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3. Additional file 6: of Genome expansion of an obligate parthenogenesis-associated Wolbachia poses an exception to the symbiont reduction model

Author

A. Kampfraath, L. Klasson, S. Anvar, R. Vossen, D. Roelofs, K. Kraaijeveld, and J. Ellers

Subjects
fungi, bacteria, biochemical phenomena, metabolism, and nutrition
Abstract

Host genome size to Wolbachia genome size excluding RPOs. Correlation between host genome size and Wolbachia genome size excluding RPOs. Red data points indicate obligate transitional and black facultative endosymbionts; all points are labelled with strain names and for the correlations with the host the four strains residing in Drosophila simulans were averaged and labeled as Dsw. (PDF 36 kb)

Published
2019
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4. Additional file 1: of Genome expansion of an obligate parthenogenesis-associated Wolbachia poses an exception to the symbiont reduction model

Author

A. Kampfraath, L. Klasson, S. Anvar, R. Vossen, D. Roelofs, K. Kraaijeveld, and J. Ellers

Subjects
parasitic diseases, bacteria, biochemical phenomena, metabolism, and nutrition, reproductive and urinary physiology
Abstract

BUSCO assessment results of 18 Wolbachia genomes included in this paper. Protein sequences of the 18 Wolbachia strains were searched for a set of 148 single copy bacterial genes (Bacteria odb9), defining the complete, fragmented and missing genes. (PDF 291 kb)

Published
2019
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5. Skin tumour surgery in primary care: do general practitioners need to improve their surgical skills?

Author

W.J.M.J. Gorgels, Marie-Jeanne P. Gerritsen, M.C.J. van Rijsingen, R. Vossen, and B.E.W.L. van Huystee

Subjects
medicine.medical_specialty, Tumour surgery, Neoplasm, Residual, Skin Neoplasms, Referral, Biopsy, Dermatologic Surgical Procedures, General Practice, Bowen's Disease, Dermatology, Primary care, Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], Surgical skills, Medicine, Humans, Melanoma, Retrospective Studies, Skin, medicine.diagnostic_test, Primary Health Care, integumentary system, business.industry, Incidence (epidemiology), Torso, Retrospective cohort study, Extremities, medicine.disease, Surgery, Keratosis, Actinic, Carcinoma, Basal Cell, Clinical Competence, Skin cancer, Facial Neoplasms, business
Abstract

Background: Due to a rapid increase in the incidence of skin cancer, it seems inevitable that general practitioners (GPs) will play a larger role in skin cancer care. Objectives: To assess surgical procedures used by GPs in skin tumour management. Methods: We performed a retrospective study of 1,898 pathology reports of skin tumours excised by GPs in 2009. Results: In 22.9% no diagnosis was provided on the application form. Mostly, once-off excisions (no preceding biopsy) were performed, 7% of the excised lesions were malignant, and 35% of incisions were incomplete. Excisions in the face and neck region were incomplete in 65.4%; 22% of melanomas were biopsied or shaved. Conclusion: This study underlines the difficulties in skin tumour management in primary care. To stimulate adequate resource use, the number of excisions of benign lesions could be lowered, and pretreatment biopsy in non-melanoma skin cancer management should be encouraged. GPs should be aware of their limitations and consider referral of high-risk malignancies.

Published
2015
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6. Limited role for histopathological examination of re-excision specimens of completely excised melanomas

Author

A.C. de Waal, Willeke A. M. Blokx, M.M. van Rossum, Lambertus A. Kiemeney, Katja K.H. Aben, and R. Vossen

Subjects
Adult, Male, Reoperation, Pathology, medicine.medical_specialty, Neoplasm, Residual, Skin Neoplasms, Cost-Benefit Analysis, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Melanoma in situ, Histopathological examination, Pathology and Forensic Medicine, Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], medicine, Humans, Melanoma, Molecular Biology, neoplasms, Re-Excision, Aged, Netherlands, Retrospective Studies, business.industry, Incidence, Large series, Cell Biology, General Medicine, Middle Aged, medicine.disease, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Female, business
Abstract

