1. Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin
- Author
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Anne, Rix, Natascha Ingrid, Drude, Anna, Mrugalla, Ferhan, Baskaya, Koon Yan, Pak, Brian, Gray, Hans-Jürgen, Kaiser, René Hany, Tolba, Eva, Fiegle, Wiltrud, Lederle, Felix Manuel, Mottaghy, and Fabian, Kiessling
- Subjects
Mice, Inbred BALB C ,Gallium Radioisotopes ,Acetates ,Kidney ,Heterocyclic Compounds, 1-Ring ,Mice ,Bacteriocins ,Liver ,Doxorubicin ,Neoplasms ,Positron Emission Tomography Computed Tomography ,Antineoplastic Combined Chemotherapy Protocols ,Animals ,Female ,Tissue Distribution ,Cisplatin ,Radiopharmaceuticals ,Peptides ,Busulfan - Abstract
Evaluation of [Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [In vitro experiments confirmed specific binding of [[
- Published
- 2019