolar fue llevado a un ambiente separado del aula de clases y se les revisó la cabeza, especialmente la zona retroauricular, los piojos en estadios adultos, ninfas o huevos fueron recogidos y depositados en viales de vidrio con alcohol a 70º y rotulados con un código para identificar a cada estudiante. Las muestras colectadas fueron transportadas al laboratorio donde fueron observados a través del estereoscopio para confirmar la infección con el parásito. Resultados: De los escolares examinados 20 dieron positivos a ésta infección, lo que equivale a una prevalencia de 32,8% y del análisis inferencial se obtuvo un Chi-cuadrado = 25,25 con un p-valor = 0,000 < 0,05, con lo que se determinó que existe relación entre la infección con piojos y el sexo de los escolares. Conclusiones: La prevalencia de infección por piojos es alta en población escolar del nivel primaria en las zonas urbanas periféricas de la ciudad de Lima y puede acrecentarse en las provincias de nuestro país, además, la pediculosis capitis tiene relación significativa con el sexo de los escolares, siendo el sexo femenino la población vulnerable para esta infección, debido a que las mujeres llevan el cabello largo lo que facilitaría la infección.

A demanda por novos materiais torna necessário o desenvolvimento de métodos de análise microestrutural para avaliar as propriedades dos materiais. O objetivo deste trabalho é o desenvolvimento de um software que, por intermédio da aquisição e do tratamento de dados, correlaciona a condutividade elétrica e a microestrutura de um material. Para isso, foi construído um software em LabVIEW que recebe tanto as informações geométricas da amostra quanto sobre as medidas de tensão obtidas por um voltímetro de alta precisão, a fim de transformar esses dados em medidas de condutividade elétrica. Para avaliar o software, foi realizada a preparação, análise metalográfica e a medição da condutividade elétrica de duas amostras de aço livre de intersticiais (IF): laminada e tratada termicamente. A partir das micrografias obtidas pelo microscópio óptico e dos valores de condutividade encontrados pelo software, observou-se que a condutividade calculada estava coerente com a microestrutura das amostras. A demanda por novos materiais torna necessário o desenvolvimento de métodos de análise microestrutural para avaliar as propriedades dos materiais. O objetivo deste trabalho é o desenvolvimento de um software que, por intermédio da aquisição e do tratamento de dados, correlaciona a condutividade elétrica e a microestrutura de um material. Para isso, foi construído um software em LabVIEW que recebe tanto as informações geométricas da amostra quanto sobre as medidas de tensão obtidas por um voltímetro de alta precisão, a fim de transformar esses dados em medidas de condutividade elétrica. Para avaliar o software, foi realizada a preparação, análise metalográfica e a medição da condutividade elétrica de duas amostras de aço livre de intersticiais (IF): laminada e tratada termicamente. A partir das micrografias obtidas pelo microscópio óptico e dos valores de condutividade encontrados pelo software, observou-se que a condutividade calculada estava coerente com a microestrutura das amostras.

This is a descriptive and exploratory qualitative study of the integrative literature review type, whose objective was to demonstrate the main factors involved in the beef cattle breeding process in Brazil. The search for the material took place considering the management of the techniques, the environment that involves the practice, in Portuguese, English and Spanish, which were indexed in the databases: Scielo, Medline, Lilacs, Redalyc and Google Scholar whose production modalities were: original articles in case study, experience report, theoretical study, research report. Initially, 1352 articles were raised, of which, after reading the titles, 402 articles were excluded, resulting in 950 articles, of which the abstracts were read, 721 articles were excluded, resulting in 229 articles that, after reading in full, 214 articles were excluded, thus resulting in a sample of 15 articles. It was found that bovine genetic improvement programs are responsible for evaluating and determining the characteristics of animals to improve the economic gains of beef cattle. Through these programs, strategies are implemented in order to obtain the best possible genetic characteristics within a given condition.