Item does not contain fulltext The Dutch melanoma guideline advises to examine one central block of the re-excision scar in case of a complete primary excision. To increase the evidence for this recommendation, we re-evaluated how often residual melanoma was found in re-excision specimens of a large series of completely excised melanomas. Of 1,209 Dutch melanoma cases, pathology reports of primary excisions were reviewed. Presence of melanoma in the margins was scored. All melanomas with a complete primary excision were included and pathology reports of re-excisions were reviewed. Presence of residual melanoma in the re-excision specimen and the number of blocks were scored. Slides of re-excision specimens containing residual melanoma were reviewed. Eventually, in four out of 812 melanomas (0.5 %) with a complete primary excision, residual melanoma was found in the re-excision specimen. The free margins of the primary melanomas in these cases ranged from 0.5-3.5 mm. In one case, the margin for melanoma in situ was 0.2 mm. In

Published
2014
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7. Chances and risks of using clicker software in XL engineering classes - From theory to practice

Author

Ursula Bach, R. Vossen, V. Stehling, and Sabina Jeschke

Subjects
Class (computer programming), Multimedia, Computer science, business.industry, Educational technology, Face (sociological concept), Information technology, computer.software_genre, Clicker, Software, Engineering education, ComputingMilieux_COMPUTERSANDEDUCATION, Mathematics education, business, computer, Audience response
Abstract

Teaching and learning in XL-classes is a huge challenge to both lecturers as well as students. While lecturers face the difficulty of speaking to a mostly loud and very heterogenic audience, students often lack the opportunity of being an active participant in class. To counteract these difficulties and give the opportunity of immediate feedback, an audience response system has been introduced in the class of information technology in mechanical engineering at RWTH Aachen University.

Published
2013
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8. Unusual proton NMR properties of tungsten(II) tris(pyrazolyl)borate hydride complexes

Author

A. Dierdorf, S. G. Feng, Joseph L. Templeton, Peter S. White, M. R. Vossen, P. A. Eldredge, A. S. Gamble, and A. J. M. Caffyn

Subjects
Tris, Hydride, Organic Chemistry, Inorganic chemistry, chemistry.chemical_element, Protonation, Nuclear magnetic resonance spectroscopy, Crystal structure, Tungsten, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Polymer chemistry, Proton NMR, Physical and Theoretical Chemistry, Boron
Published
1991
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9. Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with HIV-1 who have not previously been treated: the PENTA 5 randomized trial

