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The use of repellents is considered an alternative against biting insects, including Lutzomyia longipalpis (Diptera: Psychodidae), the main vector of the protozoan Leishmania infantum, visceral leishmaniasis's (VL) etiologic agent in the Americas. This study aimed to evaluate the repellent efficacy of icaridin nanostructured solution applied on cotton knitting fabric against L. longipalpis. Arm-in-cage tests were performed in eight volunteers at different concentrations (5%, 10%, 25%, and 50%), using L. longipalpis (n = 30). The bioassay was performed in 1, 24, 48, 72, 96, 120, and 144 h after impregnation and one test after washing the fabrics with icaridin. The total repellency rate (%R) 95% was used as a reference to define a minimum effective concentration (MEC). The results revealed that the insects' landing mean decreased significantly in different icaridin concentrations, compared with the control tests (p 0.05) and the 25% and 50% concentrations compared to lower concentration (5%) (p 0.05). The higher concentrations (25% and 50%) provided longer complete protection times (CPTs) with 120 and 144 h of protection, respectively and the %R of 100% for 72 and 96 h after impregnation, respectively. The 25% was the MEC (%R Total = 98.18%). Our results indicate, for the first time, that icaridin nanostructured solution applied on cotton knitting fabric proved to be an efficient repellent against L. longipalpis with the presence of repellent action even after washing. The concentration of 25% showed better efficiency and may become an efficient method for L. longipalpis biting control.

A moderna gestão da cadeia de suprimentos teve grande impulso com o advento da tecnologia da informação e com o desenvolvimento dos sistemas de informação, tornando-se mais bem planejada e integrada, possibilitando um melhor controle e gestão dos processos. Nesta pesquisa demonstra-se o quanto esta integração é importante para evolução da Supply Chain Management (SCM). O objetivo geral desse trabalho foi demonstrar a importância da tecnologia da informação e sistema da informação na SCM, apresentando o modelo que foi implantado para a melhoria da integração entre as empresas. Os objetivos específicos ficaram assim sequenciados: descrever a cadeia de suprimentos; demonstrar a importância da tecnologia da informação e sistemas de informação; abordar a tecnologia da informação e sistemas de informação na cadeia de suprimentos; relatar os impactos da automatização da cadeia de suprimentos e discorrer sobre a aplicação da tecnologia da informação na cadeia de suprimentos de um grupo empresarial brasileiro. O presente trabalho seguiu uma abordagem qualitativa com caráter exploratório e descritivo e a metodologia empregada foi a da pesquisa bibliográfica, que utilizou a análise de referências teóricas publicadas em livros, artigos científicos e documentos. Ao final desse trabalho foi possível avaliar que a Tecnologia da Informação vem atuando como forte aliada na evolução da SCM na busca da redução de custos e no enfrentamento da competitividade.

Purpose This paper aims to provide a more nuanced understanding of the effectiveness of the anti-money laundering (AML) regime in the UK and explore opportunities to improve policy and performance. Design/methodology/approach Qualitative research design using semi-structured interviews and a focus group with practitioners from both public and private sectors. Findings This paper identifies preventive measures are underfunded by the public sector; there is a disconnect between the regulatory requirement and the regulators’ supervisory approach leading to the ineffective application of the risk-based approach; and authorities have limited ability to stop low-utility reports. Increased collaboration across institutions and sectors, better utilisation of innovative technologies and a sustainable funding plan are needed to drive a collective response to money laundering. Research limitations/implications Few practitioners in the industry have the knowledge and expertise to discuss the topic at a strategic level and participants were limited (n = 8). Practical implications This paper adds to the growing corpus of research showing that the AML regime in the UK is ineffective and needs reform. Social implications This paper encourages practitioners to improve the AML regime, this research contributes to the reform of the existing measures against financial crime. Originality/value This paper presents new data from AML practitioners to provide a better understanding of the limitations of the AML regime in the UK.

