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2. Follow-Up Imaging Guidelines for Patients with Stage III Unresectable NSCLC: Recommendations Based on the PACIFIC Trial

Author

Jenny J. Ko, Shantanu Banerji, Normand Blais, Anthony Brade, Cathy Clelland, Devin Schellenberg, Stephanie Snow, Paul Wheatley-Price, Ren Yuan, and Barbara Melosky

Abstract

The PACIFIC trial showed a survival benefit with durvalumab through five years in stage III unresectable non-small cell lung cancer (NSCLC). However, optimal use of imaging to detect disease progression remains unclearly defined for this population. An expert working group convened to consider available evidence and clinical experience and develop recommendations for follow-up imaging after concurrent chemotherapy and radiation therapy (CRT). Voting on agreement was conducted anonymously via online survey. Follow-up imaging was recommended for all suitable patients after CRT completion regardless of whether durvalumab is received. Imaging should occur every 3 months in Year 1, at least every 6 months in Year 2, and at least every 12 months in Years 3–5. Contrast computed tomography was preferred; routine brain imaging was not recommended for asymptomatic patients. The medical oncologist should follow-up during Year 1 of durvalumab therapy, with radiation oncologist involvement if pneumonitis is suspected; medical and radiation oncologists can subsequently alternate follow-up. Some patients can transition to the family physician/community primary care team at the end of Year 2. In Years 1–5, patients should receive information regarding smoking cessation, comorbidity management, vaccinations, and general follow-up care. These recommendations provide guidance on follow-up imaging for patients with stage III unresectable NSCLC whether or not they receive durvalumab consolidation therapy.

Published
2023

4. Economic impact of using risk models for eligibility selection to the International lung screening Trial

Author

Sonya Cressman, Marianne F. Weber, Preston J. Ngo, Stephen Wade, Silvia Behar Harpaz, Michael Caruana, Alain Tremblay, Renee Manser, Emily Stone, Sukhinder Atkar-Khattra, Deme Karikios, Cheryl Ho, Aleisha Fernandes, Jing Yi Weng, Annette McWilliams, Renelle Myers, John Mayo, John Yee, Ren Yuan, Henry M Marshall, Kwun M Fong, Stephen Lam, Karen Canfell, and Martin C Tammemägi

Subjects
Pulmonary and Respiratory Medicine, Cancer Research, Oncology
Abstract

Using risk models as eligibility criteria for lung screening can reduce race and sex-based disparities. We used data from the International Lung Screening Trial(ILST; NCT02871856) to compare the economic impact of using the PLCOm2012 risk model or the US Preventative Services' categorical age-smoking history-based criteria (USPSTF-2013).The cost-effectiveness of using PLCOm2012 versus USPSTF-2013 was evaluated with a decision analytic model based on the ILST and other screening trials. The primary outcomes were costs in 2020 International Dollars ($), quality-adjusted life-years (QALY) and incremental net benefit (INB, in $ per QALY). Secondary outcomes were selection characteristics and cancer detection rates (CDR).Compared with the USPSTF-2013 criteria, the PLCOm2012 risk model resulted in $355 of cost savings per 0.2 QALYs gained (INB=$4294 at a willingness-to-pay threshold of $20 000/QALY (95 %CI: $4205-$4383). Using the risk model was more cost-effective in females at both a 1.5 % and 1.7 % 6-year risk threshold (INB=$6616 and $6112, respectively), compared with males ($5221 and $695). The PLCOm2012 model selected more females, more individuals with fewer years of formal education, and more people with other respiratory illnesses in the ILST. The CDR with the risk model was higher in females compared with the USPSTF-2013 criteria (Risk Ratio = 7.67, 95 % CI: 1.87-31.38).The PLCOm2012 model saved costs, increased QALYs and mitigated socioeconomic and sex-based disparities in access to screening.

Published
2023

5. Rich magnetic phase transitions and completely dual-spin polarization of zigzag PC3 nanoribbons under uniaxial strain

Author

Hui-Min Ni, Jing-Jing He, Fang-Wen Guo, Jia-Bei Dong, Tian-Yi Lu, Wen-Dou Cui, Jia-Ren Yuan, Yan-Dong Guo, and Xiao-Hong Yan

Subjects
General Physics and Astronomy, Physical and Theoretical Chemistry
Abstract

Strain leads to a rich magnetic phase transition in PC3NR, that is, from bandgap-tunable bipolar magnetic semiconductors to spin-gapless semiconductors to ferromagnetic metals or half-metal magnets and ±100% SP over a wide energy interval around EF.

Published
2023

7. Modulation of edge defects on dual-spin filtering in zigzag β-SiC7 nanoribbons

Author

Jing-Jing He, Fang-Wen Guo, Hui-Min Ni, Jia-Bei Dong, Wen-Dou Cui, Tian-Yi Lu, Jia-Ren Yuan, Yan-Dong Guo, and Xiao-Hong Yan

Subjects
General Physics and Astronomy, Physical and Theoretical Chemistry
Abstract

The unique edge states of the zigzag β-SiC7 nanoribbons aroused our attention, and therefore, based on first-principles calculations, we investigated their spin-dependent electronic transport properties by constructing controllable defects to modulate these special edge states. Interestingly, by introducing rectangular edge defects in the SiSi and SiC edge-terminated systems, not only the spin-unpolarized is successfully converted to completely spin-polarized, but also the direction of polarization can be switched, thus enabling a dual spin filter. The analyses further reveal that the two transmission channels with opposite spins are spatially separated and that the transmission eigenstates are highly concentrated at the relative edges. The specific edge defect introduced only suppresses the transmission channel at the same edge but reserves the transmission channel at the other edge. In addition, for the CSi and CC edge-terminated systems, an additional spin-down band exists due to spin splitting in the spin-up band at EF, so that besides the original spatially separated two spin-opposite channels, an extra spin channel is distributed at the upper edge, resulting in unidirectional fully spin-polarized transport. The peculiar spatially separated edge states and excellent spin filtering properties could open up further possibilities for β-SiC7-based electronic devices in spintronics applications.

Published
2023

8. The promise and challenge of spatial omics in dissecting tumour microenvironment and the role of AI

Author

Lee, Ren Yuan, Ng, Chan Way, Rajapakse, Menaka Priyadharsani, Ang, Nicholas, Yeong, Joe Poh Sheng, and Lau, Mai Chan

Subjects
Cancer Research, Oncology
Abstract

Growing evidence supports the critical role of tumour microenvironment (TME) in tumour progression, metastases, and treatment response. However, the in-situ interplay among various TME components, particularly between immune and tumour cells, are largely unknown, hindering our understanding of how tumour progresses and responds to treatment. While mainstream single-cell omics techniques allow deep, single-cell phenotyping, they lack crucial spatial information for in-situ cell-cell interaction analysis. On the other hand, tissue-based approaches such as hematoxylin and eosin and chromogenic immunohistochemistry staining can preserve the spatial information of TME components but are limited by their low-content staining. High-content spatial profiling technologies, termed spatial omics, have greatly advanced in the past decades to overcome these limitations. These technologies continue to emerge to include more molecular features (RNAs and/or proteins) and to enhance spatial resolution, opening new opportunities for discovering novel biological knowledge, biomarkers, and therapeutic targets. These advancements also spur the need for novel computational methods to mine useful TME insights from the increasing data complexity confounded by high molecular features and spatial resolution. In this review, we present state-of-the-art spatial omics technologies, their applications, major strengths, and limitations as well as the role of artificial intelligence (AI) in TME studies.

Published
2023

11. Supplementary Figure 1 from Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor

Author

Fred Bunz, Gregory J. Riggins, Charles M. Rudin, Alexandra Borodovsky, Jon H. Chung, Ren-Yuan Bai, and Andrew R. Larsen

Abstract

Supplementary Figure 1: (A) Survival of mice with DAOY-derived orthotopic tumors at 25 mg/kg MBZ (n=4) or mock-treated (n=3). One mouse from the mock treatment group did not develop symptoms of a growing brain tumor, and was euthanized after surviving for more than six months. This mouse was not found to have a brain tumor, and was therefore omitted from this analysis. (B) RNA was harvested from untreated and treated tumors and assessed by qRT-PCR for expression of GLI1, PTCH1, and PTCH2.

Published
2023

13. Data from Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model

Author

Gregory J. Riggins, Gary L. Gallia, Avadhut Joshi, Michelle A. Rudek, Teresia Wanjiku, Verena Staedtke, and Ren-Yuan Bai

Abstract

Purpose: Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma. Three different mebendazole polymorphs (A, B, and C) exist, and a detailed assessment of the brain penetration, pharmacokinetics, and antitumor properties of each individual mebendazole polymorph is necessary to improve mebendazole-based brain cancer therapy.Experimental Design and Results: In this study, various marketed and custom-formulated mebendazole tablets were analyzed for their polymorph content by IR spectroscopy and subsequently tested in an orthotopic GL261 mouse glioma model for efficacy and tolerability. The pharmacokinetics and brain concentration of mebendazole polymorphs and two main metabolites were analyzed by LC/MS. We found that polymorph B and C both increased survival in a GL261 glioma model, as B exhibited greater toxicity. Polymorph A showed no benefit. Polymorph B and C both reached concentrations in the brain that exceeded the IC50 in GL261 cells 29-fold. In addition, polymorph C demonstrated an AUC0–24h brain-to-plasma (B/P) ratio of 0.82, whereas B showed higher plasma AUC and lower B/P ratio. In contrast, polymorph A presented markedly lower levels in the plasma and brain. Furthermore, the combination with elacridar was able to significantly improve the efficacy of polymorph C in GL261 glioma and D425 medulloblastoma models in mice.Conclusions: Among mebendazole polymorphs, C reaches therapeutically effective concentrations in the brain tissue and tumor with fewer side effects, and is the better choice for brain cancer therapy. Its efficacy can be further enhanced by combination with elacridar. Clin Cancer Res; 21(15); 3462–70. ©2015 AACR.

