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Your search keyword '"Rho guanosine triphosphatase"' showing total 2 results
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2 results on '"Rho guanosine triphosphatase"'

1. Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes. Evidence for an autoregulatory mechanism

Author

Kristína Schenková, Francisco Rivero, Manabu Furukawa, Yoshie Miura, Jessica Berthold, Pontus Aspenström, Sonia Ramos, German Research Foundation, Fundación Ramón Areces, University of Cologne, Swedish Research Council, National Cancer Institute (US), and National Institutes of Health (US)

Subjects
rho GTP-Binding Proteins, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Rho guanosine triphosphatase, GTPase, Biology, Models, Biological, Article, Cancer profiling array, Cullin, Mice, Prenylation, Ubiquitin, Chlorocebus aethiops, Tumor Cells, Cultured, Animals, Homeostasis, Humans, BTB domain, RhoBTB, Microscopy, Confocal, Cullin Proteins, Cell Biology, Ubiquitin ligase, Cell biology, COS Cells, biology.protein, HeLa Cells
Abstract

S. R. was a recipient of a fellowship from Fundación Ramón Areces. F.R was supported by grants of the Center for Molecular Medicine Cologne (CMMC) and the Deutsche Forschungsgemeinschaft. Support by the Köln Fortune program of the Medical Faculty, University of Cologne to F.R. is also acknowledged. P.A. was supported by funds from the Ludwig Institute for Cancer Research, the Swedish Research Council and the Swedish Science Foundation. M. F. was supported by RR018759 from the National Center for Research Resources, a component of the National Institutes of Health and CA036727 from National Cancer Institute.

Published
2008

2. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse

Author

Baggavalli P. Somesh, Francisco Rivero, Farshad Khademi, Sonia Ramos, Fundación Ramón Areces, German Research Foundation, and University of Cologne

Subjects
Male, rho GTP-Binding Proteins, Subfamily, Rho guanosine triphosphatase, GTPase, Biology, Signal transduction, medicine.disease_cause, Cell Line, Mice, Gene duplication, Genetics, medicine, Tumor Cells, Cultured, Animals, Humans, Expression pattern, Amino Acid Sequence, BTB domain, RhoBTB, Gene, Phylogeny, Cytoskeleton, Genomic organization, Cancer, Binding Sites, Base Sequence, Sequence Homology, Amino Acid, Fugu, Gene Expression Profiling, General Medicine, Exons, Introns, Isoenzymes, Genes, Female, Carcinogenesis, HeLa Cells
Abstract

Members of the RhoBTB subfamily of Rho GTPases are present in vertebrates, Drosophila and Dictyostelium. RhoBTB proteins are characterized by a modular organization, consisting of a GTPase (guanosine triphosphatase) domain, a proline rich region, a tandem of two BTB (road-Complex, ramtrack, and ric à brac) domains and a C-terminal region of unknown function and might act as docking points for multiple components participating in signal transduction cascades. We have determined the genomic organization and the expression pattern of the three RHOBTB genes of human and mouse. The exon–intron organization of each gene is conserved in three vertebrate species (human, mouse and Fugu). RHOBTB1 and RHOBTB2 have a similar exon–intron organization and are closely related to the single gene encoding the RhoBTB orthologs of two insect species. By contrast, the exon–intron organization of RHOBTB3 differed substantially from that of the two other genes, indicating that this gene arose by a duplication event independent of the one that gave rise to RHOBTB1 and RHOBTB2. RHOBTB1 (located on chromosome 10) and RHOBTB3 (located on chromosome 5) appear ubiquitously expressed. However, they display a differential pattern of expression: RHOBTB1 showed high levels in stomach, skeletal muscle, placenta, kidney and testis, whereas RHOBTB3 was highly expressed in neural and cardiac tissues, pancreas, placenta and testis. RHOBTB2 (located on chromosome 8) showed much lower levels of expression than the other two human RHOBTB genes and it was most abundant in neural tissues. The expression patterns of the human and mouse genes were roughly comparable. All three genes were also detected in fetal tissues, and in a number of cell lines RHOBTB3 predominates. RHOBTB genes are upregulated in some cancer cell lines, suggesting that these proteins might participate in tumorigenesis., S.R. is the recipient of a fellowship from Fundación Ramón Areces and F.K. is the recipient of a fellowship from the Köln Fortune Program. This work was supported by the Deutsche Forschungsgemeinschaft (RI 1034/2) and by the Köln Fortune Program (Faculty of Medicine, University of Cologne).

Published
2002

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