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2 results on '"Rodriguez-Mayo, M"'

1. Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain

Author

Escribano, P, Rodriguez-Sanchez, B, Diaz-Garcia, J, Martin-Gomez, MT, Ibanez-Martinez, E, Rodriguez-Mayo, M, Pelaez, T, de la Pedrosa, EGG, Tejero-Garcia, R, Marimon, JM, Reigadas, E, Rezusta, A, Labayru-Echeverria, C, Perez-Ayala, A, Ayats, J, Cobo, F, Pazos, C, Lopez-Soria, L, Alastruey-Izquierdo, A, Munoz, P, Guinea, J, Sánchez-Reus F., and Hernaez Crespo, Silvia

Subjects
Isavuconazole, Aspergillus fumigatus, parasitic diseases, Resistance, Voriconazole, bacterial infections and mycoses, Azole
Abstract

Objectives: We aimed to assess the percentage of azole resistance in Aspergillus fumigatus in Spain. Methods: Thirty participating Spanish hospitals stored all morphologically identified A. fumigatus sensu lato clinical isolates-regardless their clinical significance-from 15 February to 14 May 2019. Isolates showing azole resistance according to the EUCAST 9.3.2 methodology were molecularly identified and the cyp51A gene was studied in A. fumigatus sensu stricto isolates. Results: Eight hundred and forty-seven isolates from 725 patients were collected in 29 hospitals (A. fumigatus sensu stricto (n = 828) and cryptic species (n = 19)). Isolates were mostly from the lower respiratory tract (94.0%; 797/847). Only cryptic species were amphotericin B resistant. Sixty-three (7.4%) out of the 847 isolates were resistant to >= 1 azole(s). Azole resistance was higher in cryptic species than in A. fumigatus sensu stricto (95%, 18/19 vs. 5.5%, 45/828); isavuconazole was associated to the lowest number of non-wild type isolates. The dominant mechanism of resistance was the presence of TR34 -L98H substitutions (n = 24 out of 63). Out of the 725 patients, 48 (6.6%) carried either cryptic species (n = 14) or A. fumigatus sensu stricto (n = 34; 4.7%) resistant isolates. Aspergillus fumigatus sensu stricto harbouring either the TR34 -L98H (n = 19) or TR46 /Y121F/T289A (n = 1) mutations were detected in patients in hospitals located at 7/24 studied cities. Discussion: Of the patients, 6.6% carry azole-resistant A. fumigatus sensu lato isolates in Spain. TR34-L98H is the dominant cyp51A gene substitutions, although its presence is not widespread. (C) 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Published
2021

2. Pseudomonas aeruginosa: A multicenter study in 136 hospitals in Spain,Pseudomonas aeruginosa: Estudio multicéntrico en 136 hospitales Españoles

Author

Bouza, E., García-Garrote, F., Cercenado, E., Marín, M., Díaz, M. S., Sánchez Romero, I., Vindel, A., Àlvarez, R. M., Fernández Pérez, F., Del Valle-Ortiz Maeztu, O., Almirante, B., Idastorza, I., Díaz García, R., Leyva León, J., Agulla Budiño, A., Rodriguez Mayo, M., Tinajas Puertas, A., Paz Vidal, I., Cachón Gracia, F., García Rodríguez, J. A., García Sánchez, J. E., Lantero Benedito, M., Undabeitia Santiesteban, E., Olarte Olarte, I., Alonso García, M. P., Rodríguez, A., Otero, I., Alvarez Fernández, M., Fontanals, D., Mariscal, D., Soriano García, F., Gadea, I., Noriega, A., Folqueira, L., Lloret Caballeira, A., Segarra, C., Cisterna Cáncer, R., Ezpeleta, C., García Lomas Barrionuevo, J., Gimeno Cardona, C., Rubio, M. C., Pinedo Sánchez, A., Jiménez Anta Losada, M. T., Almela Prades, M., Navarro Pardos, C., Carmen Aspiroz, Colomo, L. F., Mellado, P., Martínez, J., Gimeno Crespo, C., Méndez García, J., Cimadevílla, R., Urmeneta Rada, A., Martín-Scapa, C., Gasterurrutia, L., López Soria, L., Echeverría Irigoyen, J., Batlle I Surruca, J., Motjé Casas, M., Hidalgo Pérez, M. E., Gutíérrez, A., García Perea, A., Nogues, A., García, M., Torres Piñón, J., Vasallo Vidal, F. J., Pérez Revílla, A., Gómez Garcés, J. L., Dorronsoro Ibero, I., García Irure, J. J., García Aguayo, J. M., Ortiz La Tabla Ducasse, V., Martín González, C., López Gracia, J., Martín Saco, G., Santamaria Puíg, J. M., Tapiol Oliva, M. J., Navarro Gallar, F., Sánchez Santana, P., Fuster Foz, C., Salvadó, M., Torrella, M. T., Menéndez Rivas, M., Alberte Castinieiras, A., Pérez Pascual, P., Calbo Torrecillas, L., Francisco Ramírez, J. L., Sánchez Porto, A., Domínguez Jiménez, M. C., Reyes Bertos, A., Gonzalo Jiménez, M. N., Giner Almaraz, S., Nogueira, J. M., Igual Adell, R., Plata Rosales, C., Crespo Sánchez, D., Andreu, M., Plazas Ruiz, J., and Santos Rionda, M. J.

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