Escrito en honor al profesor Manuel Atienza, con motivo de su jubilación como Catedrático de Filosofía del Derecho de la Universidad de Alicante (en 2022), el artículo recuerda la construcción de la teoría de la argumentación constitucional en esa universidad española, aborda los principales modelos de deliberación de los tribunales constitucionales identificados por esta teoría en el derecho comparado, y presenta las transformaciones institucionales actuales verificadas en estos modelos con la introducción de nuevas tecnologías para la práctica de las deliberaciones virtuales. Written in honor of Manuel Atienza, on the occasion of his retirement as Professor of Philosophy of Law at the University of Alicante (in 2022), the article recalls the construction of the Theory of Constitutional Reasoning at that Spanish university, then addresses the main models of deliberation identified in constitutional courts by this theory in comparative law, and reveals the current institutional transformations verified in these models by the introduction of new technologies for the practice of virtual deliberations.

O presente artigo tem o objetivo de realizar um levantamento na literatura sobre maus tratos e guarda responsável de animais de estimação no Estado do Paraná. O artigo 225, §1º, inciso VII da Constituição Brasileira afirma que para haver harmonia no meio ambiente é essencial a proteção à fauna, sendo vedado submeter os animais à crueldade. Entre os animais que devem ser protegidos estão incluídos os animais de estimação que ocupam um espaço importante nas famílias brasileiras. Entretanto, tais animais são submetidos a maus tratos mesmo sendo domiciliados. No Estado do Paraná foram evidenciados vários casos de maus tratos a cães e gatos, inclusive entre animais de abrigo. Todavia, existem avanços no Estado do Paraná. Dois cães que teriam sido vítimas de maus tratos, conseguiram no Tribunal de Justiça do Estado o direito de constarem como partes de um processo. Por meio da análise dos artigos consultados, conclui-se que são necessárias ações educativas para aumentar o bem-estar animal e a conscientização da população sobre a importância de cuidar bem dos animais.

A asma consiste em uma doença inflamatória crônica, caracterizada por hiperresponsividade das vias aéreas inferiores e limitação variável ao fluxo aéreo, reversível espontaneamente ou com tratamento, a qual se manifesta com episódios recorrentes de sibilância, dispneia, aperto no peito e tosse, particularmente à noite e pela manhã. A crise asmática é uma importante causa de procura por atendimento médico em serviços de emergência pediátrica, devendo ser, portanto, bem compreendida e manejada. Etiologicamente, sabe-se que a asma é multifatorial e está relacionada com fatores genéticos, imunológicos e ambientais, os quais predispõem à evolução da doença e em um indivíduo suscetível. A patogênese ainda carece de esclarecimentos, mas está relacionada a uma resposta imune exacerbada do organismo, resultando em uma broncoconstrição reversível das vias aéreas inferiores. Em virtude da sua variedade etiológica, a epidemiologia é variada e a incidência depende de diversos fatores. No que tange ao diagnóstico, este é, frequentemente, clínico, baseado na história clínica e pregressa do paciente. Vale ressaltar que os pacientes costumam manter-se assintomáticos e com exame físico normal quando fora da crise asmática, ressaltando a importância de uma boa anamnese. Além disso, alguns exames complementares são utilizados, como a espirometria com prova broncodilatadora, RX e/ou TC de tórax. Após o diagnóstico, é de extrema importância a classificação do quadro quanto à gravidade e quanto ao controle, o que irá guiar o manejo terapêutico. O tratamento adequado é imprescindível, a fim de evitar evolução do quadro e piora substancial na qualidade de vida. Inicialmente, vale ressaltar que o controle ambiental de gatilhos de exacerbações consiste em uma importante medida no controle da doença. Ademais, o tratamento farmacológico é necessário, sendo feito com o uso de beta 2 agonistas de curta ou longa duração, anticolinérgicos e corticosteróides, os quais são administrados em diferentes doses e combinações, a depender da classificação de cada quadro. Em casos graves, outras opções para tratamento são o sulfato de magnésio, epinefrina, imunomoduladores e leucotrienos.