Author

J. P. Aboulker, A. Babiker, A. Compagnucci, J. H. Darbyshire, M. Debré, C. Giaquinto, D. M. Gibb, L. Harper, Y. Saidi, AS Walker, J. Darbyshire, D. Johnson, P. Kelleher, L. McGee, A Newberry, A. Poland, A. S. Walker, J P. Aboulker, I. Carrière, V. Eliette, S. Leonardo, M. Gersten, A. Jones, S. Blanche, A. B. Bohlin, K Butler, G. Castelli Gattinara, P. Clayden, R De Groot, A. Faye, C. Griscelli, I Grosch Wörner, C. Kind, H. Lyall, J. Levy, M. Mellado Pena, D. Nadal, C Peckham, J. T. Ramos Amador, L. Rosado, C. Rudin, H. Scherpbier, M Sharland, P. A. Tovo, G. Tudor Williams, N. Valerius, A. Volny Anne, U Wintergerst, V. Wahn, C. Hill, P Lepage, A. Pozniak, S. Vella, M. Hainaut, A. Peltier, S. Carlier, G. Zissis, M. Della Negra, W. Queiroz, L. P. Feitosa, D Oliveira, F. Mechinaud, F. Ballerau, A. Lepelletier, S. Billaudel, V. Ferre, I. Grosch Wörner, R. Weigel, K. Seel, C. Feiterna Sperling, D. Ohlendorf, G. Riße, C. Müller, T. Niehues, J. Ndagijimana, G. Horneff, N. Vente, R. Ganschow, T. Simon, R. Vossen, H Pfister, U. Wintergerst, G. Notheis, G. Strotmann, S Schlieben, K. Butler, E. Hayes, M. O’Mara, J. Fanning, F. Goggins, S. Moriarty, M. Byrne, L. Battisti, M. Duse, S. Timpano, E. Uberti, P. Crispino, P. Carrara, F. Fomia, A. Manca, L. Galli, M. de Martino, F. Fioredda, E. Pontali, M. Cellini, C. Baraldi, M. Portolani, M. Meacci, P. Pietrosemoli, R. Berni Canani, P. Laccetti, M. Gobbo, V. Giacomet, R. D’Elia, O. Rampon, E. Ruga, A. de Rossi, M. Zanchetta, D. Caselli, A. Maccabruni, E. Cattaneo, V Landini, S. Bernardi, A. Krzysztofiak, C. Tancredi, P. Rossi, L. Pansani, E. Palomba, C. Gabiano, A. Mazza, G. Rossetti, R. Nicolin, A. Timillero, F. Candeias, G Santos, M. L. Ramos Ribeiro, M. C. Almeida, M. H. Lourenço, R. Antunes, M. J. Mellado Pena, M L. Carillo de Albornoz, P. Martinez Santos, L. Ciria Calavia, J. Serra Devecchi, O. Delgado, N. Matamoros, A. Foot, H. Kershaw, C. Kelly, O. Caul, W. Tarnow Mordi, J. Petrie, A. McDowell, P. McIntyre, K. Appleyard, K. Sloper, V. Shah, K. Cheema, A. Aali, J. Mok, R. Russell, A. Brewster, N. Richardson, S. Burns, D. Gibb, V. Novelli, N. Klein, S. Ewen, V. Yeung, C. Ball, K. Himid, D. Nayagam, D. Graham, A. Barrie, K. Stringer, S. Jones, N. Weerasooriya, M. Zuckerman, P. Bracken, E. Cooper, T. Fisher, R. Barrie, U. Patel, V. Van Someren, K. Moshal, L. Perry, T. Gundlach, J. Norman, M. Sharland, M. Richardson, S. Donaghy, Z. Mitchla, C. Wells, J. Booth, A. Shipp, J. White, S. Head, S. Lambers, K. O’Hara, C. Stainsby, G. Du Mont, T. Solanki, S. Swanton, S. O’Shea, A. Tilsey, S. Kaye, A. Finn, S. Choo, R. Lakshman, L. Barr, G. Bell, A. Siddens, GUARINO, ALFREDO, SPAGNUOLO, MARIA IMMACOLATA, Aboulker, J. P., Babiker, A., Compagnucci, A., Darbyshire, J. H., Debré, M., Giaquinto, C., Gibb, D. M., Harper, L., Saidi, Y., Walker, A, Darbyshire, J., Johnson, D., Kelleher, P., Mcgee, L., Newberry, A, Poland, A., Walker, A. S., Aboulker, J P., Carrière, I., Eliette, V., Leonardo, S., Gersten, M., Jones, A., Blanche, S., Bohlin, A. B., Butler, K, Castelli Gattinara, G., Clayden, P., R De Groot, Faye, A., Griscelli, C., I Grosch Wörner, Kind, C., Lyall, H., Levy, J., Mellado Pena, M., Nadal, D., Peckham, C, Ramos Amador, J. T., Rosado, L., Rudin, C., Scherpbier, H., Sharland, M, Tovo, P. A., Tudor Williams, G., Valerius, N., Volny Anne, A., Wintergerst, U, Wahn, V., Hill, C., Lepage, P, Pozniak, A., Vella, S., Hainaut, M., Peltier, A., Carlier, S., Zissis, G., Della Negra, M., Queiroz, W., Feitosa, L. P., Oliveira, D, Mechinaud, F., Ballerau, F., Lepelletier, A., Billaudel, S., Ferre, V., Grosch Wörner, I., Weigel, R., Seel, K., Feiterna Sperling, C., Ohlendorf, D., Riße, G., Müller, C., Niehues, T., Ndagijimana, J., Horneff, G., Vente, N., Ganschow, R., Simon, T., Vossen, R., Pfister, H, Wintergerst, U., Notheis, G., Strotmann, G., Schlieben, S, Butler, K., Hayes, E., O’Mara, M., Fanning, J., Goggins, F., Moriarty, S., Byrne, M., Battisti, L., Duse, M., Timpano, S., Uberti, E., Crispino, P., Carrara, P., Fomia, F., Manca, A., Galli, L., de Martino, M., Fioredda, F., Pontali, E., Cellini, M., Baraldi, C., Portolani, M., Meacci, M., Pietrosemoli, P., Guarino, Alfredo, Spagnuolo, MARIA IMMACOLATA, Berni Canani, R., Laccetti, P., Gobbo, M., Giacomet, V., D’Elia, R., Rampon, O., Ruga, E., de Rossi, A., Zanchetta, M., Caselli, D., Maccabruni, A., Cattaneo, E., Landini, V, Bernardi, S., Krzysztofiak, A., Tancredi, C., Rossi, P., Pansani, L., Palomba, E., Gabiano, C., Mazza, A., Rossetti, G., Nicolin, R., Timillero, A., Candeias, F., Santos, G, Ramos Ribeiro, M. L., Almeida, M. C., Lourenço, M. H., Antunes, R., Mellado Pena, M. J., Carillo de Albornoz, M L., Martinez Santos, P., Ciria Calavia, L., Serra Devecchi, J., Delgado, O., Matamoros, N., Foot, A., Kershaw, H., Kelly, C., Caul, O., Tarnow Mordi, W., Petrie, J., Mcdowell, A., Mcintyre, P., Appleyard, K., Sloper, K., Shah, V., Cheema, K., Aali, A., Mok, J., Russell, R., Brewster, A., Richardson, N., Burns, S., Gibb, D., Novelli, V., Klein, N., Ewen, S., Yeung, V., Ball, C., Himid, K., Nayagam, D., Graham, D., Barrie, A., Stringer, K., Jones, S., Weerasooriya, N., Zuckerman, M., Bracken, P., Cooper, E., Fisher, T., Barrie, R., Patel, U., Van Someren, V., Moshal, K., Perry, L., Gundlach, T., Norman, J., Sharland, M., Richardson, M., Donaghy, S., Mitchla, Z., Wells, C., Booth, J., Shipp, A., White, J., Head, S., Lambers, S., O’Hara, K., Stainsby, C., Du Mont, G., Solanki, T., Swanton, S., O’Shea, S., Tilsey, A., Kaye, S., Finn, A., Choo, S., Lakshman, R., Barr, L., Bell, G., and Siddens, A.

