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The architectural engineering and construction (AEC) industry is undergoing a digital transformation that progressively improves its performance, productivity, and competitiveness. This digital shift is accelerated through building information modeling (BIM) which facilitates technological integrations. BIM has significantly contributed to digitizing design and management activities. However, it has not yet sufficiently demonstrated its interoperability with digital manufacturing processes, such as robotic manufacturing (RM). It is from this perspective that this work will review the current literature’s stance on the technological interoperability of BIM and RM tools through the systematic literature review (SLR) method. This literature review aims to identify research avenues to operationalize RM through BIM tools in construction. The study conducted in this research is progressive; it builds on the identified research gaps and investigates potential research avenues to be undertaken. The results revealed that computational design (CD) could serve as a bridge between BIM and RM. They also revealed that RM is operationalizable in off-site construction (OSC) through BIM and CD.

BackgroundThe Canadian government’s response to the ongoing COVID-19 pandemic included the implementation of several restrictive measures since March 2020. These actions sought to decrease social contact and increase physical distancing, including that within universities. Such constraints were required to impede the transmission of the virus; however, concerns remain about their impact on the sexual and intimate relationships of university employees and students.AimThis study examined the associations between COVID-19–related stress and sexual frequency, sexual satisfaction, and relationship satisfaction, also testing the mediating role of psychological distress.MethodsThe models were tested with Canadian data collected from university employees and students in 2 phases: the first wave in April-May 2020 (T1; n = 2754) and the second wave in November-December 2021 (T2; n = 1430), 18 months afterward. Participants completed self-report questionnaires online. Path analyses were performed to test the associations of the mediation models.OutcomesThe principal outcomes included psychological distress determined via the Patient Health Questionnaire–4, relationship satisfaction measured via the Dyadic Adjustment Scale, and sexual satisfaction and sexual frequency ascertained through a single item each.ResultsOverall, COVID-19–related stress was associated with higher psychological distress, which in turn was related to lower sexual frequency, sexual satisfaction, and relationship satisfaction. Similar results were obtained with T1 and T2 data, indicating the mediating effect of psychological distress.Clinical ImplicationsThese findings increase scholarly comprehension of the negative associations between stress/distress and sexual and romantic relationships. Sexuality and close relationships are vital to the quality of human life; thus, targeted interventions should be developed to reduce COVID-19–related stress and its impact on sexual and romantic relationships to mitigate the long-term influences of this unique global challenge.Strengths and LimitationsTo our knowledge, this study is the first to use a large sample size and replicate findings in 2 waves. Nonetheless, it is limited by the use of cross-sectional data. Longitudinal studies with the same participants are mandated to better understand the evolution of these outcomes.ConclusionCOVID-19–related stress and psychological distress were found among participating university students and employees and were associated with lower sexual satisfaction, sexual frequency, and intimate relationship satisfaction. These results were observed at the early onset of the pandemic and 18 months afterward, suggesting that the stress generated by the pandemic were not mere reactions to the onset of the pandemic but persisted over time.

Although research has shown a considerable influence of the pre-cracking phenomenon on steel-congested concrete members, only normal concrete (NC) has been considered in the literature. The intention in this paper is thus to study the effect of the pre-cracking phenomenon on the bond response of pre-cracked NC with different slump flow values and self-consolidating concrete (SCC). Initial crack widths ranging from 0.0 to 0.5 mm are studied. Results show that initial crack widths larger than 0.10 mm have a significant influence on bond properties, such that reduction factors greater than 30% and 50% are obtained for the maximum bond strength of concrete specimens exposed to initial crack widths of 0.2 mm and 0.4 mm, respectively. Results show that concrete mixtures with higher workability are less sensitive to the pre-cracking phenomenon as compared to NC mixtures. The average bond stress of steel rebar in the pre-cracked SCC is found to be similar to that of the NC with a slump flow of 200 mm, which is considerably better than for NC with a slump flow of 97 mm. Moreover, results show that 65.8, 80.6, 88.5 and 93.1% fracture energy reductions are obtained for crack widths of 0.20, 0.30, 0.40 and 0.50 mm, respectively, as compared to the small crack width of 0.15 mm.