The identification of species in animal-origin food is highly important in both quality and food safety issues. Adulteration in food is relevant for economic, religious, legislative or public health reasons. The objective of this study focused on identifying animal species (cattle, pigs and horses) in meat products in order to determine adulteration in the sale of mortadella (MO), hot dog (HD), pressed pork crackling (CP), chorizo (CH) and ham (JA). DNA was extracted from 5 different regions of each sausage and PCR was performed using species-specific primers. The species-specific region PCR amplicon was 271, 212 and 145 bp for cattle, pig, and horse meat, respectively. H.D was the only product amplified by the bovine-specific primers. The C.P and CH were amplified by the pig primers, since both products contained meat of this species. No amplification was observed in MO, H.D and JA, despite the fact that these included pork, according to the label declared by the company. These results show the existence of adulteration in the sale of these products. In the case of equine primers, no meat product has been amplified. It is concluded that there was a possible presence of adulteration in certain products, which represents a potential risk to public health and economic losses for consumers.

Acinetobacter baumannii is an important opportunistic pathogen that causes serious health-related infections, especially in intensive care units. The present study aimed to investigate the antimicrobial activity of Riparin-B (Rip-B) alone and in association with norfloxacin against multidrug-resistant clinical isolates of A. baumannii. For this, the minimum inhibitory concentrations were determined by the microdilution method. For the evaluation of resistance-modulating activity, MIC values for antibiotics were determined in the presence or absence of subinhibitory concentrations of Rip-B or chlorpromazine (CPZ). The AdeABC-AdeRS efflux system genes from these isolates were detected by PCR. Docking studies were also carried out to evaluate the interaction of Riparin-B and the AdeABC-AdeRS efflux system. The study was conducted from 2017 to 2019. The results showed that Rip-B showed weak intrinsic activity against the strains tested. On the other hand, Rip-B was able to modulate norfloxacin’s response against A. baumannii strains that express efflux pump-mediated resistance. Docking studies provided projections of the interaction between Rip-B and EtBr with the AdeB protein, suggesting that Rip-B acts by competitive inhibition with the drug. Results found by in vitro and in silico assays suggest that Rip‐B, in combination with norfloxacin, has the potential to treat infections caused by multidrug-resistant A. baumanni with efflux pump resistance.

El objetivo fue comparar los efectos de selenito de sodio (SS) y Sel-Plex® (SP) en el consumo de materia seca (CMS), ganancia diaria de peso (GDP), conversión alimenticia (CA), rendimiento de canales, Se en suero, músculos, albúmina, y globulinas en corderos Pelibuey. Cincuenta animales (PV=23.0 ± 1.1 kg; de 5 a 6 meses) se estratificaron y aleatoriamente asignaron a uno de cinco tratamientos (n=10): 1) Dieta basal, C); 2) C + 0.30 mg kg-1 MS de SS, 30SS; 3) C + 0.90 mg kg-1 MS de SS, 90SS; 4) C + 0.30 mg kg-1 MS de SP, 30SP; y 5) C + 0.90 mg kg-1 MS de SP, 90SP. No hubo efectos (P>0.05) en CMS; mientras que 90SP y 30SS mostraron GDP mayores (293 y 260 vs 245, 243, y 230 g día-1; P0.05). En Longissimus dorsi, 30SP incrementó (P0.05) en Gluteus maximus y Musculus deltoideus. La albúmina fue mayor con 30SP y 90SS; mientras que α-globulina fue mayor con 30SS y 90SP. En conclusión, 0.90 mg de SP mejoró la GDP y CA. Selenito y SP aumentaron el Se en suero hasta 0.30, y disminuyó con 0.90 mg por kilo de SP. En Longissimus dorsi, el Se se mejoró en 30SP con respecto 90SP y el C y no fue similar a 90SS y 30SS. El Se orgánico de 90SP mejoró el nivel de albúmina y α-globulinas.