Published
2023

27. Hadron-Induced Radiation Damage in LuAG:Ce Scintillating Ceramics

Author

Chen Hu, Liyuan Zhang, Ren-Yuan Zhu, Jiang Li, Benxue Jiang, Jon Kapustinsky, Michael Mocko, Ron Nelson, Xuan Li, and Zhehui Wang

Subjects
Nuclear and High Energy Physics, Nuclear Energy and Engineering, Electrical and Electronic Engineering, Nuclear Experiment
Abstract

Because of their potential low cost, bright light, and fast decay time, LuAG:Ce ceramic scintillators have attracted a broad interest in the high-energy physics community. One crucial issue for their application in future high-energy physics experiments is their radiation hardness against neutrons and protons expected at future hadron colliders. We report optical and scintillation performance of 1-mm LuAG:Ce ceramic samples doped with Mg²⁺ (and Ca²⁺) and their radiation damage induced by hadrons. While Mg²⁺ co-doping improves their light output, Ca²⁺ co-doping improves their fast to total (F/T) ratio. LuAG:Ce ceramic samples were irradiated at the Los Alamos Neutron Science Center (LANSCE), Los Alamos, NM, USA, by neutrons up to 6.7×10¹⁵ n_(eq)/cm² and by 24-GeV and 800-MeV protons at CERN PS-IRRAD up to 1.2×10¹⁵ p/cm² and at LANSCE up to 2.3×10¹⁴ p/cm², respectively. All samples show excellent radiation hardness with more than 90% of light after irradiation. The RIAC values induced by neutrons are found to be a factor of 2 smaller than lutetium–yttrium oxyorthosilicate (LYSO:Ce) crystals. The RIAC values induced by protons are also found a factor of 2 smaller than LYSO:Ce crystals in LuAG:Ce ceramic samples with good optical quality. Research and development will continue to develop LuAG:Ce scintillating ceramics with improved optical quality for future investigation.

Published
2022

28. An associative memory circuit based on physical memristors

Author

Kaixuan Zhao, Ren-Yuan Liu, Gang Dou, Yongliang Zhu, and Mei Guo

Subjects
Artificial neural network, Computer science, Cognitive Neuroscience, Memristor, Content-addressable memory, Computer Science Applications, law.invention, Synaptic weight, Neuromorphic engineering, Artificial Intelligence, law, Synaptic plasticity, Electronic engineering, Electronic circuit, Voltage
Abstract

In this paper, a physical Sr 0.97 Ba 0.03 TiO 3 - x (SBT) memristor with the voltage threshold characteristic was prepared. For characterizing the electrical characteristics of SBT memristor accurately, an adaptive voltage threshold memristor model was proposed. The synaptic plasticity of SBT memristor with different pulse stimulation was analyzed. Moreover, a Pavlov associative memory circuit was designed in the LTSPICE environment, which is composed of neuron circuit and memristive synaptic circuit. The neuron circuit can generate spike signals when the input signals exceed the threshold, and the synaptic weight can be tunable continuously by spike signals. Different from other memristive synaptic circuits, the proposed memristive synaptic circuit is based on physical SBT memristor, and the change of synaptic weight can be truly reflected in the circuit. In Pavlov’s dog experiment, when the presynaptic neuron receives the conditioned stimulus (CS) before the unconditioned stimulus (US), the synaptic weight of SBT memristor is increasing and the associative memory is building. When the presynaptic neuron receives the CS alone, or presynaptic neuron receives the CS after the US, the synaptic weight of SBT memristor is decreasing and the associative memory is losing. This phenomenon is highly similar to the building and losing processes of biological associative memory. These experimental results verify the feasibility and applicability of SBT memristor as electronic synapse in neuromorphic applications, and pave the way towards further development of artificial neural networks.

Published
2022

29. Electrically modulated reversible dual-spin filter in zigzag β-SiC7 nanoribbons

Author

Jing-Jing He, Fang-Wen Guo, Hui-Min Ni, Jia-Ren Yuan, Wen-Dou Cui, Tian-Yi Lu, Yan-Dong Guo, and Xiao-Hong Yan

Subjects
General Physics and Astronomy, Physical and Theoretical Chemistry
Abstract

The introduced gate voltage allows β-SiC7 nanoribbons to behave as an excellent electrically modulated reversible dual spin filter with surprisingly accurate control of spin polarization.

Published
2022

30. USPSTF2013 versus PLCOm2012 lung cancer screening eligibility criteria (International Lung Screening Trial): interim analysis of a prospective cohort study

Author

Martin C Tammemägi, Mamta Ruparel, Alain Tremblay, Renelle Myers, John Mayo, John Yee, Sukhinder Atkar-Khattra, Ren Yuan, Sonya Cressman, John English, Eric Bedard, Paul MacEachern, Paul Burrowes, Samantha L Quaife, Henry Marshall, Ian Yang, Rayleen Bowman, Linda Passmore, Annette McWilliams, Fraser Brims, Kuan Pin Lim, Lin Mo, Stephen Melsom, Bann Saffar, Mark Teh, Ramon Sheehan, Yijin Kuok, Renee Manser, Louis Irving, Daniel Steinfort, Mark McCusker, Diane Pascoe, Paul Fogarty, Emily Stone, David C L Lam, Ming-Yen Ng, Varut Vardhanabhuti, Christine D Berg, Rayjean J Hung, Samuel M Janes, Kwun Fong, and Stephen Lam

Subjects
Aged, 80 and over, Male, Lung Neoplasms, Oncology, Eligibility Determination, Mass Screening, Humans, Female, Articles, Prospective Studies, Middle Aged, Early Detection of Cancer, Aged
Abstract

Summary Background Lung cancer is a major health problem. CT lung screening can reduce lung cancer mortality through early diagnosis by at least 20%. Screening high-risk individuals is most effective. Retrospective analyses suggest that identifying individuals for screening by accurate prediction models is more efficient than using categorical age-smoking criteria, such as the US Preventive Services Task Force (USPSTF) criteria. This study prospectively compared the effectiveness of the USPSTF2013 and PLCOm2012 model eligibility criteria. Methods In this prospective cohort study, participants from the International Lung Screening Trial (ILST), aged 55–80 years, who were current or former smokers (ie, had ≥30 pack-years smoking history or ≤15 quit-years since last permanently quitting), and who met USPSTF2013 criteria or a PLCOm2012 risk threshold of at least 1·51% within 6 years of screening, were recruited from nine screening sites in Canada, Australia, Hong Kong, and the UK. After enrolment, patients were assessed with the USPSTF2013 criteria and the PLCOm2012 risk model with a threshold of at least 1·70% at 6 years. Data were collected locally and centralised. Main outcomes were the comparison of lung cancer detection rates and cumulative life expectancies in patients with lung cancer between USPSTF2013 criteria and the PLCOm2012 model. In this Article, we present data from an interim analysis. To estimate the incidence of lung cancers in individuals who were USPSTF2013-negative and had PLCOm2012 of less than 1·51% at 6 years, ever-smokers in the Prostate Lung Colorectal and Ovarian Cancer Screening Trial (PLCO) who met these criteria and their lung cancer incidence were applied to the ILST sample size for the mean follow-up occurring in the ILST. This trial is registered at ClinicalTrials.gov, NCT02871856. Study enrolment is almost complete. Findings Between June 17, 2015, and Dec 29, 2020, 5819 participants from the International Lung Screening Trial (ILST) were enrolled on the basis of meeting USPSTF2013 criteria or the PLCOm2012 risk threshold of at least 1·51% at 6 years. The same number of individuals was selected for the PLCOm2012 model as for the USPSTF2013 criteria (4540 [78%] of 5819). After a mean follow-up of 2·3 years (SD 1·0), 135 lung cancers occurred in 4540 USPSTF2013-positive participants and 162 in 4540 participants included in the PLCOm2012 of at least 1·70% at 6 years group (cancer sensitivity difference 15·8%, 95% CI 10·7–22·1%; absolute odds ratio 4·00, 95% CI 1·89–9·44; p

Published
2022

31. Adipose-Derived Mesenchymal Stem Cell-Derived Exosomal miR-301a-3p Regulates Airway Smooth Muscle Cells During Asthma by Targeting STAT3

Author

Feng,Chen-Ye, Bai,Shi-Yao, Li,Meng-Lu, Zhao,Jie-Yu, Sun,Jia-Min, Bao,Hui-Jing, Ren,Yuan, and Su,Xin-Ming

Subjects
STAT3, Pulmonary and Respiratory Medicine, miR-301a-3p, Journal of Asthma and Allergy, exosome, Immunology and Allergy, asthma, mesenchymal stem cell, Original Research
Abstract

