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The Q/U Imaging ExperimenT (QUIET) has observed the cosmic microwave background (CMB) at 43 and 95GHz. The 43-GHz results have been published in QUIET Collaboration et al. (2011), and here we report the measurement of CMB polarization power spectra using the 95-GHz data. This data set comprises 5337 hours of observations recorded by an array of 84 polarized coherent receivers with a total array sensitivity of 87 uK sqrt(s). Four low-foreground fields were observed, covering a total of ~1000 square degrees with an effective angular resolution of 12.8', allowing for constraints on primordial gravitational waves and high-signal-to-noise measurements of the E-modes across three acoustic peaks. The data reduction was performed using two independent analysis pipelines, one based on a pseudo-Cl (PCL) cross-correlation approach, and the other on a maximum-likelihood (ML) approach. All data selection criteria and filters were modified until a predefined set of null tests had been satisfied before inspecting any non-null power spectrum. The results derived by the two pipelines are in good agreement. We characterize the EE, EB and BB power spectra between l=25 and 975 and find that the EE spectrum is consistent with LCDM, while the BB power spectrum is consistent with zero. Based on these measurements, we constrain the tensor-to-scalar ratio to r=1.1+0.9-0.8 (r, 10 pages, 6 figures, 3 tables, submitted to ApJ, This paper should be cited as "QUIET Collaboration (2012)." v2: updated to reflect published version

The Q/U Imaging ExperimenT (QUIET) employs coherent receivers at 43GHz and 95GHz, operating on the Chajnantor plateau in the Atacama Desert in Chile, to measure the anisotropy in the polarization of the CMB. QUIET primarily targets the B modes from primordial gravitational waves. The combination of these frequencies gives sensitivity to foreground contributions from diffuse Galactic synchrotron radiation. Between 2008 October and 2010 December, >10,000hours of data were collected, first with the 19-element 43GHz array (3458hours) and then with the 90-element 95GHz array. Each array observes the same four fields, selected for low foregrounds, together covering ~1000deg^2. This paper reports initial results from the 43GHz receiver which has an array sensitivity to CMB fluctuations of 69uK sqrt(s). The data were extensively studied with a large suite of null tests before the power spectra, determined with two independent pipelines, were examined. Analysis choices, including data selection, were modified until the null tests passed. Cross correlating maps with different telescope pointings is used to eliminate a bias. This paper reports the EE, BB and EB power spectra in the multipole range ell=25-475. With the exception of the lowest multipole bin for one of the fields, where a polarized foreground, consistent with Galactic synchrotron radiation, is detected with 3sigma significance, the E-mode spectrum is consistent with the LCDM model, confirming the only previous detection of the first acoustic peak. The B-mode spectrum is consistent with zero, leading to a measurement of the tensor-to-scalar ratio of r=0.35+1.06-0.87. The combination of a new time-stream double-demodulation technique, Mizuguchi-Dragone optics, natural sky rotation, and frequent boresight rotation leads to the lowest level of systematic contamination in the B-mode power so far reported, below the level of r=0.1, 19 pages, 14 figures, higher quality figures are available at http://quiet.uchicago.edu/results/index.html; Fixed a typo and corrected statistical error values used as a reference in Figure 14, showing our systematic uncertainties (unchanged) vs. multipole; Revision to ApJ accepted version, this paper should be cited as "QUIET Collaboration et al. (2011)"

