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BackgroundImmune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited.Main bodyWe here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. Both complications were refractory to standard treatment of ICANS. Weakness of respiratory muscles required mechanical ventilation and tracheostomy while cDI was treated with desmopressin substitution for several weeks. Muscle-nerve biopsy and nerve conduction studies confirmed an axonal pattern of nerve damage. T cell-rich infiltrates and detection of the CAR transgene in muscle-nerve sections imply a direct or indirect role of CAR-T cell-mediated inflammation. In line with current treatment guidelines for GBS, intravenous immunoglobulin was administered and gradual but incomplete recovery was observed over the course of several months.ConclusionsThis case report highlights the risk of rare but severe neurological adverse events, such as acute GBS or cDI, in patients treated with CAR-T cells. It further underlines the importance of appropriate patient surveillance and systematic reporting of rare complications to eventually improve treatment.

Additional file 1: Appendix. International Severe Asthma Registry study group.

Additional file 3: Table S2. International Severe Asthma Registry bolt-on variables.

Additional file 4: Table S3. International Severe Asthma Registry optional additional research variables.

Additional file 2: Table S1. Full list of ISAR 95 core variables.

The subalgebra of diagonal elements of a quantum matrix group has been conjectured by Daniel Krob and Jean-Yves Thibon to be isomorphic to a cubic algebra, coined the quantum pseudo-plactic algebra. We present a functorial approach to the conjecture through the quantum Schur-Weyl duality between the quantum group and the Hecke algebra. The relations of the quantum diagonal subalgebra are found to be the image of the braid relations of the underlying Hecke algebra by an appropriate Schur functor which gives a straightforward proof of the conjecture., Comment: 14 pages, talk given at XIII-th International Workshop Lie Theory and Its Applications in Physics" (Varna,Bulgaria, June 2019)

We study a factor Hopf algebra $\mathfrak{PP}$ of the Malvenuto-Reutenauer convolution algebra of functions on symmetric groups ${\mathfrak{S}}=\oplus_{n\geq 0} \mathbb C[{\mathfrak{S}}_n] $ that we coined pre-plactic algebra. The pre-plactic algebra admits the Poirier-Reutenauer algebra based on Standard Young Tableaux as a factor and it is closely related to the quantum pseudo-plactic algebra introduced by Krob and Thibon in the non-commutative character theory of quantum group comodules. The connection between the quantum pseudo-plactic algebra and the pre-plactic algebra is similar to the connection between the Lascoux-Sch\"utzenberger plactic algebra and the Poirier-Reutenauer algebra. We show that the dimensions of the pre-plactic algebra are given by the numbers of alternating permutations (coined snakes after V.I. Arnold). Pre-plactic algebra is instrumental in calculating the Hilbert-Poincar\'e series of the quantum pseudo-plactic algebra., Comment: 12 pages. Comments are welcome!

We explore the Fock spaces of the parafermionic algebra introduced by H.S. Green. Each parafermionic Fock space allows for a free minimal resolution by graded modules of the graded 2-step nilpotent subalgebra of the parafermionic creation operators. Such a free resolution is constructed with the help of a classical Kostant's theorem computing Lie algebra cohomologies of the nilpotent subalgebra with values in the parafermionic Fock space. The Euler-Poincar\'e characteristics of the parafermionic Fock space free resolution yields some interesting identities between Schur polynomials. Finally we briefly comment on parabosonic and general parastatistics Fock spaces., Comment: 10 pages, talk presented at the International Workshop "Lie theory and its applications in Physics" (17-23 June 2013, Varna, Bulgaria)

We consider the parastatistics algebra with both parabosonic and parafermionic operators and show that the states in the universal parastatistics Fock space are in bijection with the Super Semistandard Young Tableaux (SSYT). Using deformation of the parastatistics algebra we get a monoid structure on SSYT which is a super version of the plactic monoid., Comment: 8 pages, based on a talk given at the VII International Workshop "Lie Theory and Its Applications in Physics" Varna, 18-24 June 2007