Chen-Ye Feng *, Shi-Yao Bai *, Meng-Lu Li, Jie-Yu Zhao, Jia-Min Sun, Hui-Jing Bao, Yuan Ren, Xin-Ming Su Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, Shenyang, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Ming SuDepartment of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University; Respiratory Disease Institution of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, People’s Republic of ChinaEmail xinming_med@126.comBackground: Asthma is a chronic inflammatory disease featured by inflammation and remodeling of airway. Adipose-derived mesenchymal stem cell (ADSCs)-derived exosomal miRNAs have been suggested as promising therapeutic manners for diseases.Methods: ADSCs and airway smooth muscle cells (ASMCs) were isolated from SD rats. Flow cytometry was conducted to detect the surface biomarkers of isolated cells. Exosomes were extracted by sequentially centrifuge method and identified by Western blotting and nanoparticle tracking analysis (NTA). Uptake of exosomes by ASMCs was detected by confocal assay. ASMCs were treated with platelet-derived growth factor-BB (PDGF-BB) to mimic cell remodeling and inflammation. Cell counting 8 (CCK-8), Transwell, and flow cytometry were performed to determine the viability, migration, and apoptosis of ASMCs. Release of inflammatory factors was detected by enzyme-linked immunosorbent assay (ELISA). Levels of RNAs and proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay. Interaction between miR-301a-3p and signal transducer and activator of transcription 3 (STAT3) was determined by luciferase reporter gene assay. The effect of Exosomal miR-301a-3p was analyzed in ovalbumin (OVA)-induced asthma mouse model.Results: ADSCs-derived exosomes could be effectively internalized by ASMCs. Exosomal miR-301a-3p notably suppressed the PDGF-BB-stimulated proliferation and migration of ASMCs, and enhanced apoptosis, as well as decreased the secretion of inflammatory factors. MiR-301a-3p directly targeted the 3ʹUTR region of STAT3. STAT3 overexpression reversed the suppressive effects of exosomal miR-301a-3p on ASMCs under PDGF-BB stimulation. The expression of miR-301a-3p and STAT3 was negative correlation in specimen from patients with asthma. Exosomal miR-301a-3p inhibited OVA-induced lung injury by targeting STAT3 in mice.Conclusion: This study exposed that exosomal miR-301a-3p from ADSCs could effectively alleviate PDGF-BB-stimulated remodeling and inflammation of ASMCs via targeting STAT3, presented ADSCs-derived exosomal miR-301a-3p as a promising therapeutic approach for asthma.Keywords: asthma, mesenchymal stem cell, exosome, miR-301a-3p, STAT3

Published
2022

32. Rich magnetic phase transitions and completely dual-spin polarization of zigzag PC

Author

Hui-Min, Ni, Jing-Jing, He, Fang-Wen, Guo, Jia-Bei, Dong, Tian-Yi, Lu, Wen-Dou, Cui, Jia-Ren, Yuan, Yan-Dong, Guo, and Xiao-Hong, Yan

Abstract

Among many modulation methods, strain engineering is often chosen for nanomaterials to produce tunable band gaps continuously. Inspired by the recently reported two-dimensional material PC

Published
2023

33. Single-shot spatial instability and electric control of polariton condensates at room temperature

Author

Gao, Ying, Ma, Xuekai, Zhai, Xiaokun, Xing, Chunzi, Gao, Meini, Dai, Haitao, Wu, Hao, Liu, Tong, Ren, Yuan, Wang, Xiao, Pan, Anlian, Hu, Wei, Schumacher, Stefan, and Gao, Tingge

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), FOS: Physical sciences, Physics - Optics, Optics (physics.optics)
Abstract

In planar microcavities, the transverse-electric and transverse-magnetic (TE-TM) mode splitting of cavity photons arises due to their different penetration into the Bragg mirrors and can result in optical spin-orbit coupling (SOC). In this work, we find that in a liquid crystal (LC) microcavity filled with perovskite microplates, the pronounced TE-TM splitting gives rise to a strong SOC that leads to the spatial instability of microcavity polariton condensates under single-shot excitation. Spatially varying hole burning and mode competition occurs between polarization components leading to different condensate profiles from shot to shot. The single-shot polariton condensates become stable when the SOC vanishes as the TE and TM modes are spectrally well separated from each other, which can be achieved by application of an electric field to our LC microcavity with electrically tunable anisotropy. Our findings are well reproduced and traced back to their physical origin by our detailed numerical simulations. With the electrical manipulation our work reveals how the shot-to-shot spatial instability of spatial polariton profiles can be engineered in anisotropic microcavities at room temperature, which will benefit the development of stable polariton-based optoeletronic and light-emitting devices.

Published
2023
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35. Enriched environment can reverse chronic sleep deprivation-induced damage to cellular plasticity in the dentate gyrus of the hippocampus

Author

Xue Shixing, Hou Xueyan, Ren Yuan, Tang Wei, and Wang Wei

Subjects
General Neuroscience
Abstract

Objective We studied whether enriched environment (EE), a classic epigenetics paradigm, can prevent cellular plasticity damage caused by chronic sleep deprivation (SD). Methods We performed SD in mice by a modified multi-platform method (MMPM). Mice in the SD group were deprived of sleep for 18 h a day. In addition, half of the mice in the chronic SD group were exposed to EE stimuli for 6 h per day. Immunostaining analyzed neurogenesis and neural progenitor cell-differentiated phenotypes in the hippocampal dentate gyrus (DG) region. Result At 13 weeks, compared with the control group, SD severely impaired the proliferation and differentiation of neural stem cells, and EE completely reversed the process. SD can induce gliosis in the mouse hippocampus, and EE can delay the process. Conclusion: Our results suggest that chronic SD may damage the neurogenesis in the DG of the hippocampus. However, enrichment stimulation can reverse the processing by promoting neuronal repair related to neuronal plasticity.

Published
2023

37. Two-particle Bose-Einstein correlations and their Lévy parameters in PbPb collisions at $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV

Author

Tumasyan, Armen, Adam, Wolfgang, Krammer, Natascha, Martins, Jordan, Sekmen, Sezen, Yang, Yu Chul, Kim, Hyunchul, Moon, Dong Ho, Asilar, Ece, Kim, Tae Jeong, Park, Jiwon, Choi, Suyong, Han, Seyoung, Hong, Byung-Sik, Mora Herrera, Clemencia, Lee, Kisoo, Lee, Kyong Sei, Lim, Jaehoon, Park, Jaebeom, Park, Sung Keun, Yoo, Jaehyeok, Goh, Junghwan, Kim, Hyunsoo, Kim, Yongsun, Lee, Seungjun, Mota Amarilo, Kevin, Almond, John, Bhyun, Ji Hwan, Choi, Junho, Jeon, Sihyun, Kim, Junho, Kim, Jae Sung, Ko, Sanghyun, Kwon, Hyejin, Lee, Haneol, Lee, Sangeun, Mundim, Luiz, Oh, Byung Hun, Oh, Sung Bin, Seo, Hyonsan, Yang, Unki, Yoon, Inseok, Jang, Woojin, Kang, Da Young, Kang, Yechan, Kim, Donghyun, Kim, Seulgi, Nogima, Helio, Ko, Byeonghak, Lee, Jason Sang Hun, Lee, Yunjae, Merlin, Jeremie Alexandre, Park, Inkyu, Roh, Youn, Song, Donghyun, Watson, Ian, Yang, Seungjin, Ha, Seungkyu, Santoro, Alberto, Yoo, Hwi Dong, Choi, Minuk, Kim, Mi Ran, Lee, Heewon, Lee, Younghoon, Yu, Intae, Beyrouthy, Taha, Maghrbi, Yasser, Dreimanis, Karlis, Pikurs, Guntis, Silva Do Amaral, Sheila Mara, Potrebko, Andris, Seidel, Markus, Veckalns, Viesturs, Ambrozas, Marijus, Carvalho Antunes De Oliveira, Alexandra, Juodagalvis, Andrius, Rinkevicius, Aurelijus, Tamulaitis, Gintautas, Bin Norjoharuddeen, Nurfikri, Hoh, Siew Yan, Sznajder, Andre, Yusuff, Imran, Zolkapli, Zukhaimira, Benitez, Jose F., Castaneda Hernandez, Alfredo, Encinas Acosta, Hedwin Aaron, Gallegos Maríñez, Luis Gabriel, León Coello, Moisés, Murillo Quijada, Javier Alberto, Sehrawat, Ashish, Valencia Palomo, Lizardo, Thiel, Mauricio, Ayala, Gabriel, Castilla-Valdez, Heriberto, Heredia-De La Cruz, Ivan, Lopez-Fernandez, Ricardo, Mondragon Herrera, Cesar Atzin, Perez Navarro, Daniel Alejandro, Sánchez Hernández, Alberto, Oropeza Barrera, Cristina, Vazquez Valencia, Fabiola, Pedraza, Isabel, Vilela Pereira, Antonio, Salazar Ibarguen, Humberto Antonio, Uribe Estrada, Cecilia, Bubanja, Itana, Mijuskovic, Jelena, Raicevic, Natasa, Ahmad, Ashfaq, Asghar, Muhammad Irfan, Awais, Ali, Awan, Muhammad Imran Malik, Gul, Muhammad, Lechner, Lukas, Bernardes, Cesar Augusto, Hoorani, Hafeez R., Khan, Wajid Ali, Avati, Valentina, Grzanka, Leszek, Malawski, Maciej, Bialkowska, Helena, Bluj, Michal, Boimska, Bozena, Górski, Maciej, Kazana, Malgorzata, Calligaris, Luigi, Szleper, Michal, Zalewski, Piotr, Bunkowski, Karol, Doroba, Krzysztof, Kalinowski, Artur, Konecki, Marcin, Krolikowski, Jan, Araujo, Mariana, Bargassa, Pedrame, Bastos, Diogo, Tomei, Thiago, Boletti, Alessio, Faccioli, Pietro, Gallinaro, Michele, Hollar, Jonathan, Leonardo, Nuno, Niknejad, Tahereh Sadat, Pisano, Matteo, Seixas, Joao, Varela, Joao, Adzic, Petar, De Moraes Gregores, Eduardo, Dordevic, Milos, Milenovic, Predrag, Milosevic, Jovan, Aguilar-Benitez, Manuel, Alcaraz Maestre, Juan, Barrio Luna, Mar, Fernandez Bedoya, Cristina, Cepeda, Maria, Cerrada, Marcos, Colino, Nicanor, Mercadante, Pedro G., De La Cruz, Begona, Delgado Peris, Antonio, Fernández Del Val, Diego, Fernández Ramos, Juan Pablo, Flix, Jose, Fouz, Maria Cruz, Gonzalez Lopez, Oscar, Goy Lopez, Silvia, Hernandez, Jose M., Josa, Maria Isabel, Novaes, Sergio F., León Holgado, Jaime, Moran, Dermot, Perez Dengra, Carlos, Pérez-Calero Yzquierdo, Antonio María, Puerta Pelayo, Jesus, Redondo, Ignacio, Redondo Ferrero, David Daniel, Romero, Luciano, Sánchez Navas, Sergio, Sastre, Javier, Padula, Sandra, Urda Gómez, Lourdes, Vazquez Escobar, Julia, Willmott, Carlos, de Trocóniz, Jorge F., Alvarez Gonzalez, Barbara, Cuevas, Javier, Fernandez Menendez, Javier, Folgueras, Santiago, Gonzalez Caballero, Isidro, González Fernández, Juan Rodrigo, Aleksandrov, Aleksandar, Palencia Cortezon, Enrique, Ramón Álvarez, Clara, Rodríguez Bouza, Víctor, Soto Rodríguez, Alejandro, Trapote, Andrea, Vico Villalba, Carlos, Brochero Cifuentes, Javier Andres, Cabrillo, Iban Jose, Calderon, Alicia, Duarte Campderros, Jordi, Antchev, Georgy, Fernandez, Marcos, Fernandez Madrazo, Celia, García Alonso, Andrea, Gomez, Gervasio, Lasaosa García, Clara, Martinez Rivero, Celso, Martinez Ruiz del Arbol, Pablo, Matorras, Francisco, Matorras Cuevas, Pablo, Piedra Gomez, Jonatan, Hadjiiska, Roumyana, Prieels, Cédric, Scodellaro, Luca, Vila, Ivan, Vizan Garcia, Jesus Manuel, Malagalage, Kithsiri, Kailasapathy, Balashangar, Sonnadara, Don Upul Jayasiri, Dhammage, Deshitha Chamikara Wickramarathna, Dharmaratna, Welathantri G. D., Liyanage, Kalpanie, Liko, Dietrich, Iaydjiev, Plamen, Perera, Nimantha, Wickramage, Nadeesha, Abbaneo, Duccio, Auffray, Etiennette, Auzinger, Georg, Baechler, Joachim, Baillon, Paul, Barney, David, Bendavid, Joshua, Bermúdez Martínez, Armando, Misheva, Milena, Bianco, Michele, Bilin, Bugra, Bin Anuar, Afiq Aizuddin, Bocci, Andrea, Brondolin, Erica, Caillol, Cécile, Camporesi, Tiziano, Cerminara, Gianluca, Chernyavskaya, Nadezda, Chhibra, Simranjit Singh, Rodozov, Mircho, Choudhury, Somnath, Cipriani, Marco, D'Enterria, David, Dabrowski, Anne, David Tinoco Mendes, Andre, De Roeck, Albert, Defranchis, Matteo Maria, Deile, Mario, Dobson, Marc, Dünser, Marc, Shopova, Mariana, Dupont, Niels, Fallavollita, Francesco, Florent, Alice, Forthomme, Laurent, Franzoni, Giovanni, Funk, Wolfgang, Ghosh, Saranya, Giani, Simone, Gigi, Dominique, Gill, Karl, Sultanov, Georgi, Glege, Frank, Gouskos, Loukas, Govorkova, Ekaterina, Haranko, Mykyta, Hegeman, Jeroen, Innocente, Vincenzo, James, Thomas, Janot, Patrick, Kaspar, Jan, Kieseler, Jan, Dimitrov, Anton, Kratochwil, Nicolaus, Laurila, Santeri, Lecoq, Paul, Leutgeb, Elias, Lourenco, Carlos, Maier, Benedikt, Malgeri, Luca, Mannelli, Marcello, Marini, Andrea Carlo, Meijers, Frans, Ivanov, Todor, Mersi, Stefano, Meschi, Emilio, Moortgat, Filip, Mulders, Martijn, Orfanelli, Styliani, Orsini, Luciano, Pantaleo, Felice, Perez, Emmanuel, Peruzzi, Marco, Petrilli, Achille, Litov, Leander, Petrucciani, Giovanni, Pfeiffer, Andreas, Pierini, Maurizio, Piparo, Danilo, Pitt, Michael, Qu, Huilin, Quast, Thorben, Rabady, Dinyar, Racz, Attila, Reales Gutiérrez, Guillermo, Pavlov, Borislav, Rovere, Marco, Sakulin, Hannes, Salfeld-Nebgen, Jakob, Scarfi, Simone, Selvaggi, Michele, Sharma, Archana, Silva, Pedro, Sphicas, Paraskevas, Stahl Leiton, Andre Govinda, Summers, Sioni, Petkov, Peicho, Tatar, Kaya, Treille, Daniel, Tropea, Paola, Tsirou, Andromachi, Wanczyk, Joanna, Wozniak, Kinga Anna, Zeuner, Wolfram Dietrich, Caminada, Lea, Ebrahimi, Aliakbar, Erdmann, Wolfram, Mikulec, Ivan, Petrov, Anton, Horisberger, Roland, Ingram, Quentin, Kaestli, Hans-Christian, Kotlinski, Danek, Lange, Clemens, Missiroli, Marino, Noehte, Lars, Rohe, Tilman, Aarrestad, Thea Klaeboe, Androsov, Konstantin, Shumka, Elton, Backhaus, Malte, Calandri, Alessandro, Datta, Kaustuv, De Cosa, Annapaola, Dissertori, Günther, Dittmar, Michael, Donegà, Mauro, Eble, Florian, Galli, Massimiliano, Gedia, Krunal, Thakur, Shalini, Glessgen, Franz, Gómez Espinosa, Tirso Alejandro, Grab, Christoph, Hits, Dmitry, Lustermann, Werner, Lyon, Anne-mazarine, Manzoni, Riccardo Andrea, Marchese, Luigi, Martin Perez, Cristina, Mascellani, Anna, Cheng, Tongguang, Nessi-Tedaldi, Francesca, Niedziela, Jeremi, Pauss, Felicitas, Perovic, Vasilije, Pigazzini, Simone, Ratti, Maria Giulia, Reichmann, Michael, Reissel, Christina, Reitenspiess, Thomas, Ristic, Branislav, Javaid, Tahir, Riti, Federica, Ruini, Daniele, Sanz Becerra, Diego Alejandro, Seidita, Roberto, Steggemann, Jan, Valsecchi, Davide, Wallny, Rainer, Amsler, Claude, Bärtschi, Pascal, Botta, Cristina, Mittal, Monika, Brzhechko, Danyyl, Canelli, Maria Florencia, Cormier, Kyle, De Wit, Adinda, Del Burgo, Riccardo, Heikkilä, Jaana Kristiina, Huwiler, Marc, Jin, Weijie, Jofrehei, Arash, Kilminster, Benjamin, Yuan, Li, Leontsinis, Stefanos, Liechti, Sascha Pascal, Macchiolo, Anna, Meiring, Peter, Mikuni, Vinicius Massami, Molinatti, Umberto, Neutelings, Izaak, Reimers, Arne, Robmann, Peter, Sanchez Cruz, Sergio, Ahmad, Muhammad, Schweiger, Korbinian, Senger, Matias, Takahashi, Yuta, Adloff, Catherine, Kuo, Chia-Ming, Lin, Willis, Rout, Prasant Kumar, Tiwari, Praveen Chandra, Yu, Shin-Shan, Ceard, Ludivine, Bauer, Gerry, Chao, Yuan, Chen, Kai-Feng, Chen, Pu-sheng, Cheng, Huajie, Hou, George Wei-Shu, Khurana, Raman, Kole, Gouranga, Li, You-ying, Lu, Rong-Shyang, Paganis, Efstathios, Hu, Zhen, Psallidas, Andreas, Steen, Arnaud, Wu, Hsin-yeh, Yazgan, Efe, Asawatangtrakuldee, Chayanit, Srimanobhas, Norraphat, Wachirapusitanand, Vichayanun, Agyel, Doruk, Boran, Fatma, Demiroglu, Zuhal Seyma, Paulitsch, Peter, Lezki, Samet, Dolek, Furkan, Dumanoglu, Isa, Eskut, Eda, Guler, Yalcin, Gurpinar Guler, Emine, Isik, Candan, Kara, Ozgun, Kayis