1. The use of mannitol in partial and live donor nephrectomy: an international survey
- Author
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Marco Cosentino, Christian Bolenz, Thomas Knoll, Francesco Francesca, Paolo Verze, Jens Rassweiler, Alessandro D'Addessi, H. Van Poppel, Francesco Sanguedolce, Clément-Claude Abbou, Gunther Janetschek, Fch D'Ancona, Scott E. Eggener, Monish Aron, P. Laguna, A Mogorovich, Thomas J. Polascik, Francesco Porpiglia, Mario Alvarez-Maestro, Udo Nagele, Rolf Muschter, Antonio Celia, Jaime Landman, Hans-Christoph Klingler, D Mladenov, Axel S. Merseburger, Federico Dehò, O. De Cobelli, Maxwell V. Meng, Alberto Breda, Riccardo Schiavina, TJ Leppert, J.U. Stolzenburg, Fernando J. Kim, Orietta Dalpiaz, Humberto Villavicencio, Pierluigi Bove, George N. Thalmann, Cosentino M, Breda A, Sanguedolce F, Landman J, Stolzenburg JU, Verze P, Rassweiler J, Van Poppel H, Klingler HC, Janetschek G, Celia A, Kim FJ, Thalmann G, Nagele U, Mogorovich A, Bolenz C, Knoll T, Porpiglia F, Alvarez-Maestro M, Francesca F, Deho F, Eggener S, Abbou C, Meng MV, Aron M, Laguna P, Mladenov D, D'Addessi A, Bove P, SCHIAVINA R., De Cobelli O, Merseburger AS, Dalpiaz O, D'Ancona FC, Polascik TJ, Muschter R, Leppert TJ, Villavicencio H., Cosentino, M, Breda, A, Sanguedolce, F, Landman, J, Stolzenburg, J. U, Verze, Paolo, Rassweiler, J, Van Poppel, H, Klingler, H. C, Janetschek, G, Celia, A, Kim, F. J, Thalmann, G, Nagele, U, Mogorovich, A, Bolenz, C, Knoll, T, Porpiglia, F, Alvarez Maestro, M, Francesca, F, Deho, F, Eggener, S, Abbou, C, Meng, M. V, Aron, M, Laguna, P, Mladenov, D, D'Addessi, A, Bove, P, Schiavina, R, De Cobelli, O, Merseburger, A. S, Dalpiaz, O, D'Ancona, F. C. H, Polascik, T. J, Muschter, R, Leppert, T. J, Villavicencio, H., Cancer Center Amsterdam, Amsterdam Public Health, and Urology
- Subjects
Nephrology ,Time Factors ,Internationality ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Antioxidants ,Dose-Response Relationship ,Drug ,Health Care Surveys ,Humans ,Kidney ,Kidney Transplantation ,Mannitol ,Nephrectomy ,Prospective Studies ,Surveys and Questionnaires ,Living Donors ,international survey ,Partial nephrectomy ,Surveys and Questionnaire ,Prospective cohort study ,Diuretics ,Kidney transplantation ,Renoprotective agent ,Settore MED/24 - UROLOGIA ,Furosemide ,Anti-Inflammatory Agent ,Anesthesia ,Antioxidant ,The use of mannitol in partial and live donor nephrectomy: an international survey ,medicine.drug ,Human ,medicine.medical_specialty ,kidney ,Time Factor ,Urology ,Quality of Care [ONCOL 4] ,Internal medicine ,medicine ,Kidney surgery ,Dose-Response Relationship, Drug ,business.industry ,mannitol ,medicine.disease ,Prospective Studie ,Health Care Survey ,Diuretic ,business ,Live donor nephrectomy - Abstract
Contains fulltext : 117852.pdf (Publisher’s version ) (Closed access) PURPOSE: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. MATERIALS AND METHODS: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. RESULTS: Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. CONCLUSIONS: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.
- Published
- 2013