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3 results on '"Roland, Lauren T."'

1. International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Author

Wise, Sarah K, Damask, Cecelia, Roland, Lauren T, Ebert, Charles, Levy, Joshua M, Lin, Sandra, Luong, Amber, Rodriguez, Kenneth, Sedaghat, Ahmad R, Toskala, Elina, Villwock, Jennifer, Abdullah, Baharudin, Akdiş, Cezmi, Alt, Jeremiah A, Ansotegui, Ignacio J, Azar, Antoine, Baroody, Fuad, Benninger, Michael S, Bernstein, Jonathan, Brook, Christopher, Campbell, Raewyn, Casale, Thomas, Chaaban, Mohamad, Chew, Fook Tim, Chambliss, Jeffrey, Cianferoni, Antonella, Custovic, Adnan, Davis, Elizabeth Mahoney, DelGaudio, John M, Ellis, Anne K, et al, and University of Zurich

Subjects
microbiome, 10045 Clinic for Otorhinolaryngology, cockroach, sensitization, immunoglobulin E, socioeconomic, eosinophilic esophagitis, pet dander, systematic review, cough, subcutaneous immunotherapy, conjunctivitis, Immunology and Allergy, house dust mite, cromolyn, atopic dermatitis, based medicine, leukotriene, inhalant allergy, transcutaneous immunotherapy, pollen, epidemiology, IgE, immunotherapy, biologic, environment, probiotic, avoidance, corticosteroid, sinusitis, specific IgE, 610 Medicine & health, antihistamine, validated survey, sublingual immunotherapy, rhinitis, saline, occupational rhinitis, decongestant, rhinosinusitis, perennial, food allergy, allergic rhinitis, allergen extract, evidence, asthma, seasonal, allergy, epicutaneous, total IgE, pediatric, Otorhinolaryngology, consensus, allergen immunotherapy, omalizumab
Published
2023
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2. Short-term chemosensory distortions and phantoms in COVID-19

Author

Gurrola, José G, Chang, Jolie L, Roland, Lauren T, Loftus, Patricia A, and Cheung, Steven W

Subjects
taste, Clinical Research, COVID‐19, Neurosciences, smell, COVID-19, chemosensory dysfunction
Abstract

ObjectiveTo identify differentiation features of chemosensory dysfunction in COVID-19 infection and their primary drivers.Study designCross-sectional cohort comparison.MethodsA national anonymous survey was used to query participants regarding nasal symptoms and chemosensory dysfunction including sensitivity levels, and presence or absence of distortions and phantoms within the 6-week time window surrounding their COVID-19 testing and survey completion.ResultsThree-hundred and sixty-four respondents who reported COVID-19 positive (COVID+; n = 176) or COVID-19 negative (COVID-; n = 188) test results completed the survey. The COVID+ cohort had higher occurrence rates for: (a) chemosensory sensitivity impairments (67.0% vs 30.3%; P

Published
2021

3. Smell and taste symptom-based predictive model for COVID-19 diagnosis

Author

Roland, Lauren T, Gurrola, Jose G, Loftus, Patricia A, Cheung, Steven W, and Chang, Jolie L

Subjects
Adult, Male, Fever, Immunology, Cohort Studies, taste, Betacoronavirus, COVID-19 Testing, Theoretical, Models, smell, Humans, Viral, receiver operating characteristic curve, Pandemics, Clinical Laboratory Techniques, SARS-CoV-2, Predictors, Receiver Operating Curve, COVID-19, Pneumonia, Middle Aged, ROC Curve, Symptoms, Female, Coronavirus Infections
Abstract

BackgroundThe presentation of coronavirus 2019 (COVID-19) overlaps with common influenza symptoms. There is limited data on whether a specific symptom or collection of symptoms may be useful to predict test positivity.MethodsAn anonymous electronic survey was publicized through social media to query participants with COVID-19 testing. Respondents were questioned regarding 10 presenting symptoms, demographic information, comorbidities, and COVID-19 test results. Stepwise logistic regression was used to identify predictors for COVID-19 positivity. Selected classifiers were assessed for prediction performance using receiver operating characteristic (ROC) curve analysis.ResultsA total of 145 participants with positive COVID-19 testing and 157 with negative results were included. Participants had a mean age of 39 years, and 214 (72%) were female. Smell or taste change, fever, and body ache were associated with COVID-19 positivity, and shortness of breath and sore throat were associated with a negative test result (p < 0.05). A model using all 5 diagnostic symptoms had the highest accuracy with a predictive ability of 82% in discriminating between COVID-19 results. To maximize sensitivity and maintain fair diagnostic accuracy, a combination of 2 symptoms, change in sense of smell or taste and fever was found to have a sensitivity of 70% and overall discrimination accuracy of 75%.ConclusionSmell or taste change is a strong predictor for a COVID-19-positive test result. Using the presence of smell or taste change with fever, this parsimonious classifier correctly predicts 75% of COVID-19 test results. A larger cohort of respondents will be necessary to refine classifier performance.

Published
2020

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