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9 results on '"Proshina, E. S."'

1. [The peculiarities of the influenza epidemics in some areas of Russia during 2012-2013 season. The influenza A (H1N1) pdm09 virus domination in European countries]

Author

Lvov, D. K., Burtseva, E. I., Shchelkanov, M. Yu, Kolobukhina, L. V., Feodoritova, E. L., Trushakova, S. V., Kirillova, E. S., Breslav, N. V., Beljaev, A. L., Merkulova, L. N., Vartanian, R. V., Fedyakina, I. T., Bogdanova, V. S., Proshina, E. S., Kirillov, I. M., Kisteneva, L. B., Ivanova, V. T., Oskerko, T. A., Silujanova, E. V., Evgeniya Mukasheva, Krasnoslobotsev, K. G., Lavrischeva, V. V., Alkhovsky, S. V., Prilipov, A. G., Samokhvalov, E. I., Aristova, V. A., Morozova, T. N., Garina, E. O., and Malishev, N. A.

Subjects
Europe, Influenza A Virus, H1N1 Subtype, Influenza, Human, Humans, Epidemics, Antiviral Agents, Russia
Abstract

The peculiarities of the influenza viruses circulation in 2012-2013 are discussed. The results were obtained in 10 cities of Russia, where basic laboratories of the Influenza Ecology and Epidemics Center of on the basis of Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, are situated. The increasing rate of the ARD morbidity caused by influenza viruses was observed in January-March 2013. The highest indices of the morbidity were detected during 6-7 weeks with the following decreasing rate till threshold levels to week 14. The influenza A (H1N1) pdm09, A (H3N2), and B viruses were the cause of the epidemic, but their activity differed over areas of Russia. The results of study of the antigenic and genetic properties of the influenza strains demonstrated closed relatives with respect to vaccine strains. In addition, some heterogeneity of the circulating strains and their drift variants were found as well. All tested strains were sensitive to oseltamivir (excluding one A (H1N1) pdm09 strain), zanamivir, arbidol, and remained resistant to rimantadine. The ratio of the ARD viruses was comparable with the last epidemic seasons.

Published
2014

2. Influenza epidemic development in some regions of Russia and in countries of the North hemisphere during 2013-2014

Author

Lvov, D. K., Burtseva, E. I., Shchelkanov, M. Yu, Kolobukhina, L. V., Feodoritova, E. L., Trushakova, S. V., Elena Kirillova, Beljaev, A. L., Merkulova, L. N., Vartanian, R. V., Kisteneva, L. B., Ivanova, V. T., Oskerko, T. A., Silujanova, E. V., Mukasheva, E. A., Krasnoslobodtsev, K. G., Garina, E. O., Alkhovsky, S. V., Prilipov, A. G., Fedyakina, I. T., Bogdanova, V. S., Proshina, E. S., Samohvalov, E. I., Aristova, V. A., Klrillov, I. M., and Malishev, N. A.

3. [Trends in the spread of pandemic influenza A(H1N1) swl in the Far East in 2009]

Author

Shchelkanov, M. I. U., L Vov, D. N., Fediakina, I. T., Baranov, N. I., Gorelikov, V. N., Reznik, V. I. A., Zdanovskaia, N. I., Pukhovskaia, N. M., Avdoshina, L. N., Shapiro, N. I., Snetkova, I. P., Kozhan, V. N., Iarovenko, G. M., Kalaeva, E. E., Gromova, M. A., Elovskiĭ, O. V., Eremeeva, I. V., Dovgal, M. A., Kuchenkov, A. A., Anan Ev, V. I. U., Burtnik, V. I., Leonid Ivanov, Garbuz, I. A., Podolianko, I. A., Grigor Ev, S. N., Proshina, E. S., Samokhvalov, E. I., Al Khovskiĭ, S. V., Burtseva, E. I., Prilipov, A. G., Abbasova, E. I., Mironenko, E. S., Kolobukhina, L. V., Deriabin, P. G., Ott, V. A., Maslov, D. V., Ianovich, V. A., and L Vov, D. K.