Topaksu, Aysel, Kiminsu, Ugur, Onengut, Gulsen, Yi, Kai, Ozdemir, Kadri, Polatoz, Ayse, Simsek, Ali Eren, Tali, Bayram, Tok, Ufuk Guney, Turkcapar, Semra, Uslan, Ebru, Zorbakir, Ibrahim Soner, Karapinar, Guler, Ocalan, Kadir, Chen, Guo-Ming, Yalvac, Metin, Akgun, Bora, Atakisi, Ismail Okan, Gulmez, Erhan, Kaya, Mithat, Kaya, Ozlem, Tekten, Sevgi, Cakir, Altan, Cankocak, Kerem, Komurcu, Yildiray, Chen, He-Sheng, Sen, Sercan, Aydilek, Orhan, Cerci, Salim, Hacisahinoglu, Burak, Hos, Ilknur, Isildak, Bora, Kaynak, Berkan, Ozkorucuklu, Suat, Simsek, Cagdas, Sunar Cerci, Deniz, Chen, Mingshui, Grynyov, Boris, Levchuk, Leonid, Anthony, David, Brooke, James John, Bundock, Aaron, Clement, Emyr, Cussans, David, Flacher, Henning, Glowacki, Maciej, Goldstein, Joel, Iemmi, Fabio, Heath, Helen F., Kreczko, Lukasz, Krikler, Benjamin, Paramesvaran, Sudarshan, Seif El Nasr-Storey, Sarah, Smith, Vincent J., Stylianou, Nicolas, Walkingshaw Pass, Katie, White, Robert, Ball, Austin, Jiang, Chun-Hua, Bell, Ken W., Belyaev, Alexander, Brew, Christopher, Brown, Robert M., Cockerill, David J. A., Cooke, Charlotte, Ellis, Katherine Victoria, Harder, Kristian, Harper, Sam, Holmberg, Mei-li, Kapoor, Anshul, Jain, Shilpi, Linacre, Jacob, Manolopoulos, Konstantinos, Newbold, Dave M., Olaiya, Emmanuel, Petyt, David, Reis, Thomas, Salvi, Giovanna, Schuh, Thomas, Shepherd-Themistocleous, Claire, Liao, Hongbo, Tomalin, Ian R., Williams, Thomas, Bainbridge, Robert, Bloch, Philippe, Bonomally, Shameena, Borg, Johan, Brown, Christopher Edward, Buchmuller, Oliver, Cacchio, Vincenzo, Carrillo Montoya, Camilo Andres, Liu, Zhenan, Cepaitis, Vilius, Chahal, Gurpreet Singh, Colling, David, Dancu, Julia Suzana, Dauncey, Paul, Davies, Gavin, Davies, Joe, Della Negra, Michel, Fayer, Simon, Fedi, Giacomo, Schieck, Jochen, Milosevic, Vukasin, Hall, Geoffrey, Hassanshahi, Mohammad Hassan, Howard, Alexander, Iles, Gregory, Langford, Jonathon, Lyons, Louis, Magnan, Anne-Marie, Malik, Sarah, Martelli, Arabella, Mieskolainen, Mikael, Monti, Fabio, Monk, David Gabriel, Nash, Jordan, Pesaresi, Mark, Radburn-Smith, Benjamin Charles, Raymond, David Mark, Richards, Alexander, Rose, Andrew, Scott, Edward, Seez, Christopher, Shukla, Raghunandan, Sharma, Ramkrishna, Tapper, Alexander, Uchida, Kirika, Uttley, George Peter, Vage, Liv Helen, Virdee, Tejinder, Vojinovic, Milos, Wardle, Nicholas, Webb, Samuel Nathan, Winterbottom, Daniel, Coldham, Kathryn, Tao, Junquan, Cole, Joanne, Khan, Akram, Kyberd, Paul, Reid, Ivan, Abdullin, Salavat, Brinkerhoff, Andrew, Caraway, Bryan, Dittmann, Jay, Hatakeyama, Kenichi, Kanuganti, Ankush Reddy, Thomas-Wilsker, Joshuha, McMaster, Brooks, Saunders, Mark, Sawant, Siddhesh, Sutantawibul, Chosila, Toms, Maria, Wilson, Jonathan, Bartek, Rachel, Dominguez, Aaron, Huerta Escamilla, Conett, Uniyal, Rishabh, Wang, Jin, Vargas Hernandez, Andres Mateus, Chudasama, Ruchi, Cooper, Seth, Di Croce, Davide, Gleyzer, Sergei V., Perez, Cilicia Uzziel, Rumerio, Paolo, Usai, Emanuele, West, Christopher, Akpinar, Alp, Zhang, Huaqiao, Albert, Andreas, Arcaro, Daniel, Cosby, Christopher, Demiragli, Zeynep, Erice, Carlos, Fontanesi, Elisa, Gastler, Daniel, May, Samuel, Rohlf, James, Salyer, Kaitlin, Zhao, Jingzhou, Sperka, David, Spitzbart, Daniel, Suarez, Indara, Tsatsos, Anna, Yuan, Siqi, Benelli, Gabriele, Coubez, Xavier, Cutts, David, Hadley, Mary, Heintz, Ulrich, Agapitos, Antonis, Hogan, Julie Managan, Kwon, Taeun, Landsberg, Greg, Lau, Ka Tung, Li, Daniel, Luo, Jingyu, Narain, Meenakshi, Pervan, Nikolas, Sagir, Sinan, Simpson, Farrah, An, Ying, Wong, Wing Yan, Yan, Xuli, Yu, David, Zhang, Wenyu, Abbott, Mark Samuel, Bonilla, Johan, Brainerd, Christopher, Breedon, Richard, Calderon De La Barca Sanchez, Manuel, Chertok, Maxwell, Schöfbeck, Robert, Ban, Yong, Conway, John, Cox, Peter Timothy, Erbacher, Robin, Haza, Grace, Jensen, Frank, Kukral, Ota, Mocellin, Giovanni, Mulhearn, Michael, Pellett, Dave, Regnery, Brendan, Levin, Andrew, Yao, Yao, Zhang, Fengwangdong, Bachtis, Michail, Cousins, Robert, Datta, Abhisek, Hauser, Jay, Ignatenko, Mikhail, Iqbal, Muhammad Ansar, Lam, Tyler, Manca, Elisabetta, Li, Congqiao, Nash, William Arthur, Saltzberg, David, Stone, Brent, Valuev, Vyacheslav, Clare, Robert, Gary, J. William, Gordon, Michael, Hanson, Gail, Long, Owen Rosser, Manganelli, Nicholas, Li, Qiang, Si, Weinan, Wimpenny, Stephen, Branson, James G., Cittolin, Sergio, Cooperstein, Stephane, Diaz, Daniel, Duarte, Javier, Gerosa, Raffaele, Giannini, Leonardo, Guiang, Jonathan, Lyu, Xudong, Kansal, Raghav, Krutelyov, Vyacheslav, Lee, Robert, Letts, James, Masciovecchio, Mario, Mokhtar, Farouk, Pieri, Marco, Quinnan, Melissa, Sathia Narayanan, Balaji Venkat, Sharma, Vivek, Mao, Yajun, Tadel, Matevz, Vourliotis, Emmanouil, Würthwein, Frank, Xiang, Yifan, Yagil, Avraham, Campagnari, Claudio, Citron, Matthew, Collura, Giulia, Dorsett, Alex, Incandela, Joe, Qian, Si-Jin, Kilpatrick, Matthew, Kim, Jaebak, Li, Amina Jinzi, Masterson, Phillip, Mei, Hualin, Oshiro, Michael, Richman, Jeffrey, Sarica, Ulascan, Schmitz, Ryan, Setti, Francesco, Sun, Xiaohu, Sheplock, James, Siddireddy, Prasanna, Stuart, David, Wang, Sicheng, Bornheim, Adolf, Cerri, Olmo, Dutta, Irene, Latorre, Anthony, Lawhorn, Jay Mathew, Mao, Jiajing, Wang, Dayong, Newman, Harvey B., Nguyen, Thong, Spiropulu, Maria, Vlimant, Jean-Roch, Wang, Christina, Xie, Si, Zhu, Ren-Yuan, Alison, John, An, Sitong, Andrews, Michael Benjamin, Xiao, Jie, Bryant, Patrick, Dutta, Valentina, Ferguson, Thomas, Harilal, Abhirami, Liu, Chuyuan, Mudholkar, Tanmay, Murthy, Sindhu, Paulini, Manfred, Roberts, Andrew, Sanchez, Alejandro, Schwarz, Dennis, Yang, Heng, Terrill, Wesley, Cumalat, John Perry, Ford, William T., Hassani, Abbas, Karathanasis, George, MacDonald, Emily, Marini, Filippo, Perloff, Alexx, Savard, Claire, Schonbeck, Nicolas, Lu, Meng, Stenson, Kevin, Ulmer, Keith, Wagner, Stephen Robert, Zipper, Noah, Alexander, James, Bright-Thonney, Samuel, Chen, Xuan, Cranshaw, Derek James, Fan, Jason, Fan, Xingchen, You, Zhengyun, Gadkari, Divya, Hogan, Shaun, Monroy, Jose, Patterson, Juliet Ritchie, Reichert, Joseph, Reid, Michael, Ryd, Anders, Thom, Julia, Wittich, Peter, Zou, Rui, Lu, Nan, Albrow, Michael, Alyari, Maral, Apollinari, Giorgio, Apresyan, Artur, Bauerdick, Lothar A. T., Berry, Douglas, Berryhill, Jeffrey, Bhat, Pushpalatha C., Burkett, Kevin, Butler, Joel Nathan, Gao, Xuyang, Canepa, Anadi, Cerati, Giuseppe Benedetto, Cheung, Harry, Chlebana, Frank, Di Petrillo, Karri Folan, Dickinson, Jennet, Elvira, Victor Daniel, Feng, Yongbin, Freeman, Jim, Gandrakota, Abhijith, Leggat, Duncan, Gecse, Zoltan, Gray, Lindsey, Green, Dan, Grünendahl, Stefan, Guerrero, Daniel, Gutsche, Oliver, Harris, Robert M., Heller, Ryan, Herwig, Theodor Christian, Hirschauer, James, Okawa, Hideki, Horyn, Lesya, Jayatilaka, Bodhitha, Jindariani, Sergo, Johnson, Marvin, Joshi, Umesh, Klijnsma, Thomas, Klima, Boaz, Kwok, Ka Hei Martin, Lammel, Stephan, Lincoln, Don, Zhang, Yu, Lipton, Ron, Liu, Tiehui, Madrid, Christopher, Maeshima, Kaori, Mantilla, Cristina, Mason, David, McBride, Patricia, Merkel, Petra, Mrenna, Stephen, Nahn, Steve, Lin, Zhen, Ngadiuba, Jennifer, Noonan, Daniel, Norberg, Scarlet, Papadimitriou, Vaia, Pastika, Nathaniel, Pedro, Kevin, Pena, Cristian, Ravera, Fabio, Reinsvold Hall, Allison, Ristori, Luciano, Lu, Chenfeng, Sexton-Kennedy, Elizabeth, Smith, Nicholas, Soha, Aron, Spiegel, Leonard, Strait, James, Taylor, Lucas, Tkaczyk, Slawek, Tran, Nhan Viet, Uplegger, Lorenzo, Vaandering, Eric Wayne, Sonawane, Mangesh, Xiao, Meng, Zoi, Irene, Avery, Paul, Bourilkov, Dimitri, Cadamuro, Luca, Chang, Philip, Cherepanov, Vladimir, Field, Richard D., Koenig, Evan, Kolosova, Marina, Konigsberg, Jacobo, Avila, Carlos, Korytov, Andrey, Kuznetsova, Ekaterina, Lo, Kin Ho, Matchev, Konstantin, Menendez, Nicholas, Mitselmakher, Guenakh, Muthirakalayil Madhu, Arun, Rawal, Neha, Rosenzweig, Daniel, Rosenzweig, Suzanne, Barbosa Trujillo, Diego Andres, Shi, Kun, Wang, Jian, Wu, Zhenbin, Adams, Todd, Askew, Andrew, Bower, Nicholas, Habibullah, Redwan, Hagopian, Vasken, Kolberg, Ted, Martinez, German, Cabrera, Andrés, Prosper, Harrison, Viazlo, Oleksandr, Wulansatiti, Meutia, Yohay, Rachel, Zhang, Jingyu, Baarmand, Marc M., Butalla, Stephen, Elkafrawy, Tamer, Hohlmann, Marcus, Kumar Verma, Ravindra, Florez, Carlos, Rahmani, Mehdi, Yumiceva, Francisco, Adams, Mark Raymond, Cavanaugh, Richard, Dittmer, Susan, Evdokimov, Olga, Gerber, Cecilia Elena, Hofman, David Jonathan, De Souza Lemos, Dener, Merritt, Anna