1. Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2
- Author
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Diana Luz, Juárez-Flores, Ingrid, González-Casacuberta, Mario, Ezquerra, María, Bañó, Francesc, Carmona-Pontaque, Marc, Catalán-García, Mariona, Guitart-Mampel, Juan José, Rivero, Ester, Tobias, Jose Cesar, Milisenda, Eduard, Tolosa, Maria Jose, Marti, Ruben, Fernández-Santiago, Francesc, Cardellach, Constanza, Morén, and Glòria, Garrabou
- Subjects
Adult ,Male ,Heterozygote ,Parkinson Disease ,Middle Aged ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Mitochondrial Dynamics ,Mitochondria ,Phenotype ,Mutation ,Autophagy ,Humans ,Female ,Aged - Abstract
Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autophagy in LRRK2Fibroblasts from six non-manifesting LRRK2A similar mitochondrial phenotype of NM-LRRK2Enhanced mitochondrial performance of NM-LRRK2
- Published
- 2018