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Your search keyword '"Poornachander Reddy Guda"' showing total 2 results
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2 results on '"Poornachander Reddy Guda"'

1. Tissue nanotransfection causes tumor regression by its effect on nanovesicle cargo that alters microenvironmental macrophage state

Author

Gayle M. Gordillo, Poornachander Reddy Guda, Kanhaiya Singh, Ayan Biswas, Ahmed S. Abouhashem, Yashika Rustagi, Abhishek Sen, Manishekhar Kumar, Amitava Das, Subhadip Ghatak, Savita Khanna, Chandan K. Sen, and Sashwati Roy

Subjects
Pharmacology, Drug Discovery, Genetics, Molecular Medicine, Molecular Biology
Abstract

Extracellular vesicles (EVs) are nanovesicles released by all eukaryotic cells. This work reports the first nanoscale fluorescent visualization of tumor-originating vesicles bearing an angiogenic microRNA (miR)-126 cargo. In a validated experimental model of lethal murine vascular neoplasm, tumor-originating EV delivered its miR-126 cargo to tumor-associated macrophages (TAMs). Such delivery resulted in an angiogenic (LYVE

Published
2023
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2. Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Author

Andrew Clark, Subhadip Ghatak, Poornachander Reddy Guda, Mohamed S. El Masry, Yi Xuan, Amy Y. Sato, Teresita Bellido, and Chandan K. Sen

Subjects
Biomedical Engineering, Medicine (miscellaneous), Cell Biology, Developmental Biology
Abstract

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

Published
2022
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