Henckel, Fraga, Jorge, Mills, Corrinne, Oh, Geonhee, Roy, Titas, Rudrabhatla, Sahithi, Tonjes, Marguerite, Varelas, Nikos, Wang, Xiao, Ye, Zhenyu, Yoo, Jieun, Alhusseini, Mohammad, Mejia Guisao, Jhovanny, Dilsiz, Kamuran, Emediato, Luiz, Karaman, Gurkan, Köseyan, Ohannes Kamer, Merlo, Jean-Pierre, Mestvirishvili, Alexi, Nachtman, Jane, Neogi, Orgho, Ogul, Hasan, Onel, Yasar, Ramirez, Felipe, Penzo, Aldo, Snyder, Christina, Tiras, Emrah, Amram, Oz, Blumenfeld, Barry, Corcodilos, Lucas, Davis, Jeffrey, Gritsan, Andrei, Kyriacou, Savvas, Maksimovic, Petar, Rodriguez, Manuel, Roskes, Jeffrey, Sekhar, Sanjana, Swartz, Morris, Vámi, Tamás Álmos, Abreu, Andrés, Alcerro Alcerro, Luis Fernando, Anguiano, Justin, Baringer, Philip, Bean, Alice, Flowers, Zachary, Ruiz Alvarez, José David, King, Jack, Krintiras, Georgios, Lazarovits, Margaret, Le Mahieu, Cole, Lindsey, Cole, Marquez, Juan, Minafra, Nicola, Murray, Michael, Nickel, Matthew, Rogan, Christopher, Templ, Sebastian, Giljanovic, Duje, Royon, Christophe, Salvatico, Riccardo, Sanders, Stephen, Smith, Caleb, Wang, Quan, Wilson, Graham, Allmond, Braden, Duric, Senka, Ivanov, Andrew, Kaadze, Ketino, Godinovic, Nikola, Kalogeropoulos, Alexis, Kim, Doyeong, Maravin, Yurii, Mitchell, Tyler, Modak, Atanu, Nam, Kyungwook, Roy, Dennis, Rebassoo, Finn, Wright, Douglas, Adams, Eric, Lelas, Damir, Baden, Drew, Baron, Owen, Belloni, Alberto, Bethani, Agni, Eno, Sarah Catherine, Hadley, Nicholas John, Jabeen, Shabnam, Kellogg, Richard G., Koeth, Timothy, Lai, Yihui, Puljak, Ivica, Lascio, Samuel, Mignerey, Alice, Nabili, Sara, Palmer, Christopher, Papageorgakis, Christos, Wang, Long, Wong, Kak, Busza, Wit, Cali, Ivan Amos, Chen, Yi, Antunovic, Zeljko, D'Alfonso, Mariarosaria, Eysermans, Jan, Freer, Chad, Gomez Ceballos, Guillelmo, Goncharov, Maxim, Harris, Philip, Kovalskyi, Dmytro, Krupa, Jeffrey, Lee, Yen-Jie, Long, Kenneth, Kovac, Marko, Mironov, Camelia, Paus, Christoph, Rankin, Dylan, Roland, Christof, Roland, Gunther, Shi, Zhaozhong, Stephans, George, Wang, Jing, Wang, Zhangqier, Wyslouch, Bolek, Sculac, Toni, Yang, Tianyu, Chatterjee, Rajdeep Mohan, Crossman, Bryan, Hiltbrand, Joshua, Joshi, Bhargav Madhusudan, Kapsiak, Charles, Krohn, Michael, Kubota, Yuichi, Mahon, Devin, Mans, Jeremy, Brigljevic, Vuko, Revering, Michael, Rusack, Roger, Saradhy, Rohith, Schroeder, Neil, Strobbe, Nadja, Wadud, Mohammad Abrar, Cremaldi, Lucien Marcus, Bloom, Kenneth, Bryson, Miranda, Claes, Daniel R., Chitroda, Bhakti Kanulal, Fangmeier, Caleb, Finco, Linda, Golf, Frank, Joo, Changwoo, Kamalieddin, Rami, Kravchenko, Ilya, Reed, Ian, Siado, Joaquin Emilo, Snow, Gregory R., Tabb, William, Ferencek, Dinko, Wightman, Andrew, Yan, Furong, Zecchinelli, Angelo Giacomo, Agarwal, Garvita, Bandyopadhyay, Hirak, Hay, Lauren, Iashvili, Ia, Kharchilava, Avto, McLean, Christine, Morris, Margaret, Andrejkovic, Janik Walter, Waltenberger, Wolfgang, Mishra, Saswat, Nguyen, Duong, Pekkanen, Juska, Rappoccio, Salvatore, Williams, Ac, Alverson, George, Barberis, Emanuela, Haddad, Yacine, Han, Yixiao, Krishna, Amrutha, Li, Jingyan, Roguljic, Matej, Lidrych, Jindrich, Madigan, Gabriel, Marzocchi, Badder, Morse, David Michael, Nguyen, Vivan, Orimoto, Toyoko, Parker, Ashley, Skinnari, Louise, Tishelman-Charny, Abraham, Wamorkar, Tanvi, Starodumov, Andrei, Wang, Bingran, Wisecarver, Andrew, Wood, Darien, Bhattacharya, Saptaparna, Bueghly, James, Chen, Ziheng, Gilbert, Andrew, Hahn, Kristan Allan, Liu, Yihan, Odell, Nathaniel, Susa, Tatjana, Schmitt, Michael Henry, Velasco, Mayda, Band, Reyer, Bucci, Rachael, Cremonesi, Matteo, Das, Abhishek, Goldouzian, Reza, Hildreth, Michael, Hurtado Anampa, Kenyi, Jessop, Colin, Attikis, Alexandros, Lannon, Kevin, Lawrence, John, 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Alessandra, Giacomelli, Paolo, Giommi, Luca, Grandi, Claudio, Guiducci, Luigi, Lo Meo, Sergio, Lunerti, Leonardo, Marcellini, Stefano, Masetti, Gianni, Jain, Sandhya, Navarria, Francesco, Perrotta, Andrea, Primavera, Federica, Rossi, Antonio, Rovelli, Tiziano, Siroli, Gian Piero, Costa, Salvatore, Di Mattia, Alessandro, Potenza, Renato, Tricomi, Alessia, Lemaitre, Vincent, Tuve, Cristina, Barbagli, Giuseppe, Bardelli, Giulio, Camaiani, Benedetta, Cassese, Antonio, Ceccarelli, Rudy, Ciulli, Vitaliano, Civinini, Carlo, D'Alessandro, Raffaello, Focardi, Ettore, Mondal, Kuntal, Latino, Giuseppe, Lenzi, Piergiulio, Lizzo, Mattia, Meschini, Marco, Paoletti, Simone, Sguazzoni, Giacomo, Viliani, Lorenzo, Benussi, Luigi, Bianco, Stefano, Meola, Sabino, Hussain, Priya Sajid, Taliercio, Angela, Piccolo, Davide, Bozzo, Marco, Chatagnon, Pierre, Ferro, Fabrizio, Robutti, Enrico, Tosi, Silvano, Benaglia, Andrea, Boldrini, Giacomo, Brivio, Francesco, Cetorelli, Flavia, Tran, Tu Thong, De Guio, Federico, Dinardo, Mauro Emanuele, Dini, Paolo, Gennai, Simone, Ghezzi, Alessio, Govoni, Pietro, Guzzi, Luca, Lucchini, Marco Toliman, Malberti, Martina, Malvezzi, Sandra, Vischia, Pietro, Massironi, Andrea, Menasce, Dario, Moroni, Luigi, Paganoni, Marco, Pedrini, Daniele, Pinolini, Bianca Sofia, Ragazzi, Stefano, Redaelli, Nicola, Tabarelli de Fatis, Tommaso, Zuolo, Davide, Wertz, Sébastien, Buontempo, Salvatore, Cagnotta, Antimo, Carnevali, Francesco, Cavallo, Nicola, De Iorio, Agostino, Fabozzi, Francesco, Iorio, Alberto Orso Maria, Lista, Luca, Paolucci, Pierluigi, Rossi, Biagio, Alves, Gilvan, Sciacca, Crisostomo, Azzi, Patrizia, Bacchetta, Nicola, Bisello, Dario, Bortignon, Pierluigi, Bragagnolo, Alberto, Checchia, Paolo, Dorigo, Tommaso, Gasparini, Fabrizio, Gasparini, Ugo, Coelho, Eduardo, Grosso, Gaia, Layer, Lukas, Lusiani, Enrico, Margoni, Martino, Meneguzzo, Anna Teresa, Michelotto, Michele, Pazzini, Jacopo, Ronchese, Paolo, Rossin, Roberto, Simonetto, Franco, Hensel, Carsten, Strong, Giles, Tosi, Mia, Yarar, Hevjin, Zanetti, Marco, Zotto, Pierluigi, Zucchetta, Alberto, Zumerle, Gianni, Abu Zeid, Shimaa, Aimè, Chiara, Braghieri, Alessandro, Moraes, Arthur, Calzaferri, Simone, Fiorina, Davide, Montagna, Paolo, Re, Valerio, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Vitulo, Paolo, Asenov, Patrick, Bilei, Gian Mario, Rebello Teles, Patricia, Ciangottini, Diego, Fanò, Livio, Magherini, Matteo, Mantovani, Giancarlo, Mariani, Valentina, Menichelli, Mauro, Moscatelli, Francesco, Piccinelli, Andrea, Presilla, Matteo, Rossi, Alessandro, Aldá Júnior, Walter Luiz, Santocchia, Attilio, Spiga, Daniele, Tedeschi, Tommaso, Azzurri, Paolo, Bagliesi, Giuseppe, Bertacchi, Valerio, Bhattacharya, Rajarshi, Bianchini, Lorenzo, Boccali, Tommaso, Bossini, Edoardo, Jeitler, Manfred, Alves Gallo Pereira, Miguel, Bruschini, Davide, Castaldi, Rino, Ciocci, Maria Agnese, D'Amante, Valeria, Dell'Orso, Roberto, Donato, Silvio, Giassi, Alessandro, Ligabue, Franco, Matos Figueiredo, Diego, Messineo, Alberto, Barroso Ferreira Filho, Mapse, Musich, Marco, Palla, Fabrizio, Parolia, Shubhi, Ramirez-Sanchez, Gabriel, Rizzi, Andrea, Rolandi, Gigi, Roy Chowdhury, Suvankar, Sarkar, Tanmay, Scribano, Angelo, Spagnolo, Paolo, Brandao Malbouisson, Helena, Tenchini, Roberto, Tonelli, Guido, Turini, Nicola, Venturi, Andrea, Verdini, Piero Giorgio, Barria, Patrizia, Campana, Mattia, Cavallari, Francesca, Del Re, Daniele, Di Marco, Emanuele, Carvalho, Wagner, Diemoz, Marcella, Longo, Egidio, Meridiani, Paolo, Organtini, Giovanni, Pandolfi, Francesco, Paramatti, Riccardo, Quaranta, Claudio, Rahatlou, Shahram, Rovelli, Chiara, Santanastasio, Francesco, Chinellato, Jose, Soffi, Livia, Tramontano, Raffaella, Amapane, Nicola, Arcidiacono, Roberta, Argiro, Stefano, Arneodo, Michele, Bartosik, Nazar, Bellan, Riccardo, Bellora, Andrea, Biino, Cristina, Da Costa, Eliza Melo, Cartiglia, Nicolo, Costa, Marco, Covarelli, Roberto, Demaria, Natale, Grippo, Michael, Kiani, Bilal, Legger, Federica, Luongo, Fabio, Mariotti, Chiara, Maselli, Silvia, Da Silveira, Gustavo Gil, Mecca, Alberto, Migliore, Ernesto, Monteno, Marco, Mulargia, Roberto, Obertino, Maria Margherita, Ortona, Giacomo, Pacher, Luca, Pastrone, Nadia, Pelliccioni, Mario, Ruspa, Marta, De Jesus Damiao, Dilson, Shchelina, Ksenia, Siviero, Federico, Sola, Valentina, Solano, Ada, Soldi, Dario, Staiano, Amedeo, Tarricone, Cristiano, Tornago, Marta, Trocino, Daniele, Umoret, Giulio, Dos Santos Sousa, Vitor, Vagnerini, Antonio, Vlasov, Evgueni, Belforte, Stefano, Candelise, Vieri, Casarsa, Massimo, Cossutti, Fabio, Della Ricca, Giuseppe, Sorrentino, Giulia, Dogra, Sunil, Huh, Changgi, Fonseca De Souza, Sandro, Kim, Bobae, Kim, Dong Hee, Kim, Gui Nyun, Kim, Jiwoong, Lee, Jeongeun, Lee, Seh Wook, Moon, Chang-Seong, Oh, Young Do, Pak, Sang Il, Ryu, Min Sang, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and CMS

