1. Serum markers of Iron metabolism in individuals with diabetes mellitus from a population with high prevalence of anaemia
- Author
-
Sindu Pc and Ramakrishnan Vr
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Population ,Inflammation ,03 medical and health sciences ,Diabetes mellitus ,0302 clinical medicine ,Intestinal mucosa ,Hepcidin ,Internal medicine ,medicine ,education ,Ferritin ,lcsh:R5-920 ,education.field_of_study ,biology ,medicine.diagnostic_test ,business.industry ,nutritional and metabolic diseases ,Mononuclear phagocyte system ,Iron metabolism ,medicine.disease ,hsCRP ,lcsh:RK1-715 ,030104 developmental biology ,Endocrinology ,lcsh:Dentistry ,030220 oncology & carcinogenesis ,biology.protein ,Serum iron ,medicine.symptom ,lcsh:Medicine (General) ,business - Abstract
Introduction: Diabetes mellitus cause rise in the levels of cytokines which increases hepcidin secretion from liver. Hepcidin inhibits the release of iron from macrophages of reticuloendothelial cells and decreases the transport of iron from intestinal mucosa to blood. Anaemia of chronic inflammation cause rise in cytokines which leads to retention of iron at the stores as ferritin and fall in serum iron. Aim: The present study was conducted to estimate serum markers of iron metabolism, serum iron, ferritin and haemoglobin and hsCRP from individuals with diabetes mellitus and in the control groups and to make comparison of these parameters. Materials and methods: A total of 34 subjects were enrolled aged between 25 -50 years 17 subjects with diabetes mellitus and 17 age matched controls. Fasting blood samples were taken Hb, serum glucose; iron ferritn and hsCRP were estimated. Results: We have observed that mean haemoglobin in both the groups were in the anemic level (
- Published
- 2016