Objetivou-se, evidenciar à luz da literatura científica, a percepção de gestantes acerca das complicações da infecção por zika vírus. Trata-se de revisão narrativa da literatura, do tipo descritiva-exploratória. A busca de dados foi realizada no período de outubro a novembro de 2022, de forma pareada e independente por dois pesquisadores nas bases de dados indexadas a BVS. Foram aplicados os seguintes filtros; artigos completos, disponíveis para download e leitura na íntegra; publicados nos três idiomas (português, inglês e espanhol). Salienta-se que neste estudo não será delimitado o recorte temporal de publicação dos artigos identificados, visto que buscou-se elevar abrangência da busca. Foram incluídos os artigos que versassem acerca da temática em estudo, excluindo as duplicatas, os resumos e relatos de experiências. Assim, obtiveram-se dez artigos para compor amostra final. Mediante o processo analítico dos estudos, evidenciou-se que as gestantes reconhecem que a infecção pelo Zika vírus, é uma doença que poderá repercutir negativamente na saúde materna-fetal e no desenvolvimento da gestação, podendo propiciar graves complicações, principalmente para os fetos. Portanto, faz-se necessário na implementação de cuidados pré-natais integrais, holísticos e, sobretudo de qualidade que visem a prevenção e controle do zika vírus, em especial durante a gravidez.

À la convergence de l’odontologie pédiatrique, de l’orthodontie et de la chirurgie orale la prise en charge des dents incluses est multidisciplinaire et nécessitera fréquemment le recours à un examen CBCT afin d’évaluer les options thérapeutiques (désinclusion chirurgico-orthodontique, avulsion, réimplantation, abstention), les atteintes des dents adjacentes, les voies d’abord chirurgicales et risques anatomiques associés dès lors que les limites des examens 2D sont atteintes. Par une large iconographie clinique nous aborderons les différentes étiologies des inclusions ainsi qu’une méthodologie simple d’analyse des volumes CBCT permettant au clinicien d’exploiter pleinement tous les éléments pouvant être mis en évidence sur ce type d’examen.

Cluster B personality disorders (PDs) share specific traits that can result in interpersonal conflict. As therapeutic working alliance has a strong relationship with improved outcomes, there is interest in understanding the relationship between PDs, working alliance, and clinical outcomes. This is especially compelling in inpatient populations, where symptoms are severe, and patients are working with a treatment team. The aims of this study were to (a) assess whether higher team working alliance is associated with lower depressive symptoms, (b) assess whether patients with Cluster B PD traits have worse working alliance with their team than patients without those Cluster B PD traits, and (c) assess whether higher team working alliance is associated with lower depressive symptoms when Cluster B PD traits are present. Team working alliance was measured at baseline and at discharge for 3,406 inpatients at a psychiatric hospital. Improved team working alliance was associated with lower depression scores at discharge. Patients with borderline personality disorder traits had worse team working alliance, whereas patients with narcissistic personality disorder and antisocial personality disorder traits had similar working alliance scores as other patients. Borderline personality disorder and antisocial personality disorder traits moderated the association between team working alliance and depressive symptoms differently. Findings suggest that team working alliance works similarly to therapist working alliance. Of clinical importance is the finding that team working alliance and its relationship with depression symptoms differ based on Cluster B PD traits, and the importance of strong working alliance regardless of interpersonal challenges due to personality pathology. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A identidade de um indivíduo pode ser unitária e múltipla, revelada e construída, estável e fluida, e, ainda, pessoal e social. Dessa forma, o objetivo deste artigo é analisar a formação das identidades dos sujeitos indígenas em época hodierna. A metodologia da pesquisa é qualitativa e firma-se em um estudo teórico-conceitual e bibliográfico. A base da fundamentação teórica consiste, sobretudo, nos estudos de Berger e Luckmann (2008), Bessa Freire (2004), Stavenhagen(2000), Munduruku (2012), Bruner (1997), Bauman (1999), Rajagopalan (2003). Em linhas gerais, o estudo concluiu que a identidade dos povos indígenas encontra-se em crise por se situarem em um espaço de contradições e de estranheza sobre o conhecimento, o lugar e o contexto, aos quais pertencem.

Este artigo investiga o estado do conhecimento em teses e dissertações como um dos caminhos para a pesquisa em História da Educação, em específico, sobre a história do Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso (IFMT), situado na Região Centro-Oeste do Brasil. Foram selecionadas produções acadêmicas discentes dos programas nacionais de pós-graduação stricto sensu, expressa em teses de doutorado e dissertações de mestrado, que percorreram a história do IFMT entre os anos de 1909 e 2008. Ao constituir-se parte de uma pesquisa de doutoramento em andamento, o objetivo foi mapear e analisar pesquisas acadêmicas relacionadas ao tema em estudo, recortes temáticos-históricos e abordagens metodológicas empregadas nas pesquisas.