Subjects
Siberia, Dogs, Influenza A Virus, H1N1 Subtype, Epidemiological Monitoring, Influenza, Human, Animals, Humans, Chick Embryo, Antibodies, Viral, Cell Line, Disease Outbreaks, Environmental Monitoring
Abstract

The paper describes the trend in the spread of pandemic influenza A(H1N1) swl virus in the Far East, which started in this region 2-3 months later than that in the European part of Russia. By mid-October seasonal epidemic influenza was practically displaced by pandemic one.

4. Trends in the spread of pandemic influenza A(H1N1) swi in the Far East in 2009

Author

Shchelkanov, M. Y., Lvov, D. N., Fedyakina, I. T., Baranov, N. I., Gorelikov, V. N., Reznik, V. Y., Zdanovskaya, N. I., Pukhovskaya, N. M., Avdoshina, L. N., Shapiro, N. I., Snetkova, I. P., Kozhain, V. N., Yarovenko, G. M., Kalayeva, E. E., Gromova, M. A., Elovsky, O. V., Eremeyeva, Yu V., Dovgal, M. A., Kuchenkov, A. A., Ananyav, V. Y., Burtnik, V. I., Ivanov, L. I., Garbuz, Yu A., Podolyanko, I. A., Grigoryov, S. N., Proshina, E. S., Samokhvalov, E. I., Sergey Alkhovsky, Burtsava, E. I., Prilipov, A. G., Abbasovar, E. I., Mironanko, E. S., Kolobukhina, L. V., Deryabin, P. G., Ott, V. A., Maslov, D. V., Yanovlch, V. A., and Lvov, D. K.

5. Etiotropic therapy of influenza: Lessons from the last pandemic

Author

Kolobukhina, L. V., Shchelkanov, M. Yu, Merkulova, L. N., Bazarova, M. V., Elena Burtseva, Samokhvalov, E. I., Alkhovsky, S. V., Prilipov, A. G., Fedyakina, I. T., Proshina, E. S., Aristova, V. A., Morozova, T. N., Sutochnikova, O. A., Ponomarenko, R. A., Malyshev, N. A., Maslov, A. M., and Chuchalin, A. G.

6. Correlation between the receptor specificity of pandemic influenza a (H1N1)pdm09 virus strains isolated in 2009-2011 and the structure of the receptor-binding site and the probability of fatal primary viral pneumonia

Author

Lvov, D. K., Yu Shchelkanov, M., Bovin, N. V., Malyshev, N. A., Chuchalin, A. G., Kolobukhina, L. V., Prilipov, A. G., Bogdanova, V. S., Alkhovsky, S. V., Samokhvalov, E. I., Fedyakina, I. T., Burtseva, E. I., Deryabin, P. G., Zhuravleva, M. M., Shevchenko, E. S., Lavrishcheva, V. V., Lvov, D. N., Proshina, E. S., Starikov, N. S., Morozova, T. N., Bazarova, M. V., Grigoryeva, T. A., Kirillov, I. M., Shidlovskaya, E. V., Kelli, E. I., Malikov, V. E., Yashkulov, K. B., Yu Ananyev, V., Baranov, N. I., Gorelikov, V. N., Tsoi, O. V., Garbuz, Y. A., Ya Reznik, V., Leonid Ivanov, Yu Fedelesh, I., Ponomarenko, R. A., Sakharova, E. A., Lebedev, G. B., and Maslov, A. I.

Subjects
Binding Sites, Polymers, Sialoglycoproteins, Molecular Mimicry, Pneumonia, Viral, Survival Analysis, Russia, Viral Proteins, Hemagglutinins, Influenza A Virus, H1N1 Subtype, Amino Acid Substitution, Influenza, Human, Humans, Receptors, Virus, Pandemics, Probability
Abstract