Background Triatomines are responsible for the vector transmission of the protozoan parasite Trypanosoma cruzi, which causes Chagas disease. Triatoma brasiliensis is the main vector of the parasite in Brazil, and dogs are an important reservoir of the parasite. The aim of this study was to evaluate the insecticidal effect of fluralaner (Bravecto®) on T. brasiliensis after a blood meal in treated dogs. Methods Healthy mongrel dogs (n = 8) were recruited from the Zoonoses Control Center (ZCC) in the city of Natal, Rio Grande do Norte, Brazil, and randomized into two groups, a fluralaner (Bravecto®)-treated group (n = 4) and a control group (n = 4). Colony-reared third-, fourth- and fifth-instar nymphs of T. brasiliensis nymphs (n = 10) were allowed to feed on dogs from both groups for 30–40 min, once monthly, for up to 12 months. Bug mortality was observed up to 5 days after each blood meal. Results Mortality in triatomines which had a blood meal on fluralaner (Bravecto®)-treated dogs was 100% for up to 7 months after treatment, with mortality decreasing to 66.4% after 8 months, 57% after 9 months, 35% after 10 months, 10% after 11 months and 0% after 12 months. The mortality of triatomines that fed on non-treated control dogs was always ≤ 2.5%. Conclusions Our results suggest that fluralaner (Bravecto®) treatment of dogs induces long-term mortality of T. brasiliensis after the blood meal. This is a potential approach to be used to control vector transmission of T. cruzi, the etiological agent of Chagas disease, especially in endemic areas. Graphical Abstract

Purpose To develop and validate a chest cavity simulator for teaching video-assited thoracic surgery (VATS). Methods The first phase of the study consisted of developing a chest cavity simulator. A quasi-experimental study was performed in the second phase, and 25 surgeons and residents participated in a three-stage pulmonary suture experiment. The videos were recorded and timed. Generalized linear regression models for repeated measures were used to analyze the outcome change over time. Results The chest cavity simulator consists of a console simulating the left hemithorax. Among the participants, 96% rated the design, visual aspect, positioning ergonomics, and triangulation of the portals as very good or excellent (face validity). There was a decrease in suturing time in step 1 from 435.7 ± 105 to 355.6 ± 76.8 seconds compared to step 3 (p = 0.001). The evaluation of the simulation effectiveness and performance (content validity) was rated as very good or excellent by 96% ofparticipants. The most experienced surgeon showed significant reduction in procedure time (p = 0.021) (construct validity). Conclusions The thoracic cavity simulator is realistic, showing content and construct validity, and can be used in VATS training. The simulation model allowed skill gain in the endoscopic suture.

Objetivo: mapear a distribuição de mosquitos Aedes spp. em zona urbana do município de Picos, Piauí, associando a variáveis climáticas e identificar os sorotipos circulantes do virus Dengue em Aedes aegypti. Métodos: foram instaladas 30 armadilhas do tipo larvitrampas em 10 bairros da zona urbana do município. As larvas foram coletadas, semanalmente, no período de fevereiro de 2017 a julho de 2019, e encaminhadas para o laboratório onde foram identificadas e contadas. O número de larvas foi associado a dados meterológicos. Após as larvas atigirem a fase adulta, os mosquito A. aegypti foram segregados em pools com 6 exemplares e submetidos a RT-PCR e Nested-PCR para detecção do sorotipo DENV. Resultados: um total de 44.798 larvas de Aedes spp foram coletadas em área urbana de Picos durante o período de estudo. O aumento das chuvas e diminuição da temperatura, principalmente nos meses de fevereiro e março, contribuiram para o aumento da infestação desses vetores no mês de abril. No estudo, foi coletado duas larvas de Haemagogus spegazzinii, potencial vetor de febre amarela. A maior ocorrência no município foi da espécie A. aegypti (96,43%), presente em todos bairros estudados, com predominancia em ambiente intradomicíliar, enquanto o A. albopictus (3,57%) ocupa ambiente peridomicíliar. As análises moleculares de A. aegypti apresentaram positividade para o vírus DENV 1 e DENV 3, demonstrando a existência de transmissão transovariana. Conclusão: Esse estudo demonstrou a ocorrência concomitante de A. aegypti e A. albopictus em zona urbana e a co-circulação dos sorotipos 1 e 3 da dengue. O monitoramento entomológico e da circulação viral são importantes ferramentas para indicar áreas de maior infestação de mosquitos vetores e prevenir futuros surtos, fornecendo subsídios para o planejamento de ações voltadas ao controle e a prevenção de arboviroses , através da secretária de saúde e órgãos competentes na região.