Buscando tentativas para manter atividades educativas, como também a vinculação dos estudantes, muitos países e instituições de ensino adotaram a educação remota como alternativa. Neste contexto pandêmico a educação a distância – EAD, que consiste em um processo de ensino/aprendizagem e proporciona todo um aparato de materiais que são desenvolvidos por uma equipe de profissionais preparados para adequação da EAD com conteúdo e metodologias voltadas para inter-relação das tecnologias de informação. A metodologia utilizada na composição deste trabalho, com base na pesquisa bibliográfica, estruturada por meio de leituras em artigos científicos e de sites. A pesquisa de cunho qualiquantitativa. Os resultados corroboram para fundamentação dos resultados. Para tanto, utilizou-se um questionário na plataforma do Google Forms elaborado, com perguntas abertas e fechadas sobre o tema em questão. O público envolvido foram todos alunos e professores da Universidade Estadual do Maranhão no qual obtivemos o total de 187 alunos e 21 professores totalizando 208 entrevistados. As entrevistas deram-se de forma remota na qual o questionário foi disponibilizado via WhatsApp e também no Instagram no período de agosto de 2020 à março de 2021. Na observância da análise dos dados constatou-se que mesmo dispondo de inúmeras tecnologias alguns alunos não possuem acesso aos recursos necessários para realização de suas atividades educacionais. Diante destas informações percebe que há falta de recursos tecnológicos aos discentes e que, favorece de certa forma o processo de exclusão, e desta forma inviabiliza o processo de aprendizagem.

From the creation of new corn genomics to meet production demands, it is necessary to evaluate how these new cultivars react to the different environments that exist in Brazil. Front this, the objective of this study was to evaluate the effects of different levels of N and K used to topdressing fertilization on agronomic characteristics of two corn varieties at Amazon environmental conditions. The experimental design was randomized in block using a factorial scheme (2 x 4 x 4), with two corn varieties (BRS Caimbé and BR 5011 Sertanejo), four N dosages (0, 60, 100, and 140 kg.ha-1) and four K dosages (0, 20, 60, and 90 kg.ha-1). Each plot was constituted by five lines of 20 m of length and 2.40 m of width, with a space of 0.60 m among these, totalizing an area of 48 m2 per plot. Data collected were subjected to ANOVA and, subsequently, to Tukey test at 5% of significance. Caimbé corn variety presented higher (p < 0.05) number of plants, plant weight, and spikes per plot. High dosages of N and K provided high (p < 0.05) number of plants, plant weight, and spikes per plot. Caimbé corn variety presented higher (p < 0.05) spike weight and size. Other variables did not present significant (p > 0.05) results. High dosages of N provided high (p < 0.05) stem diameter and weight, leaf weight, spike size, and low spike weight. Lower levels of K caused low (p < 0.05) plant height, first spike height insertion, stem diameter, and spike weight.

El objetivo del presente trabajo fue determinar los parámetros productivos y reproductivos de cuyes de la raza Perú, ubicados a 3.676 metros sobre el nivel del mar en la sierra del Perú. Para ello, se utilizaron registros productivos y reproductivos de 1.336 cuyes (653 hembras y 683 machos) del Programa de Mejoramiento Genético de Cuyes (PMGC) de la Universidad Nacional de Huancavelica (UNH). Los parámetros productivos evaluados fueron: los pesos al nacimiento (PN), de camada al nacimiento (PCN), al destete (PD), de camada al destete (PCD), al mes (P1M), a los dos meses (P2M) y a los tres meses (P3M). Los parámetros reproductivos evaluados fueron: tamaño de camada al nacimiento (TCN), número de nacidos vivos (NV) y tamaño de camada al destete (TCD). Los parámetros productivos y reproductivos fueron estimados mediante estadística descriptiva; así mismo, se evaluó la influencia del sexo, número de parto y tamaño de camada sobre los parámetros productivos a través del análisis de la varianza, utilizando la opción lm (linear model) del programa estadístico R. Se obtuvieron los siguientes valores: 148,58 gramos (g), 3,19; 2,86; 418,26 g; 290,97 g; 2,86; 794,86 g; 399,99 g; 576,64 g y 768,94 g para PN, TCN, NV, PCN, PD, TCD, PCD, P1M, P2M y P3M, respectivamente. El tamaño de camada y el número de parto tienen efecto sobre los parámetros productivos estudiados, por otro lado, el sexo tiene influencia únicamente sobre P2M y P3M.

