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1. Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy

Author

Catharine West, Se, Davidson, Pool C, Rd, James, and Pf, Schofield

Subjects
Cell Survival, Cesium Radioisotopes, Gamma Rays, Rectal Neoplasms, Neoplasms, Colonic Neoplasms, Humans, Uterine Cervical Neoplasms, Female, In Vitro Techniques, Tumor Stem Cell Assay
Abstract

The relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome.

Published
1991

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