Subjects
heavy ion: scattering, mass, transverse, mass: transverse, CMS, scaling, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], two-particle, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), correlation: Bose-Einstein, hydrodynamics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], TeV, 5020 GeV-cms/nucleon, correlation function, Nuclear Experiment (nucl-ex), nucleon, pair, Nuclear Experiment, correlation, Bose-Einstein, experimental results
Abstract

Two-particle Bose-Einstein momentum correlation functions are studied for charged-hadron pairs in lead-lead collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV. The data sample, containing 4.27$\times10^{9}$ minimum bias events corresponding to an integrated luminosity of 0.607 nb$^{-1}$, was collected by the CMS experiment in 2018. The experimental results are discussed in terms of a L\'evy-type source distribution. The parameters of this distribution are extracted as functions of particle pair average transverse mass and collision centrality. These parameters include the L\'evy index or shape parameter ($\alpha$), the L\'evy scale parameter ($R$), and the correlation strength parameter ($\lambda$). The source shape, characterized by $\alpha$, is found to be neither Cauchy nor Gaussian, implying the need for a full L\'evy analysis. Similarly to what was previously found for systems characterized by Gaussian source radii, a hydrodynamical scaling is observed for the L\'evy $R$ parameter. The $\lambda$ parameter is studied in terms of the core-halo model., Comment: Submitted to Physical Review C. All figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/HIN-21-011 (CMS Public Pages)

Published
2023
Full Text
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42. A High Magnetic Flux Density Lorentz Force Magnetic Bearing Design Method with Suction and Combined Magnetic Steel

Author

Xiaocen Chen, Yin Zengyuan, Ren Yuan, Cai Yuanwen, and Wang Weijie

Subjects
Physics, symbols.namesake, Multidisciplinary, Suction, symbols, Torque, Magnetic bearing, Mechanics, Current (fluid), Lorentz force, Magnetic flux, Standard deviation, Magnetic field
Abstract

In order to solve the problems of low magnetic flux density and non-uniformity of magnetic flux density of traditional Lorentz force magnetic bearing (LFMB), a combined magnetic steel single closed magnetic loop magnetic bearing with suction type is designed. Firstly, the magnetic field intensity and magnetic field uniformity of the traditional LFMB are analyzed, and the existing problems of the traditional LFMB are pointed out. Then, a new LFMB structure is designed. The concepts of magnetic field mean value and standard deviation are introduced to describe magnetic field intensity and magnetic field uniformity. By analysis of the 2-D and 3-D magnetic flux characteristics of the proposed LFMB, it can be seen that the magnetic flux density of the new LFMB is 0.67–0.74 T, and the magnetic flux uniformity is 0.009–0.0192. By comparing the conditions of applied current and 0 current, we can see that the structure designed in this paper can reduce the influence of current on the magnetic field uniformity. Finally, by comparing the control effects of the traditional structure and the proposed LFMB structure, it can be concluded that the proposed method can reduce the power consumption and improve the precision of the output torque.

Published
2021

43. Electrically modulated reversible dual-spin filter in zigzag β-SiC

Author

Jing-Jing, He, Fang-Wen, Guo, Hui-Min, Ni, Jia-Ren, Yuan, Wen-Dou, Cui, Tian-Yi, Lu, Yan-Dong, Guo, and Xiao-Hong, Yan

Abstract

Compared with traditional magnetic approaches, electrical modulation of spin-polarized current can greatly reduce the energy consumption and scale of nanodevices and improve their operating speed, which has become a promising research field in spintronics. Motivated by the latest reported novel two-dimensional material β-SiC

Published
2022

44. The regulatory and transcriptional landscape associated with triterpenoid and lipid metabolisms by the bHLH-zip transcription factor SREBP in the medicinal fungus Ganoderma lingzhi

Author

Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, and Gao-Qiang Liu

Abstract

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. Here, the genome of Ganoderma lingzhi was de novo sequenced. Using DAP-seq, we identified putative targets of the transcription factor SREBP, including the genes of triterpenoid synthesis and lipid metabolism. Interactions between SREBP and the targets were verified by EMSA. RNA-seq showed that SREBP targets, mevalonate kinase and 3-hydroxy-3-methylglutaryl CoA synthetase in mevalonate pathway, sterol isomerase and lanosterol 14-demethylase in ergosterol biosynthesis, were significantly upregulated in the SREBP overexpression strain. In addition, 3 targets involved in glycerophospholipid/glycerolipid metabolism were upregulated. Then, the contents of mevalonic acid, lanosterol, ergosterol and 13 different GAs as well as a variety of lipids were significantly increased in this strain. Furthermore, the effects of SREBP overexpression on triterpenoid and lipid metabolisms were recovered when OE::SREBP strain were treated with exogenous fatostatin, a specific inhibitor of SREBP. Taken together, our genome-wide study clarified the role of SREBP in triterpenoid and lipid metabolisms of G. lingzhi.