Abstract

Introduction Treatment options for children with HIV-1 are limited. We aimed to compare activity and safety of three dualnucleoside analogue reverse-transcriptase inhibitor (NRTI) regimens with or without a protease inhibitor in previously untreated children with HIV-1. Methods In our multicentre trial, we randomly assigned 36 children to zidovudine and lamivudine, 45 to zidovudine and abacavir, and 47 to lamivudine and abacavir. Children who were symptomfree (n=55) were also randomly assigned to receive nelfinavir or placebo. Children with more advanced disease received open-label nelfinavir (73). Primary endpoints were change in plasma HIV-1 RNA at 24 and 48 weeks for the NRTI comparison and occurrence of serious adverse events for both randomised comparisons. Analyses were by intention to treat. Findings Children had a median CD4 percentage of 22% (IQR 15–29) and a mean HIV-1 RNA concentration of 5·0 log copies/mL (SD 0·8). One child was lost to follow-up and one died of sepsis. At 48 weeks, in the zidovudine/lamivudine, zidovudine/abacavir, and lamivudine/abacavir groups, mean HIV-1 RNA had decreased by 1·71, 2·19, and 2·63 log copies/mL, respectively (estimated in absence of nelfinavir) (p=0·02 after adjustment for baseline factors). One child had a hypersensitivity reaction to abacavir; and three with possible reactions stopped abacavir. There were 24 serious adverse events—six in the symptom-free children (all on nelfinavir), but none were attributed to nelfinavir. Interpretation Regimens containing abacavir were more effective than zidovudine/lamivudine. Such regimens could be combined with protease inhibitors and non-nucleoside reverse transcriptase inhibitors for safe and effective treatment of previously untreated children with HIV-1.

Published
2002

10. The EUROGEM map of human chromosome X

Author

M A, Aldred, T, Flint, R, Vossen, K, Wakefield, M A, Ferguson-Smith, M, Lush, D, Rubinsztein, T, Kruse, A, Loizedda, and B, Bakker

Subjects
X Chromosome, Genetic Linkage, Chromosome Mapping, Humans
Published
1994

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