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Your search keyword '"Poelstra, K"' showing total 17 results
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17 results on '"Poelstra, K"'

1. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis

Author

Prakash, J., de Borst, M.H., van Loenen-Weemaes, A.M., Lacombe, M., Opdam, F.L., van Goor, H., Meijer, D.F.K., Moolenaar, F., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen, respiratory tract diseases
Published
2008

2. Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury

Author

Prakash, J., de Borst, M.H., Lacombe, M., Opdam, F.L., Klok, P.A., van Goor, H., Meijer, D.K., Moolenaar, F., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen
Published
2008

3. Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury

Author

Prakash, J., de Borst, M.H., Lacombe, M., Opdam, F.L., Klok, P.A., van Goor, H., Meijer, D.K., Moolenaar, F., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen
Published
2008

4. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis

Author

Prakash, J., de Borst, M.H., van Loenen-Weemaes, A.M., Lacombe, M., Opdam, F.L., van Goor, H., Meijer, D.F.K., Moolenaar, F., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen
Published
2008

6. Intracellular delivery of the p38 mitogen-activated protein kinase Inhibitor SB202190 [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular Cells: a novel strategy to treat renal fibrosis

Author

Prakash, J., Sandovici, M., Saluja, V., Lacombe, M., Schaapveld, R.Q.J., de Borst, M.H., van Goor, H., Henning, R.H., Proost, J.H., Moolenaar, F., Keri, G., Meijer, D.F.K., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, Sub Drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen
Published
2006

8. Intracellular delivery of the p38 mitogen-activated protein kinase Inhibitor SB202190 [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular Cells: a novel strategy to treat renal fibrosis

Author

Prakash, J., Sandovici, M., Saluja, V., Lacombe, M., Schaapveld, R.Q.J., de Borst, M.H., van Goor, H., Henning, R.H., Proost, J.H., Moolenaar, F., Keri, G., Meijer, D.F.K., Poelstra, K., Kok, R.J., Advanced drug delivery systems/drug targeting, Sub Drug targeting, and Dep Farmaceutische wetenschappen

Subjects
Pharmacology, Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen
Published
2006

11. Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion

Author

Barbro Melgert, Olinga P, Weert B, Mj, Slooff, Dk, Meijer, Poelstra K, and Gm, Groothuis

Subjects
Perfusion, Taurocholic Acid, Cholagogues and Choleretics, Liver, Liver Function Tests, Humans, Lidocaine, Umbelliferones, Anesthetics, Local, Glucocorticoids, Dexamethasone, Serum Albumin
Abstract

We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis in man, have been extensively studied in animals, but little is known about the uptake and handling by human livers. Human liver tissue was obtained from livers procured from multiorgan donors and from cirrhotic livers of patients. To assess tissue viability, perfusate glutamate-oxalacetate-transaminase (GOT), glutamate-pyruvate-transaminase (GPT), and lactate dehydrogenase (LDH) levels were determined. To assess tissue functionality, the uptake of taurocholic acid and phase I and II metabolism of lidocaine and 7-hydroxycoumarin were determined. Uptake of a drug-targeting preparation was studied with Dexa(10)-HSA, which is designed for targeting of dexamethasone to nonparenchymal cells in the liver. During a 90-min perfusion period, no elevation of either GOT, GPT, or LDH was found. Both healthy control livers and cirrhotic livers showed phase I and II drug metabolism and functional taurocholic acid uptake. Studies with Dexa(10)-HSA revealed that 60 min after administration, 40% of the dose had been taken up by control livers and only 5% by cirrhotic livers. In control livers, Kupffer and endothelial cells had taken up Dexa(10)-HSA, whereas in cirrhotic livers only Kupffer cells were responsible for the uptake. Viability parameters and liver function tests clearly showed the applicability of this method. In the perfusion set-up, we showed uptake of the drug-targeting preparation Dexa(10)-HSA by healthy and cirrhotic human liver tissue, although the distribution patterns differed. This demonstrates the need to study new concepts in (diseased) human tissue.

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