Additional file 1: Table S1. Lutzomyia longipalpis mortality (%) after blood meal (determined up to 120 h after blood meal) on fluralaner (Bravecto®)-treated dogs for up to 12 months post-treatment.

Background Fibromyalgia (FM) is a clinical syndrome characterized by diffuse pain associated with other symptoms such as fatigue, sleep disturbance and mood. It presents a series of differential diagnoses such as thyroid disorders, hypoparathyroidism, systemic inflammatory diseases and myopathies. Hypothyroidism is a disease with a prevalence of 4-6% of the population, having many symptoms in common with FM, such as fatigue, mood changes, constipation, and diffuse pain in some cases. Objectives The purpose is to evaluate the association between FM and thyroid disorders. Methods A retrospective monocentric case-control study in a tertiary hospital, with patients and controls having regular follow-up. The cases were composed of women over 40 years old, diagnosed with FM by the criteria ACR 1990 and ACR 2010, without autoimmune disease or other confounding diseases for pain. The control consisted of women over 40 years old, without autoimmune diseases. Laboratory tests included TSH and free T4 in all patients. Evaluation by ANA, anti-TPO and anti-thyroglobulin antibodies, only when appropriate. The sample was classified into euthyroid, clinical and subclinical hyperthyroid, clinical and subclinical hypothyroid. Statistical analysis included Fischer’s T-tests and others where appropriate. The p value was significant when ≤ 0.05. Results The sample consisted of 142 patients (median age of 58 years) and controls with 136 patients (median age of 67 years). Patients with FM had a greater number of thyroid disorders (31.7%) than controls (14.7%) (p = 0,001). FM patients had a TSH higher than the controls (mean 9.06 vs 2.96; p = 0,0026), with a lower free T4 (mean 1.06 vs 1.31; p = 0,0001). ANA, anti-TPO and anti-thyroglobulin antibodies analysis showed no differences between both groups (p = 1; p = 0,08, p = 1; respectively), when performed. Because of the small difference in median age between the two groups, a sub analysis was performed separating patients between the ages of 40 to 60 years and over 60 years. The same results previously seen were found. Conclusion Patients with FM had a greater association with clinical hypothyroidism. However, we did not find any association with autoantibodies in our casuistic. References [1] Claw, DJ, JAMA, volume 311, pagina 1547, 2014. [2] Hollowell JG, J Clin Endocrinol Metab, 87:489, 2002. [3] Suk, JH, Experimental and Clinical Endocrinology and Diabetes, 120: 401, 2012. [4] J.Rodriguez-Espinosa, Reumatologia Clinica, 2:70, 2006. [5] J. Ahmad, Rheumatology International, 35:1415, 2015. Disclosure of Interests Marco Antonio G Pontes Filho Speakers bureau: Novartis and Janssen, DIOGO SOUZA DOMICIANO: None declared, Rafael Pontes Andreussi: None declared, Leonardo Rodrigues da Silva: None declared

Objective: The aim is to report the experiences during the practical experiences in the territory assigned to a basic health unit provided by the module of Integral Health Care I. Methods: Case studies resulting from a process of critical reflections about practical experiences by medical students in a basic health unit from August to December 2015. Results: Through the module of Integral Health Care I, students were allowed to recognize the assigned area of a family health team, as well as to develop the territorialization process and to classify the demographic, epidemiological, socioeconomic and environmental profile in that place; in addition to perform other activities as a singular therapeutic project and intervention project. Conclusion: The activities developed motivated the students to be able to apply the concepts of family and community medicine in primary health care, in addition to bringing them closer to the reality of this work process. Descriptors: Integral Health Care; Family Health Strategy; Physician-Patient Relationship; Basic Health Unit.