Background:Research partnership approaches that engage community members within the research team (for example, integrated knowledge translation, community-based participatory research) are typically used to enhance the relevance and usefulness of research findings. However, research outcomes generated through partnered research do not de facto address the priorities of those most affected nor take inclusion or power dynamics into consideration. Consensus methods (for example, Delphi, Deliberative Dialogue) can be used to develop evidence-based solutions by addressing the groups’ needs and priorities. Limited research has examined how consensus methods are used by research partnerships. Aims and objectives:Using the PRISMA-ScR checklist as a guide, this scoping review sought to better understand the use of consensus methods in research partnerships. Methods:The search strategy involved four databases (MEDLINE, PsycINFO, EMBASE and CINAHL Plus). A total of 6,654 citations were screened, 404 were advanced for full text review, and 34 studies met eligibility criteria. Data from the 34 studies were extracted and iteratively analysed by three members of our research team. Findings:At least 11 different consensus methods were used with variations of the Delphi being most common. Issues of inclusion and power dynamics were rarely discussed. Overall, there was limited reporting of consensus methods, partnership approaches, and/or power dynamics. Discussion and conclusions:This review extends the literature by providing an overview of consensus methods that have been conducted in research partnerships and how they have been executed. We offer initial considerations for conducting and reporting on the use of consensus methods in research co-production.

Technology holds great potential for promoting health equity for rural populations, who have more chronic illnesses than their urban counterparts but less access to services. Yet, more participatory research approaches are needed to gather community-driven health technology solutions. The purpose was to collaboratively identify and prioritize action strategies for using technology to promote rural health equity through community stakeholder engagement.Concept mapping, a quantitative statistical technique, embedded within a qualitative approach, was used to identify and integrate technological solutions towards rural health equity from community stakeholders in three steps: (1) idea generation; (2) sorting and rating feasibility/importance and (3) group interpretation. Purposeful recruitment strategies were used to recruit key stakeholders and organizational representatives from targeted rural communities.Overall, 34 rural community stakeholders from western Canada (76% female, mean age = 55.4 years) participated in the concept mapping process. In Step 1, 84 ideas were generated that were reduced to a pool of 30. Multidimensional scaling and cluster analysis resulted in a six-cluster map representing how technological solutions can contribute toward rural health equity. The clusters of ideas included technological solutions and applications, but also ideas to make health care more accessible regardless of location, training and support in the use of technology, ensuring digital tools are simplified for ease of use, technologies to support collaboration among healthcare professionals and ideas for overcoming challenges to data sharing across health systems/networks. Each cluster included ideas that were rated as equally important and feasible. Key themes included organizational and individual-level solutions and connecting patients to newly developed technologies.Overall, the grouping of solutions revealed that technological applications require not only access but also support and collaboration. Concept mapping is a tool that can engage rural community stakeholders in the identification of technological solutions for promoting rural health equity.Rural community stakeholders were involved in the generation and interpretation of technological solutions towards rural health equity in a three-step process: (1) individual brainstorming of ideas, (2) sorting and rating all ideas generated and (3) collective interpretation and group consensus on final results.

Case-control studies have shown that patients with Crohn's disease (CD) have a microbial composition different from healthy individuals. Although the causes of CD are unknown, epidemiologic studies suggest that diet is an important contributor to CD risk, potentially via modulation of bacterial composition and gut inflammation. We hypothesized that long-term dietary clusters (DCs) are associated with gut microbiome compositions and gut inflammation. Our objectives were to identify dietary patterns and assess whether they are associated with alterations in specific gut microbial compositions and subclinical levels of gut inflammation in a cohort of healthy first-degree relatives (FDRs) of patients with CD.As part of the Genetic, Environmental, Microbial (GEM) Project, we recruited a cohort of 2289 healthy FDRs of patients with CD. Individuals provided stool samples and answered a validated food frequency questionnaire reflecting their habitual diet during the year before sample collection. Unsupervised analysis identified 3 dietary and 3 microbial composition clusters.DC3, resembling the Mediterranean diet, was strongly associated with a defined microbial composition, with an increased abundance of fiber-degrading bacteria, such as Ruminococcus, as well as taxa such as Faecalibacterium. The DC3 diet was also significantly associated with lower levels of subclinical gut inflammation, defined by fecal calprotectin, compared with other dietary patterns. No significant associations were found between individual food items and fecal calprotectin, suggesting that long-term dietary patterns rather than individual food items contribute to subclinical gut inflammation. Additionally, mediation analysis demonstrated that DC3 had a direct effect on subclinical inflammation that was partially mediated by the microbiota.Overall, these results indicated that Mediterranean-like dietary patterns are associated with microbiome and lower intestinal inflammation. This study will help guide future dietary strategies that affect microbial composition and host gut inflammation to prevent diseases.

Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has been increasingly recognized in recent years. Herein, we describe the optimization of a series of imidazothiadiazole PAR4 antagonists to a first-in-class clinical candidate, BMS-986120 (

Objective: This study examined the prospective relationship from student inattention symptoms to changes in their psychological need satisfaction (PNS) during their transition to secondary school. In doing so, it has explored whether this temporal association was moderated by teachers’ involvement (TI). Method: A sample of 688 students (46% male; Mage = 11.82) followed in Grade 6 and Secondary 1 was selected from a stratified random list. Results: Inattention symptoms predicted a decrease in autonomy and competence need satisfaction, after adjusting for gender, anxiety, aggression, and PNS at baseline. In addition, TI in Secondary 1 attenuated the association between inattention and autonomy need satisfaction decline. TI also predicted a smaller decrease in competence need satisfaction, over and above the contribution of inattention. Conclusions: Results support the importance of TI in PNS of students who are struggling with inattention throughout a critical transition. Implications for educational practices and research are discussed.

Background Collective agreement about the importance of centering equity in health research, practice, and policy is growing. Yet, responsibility for advancing equity is often situated as belonging to a vague group of ‘others’, or delegated to the leadership of ‘equity-seeking’ or ‘equity-deserving’ groups who are tasked to lead systems transformation while simultaneously navigating the violence and harms of oppression within those same systems. Equity efforts also often overlook the breadth of equity scholarship. Harnessing the potential of current interests in advancing equity requires systematic, evidence-guided, theoretically rigorous ways for people to embrace their own agency and influence over the systems in which they are situated. ln this article, we introduce and describe the Systematic Equity Action-Analysis (SEA) Framework as a tool that translates equity scholarship and evidence into a structured process that leaders, teams, and communities can use to advance equity in their own settings. Methods This framework was derived through a dialogic, critically reflective and scholarly process of integrating methodological insights garnered over years of equity-centred research and practice. Each author, in a variety of ways, brought engaged equity perspectives to the dialogue, bringing practical and lived experience to conversation and writing. Our scholarly dialogue was grounded in critical and relational lenses, and involved synthesis of theory and practice from a broad range of applications and cases. Results The SEA Framework balances practices of agency, humility, critically reflective dialogue, and systems thinking. The framework guides users through four elements of analysis (worldview, coherence, potential, and accountability) to systematically interrogate how and where equity is integrated in a setting or object of action-analysis. Because equity issues are present in virtually all aspects of society, the kinds of ‘things’ the framework could be applied to is only limited by the imagination of its users. It can inform retrospective or prospective work, by groups external to a policy or practice setting (e.g., using public documents to assess a research funding policy landscape); or internal to a system, policy, or practice setting (e.g., faculty engaging in a critically reflective examination of equity in the undergraduate program they deliver). Conclusions While not a panacea, this unique contribution to the science of health equity equips people to explicitly recognize and interrupt their own entanglements in the intersecting systems of oppression and injustice that produce and uphold inequities.