Over the last several decades, inpatient psychiatric length of stay (LOS) has been greatly reduced to the detriment of patients. Latent variable mixture modeling, can be used to improve the quality of care for patients by identifying unobserved subgroups and optimize treatment variables, including LOS. This study had three objectives (1) to replicate the findings made by Oh et al. in a distinct sample, (2) to examine demographic differences related to inpatient treatment trajectories, and (3) to relate additional variables to each trajectory. We collected data on six key mental illness factors and information on felonies, misdemeanors, history of stopping psychiatric medication and psychotherapy, length of time in psychotherapy, and the number of therapists and psychiatrists from 489 patients at an inpatient psychiatric hospital. We derived latent mental illness scores after applying growth mixture modeling to these data. We identified three distinct trajectories of mental illness change: High-Risk, Rapid Improvement (HR-RI), Low-Risk, Partial Response (LR-PR), and High-Risk, Gradual Improvement (HR-GI). The HR-GI group was more likely to have patients who were female, Asian, younger, Yearly Income (YI)$20,000, that spent more time in psychotherapy throughout their life, and had the longest LOS while inpatient. The LR-PR group had was more likely to be male, Hispanic/Latino and multiracial, older, YI$500,000, have a history of misdemeanors, and this group had the shortest LOS (p .05). These findings replicate and extend our previous findings in Oh et al. (2020a) and highlight the clinical utility of agnostically determining the treatment trajectories.

Resistance training is recommended for preventing sarcopenia, but the benefits for the quality and quantity of muscle mass are uncertain.To assess the effects of high-intensity resistance training (HIRT) on clinical and magnetic resonance imaging (MRI) parameters in women with sarcopenia.A researcher-blinded randomized clinical trial was conducted. Community-dwelling older women with sarcopenia were randomized to six months of HIRT or a control group (CG). Body composition was assessed with bioimpedance equipment, and participants underwent strength and functional performance tests (short physical performance battery [SPPB] and gait speed). MRI scans of the thigh were taken to quantify muscle mass and quality.Thirty-eight women completed the study (20 in the HIRT group). Sarcopenia remitted in 50 % of the HIRT group. HIRT elicited a significant group × time interaction effect for muscle mass (p = 0.027; ȠHIRT led to the remission of sarcopenia in half of the older women, as seen in muscle mass, strength, and functional performance and MRI biomarkers, with significant increases in muscle quality. REGISTERED IN CLINICALTRIALS.GOV: NCT03834558.

The imbalance between water supply and demand highlights the vulnerability of many people and the prospect of an uncertain future for water supply. This work aims to compare the Urban Water Security Index (UWSI) with three other methodologies (percentage flow duration curve, Urban Water Sustainability Indicator, and accumulated data from the Drought Monitor) for the municipality of Guarabira, Paraíba, Brazil. The results show water security based on the amount of water in the study area. However, there is a need for proposals for assessing urban water security to be based on local sustainability. Water-sensitive planning is the solution to maintaining and conserving natural resources for future generations in the face of impacts, particularly climate change and population growth. The methodology applied in this work can contribute to the investigation of probable and specific causes of water insecurity and gives evidence of improvement in the concept of water security based on the urban metabolism of water.