Published
2022

46. Urinary Large Cell Neuroendocrine Carcinoma

Author

Bernhard J. Eigl, Malcolm Hayes, Chen Zhou, Gang Wang, Carlos F. Villamil, Ren Yuan, Charles C. Guo, and Peter C. Black

Subjects
Adult, Male, medicine.medical_specialty, Databases, Factual, Urinary system, Cystectomy, Small-cell carcinoma, Gastroenterology, Pathology and Forensic Medicine, Ureter, Internal medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm Invasiveness, large cell neuroendocrine carcinoma, bladder, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Urinary bladder, biology, Ureteral Neoplasms, business.industry, Carcinoma in situ, Chromogranin A, Retrospective cohort study, Original Articles, Middle Aged, clinicopathologic, medicine.disease, Neoadjuvant Therapy, Carcinoma, Neuroendocrine, Treatment Outcome, medicine.anatomical_structure, Urinary Bladder Neoplasms, urinary, Chemotherapy, Adjuvant, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Synaptophysin, biology.protein, Carcinoma, Large Cell, Female, Surgery, Anatomy, business
Abstract

Supplemental Digital Content is available in the text., Large cell neuroendocrine carcinoma (LCNEC) of the urinary tract is a rare disease. We present a relatively large retrospective cohort of urinary LCNEC, 20 from the urinary bladder, and 2 from the ureter, from a single institution. The patients included 16 men and 6 women with a median age of 74.5 years. Most LCNEC presented at an advanced stage with tumors invading the muscularis propria and beyond (21/22). Eight cases were pure LCNEC, while 14 cases were mixed with other histologic types, including conventional urothelial carcinoma (n=9), carcinoma in situ (n=7), small cell carcinoma (n=6), and urothelial carcinoma with glandular (n=3) features. Most LCNEC expressed neuroendocrine markers synaptophysin (22/22), chromogranin (13/16), CD56 (7/7), TTF1 (8/8), and INSM1 (2/3). They were negative for common urothelial markers including HMWCK (0/3), p40/p63 (0/6), CK20 (0/10), and had variable GATA3 staining (4/8). Ki-67 stained 25% to nearly 100% tumor cell nuclei. Patient survival was associated with cancer stage, and pure LCNEC showed worse survival than mixed LCNEC. Compared with small cell carcinoma at similar stages from a prior study, LCNEC had a worse prognosis only when patients developed metastatic disease. For organ-confined LCNEC, neoadjuvant chemotherapy followed by radical resection is the treatment option to achieve long-term survival.

Published
2021

47. The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi

Author

Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, Bi-Yang Liu, and Gao-Qiang Liu

Subjects
Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Abstract

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. Here, the genome of Ganoderma lingzhi is de novo sequenced. Using DNA affinity purification sequencing, we identify putative targets of the transcription factor sterol regulatory element-binding protein (SREBP), including the genes of triterpenoid synthesis and lipid metabolism. Interactions between SREBP and the targets are verified by electrophoretic mobility gel shift assay. RNA-seq shows that SREBP targets, mevalonate kinase and 3-hydroxy-3-methylglutaryl coenzyme A synthetase in mevalonate pathway, sterol isomerase and lanosterol 14-demethylase in ergosterol biosynthesis, are significantly upregulated in the SREBP overexpression (OE::SREBP) strain. In addition, 3 targets involved in glycerophospholipid/glycerolipid metabolism are upregulated. Then, the contents of mevalonic acid, lanosterol, ergosterol and 13 different GAs as well as a variety of lipids are significantly increased in this strain. Furthermore, the effects of SREBP overexpression on triterpenoid and lipid metabolisms are recovered when OE::SREBP strain are treated with exogenous fatostatin, a specific inhibitor of SREBP. Taken together, our genome-wide study clarify the role of SREBP in triterpenoid and lipid metabolisms of G. lingzhi.

Published
2022

48. High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression

Author

Wen-Jiao Xue, Cheng-Feng He, Ren-Yuan Zhou, Xiao-Die Xu, Lv-Xuan Xiang, Jian-Tao Wang, Xin-Ru Wang, Hou-Guang Zhou, and Jing-Chun Guo

Subjects
Neurons, Repressor Proteins, Mice, Cellular and Molecular Neuroscience, Glucose, Diabetes Mellitus, Type 2, TOR Serine-Threonine Kinases, Autophagy, Palmitic Acid, Animals, Membrane Proteins, Molecular Biology
Abstract

Cell senescence is a basic aging mechanism. Previous studies have found that the cellular senescence in adipose tissue and other tissues, such as the pancreas, muscle and liver, is associated with the pathogenesis and progression of type 2 diabetes; however, strong evidence of whether diabetes directly causes neuronal senescence in the brain is still lacking. In this study, we constructed a high glucose and palmitic acid (HGP) environment on PC12 neuronal cells and primary mouse cortical neurons to simulate diabetes. Our results showed that after HGP exposure, neurons exhibited obvious senescence-like phenotypes, including increased NRSF/REST level, mTOR activation and cell autophagy suppression. Downregulation of NRSF/REST could remarkably alleviate p16, p21 and γH2A.X upregulations induced by HGP treatment, and enhance mTOR-autophagy of neurons. Our results suggested that the diabetic condition could directly induce neuronal senescence, which is mediated by the upregulation of NRSF/REST and subsequent reduction of mTOR-autophagy.

Published
2022

49. Epidemiological Characteristics of COVID-19 Outbreak in Yangzhou, China, 2021

Author

Yu-Dong Zhang, Ding Chen, Lei Hu, Liang Shen, Ren-Yuan Wu, Fu-Ming Cao, Jian-Qiang Xu, and Liang Wang

Subjects
Microbiology (medical), Microbiology
Abstract

ObjectiveEpidemiological characteristics of COVID-19 outbreak in Yangzhou city caused by the highly contagious Delta variant strain of SARS-CoV-2 virus were investigated in this retrospective descriptive study to provide prevention and control guidelines for outbreaks in the future.MethodsAll the epidemiological data used in this study were collected manually from the official website of the Yangzhou Municipal Health Committee from 28 July to 26 August 2021, and then were analyzed systematically and statistically in this study.ResultsA total of 570 COVID-19 cases were reported during the short-term outbreak in Yangzhou City. The ages of infected individuals ranged from 1 to 90 years with the average age at 49.47 ± 22.69 years. As for gender distributions, the ratio of male- to-female patients was 1:1.36 (242:328). Geographic analysis showed that 377 patients (66.1%) were in Hanjiang District while 188 patients (33.0%) were in Guangling District. Clinical diagnosis showed that 175 people (30.7%) had mild symptoms, 385 people were in moderate conditions (67.5%), and 10 people were in severe situations (1.8%). Significant age differences were found among the three groups (P < 0.001). However, no significant difference was identified in terms of gender ratio (P > 0.05). Based on the transmission chain formed by 6 generations of infected persons with a clear transmission relationship, the age showed a gradually decreasing trend, while the median time of diagnosis in 2 adjacent generations was 3 days. In addition, the estimated basic reproduction number R0 of the Delta variant was 3.3651 by the classical Susceptible, Infectious, and/or Recovered (SIR) model.ConclusionThe Delta variant of SARS-CoV-2 was highly infectious and has obvious clustering characteristics during the Yangzhou outbreak in China.

Published
2022

50. Aestuariimicrobium ganziense sp. nov., a new Gram-positive bacterium isolated from soil in the Ganzi Tibetan autonomous prefecture, China

Author

Yu Geng, Meng-Liang Wen, Shu-Kun Tang, Le-Le Li, Hui-Ren Yuan, Jiang-Yuan Zhao, and Ming-Gang Li

Subjects
DNA, Bacterial, Gram-positive bacteria, Diaminopimelic Acid, Tibet, Biochemistry, Microbiology, Soil, 03 medical and health sciences, Genus, RNA, Ribosomal, 16S, Botany, Genetics, Molecular Biology, Genome size, Phospholipids, Phylogeny, Soil Microbiology, 030304 developmental biology, Base Composition, 0303 health sciences, Strain (chemistry), biology, Phylogenetic tree, 030306 microbiology, Fatty Acids, Sequence Analysis, DNA, General Medicine, Propionibacteriaceae, biology.organism_classification, 16S ribosomal RNA, Bacterial Typing Techniques, Chemotaxonomy, Bacteria
Abstract

A novel Gram-stain positive, oval shaped and non-flagellated bacterium, designated YIM S02566T, was isolated from alpine soil in Shadui Towns, Ganzi County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province, PR China. Growth occurred at 23–35°C (optimum, 30°C) in the presence of 0.5-4 % (w/v) NaCl (optimum, 1%) and at pH 7.0–8.0 (optimum, pH 7.0). The phylogenetic analysis based on 16S rRNA gene sequence revealed that strain YIM S02566T was most closely related to the genus Aestuariimicrobium, with Aestuariimicrobium kwangyangense R27T and Aestuariimicrobium soli D6T as its closest relative (sequence similarities were 96.3% and 95.4%, respectively). YIM S02566T contained LL-diaminopimelic acid in the cell wall. MK-9(H4) was the predominant menaquinone. The major fatty acid patterns were anteiso-C15:0 (60.0%). The major polar lipid was DPG. The genome size of strain YIM S02566T was 3.1 Mb, comprising 3078 predicted genes with a DNA G + C content of 69.0 mol%. Based on these genotypic, chemotaxonomic and phenotypic evidences, strain YIM S02566T was identified as a novel species in the genus Aestuariimicrobium, for which the name Aestuariimicrobium ganziense sp. nov. is proposed. The type strain is YIM S02566T (= CGMCC 1.18751 T =KCTC 49477 T).

Published
2021

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