Search

In order to behave adaptively and to successfully interact with our environment, we must learn from the consequences of our actions. Anticipation and processing of rewards is omni-present in modern behavioral experiments since it regulates interaction and is altered in a diverse set of psychiatric disorders. Our understanding of neural processes underlying the feedback on reward or punishment has largely advanced due to research in electroencephalography (EEG). Within this context, the feedback-Related Negativity (FRN), an event-related potential (ERP) and EEG variable tracts responsiveness to reward and reward learning. Furthermore, it is a valuable assessment tool for a modern descriptive-dimensional diagnostic system by the National Institute for Mental Health (NIMH) called Research-Domain-Criteria (RDoC). It needs to be discussed whether FRN can functionally act as a biomarker passing certain criteria from a theoretical and mechanistic point of view. Showing consistency in related psychopathologies would imply great capacity of FRN in future EEG-research and diagnostic investigation. In this regard, we will use the Internalizing-Externalizing-Spectrum (IES), a well-established nosology system, testing the practicality of FRN along a continuous psychopathology system in a metanalytic approach.

Frontiers in psychology 13, 762079 (2022). doi:10.3389/fpsyg.2022.762079, Published by Frontiers Research Foundation, Lausanne

The absolute neutrino mass is still a missing parameter in the modern landscape of particle physics.The HOLMES experiment aims to perform a direct measurement of the neutrino mass with a sensitivity of the order of 2 eV. The neutrino mass will be studied through the calorimetric measurement of the decay products of the weak process decay of 163 Ho. To achieve the target sensitivity, HOLMES will combine the use of 1000 low temperature TES microcalorimeters with the use of a sophisticated software, designed for the signal processing and data analysis. The detector and readout technology will be pushed to their limits in order to preserve the detectors performance and the high multiplexing factor at the same time. This contribution will provide an overview on the status of the major tasks that will bring HOLMES to life: from the isotope production and embedding to the detector production and readout.