Anxiety is a normal behavioral component. When it is too frequent or appears in inappropriate contexts, it can be considered pathological. Benzodiazepines (BDZs) are drugs with clinical success in anxiety treatment. BDZs act as allosteric modulators of the γ- aminobutyric acid A receptor (GABAAR). However, these drugs cause adverse effects. Despite the therapeutic advances obtained with BDZs, the search for anxiolytics with fewer adverse effects is ongoing. Studies with monoterpene (–)-borneol [(–)-BOR] demonstrated pharmacological properties such as a partial agonist effect of GABAAR and an anticonvulsive effect. On the other hand, no work has been developed evaluating the anxiolytic/sedative potential. The objective of this study was to investigate the anxiolytic/sedative effects of (–)-BOR in animal models at doses of 25, 50, and 100 mg/kg (i.p.) and whether there was a molecular interaction with GABAAR. The anxiolytic effect of monoterpene (–)-BOR was tested on Swiss mice (25–30 g) in three anxiety models: the elevated plus maze test, the open field test, and the light-dark box test. The thiopental-induced sleep time model was a drug screen for the sedative and hypnotic activity related to GABAARs. In the molecular docking, the interaction between the GABAAR molecule and (–)-BOR was performed using the AutoDock 4.2.6 program. The results demonstrated that (–)-BOR has sedative and anxiolytic activity. The molecular docking study revealed that (–)-BOR can interact with GABAARs through hydrogen bonds.

INTRODUCCIÓN La aparición del síndrome de Meigs o pseudomeigs caracterizado por presencia de tumor ovárico, ascitis, derrame pleural es menos frecuente en este grupo de edad por lo que es infradiagnosticado retrasando el tratamiento oportuno. Debido a eso es detectado hasta en estadios avanzados ocasionando disfuncionalidad en poco tiempo. CASO CLÍNICO Mujer de 91 años conocida con hipertensión arterial sistémica, Diabetes Mellitus, uso de bastón monopodálico, con valoración geriátrica inicial: Katz A-B-G, Lawton y Brody 7-3-1, Barthel 85-75-35, pre frágil, sin queja de memoria. Acudió por hiporexia de 1 mes de evolución, evacuaciones diarreicas asociados a episodios de incontinencia fecal, disnea que progreso a pequeños esfuerzos, ascitis y edema de miembros inferiores. CONCLUSIÓN Es importante considerar estos síndromes como diagnóstico diferencial en pacientes que presenten súbitamente derrame pleural, ascitis o ambos con el fin de no retrasar el tratamiento oportuno y preservar la funcionalidad en el mayor grado posible. Background The appearance of Meigs syndrome or pseudomeigs characterized by the presence of an ovarian tumor, ascites, pleural effusion is less frequent in this age group, which is why it is underdiagnosed, delaying timely treatment. Because of this, it is detected even in advanced stages, causing dysfunction in a short time. Clinical Case A 91-year-old woman with systemic arterial hypertension, Diabetes Mellitus, use of monopodal with initial geriatric assessment: Katz A-B-G, Lawton and Brody 7-3-1, Barthel 85-75-35, pre-frail, without complaint of memory. He came due to hyporexia of 1 month evolution, diarrhea associated with episodes of fecal incontinence, dyspnea that progressed with small efforts, ascites and edema of the lower limbs. Conclusión It is important to consider these syndromes as a differential diagnosis in patients who suddenly present with pleural effusion, ascites, or both in order not to delay timely treatment and to preserve functionality to the greatest possible degree.

Context Feeding dairy cows with plant oils rich in unsaturated fatty acids is a recommended strategy for increasing the proportion of polyunsaturated fatty acids in milk for human consumption. Aims We evaluated the effects of supplementation with peanut oil (high oleic acid content) and sunflower oil (high linoleic acid content) on the fatty acid profile and oxidative stability of milk and the expression of oxidative stress response, lipogenic-related and insulin-like growth factor 1 (IGF-1) genes in pasture-fed Jersey cows in early lactation. Methods Twenty-four cows were distributed in a randomised block design. Treatments were four dietary supplements of concentrate alone, or concentrate plus oil (59.6 g/kg dry matter): peanut oil, sunflower oil, or a 1:1 (v/v) mixture of peanut and sunflower oils. Analyses were performed at 30 and 60 days in milk. Key results Both peanut oil and mixed oil diets increased the hypocholesterolemic/hypercholesterolemic ratio (P