The receptor specificity (RS) of pandemic influenza A(H1N1) pdm09 virus strains deposited into the State Collection of Viruses of the Russian Federation, D. I. Ivanovsky Research Institute of Virology, Ministry of Health and Social Development of Russia, in the 2009-2010 and 2010-2011 epidemic seasons to a panel of 9 sialoglycopolymers (SGP). The strains were divided into 3 groups according to the W(3/6) index proposed by the authors, which was equal to the amount of reactivities to unbranched alpha2-3-SGP to that of reactivities to unbranched alphal-6-SGP: W(3/6)or = 1.0; 1.0W(3/6)or = 1.5. The W(3/6)or = 1.5 group showed a predominance of a2-3-RS, attended by the high incidence of fatal primary viral pneumonias (FPVP) (60.0%) and amino acid replacements in the HA1 receptor-binding site (RBS) (80.0%): D222{G, N} and Q223R. The 1.0W(3/6)or = 1.5 group was characterized by mixed alpha2-3/alpha2-6-RS with the incidence of FPVP (29.7%) and amino acid replacements in the HA1 RBS (40.5%) (D222{G, N, V} and Q223), respectively. In the W(3/6)or = 1.0 group, alpha2-6-RS was prevalent, FPVPs were absent and amino acid replacements in HA1 RBS (D222{G, E}) were seen only in 6.0% of cases. The number of strains with increased specificity to alpha2-3-sialosides increased in the 2010-2011 epidemic season as compared to the previous season. With their further spread among the population, there may be a rise in cases of severe primary viral pneumonias with possible fatal outcomes, which can be, however, accompanied by a decrease in the capacity of mutants to air-dropwise transmission.

7. A possible association of fatal pneumonia with mutations of pandemic influenza A/H1N1 sw1 virus in the receptor-binding site of the HA1 subunit

Author

Lvov, D. K., Burtseva, E. I., Prilipov, A. G., Bogdanova, V. S., Yu Shchelkanov, M., Bovin, N. V., Samokhvalov, E. I., Fedyakina, I. T., Deryabin, P. G., Kolobukhina, L. V., Shtyrya, Yu A., Shevchenko, E. S., Malyshev, N. A., Merkulova, L. N., Bazarova, M. V., Maslov, A. I., Ishchenko, N. M., Iskhakova, E. A., Alkhovsky, S. V., Grebennikova, T. V., Galina Sadykova, Lvov, D. N., Zhuravleva, M. M., Yamnikova, S. S., Shlyapnikova, O. V., Poglazov, A. B., Trushakova, S. V., Lavrishcheva, V. V., Aristova, V. A., Proshina, E. S., Vereshchagin, N. N., Kuzmichev, A. G., Yashkulov, K. B., Dzhambinov, S. D., Ts Bushkiyeva, B., Eliseyeva, S. M., Bystrakov, S. I., Sokolova, I. A., Dzhaparidze, N. I., Ledenev, Yu A., Rosolovsky, A. P., Gareyev, R. V., Boldyreva, V. V., Yu Ananyev, V., Baranov, N. I., Gorelikov, V. N., Garbuz, Yu A., Ya Reznik, V., Ivanov, L. I., Zdanovskaya, N. I., Sergeyeva, N. M., Podolyanko, I. A., Elovsky, O. V., Gromova, M. A., Kalayeva, E. E., Grigoryev, S. N., Eremeyeva, Yu V., Dovgal, M. A., Yu Fedelesh, I., Sakharova, E. A., Burtnik, V. I., Avdoshina, L. N., Shapiro, N. P., Maslov, D. V., Yanovich, V. A., Ott, V. A., and Lebedev, G. B.

Subjects
Male, Binding Sites, Virulence, Pneumonia, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Polymerase Chain Reaction, Disease Outbreaks, Russia, Protein Subunits, Influenza A Virus, H1N1 Subtype, Pregnancy, Sequence Analysis, Protein, Influenza, Human, Humans, Receptors, Virus, Female, Pregnancy Complications, Infectious, Lung
Abstract

