Search

Your search keyword '"Redlich, R."' showing total 2 results
Start Over Author "Redlich, R." Language undetermined
2 results on '"Redlich, R."'

2. Influence of electroconvulsive therapy on white matter structure in a diffusion tensor imaging study

Author

Irene Bollettini, Ramona Leenings, Volker Arolt, Katharina Dohm, Jonathan Repple, Felix Stahl, Dario Zaremba, Verena Enneking, Claas Kaehler, Nils Opel, Katharina Förster, Elisabeth J. Leehr, Jochen Bauer, Udo Dannlowski, Harald Kugel, Ronny Redlich, Nils R. Winter, Tim Hahn, Francesco Benedetti, Dominik Grotegerd, Susanne Meinert, Christian Bürger, Walter Heindel, Daniel Emden, Joscha Böhnlein, Repple, J., Meinert, S., Bollettini, I., Grotegerd, D., Redlich, R., Zaremba, D., Burger, C., Forster, K., Dohm, K., Stahl, F., Opel, N., Hahn, T., Enneking, V., Leehr, E. J., Bohnlein, J., Leenings, R., Kaehler, C., Emden, D., Winter, N. R., Heindel, W., Kugel, H., Bauer, J., Arolt, V., Benedetti, F., and Dannlowski, U.

Subjects
Adult, Male, FA, medicine.medical_specialty, medicine.medical_treatment, behavioral disciplines and activities, White matter, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Electroconvulsive therapy, Internal medicine, mental disorders, Fractional anisotropy, medicine, Humans, Prospective Studies, Electroconvulsive Therapy, Prospective cohort study, Applied Psychology, Depressive Disorder, Major, business.industry, MD, ECT, Biomarker, Middle Aged, medicine.disease, White Matter, White matter changes, 030227 psychiatry, Psychiatry and Mental health, Diffusion Tensor Imaging, medicine.anatomical_structure, Therapy response, DTI, Case-Control Studies, depression, Cardiology, Major depressive disorder, Female, business, Biomarkers, 030217 neurology & neurosurgery, Diffusion MRI
Abstract

BackgroundElectroconvulsive therapy (ECT) is a fast-acting intervention for major depressive disorder. Previous studies indicated neurotrophic effects following ECT that might contribute to changes in white matter brain structure. We investigated the influence of ECT in a non-randomized prospective study focusing on white matter changes over time.MethodsTwenty-nine severely depressed patients receiving ECT in addition to inpatient treatment, 69 severely depressed patients with inpatient treatment (NON-ECT) and 52 healthy controls (HC) took part in a non-randomized prospective study. Participants were scanned twice, approximately 6 weeks apart, using diffusion tensor imaging, applying tract-based spatial statistics. Additional correlational analyses were conducted in the ECT subsample to investigate the effects of seizure duration and therapeutic response.ResultsMean diffusivity (MD) increased after ECT in the right hemisphere, which was an ECT-group-specific effect. Seizure duration was associated with decreased fractional anisotropy (FA) following ECT. Longitudinal changes in ECT were not associated with therapy response. However, within the ECT group only, baseline FA was positively and MD negatively associated with post-ECT symptomatology.ConclusionOur data suggest that ECT changes white matter integrity, possibly reflecting increased permeability of the blood–brain barrier, resulting in disturbed communication of fibers. Further, baseline diffusion metrics were associated with therapy response. Coherent fiber structure could be a prerequisite for a generalized seizure and inhibitory brain signaling necessary to successfully inhibit increased seizure activity.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results