3 results on '"Prineas, RJ"'
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2. Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events
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Jacobs, DR, Woo, JG, Sinaiko, AR, Daniels, SR, Ikonen, J, Juonala, M, Kartiosuo, N, Lehtimäki, T, Magnussen, CG, Viikari, JSA, Zhang, N, Bazzano, LA, Burns, TL, Prineas, RJ, Steinberger, J, Urbina, EM, Venn, AJ, Raitakari, OT, Dwyer, T, Tampere University, Clinical Medicine, and Department of Clinical Chemistry
- Subjects
Adult ,Male ,Adolescent ,General Medicine ,Middle Aged ,Article ,Young Adult ,Cholesterol ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Child, Preschool ,Humans ,Female ,3111 Biomedicine ,Prospective Studies ,Child - Abstract
BACKGROUND: Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease, but links to clinical events are unclear. METHODS: In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohort (i3C) Consortium, we evaluated whether childhood risk factors (at the ages of 3 to 19 years) were associated with cardiovascular events in adulthood after a mean follow-up of 35 years. Body-mass index, systolic blood pressure, total cholesterol level, triglyceride level, and youth smoking were analyzed with the use of i3C-derived age- and sex-specific z scores and with a combined-risk z score that was calculated as the unweighted mean of the five risk z scores. An algebraically comparable adult combined-risk z score (before any cardiovascular event) was analyzed jointly with the childhood risk factors. Study outcomes were fatal cardiovascular events and fatal or nonfatal cardiovascular events, and analyses were performed after multiple imputation with the use of proportional-hazards regression. RESULTS: In the analysis of 319 fatal cardiovascular events that occurred among 38,589 participants (49.7% male and 15.0% Black; mean [±SD] age at childhood visits, 11.8±3.1 years), the hazard ratios for a fatal cardiovascular event in adulthood ranged from 1.30 (95% confidence interval [CI], 1.14 to 1.47) per unit increase in the z score for total cholesterol level to 1.61 (95% CI, 1.21 to 2.13) for youth smoking (yes vs. no). The hazard ratio for a fatal cardiovascular event with respect to the combined-risk z score was 2.71 (95% CI, 2.23 to 3.29) per unit increase. The hazard ratios and their 95% confidence intervals in the analyses of fatal cardiovascular events were similar to those in the analyses of 779 fatal or nonfatal cardiovascular events that occurred among 20,656 participants who could be evaluated for this outcome. In the analysis of 115 fatal cardiovascular events that occurred in a subgroup of 13,401 participants (31.0±5.6 years of age at the adult measurement) who had data on adult risk factors, the adjusted hazard ratio with respect to the childhood combined-risk z score was 3.54 (95% CI, 2.57 to 4.87) per unit increase, and the mutually adjusted hazard ratio with respect to the change in the combined-risk z score from childhood to adulthood was 2.88 (95% CI, 2.06 to 4.05) per unit increase. The results were similar in the analysis of 524 fatal or nonfatal cardiovascular events. CONCLUSIONS: In this prospective cohort study, childhood risk factors and the change in the combined-risk z score between childhood and adulthood were associated with cardiovascular events in midlife. (Funded by the National Institutes of Health.)
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- 2022
3. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project
- Author
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Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L., De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L., Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, HE, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F., Beck, D, Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Rorive, G, Hannot, R., Adrienne, A, Luyckx, A, Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Webber, K, Skodova´, Z, Pisa, Z., Berka, L., Cicha, Z., Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M., Pikhartova´, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A., Quitsau Lund, S, Tuomilehto, J, Puska, P., Vartiainen, E., Korhonen, H., Jousilahti, M, Ducimetie`re, P, Richard, JL, Bingham, A., Lang, T, Amouyel, P, Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N., Savouret, M, Houset, M., Pierau, F., Goetz, V, Ferrie`res, J, Ruidavets, JB, Cambou, JP, Rodier, P., Saulet, C, Greiser, E., Herman, B., Stu¨demann, G, Nu¨ssel, E., Osto¨r Lamm, E., Scheidt, R., Morgenstern, W., Stadler, M, Ganova, M, Keil, U, Tietze, M., Banos, R., Do¨ring, A., Filipiak, B, Barth, W, Heinemann, L, Muche, J., Schmalfuss, S., Assmann, A., Bo¨thig, S., Voigt, G., Brasche, S., Quietzsch, D., Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, II, Stefa´nsdo´ttir, I, Thorsteinsson, T., Sigvaldason H, Menotti, A, Giampaoli, S., Verdecchia, A, Righetti, G., De Pasquale, B., Di Raimo, P, Forte, E., Majetta, A, Vanuzzo, D, Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Zilio, G, Cesana, GC, Ferrario, M, Sega, R., Mocarelli, P, BRAMBILLA, PAOLO, Bluzhas, J, Domarkiene, S., Tamosiunas, A., Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A., Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E., Pazucha, T., Malczewska, M., Mo´rawska, I, Rywik, SL, Broda,V, Polakowska, M., Kurjata, P, Varlamova, A, Britov, A., Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y.u. P, Malyutina, S., Gafarov, V, Feigin, V, Sans, S., Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P., Rosengren, A., Lappas, G, Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Gutzwiller, F, Paccaud, F., Rickenbach, M., Wietlisbach, V., Barazzoni, F, Mainieri, F., Tullen, B, Evans, V, McCrum, EE, Falconer, T, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Crombie, V, Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Morrisson, C, Planojevic, M, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S. R. A., Bo¨thig8, S., Watson, M. J., Hill, M., Price, A, Kuulasmaa, K., Tuomilehto, J., Ruokokoski, E, Rajakangas, A. M., Ma¨kinen, M., Virman Ojanen, T, Palonen, L., Akkila, J, Cepaitis, Z., Molarius, A., Moltchanov, V., Tolonen, H, Grafnetter, D, Dobson, A., Fortmann, SP, Shatchkute, A, Zaitsev, V, Epstein, FH, Feinleib, M, Karvonen, MJ, Prineas, RJ, Williams, OD, Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova´, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M, Pikhartova´, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu¨demann, G, Nu¨ssel, E, Osto¨r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do¨ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo¨thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, I, Stefa´nsdo´ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo´rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S, Bo¨thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma¨kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, and Williams, O
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Adult ,Male ,Canada ,medicine.medical_specialty ,BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,Waist ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Logistic regression ,Body Mass Index ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Triglycerides ,Abdominal obesity ,Adiposity ,Dyslipidemias ,Nutrition and Dietetics ,business.industry ,Cholesterol, HDL ,Smoking ,Australia ,nutritional and metabolic diseases ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Health Surveys ,Europe ,Menopause ,Cross-Sectional Studies ,Logistic Models ,Endocrinology ,Dyslipidemia ,Quartile ,Obesity, Abdominal ,Female ,Waist Circumference ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,New Zealand ,Demography - Abstract
Background and aims: The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. Methods and results: 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women).Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. Conclusion: standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes
- Published
- 2013
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