The present work, entitled Some peculiarities of the use of definite articles in proper nouns (anthroponyms and toponyms): a semantic approach in a comparative perspective between Mozambican Portuguese and European Portuguese, has as main objective to analyze the use of definite articles in proper nouns ( anthroponyms and toponyms) in Mozambican Portuguese. In this sense, we try to describe the different contexts in which the presence/absence of definite articles in proper names (anthroponyms and toponyms) occurs in European Portuguese (EP), we also try to compare the use of definite articles in proper names (anthroponyms and toponyms) in Mozambican Portuguese (PM) with European Portuguese (PE). The study is of a descriptive nature and to carry out the data analysis, a written corpus was built that resulted from the application of two linguistic tests, namely a provoked production test (filling in empty spaces in Portuguese sentences), composed of thirteen ( 13) sentences and a test of grammaticality and/or acceptability judgments, consisting of twenty-six (26) sentences. The inquiry was directed to eighty (80) students of the 10th Grade of the Secondary School of Tete. The analyzed data allowed us to verify that in the variety of Mozambican Portuguese, speakers constantly omit the definite articles in sentences with simple anthroponyms in different positions and contexts, thus creating a difference with European Portuguese; they omit definite articles in contexts where simple toponyms occur (referring to place names that designate landforms), in a predicative syntactic position of the subject; in short, the study allowed us to verify several differences in the two varieties of Portuguese, with regard to the use and/or omission of definite articles in different contexts.

In recent years, there has been a significant increase in demand for collagen biostimulators in aesthetic medicine. Collagen biostimulators are compounds that increase the production of collagen in the skin, improving the appearance and reducing the signs of aging. Botulinum toxin is one of the most popular and consumed aesthetic procedures worldwide, being widely used to reduce expression lines and facial wrinkles. The combination of filler with hyaluronic acid, botulinum toxin and collagen biostimulators has been frequently used in facial harmonization, providing more natural and lasting results. A possible hypothesis about the drug interaction between botulinum toxin and collagen biostimulators, when used in the same session, is that the combination of these treatments may interfere with each other's effectiveness. Thus, the objective of this bibliographical review was to evaluate the available studies on the drug interaction between botulinum toxin and collagen biostimulators when used in the same session. In this sense, it was observed that the combined use of botulinum toxin and collagen biostimulators requires caution and attention when choosing the application technique and the period of use of botulinum toxin in relation to collagen biostimulators. The interaction between the procedures due to their mechanisms of action and inflammatory stimuli is evident.

O estado de pandemia que teve início em 2019, com o primeiro caso e estende-se até́ a atualidade, tem como agente causal o SARS-COV-2, reconhecido pela OMS (Organização Mundial de Saúde) como uma doença respiratória que é denominada como COVID-19 . O vírus apresentou uma alta taxa de transmissibilidade e também apresentou alto índice de mortalidade na população mundial, com mais de três milhões de pessoas mortas no mundo, sendo dessas no Brasil mais de quinhentos mil.² No caso das gestantes, em função de sua condição de imunossupressão, quando apresentam a forma sintomática da COVID 19 podem desenvolver maiores complicações respiratórias e evoluir para óbito, sendo assim mais suscetíveis a permanência em unidade de terapia intensiva.4,5O presente estudo tem por objetivo geral entender o perfil clínico e epidemiológico das gestantes e puérperas que evoluíram para óbito e fizeram uso de unidade de terapia intensiva, com diagnóstico confirmado de COVID 19, no ano de 2020, no Estado de Pernambuco. Trata-se de um estudo com abordagem quantitativa de caráter transversal e retrospectivo. A coleta de dados foi realizada através de pesquisa no Sistema de Informação da Vigilância Epidemiológica da Gripe (SIVE Gripe), foram coletadas informações acerca dos dados sociodemográficos das mulheres, seus antecedentes pessoais, dados obstétricos, internação em UTI, suporte ventilatório, uso de retrovirais e desfecho duro. Como resultados, das 210 mulheres estudadas, 82% eram pardas, cerca de 80% das mulheres estavam no terceiro trimestre (59,5%) ou puérperas (25,2%). Das que estiveram na UTI, 75% utilizaram suporte ventilatório, 17% usaram retrovirais, 14% da amostra evoluiu para óbito