1. Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali
- Author
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Amadou Toure, Souleymane Coulibaly, K Traoré, Modibo Kouyate, Yaya Ibrahim Coulibaly, Hamza B. Toure, Housseini Dolo, Arouna Togora, Mahamadou Diakite, Modibo Sangare, Adama Karembe, Daniel H. Geschwind, C.O. Guinto, Seydou Doumbia, Seidina A. S. Diakite, and Gordon A. Awandare
- Subjects
University of Sciences ,AUC ,CHU ,DNS ,ICD-10, International Statistical Classification of Diseases and Related Health Problems-10 ,Autism ,AMALDEME, Malian association for mental deficiencies ,M-CHAT-R, Modified checklist for autism in toddlers-Revised ,Mali ,Negative predictive value ,CSCOM ,lcsh:RC346-429 ,AUC, Area under the Curve ,0302 clinical medicine ,Positive likelihood ,Modified checklist for autism in toddlers-Revised ,DNS, National direction of health ,PPV, Positive predictive value ,030212 general & internal medicine ,Modified checklist for autism in toddlers-Revised/Follow up ,CSRef ,Pediatric ,DRS, Regional direction of health ,screening and diagnosis ,Malian association for mental deficiencies ,Social communication ,4. Education ,Autism spectrum disorders ,DSM-V ,Checklist ,3. Good health ,Diagnostic and Statistical Manual of Mental Disorders ,Detection ,Mental Health ,Neurology ,Community health ,Original Article ,FAPH, Faculty of Pharmacy ,USTTB ,CSCOM, Community health centers ,4.2 Evaluation of markers and technologies ,Clinical psychology ,Positive predictive value ,Area under the Curve ,Regional direction of health ,Intellectual and Developmental Disabilities (IDD) ,University hospital centers ,Social communication questionnaire ,CHU, University hospital centers ,FMOS ,Context (language use) ,PPV ,Techniques and Technologies of Bamako ,ASD ,FAPH ,National direction of health ,NPV ,03 medical and health sciences ,LR+, Positive likelihood ,ICD-10 ,Clinical Research ,medicine ,NPV, Negative predictive value ,LR+ ,Screening tool ,District health centers ,DSM-V, Diagnostic and Statistical Manual of Mental Disorders ,LR-, Negative likelihood ,LR ,SCQ, Social communication questionnaire ,USTTB, University of Sciences, Techniques and Technologies of Bamako ,International Statistical Classification of Diseases and Related Health Problems-10 ,Faculty of Pharmacy ,Negative likelihood ,lcsh:Neurology. Diseases of the nervous system ,National health ,business.industry ,Prevention ,Social environment ,M-CHAT-R ,Community health centers ,CSRef, District health centers ,medicine.disease ,AMALDEME ,Faculty of medicine and odonto-stomatology ,Brain Disorders ,M-CHAT-R/F ,ASD, Autism spectrum disorders ,DRS ,M-CHAT-R/F, Modified checklist for autism in toddlers-Revised/Follow up ,business ,SCQ ,030217 neurology & neurosurgery ,FMOS, Faculty of medicine and odonto-stomatology - Abstract
Background: Early screening is crucial for early autism spectrum disorders (ASD) diagnosis and intervention. ASD screening tools have mostly been constructed based on the Western cultural context. We hypothesized that their use in Mali may require a prior validation. Objective: To validate the modified checklist for autism in toddlers-Revised (M-CHAT-R) and the social communication questionnaire (SCQ) in the Malian sociocultural context for ASD screening. Study design: We administered M-CHAT-R and SCQ in 947 toddlers aged 16–30 months old at the district and community health centers in Bamako and 120 patients (60 autistic and 60 age and sex matched controls) aged ≥4 years old at the psychiatry department in Bamako. Toddlers at moderate to high risk of ASD underwent M-CHAT-R/F and clinical evaluation by an ASD multidisciplinary team. M-CHAT-R and SCQ were evaluated for cultural appropriateness by Malian anthropologists. The sensitivity, specificity, PPV, NPV were determined for both M-CHAT-R and SCQ. Health professionals have been trained during ASD seminary on how to use M-CHAT-R and SCQ for ASD screening in Bamako. Results: We found for the M-CHAT-R a sensitivity of 50%, a specificity of 100%, a PPV of 100% and a NPV of 87%. The SCQ had a sensitivity of 71%, a specificity of 72%, a PPV of 73% and a NPV of 70%. We have found four out of 20 items on the M-CHAT-R that were culturally inappropriate in the Malian context. Discussion: M-CHAT-R and SCQ can be used for early autism screening in Mali. In the future, we plan to train a descent number of Malian physicians in chief and pediatricians at the district hospitals across the country to integrate the early ASD screening into the national health system. Conclusion: M-CHAT-R has a perfect specificity and SCQ a fair diagnostic accuracy for ASD in Mali. Keywords: M-CHAT-R, SCQ, NPV, PPV, Mali
- Published
- 2019