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Medical therapy for hydrocephalus includes the administration of medications to limit the production of the cerebrospinal fluid (CSF) resulting in reduced intracranial pressure (ICP). This report describes the clinical findings in one dog with congenital hydrocephalus that was unresponsive to conventional medical treatment (steroids) but demonstrated good response to omeprazole when this drug was added to the steroid. Omeprazole might decrease the CSF production by about 26% according to experimental studies with healthy dogs, but the usage of the omeprazole in clinical trials with affected dogs such as hydrocephalic animals is lacking. The results of this report might suggest that omeprazole can be used added to steroids to ameliorate the neurological status in dogs with increased ICP by hydrocephalus.

Feline morbillivirus was first identified in healthy and diseased stray cats captured in Hong Kong. Recently, it was demonstrated that the virus circulates within cat populations in Japan, Italy, Germany, and the USA. Importantly, an association between feline morbillivirus infection and chronic kidney disease was suggested by histological analysis of kidney tissue of infected cats. The aim of this study was to verify the presence and examine the genetic diversity of feline morbilliviruses associated with infections of domestic cats in Brazil. Seventeen cats without clinical manifestations of urinary tract diseases from a multi-cat household and 35 random client-owned cats admitted to the Teaching Veterinary Hospital for a variety of reasons were evaluated for paramyxoviral infection and the presence of uropathy. A fragment of the paramyxoviral L gene was amplified from urine samples using a reverse transcription semi-nested PCR assay. For the first time, we detected a feline morbillivirus strain that was genetically related to viral strains previously characterized in Japan in urine samples from cats in South America, in Brazil. This together with the recent description of feline morbillivirus identification within cat populations in the USA, suggests a possible widespread distribution of this viral agent on the American continent. Our data demonstrated feline morbillivirus RNA shedding mostly in the urine of cats without clinical, laboratorial, or ultrasonographic signs of urinary tract diseases. In contrast to previously published findings that associated feline morbillivirus infection with chronic kidney disease, we did not observe a clear relationship between feline morbillivirus RNA shedding in urine and kidney disease in the cats evaluated.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:50Z No. of bitstreams: 1 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) Made available in DSpace on 2013-08-22T18:59:50Z (GMT). No. of bitstreams: 1 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) Previous issue date: 2007-04-01 Made available in DSpace on 2013-09-30T19:57:14Z (GMT). No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Previous issue date: 2007-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:51Z No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Made available in DSpace on 2014-05-20T15:14:51Z (GMT). No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Previous issue date: 2007-04-01 O desvio vascular portossistêmico pode ser congênito ou adquirido nos cães. A enfermidade pode levar a alterações neurológicas decorrentes de encefalopatia hepática e a hiperamonenia é um dos mecanismos implicados na fisiopatologia deste quadro. O tratamento clínico visa a reduzir os níveis séricos de amônia com o uso de antibióticos e lactulose. em humanos com hepatopatias, os probióticos podem ser utilizados para reduzir a hiperamonemia. A resposta clínica e laboratorial de um cão com desvio vascular portossistêmico foi demonstrada com a utilização de lactulose e de probiótico, isoladamente e associados, sendo que a melhor evolução foi obtida na terapia conjunta. The portosystemic shunt may be congenital or acquired in dogs. The disease can cause neurologic signs manifested by hepatic encephalopathy. The hyperammonemia is a mechanism involved on the physiopathology of this disorder. The objective of the clinical treatment is to decrease the levels of ammonia with antibiotics and lactulose. In human medicine, probiotics are used to reduce the hyperammonemia in patients with hepatic diseases. This report compares the use of lactulose and probiotic monotherapy and in association in a dog with congenital portosystemic shunt, showing the patient s clinical and laboratorial evolutions. The better clinical and laboratorial reponse was obtained with the association of lactulose and probiotic. Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária

Osteoarthritis (OA) is the most common joint disease in both humans and animals, and it results in movement restriction and pain at the affected area. This disorder affects more than 25% of people over 60 years of age, and it is considered universal for 70-year-old people. OA is estimated to affect over 20% of the canine population from the United States of America. The present study aimed to evaluate the treatment of rats that were surgically induced to OA using two different drug therapies, one with pentosan polysulfate, one with betamethasone, and one with chondroitin sulfate/ glucosamine. In order to produce joint disease, the cranial cruciate ligament was surgically transected. Animals were kept and treated for eight days after surgery and were assessed via both radiographies and tomographies taken before surgery and eight weeks later. All animals were euthanized having both macroscopic and microscopic analysis performed to evaluate the disorder progression and therapeutic action. Macroscopic analysis showed lesion in the knees subjected to OA induction. The untreated animals presented major lesions whereas the treated ones presented mild to moderate lesions. In conclusion, pentosan polysulfate is recommendable for the treatment of iatrogenic joint lesions in rats since the other treatments showed no significant difference.

The bioelectrical impedance is a method that applies impedance technology in the study of physical composition by evaluation of electrical conductivity difference on each organism tissue. The results of bioelectrical impedance (BIC) are expressed by the resistance (R) and reactance (Xc) primary measures. This study was carried out to verify the viability of the use of three different electrodes on the repeatability of R and Xc values in adult cats. The averages of R and Xc estimated by adhesive and acupuncture needles did not differ from each other (p?0.05) and the smaller values of the variation coefficient acquired with these electrodes signaled for a better reproducibility of the results when compared with hypodermic needle. The different types of electrode did not interfere on the LBM estimated by specific equation, but the acupuncture needle electrode was the most stable and easily applicable. The LBM values determined with the different types of electrode were higher (p?0.05) than the LBM dual-energy X-ray absorptiometry (DEXA) values, probably due to the specific equation to LBM estimation used in this study. KEY WORDS: Body composition, feline, impedance, lean body mass.