1. Does the Vitamin D Deficiency Have Any Role in Severity or Prolongation of Seizure? A Pilot Study in Iran
- Author
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Grishaev Denis, Ratnoo Saroj, Shtyrlin Yurii, Sokolovich Evgenii, Dmitry Vladimirovich Bagrov, Varadwaj Pritish, Liu Li, Shtro Anna, C. Yadav Tara, Xu Zhiru, Wang Jiahui, Irina Aleksandrovna Gavrish, Chen Rui, Vinogradova Tatiana, Singh Jyotsna, Khaziev Rail, Oksana Borisovna Polivanova, Tripathi Vijay, Ferreira dos Santos Wagner, Mikhailovna Korotkova Аnastasia, Dmitry Aleksandrovich Ksenofontov, Dianna Bagdasarovna Kosyan, Selvaraj Chandrabose, Manicheva Olga, Dmitry Vladimirovich Klinov, Gnezdilov Oleg, Tripathi Pooja, Kushwaha Sandeep, Pruthi Vikas, Balakin Konstantin, Gabbasova Raylya, Chandra Ishwar, Agarwal Vidhu, Yan Renjie, K. Singh Sanjeev, Anatoly Alexandrovich Fenin, Galochkina Anastasia, S. Maurya Neha, Nikolaeva Yulia, Shtyrlin Nikita, Tahernia Leila, Kamali Koorosh, Shi Jian, Panwar Umesh, Pavelyev Roman, Marina Yurievna Koroleva, Teimourtash Shahin, Rathee Seema, Noorbakhsh Samileh, Vafaee-Shahi Mohammad, Yablonskiy Petr, Ekaterina Nikolaevna Baranova, Prasad Ramasare, S. Badv Reza, Nigmatullin Raushan, Svyatoslav Valerievich Lebedev, Mikhail Yurievich Cherednichenko, A. Lal Jonathan, K. Srivastava Amit, Raghuwanshi Navdeep, Dogonadze Marine, Kazemi Alinaghi, and Mani Ashutosh
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medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Public Health, Environmental and Occupational Health ,Prolongation ,030209 endocrinology & metabolism ,medicine.disease ,Gastroenterology ,vitamin D deficiency ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,medicine ,business ,Food Science - Abstract
Background: Based on previous studies, vitamin D deficiency could lead to nerve stimulation. The purpose of the present study was to determine frequency and duration of seizures in children with idiopathic epilepsy in two groups; normal level of vitamin D versus decreased level of vitamin D. Methods: This pilot, comparative study was carried out in Zanjan University of Medical Sciences on total 40 children aging between 2 to 12 years old (23 male and 17 female) with the diagnosis of idiopathic epilepsy. All patients were receiving anti-epileptic drugs. The initial questionnaire was completed by each parent. Total 40 epileptic cases were examined in close follow-ups every three months, during total 9 months. Meanwhile, the frequency and duration of each seizure were recorded in questionnaire at every three-month period. Vitamin D blood samples were analyzed at the beginning of the study and after 9 months following the study. Serum levels of Vitamin D were analyzed by ELISA method (Elecsys2010, RocheCo, Germany; STAR FAX; 2100), simultaneously, Vitamin D level Results: In all 40 patients, vitamin D level less than 30 ng/ml was detected in 32% (13 patients) at the beginning of study and 35% (14 patients) in 9 months later (13 patients were common between the two groups). There was no significant relationship between the frequency of seizures, the duration of seizures and vitamin D levels in patients. The relationship between positive family history of epilepsy and the number of seizures was reported significant. The frequency of vitamin D deficiency was higher in female cases in final evaluation. Conclusion: In the present study, a considerable correlation was detected between the frequency of seizures and positive history of seizure in the family. The frequency of vitamin D deficiency was higher in female cases in final analysis. No significant relationship was detected between the number of seizures, the mean duration of seizures and serum level of Vitamin D in children who received anticonvulsant drugs. However, vitamin D deficiency in patients was not overlooked in order to prevent known complications. We recommend a randomized clinical trial in the future with an adequate sample size. Moreover, a non-epileptic control group in study would be useful.
- Published
- 2020
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