Os schwannomas são tumores em sua maioria benignos, derivados das células de Schwann (células da glia pertencentes ao sistema nervoso periférico que ajudam a separar e isolar neurônios de estruturas adjacentes), normalmente localizados em nervos intracranianos, principalmente no VIII par (neuroma acústico). Quando extradurais, sua apresentação mais comum é através de massas tumorais que podem comprimir estruturas adjacentes, tornando-se sintomático, como é o caso dos schwannomas intratorácicos (presentes mais comumente no mediastino posterior). Este trabalho apresenta o relato de caso de um schwannoma tratado por videotoracoscopia e uma revisão literária sobre o assunto.

[ES] Dogos (2011), el segundo libro de poesía de Antonio Portela, está lleno de misterios. En él nada está dejado al azar y el orden de los factores altera el producto, por lo que debemos analizarlo poema por poema, escalón por escalón. No en vano, su propuesta de ascensión mística se convierte en la alegoría de una cumbre de autoconocimiento poético y vital al alcance de pocos. Autónomo e independiente, posiblemente a contracorriente de las tendencias poéticas actuales, Portela homenajea a sus poetas clásicos favoritos y a David Bowie a través de treinta y un poemas equivalentes a otras tantas canciones del cantante británico, ennobleciendo así sus palabras y logrando que sus ídolos vivan en él. [EN] Dogos (2011), the second poetry book by Antonio Portela, is full of mysteries. Since the work trusts nothing to chance and the order of his factors alters the product, we should analyze it step by step, poem by poem. Indeed his proposal of a mystical allegory, which consists in a rising path towards a peak of poetic and vital self-knowledge, is not within reach of most people. Autonomous, independent and probably against the current poetic trends, Portela pays tribute both to his favorite classic poets and to David Bowie´s thirty-one songs, in order to ennoble his words and immortalize his idols in his verses.

Hepatic transplantation is inevitably associated with periods of complete ischemia. However, the clamping of hepatic vascular pedicle is limited by the consequences of the post-ischemic injury to the liver.To determine the main metabolic alterations caused for the hepatic ischemia and the probable hepatoprotective effect cyclosporin.Normothermic hepatic ischemia during 60 minutes was induced in the rats. The time-course (0, 1, 6, 24 hours) of changes in blood and in the hepatic concentrations of lactate, pyruvate, glucose, ketone bodies and in the ratio of acetoacetate/3-hydroxybutyrate, as well as the cytoplasmic and mitochondrial redox state of the liver cells were determined. A group of animals was daily pre-treated with cyclosporine (10 mg/kg) during 4 days until the induction of hepatic ischemia, then they studied 1 hour after hepatic revascularization. Hepatic ischemia caused elevation in the concentrations of lactate in the liver, suggesting that a pronounced level of anaerobic metabolism occurred during the ischemia period. Liver ischemia promoted yet a fall in the concentration and in the ratio of ketone bodies (acetoacetate/3-hydroxybutyrate) in the arterial blood in the studied period of one hour post-revascularization, perhaps reflecting impairment of ketogenesis as a result of the ischemic injury.The treatment with cyclosporine cause elevation in the concentration of ketone bodies and in the ratio of acetoacetate/3-hydroxybutyrate in the arterial blood 1 hour after reperfusion of the liver, suggesting that these drugs may accelerate the recovery of the ischemic hepatic lesion with reactivation of ketogenesis.

Nuestra intención con este estudio no consiste en subrayar la originalidad de los textos del escritor mexicano Guillermo Samperio, ya analizada en artículos precedentes, sino poner de relieve su actitud abierta y flexible a la hora de leer y escribir. La carencia de prejuicios en la elección de sus afinidades literarias y culturales lo condujo a la felicidad por el camino de la independencia de criterio. En este sentido, realizamos un breve recorrido por las principales corrientes de pensamiento que subyacen en su literatura: las vanguardias, la neovanguardia y la posmodernidad. El comentario de este panorama nos ayudará a entender la predilección samperiana por la microficción, en el marco del hibridismo genérico, y su empleo de la metáfora como destacado recurso estilístico.