The distribution of 12C16O J=9-8 (1.037 THz) emission has been mapped in OMC-1 at 35 points with 84" resolution. This is the first map of this source in this transition and only the second velocity-resolved ground-based observation of a line in the terahertz frequency band. There is emission present at all points in the map, a region roughly 4' by 6' in size, with peak antenna temperature dropping only near the edges. Away from the Orion KL outflow, the velocity structure suggests that most of the emission comes from the OMC-1 photon-dominated region, with a typical linewidthof 3-6 km/s. Large velocity gradient modeling of the emission in J=9-8 and six lower transitions suggests that the lines originate in regions with temperatures around 120 K and densities of at least 10^(3.5) cm^(-3) near theta^(1) C Ori and at the Orion Bar, and from 70 K gas at around 10^(4) cm^(-3) southeast and west of the bar. These observations are among the first made with the 0.8 m Smithsonian Astrophysical Observatory Receiver Lab Telescope, a new instrument designed to observe at frequencies above 1 THz from an extremely high and dry site in northern Chile., Minor changes to references, text to match ApJ version

Amyloid deposits regress when the supply of fibril precursor proteins is sufficiently reduced, indicating that amyloid fibrils are degradable in vivo. Serum amyloid P component (SAP), a universal constituent of amyloid deposits, efficiently protects amyloid fibrils from proteolysis in vitro, and may contribute to persistence of amyloid in vivo. Drugs that prevent binding of SAP to amyloid fibrils in vivo should therefore promote regression of amyloid and we are actively seeking such agents. A complementary strategy is identification of critical molecular processes in fibrillogenesis as targets for pharmacological intervention. All amyloidogenic variants of apolipoprotein AI contain an additional positive charge in the N-terminal fibrillogenic region of the protein. This is unlikely to be a coincidence and should be informative about amyloidogenesis by this protein. The two amyloidogenic variants of human lysozyme, caused by the first natural mutations found in its gene, provide a particularly powerful model system because both the crystal structure and folding pathways of wild-type lysozyme are so well characterized. The amyloidogenic variant lysozymes have similar 3D crystal structures to the wild type, but are notably less thermostable. They unfold on heating, lose enzymic activity, and aggregate to form amyloid fibrils in vitro.

We present polarization observations of two Galactic plane fields centered on Galactic coordinates (l,b)=(0 deg,0 deg) and (329 deg, 0 deg) at Q- (43 GHz) and W-band (95 GHz), covering between 301 and 539 square degrees depending on frequency and field. These measurements were made with the QUIET instrument between 2008 October and 2010 December, and include a total of 1263 hours of observations. The resulting maps represent the deepest large-area Galactic polarization observations published to date at the relevant frequencies with instrumental rms noise varying between 1.8 and 2.8 uK deg, 2.3-6 times deeper than corresponding WMAP and Planck maps. The angular resolution is 27.3' and 12.8' FWHM at Q- and W-band, respectively. We find excellent agreement between the QUIET and WMAP maps over the entire fields, and no compelling evidence for significant residual instrumental systematic errors in either experiment, whereas the Planck 44 GHz map deviates from these in a manner consistent with reported systematic uncertainties for this channel. We combine QUIET and WMAP data to compute inverse-variance-weighted average maps, effectively retaining small angular scales from QUIET and large angular scales from WMAP. From these combined maps, we derive constraints on several important astrophysical quantities, including a robust detection of polarized synchrotron spectral index steepening of ~0.2 off the plane, as well as the Faraday rotation measure toward the Galactic center (RM=-4000 +/- 200 rad m^-2), all of which are consistent with previously published results. Both the raw QUIET and the co-added QUIET+WMAP maps are made publicly available together with all necessary ancillary information., 22 pages, 18 figures; accepted for publication in ApJ; data are available on Lambda (http://lambda.gsfc.nasa.gov)

The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the Cosmic Microwave Background, targeting the imprint of inflationary gravitational waves at large angular scales (~ 1 degree). Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4 m side-fed Dragonian telescope. The polarimeters which form the focal planes use a highly compact design based on High Electron Mobility Transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 uK sqrt(s)) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0.1. The 84-element W-band polarimeter array has a sensitivity of 87 uK sqrt(s) at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0.01. The two arrays together cover multipoles in the range l= 25-975. These are the largest HEMT-based arrays deployed to date. This article describes the design, calibration, performance of, and sources of systematic error for the instrument.