The paper gives the results of sequence analysis of 150 positive samples in real-time RT-PCR, including 47 autopsy materials from patients (including 10 pregnant women), who died from fatal pneumonia mainly in November-December 2009, in whom the lifetime etiological diagnosis had not been made and hence no early etiotropic therapy performed. 70% of the primary materials from the deceased patients were found to have pandemic influenza A(H1N1) v mutants in the lung tissue with D222G (15%), D222N (15%), D222E (2%) substitutions, as well as a mixture of mutants (38%). Nasopharyngeal lavages from 3 Chukotka deceased patients exhibited only consensus (nonmutant) D222 virus variants; there was a mixture of consensus and mutant virus variants in the trachea and a mixture of mutant ones in the lung. Preliminary data from the study of the interaction of the hemagglutinin of two strains having D222G and D222N mutations with 9 oligosaccharides imitating the variants of cell receptors for influenza A virus suggest that there is a double receptor specificity for alpha2'-3' and alpha2'-6'-sialosides with a preponderance of alpha2'-3'-specificity. Further spread of the mutants that have acquired a high virulence and preserved their capacity for the respiratory route of human infection may lead to the situation similar to that seen in the 1918-1919 pandemic. Another scenario for evolution of the virus is to preserve its receptor specificity for alpha2'-3'-sialosides and high virulence with losses of alpha2'-6' specificity and capacity for aerosol transmission, by damping the pandemic.

8. Pandemic flu in russia: Special features of a clinical course and the absence of early etiotropic therapy as a risk factor of severe forms of the disease

Author

Kolobukhina, L. V., Merkulova, L. N., Schelkanov, M. Y., Burtseva, E. I., Lavrischeva, V. V., Samokhvalov, E. I., Alkhovsky, S. V., Prilipov, A. G., Proshina, E. S., Avdeev, S. N., Sutochnikova, O. A., Bazarova, M. V., Kelti, E. I., Tserukalova, N. D., Blank, I. A., Shestakova, O. M., Kolivashko, O. N., Arseneva, T. V., Ambrosi, O. E., Andrey Shuldyakov, Popov, A. F., Simakova, A. I., Malyshev, N. A., Chuchalin, A. G., and Lvov, D. K.

9. The specific features of the cocirculation of influenza viruses in the 2010-2011 postpandemic period according to the results of activities of the D. I. Ivanovsky research institute of Virology, Ministry of health and social development of Russia

Author

Elena Burtseva, Lvov, D. K., Yu Shchelkanov, M., Kolobukhina, L. V., Prilipov, A. G., Alkhovsky, S. V., Lavrishcheva, V. V., Shevchenko, E. S., Fedyakina, I. T., Ivanova, V. T., Belyakova, N. V., Proshina, E. S., Abramov, D. D., Trushakova, S. V., Merkulova, L. N., Vartyanyan, R. V., Kisteneva, L. B., Samokhvalov, E. I., Oskerko, T. A., Feodoritova, E. L., Siluyanova, E. V., Mukasheva, E. A., Belyaev, A. L., Malikov, V. E., and Malyshev, N. A.

Subjects
Adult, Adolescent, Coinfection, Adenoviridae Infections, Influenza A Virus, H3N2 Subtype, Academies and Institutes, Antiviral Agents, Respirovirus Infections, Respirovirus, Adenoviridae, Russia, Influenza B virus, Influenza A Virus, H1N1 Subtype, Oseltamivir, Rimantadine, Child, Preschool, Drug Resistance, Viral, Influenza, Human, Humans, Seasons, Child, Pandemics
Abstract

The paper gives the results of monitoring the circulation of influenza viruses in the 2010-2011 season, that covers the second year of circulation of pandemic A(H1N1)v virus strains, and their interaction with seasonal A (H3N2) and B strains. Unlike the previous season, the beginning of an increase in morbidity was recorded in January 2011; its peak in the most of contiguous areas was noted at 5-7 weeks of 2011, with its further decline to threshold levels at week 11 of 2011. Preschool and school children were most involved in the epidemic process. Three influenza virus strains (A(H1N1)v, A(H3N2), and B) were found to circulate. Differences were found in the level of participation of the isolated strains in individual areas of the Russian Federation. Detailed typing of the isolated strains determined the compliance of the vast majority of them with vaccine viruses. The pandemic influenza A(H1N1)v virus strains retained their susceptibility to oseltamivir and were resistant to rimantadine. The participation of non-influenza acute respiratory viral infection pathogens was estimated as follows: 11.9% for parainfluenza viruses, 5.9% for adenoviruses, and 3.5% for PC viruses, and 0.7% for pneumonia Mycoplasma, which was comparable with the previous epidemic seasons.

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