The arcuate nucleus of the hypothalamus (ARC) is considered a major site for the integration of metabolic signals and the regulation of energy balance. In the ARC, ‘catabolic’ pro-opiomelanocortin (POMC) and ‘anabolic’ agouti-related peptide (AgRP)-expressing neurons are widely recognized for their role in the regulation of energy homeostasis. Leptin and glucagon-like peptide 1 (GLP-1) are two important hormonal signals of the energy state that can mediate some of their effects through POMC and AgRP neurons. However, recent work suggests that unidentified GABAergic neurons of the ARC may also be crucial for the integration of metabolic signals and the regulation of energy balance. Based on RNAseq studies, we recently identified an uncharacterized neuronal population of the ARC that robustly express the New arcuate transcript ( Nat). According to their localization and GABAergic phenotype, we hypothesize that Nat-expressing neurons are sensitive to various metabolic signals and that they play an important role in the control of energy homeostasis. Therefore, we aimed to characterize the molecular signature of Nat-expressing neurons in the ARC. We also aimed to determine whether leptin and GLP-1 can modulate the activity of these neurons.We first used the RNAscope® multiplex in situ hybridization technology on coronal brain slices from male mice. This allowed us to validate the GABAergic nature of Nat-expressing neurons, to confirm that they are distinct from POMC and AgRP neurons, and to determine whether they express the leptin and GLP-1 receptors ( Lepr and Glp1r respectively). We then administered leptin and the GLP1R agonist liraglutide to mice and evaluated C-FOS immunoreactivity in Nat-expressing neurons of the ARC.We found that Nat-expressing neurons represent a GABAergic population highly enriched in the ARC, and distinct from POMC and AgRP neurons. Subsets of Nat-expressing neurons co-express Lepr (18.3%), while others co-express Glp1r (35.3%). Finally, C-FOS immunoreactivity suggests that the activity of Nat-expressing neurons can be modulated in response to some metabolic signals. Together, our results suggest a potential role for Nat-expressing neurons in the integration of various metabolic cues. The recent development of a novel Nat-IRES-Cre mouse model will allow us to better characterize the metabolic functions of this new GABAergic neuronal population of the ARC. This work was supported by funding from the Canada Research Chairs Program (to A.C.), the Montreal Diabetes Research Center (to A.C.), the foundation of the Quebec Heart and Lung Institute (FIUCPQ, to A.C), and the Fonds d'enseignement et de recherche (FER) of the Faculty of Pharmacy of Université Laval (to N.J.M. and A.C.). N.J.M. was supported by a Sentinel North Partnered Research Chair in Sleep Pharmacometabolism (Canada First Research Excellence Fund) and a Fonds de Recherche du Québec – Santé (FRQS) Research Scholar J1 award. O.L. was supported by a Canada graduate scholarship (CIHR) and a Fonds de Recherche du Québec – Santé (FRQS) graduate scholarship. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Histaminergic neurons are a population of wake-active neurons confined to the tuberomammillary nucleus (TMN) in the posterior hypothalamus. They form a crucial component of the ‘sleep switch’ in the brain and promote arousal when activated. The histaminergic neurons are strongly innervated by ventrolateral preoptic area (VLPO) neurons expressing galanin, a neuropeptide associated with sleep promotion. While recent studies have confirmed the importance of VLPO projections to the TMN in initiating and maintaining sleep, the ability of galanin to modulate the activity of the wake-promoting histaminergic neurons of the TMN has largely been overlooked. Therefore, we aimed to determine the mechanisms by which galanin alters the electrical excitability of genetically identified histaminergic neurons. We hypothesized that galanin inhibits histaminergic neuron activity via direct post-synaptic activation of galanin 1 receptors (GalR1). Whole-cell patch-clamp electrophysiology was performed on hypothalamic brain slices from mice expressing tdTomato fluorescence in cells expressing histidine decarboxylase (HDC), the sole enzyme required for histamine synthesis (HDCCre::tdTomato mice). RNAscope® in situ hybridization was used to explore Gal1R mRNA expression in HDC expressing neurons. Whole-cell current-clamp recordings in male mice revealed that galanin (100nM) inhibits the majority of HDC neurons. The galanin-induced inhibition was associated with a hyperpolarization of the membrane potential and a decrease in firing frequency. Consistent with our hypothesis, a selective galanin 2 receptor (Gal2R) agonist (M1145 - 200nM) had no effect on male HDC neuron activity. RNAscope® studies in male mice revealed co-expression of Gal1R mRNA in a large proportion of HDC-expressing neurons. Interestingly, the galanin-induced inhibition of HDC neuron electrical excitability was less pronounced in female mice. Overall, our data point to an important role of post-synaptic Gal1Rs expressed on histaminergic neurons in mediating galanin’s inhibitory effects in the TMN. Our data also suggest that sex differences exist in histaminergic neuron responsiveness to galanin. These findings are consistent with the idea that some of the sleep promoting effects of VLPO neuron activation occur through galanin’s ability to inhibit the wake-active histaminergic neurons. Sleep Research Society (SRS), Canada First Research Excellence Fund (Sentinel North Partnered Research Chair in Sleep Pharmacometabolism), Fondation Institut Universitaire de Cardiologie et de Pneumologie de Quebec (FIUCPQ), Fonds de recherche de Quebec - Sante (FRQS). This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

This cohort study compared children’s recreational screen time with screen time before the COVID-19 pandemic and during 3 pandemic waves to examine whether changes in screen time were greater than those associated with age.

Gentle algebras are in bijection with admissible dissections of marked oriented surfaces. In this paper, we further study the properties of admissible dissections and we show that silting objects for gentle algebras are given by admissible dissections of the associated surface. We associate to each gentle algebra a line field on the corresponding surface and prove that the derived equivalence class of the algebra is completely determined by the homotopy class of the line field up to homeomorphism of the surface. Then, based on winding numbers and the Arf invariant of a certain quadratic form over $\mathbb Z_2$, we translate this to a numerical complete derived invariant for gentle algebras., 26 pages. v2: enhanced introduction. v3: updated references

Canadian engagement in global and public health includes a long history of centering issues of equity in practice, policy, and research. In 2015, through a series of deliberative dialogues about what ethical standards should guide how people engage in global health research, the Canadian Coalition for Global Health Research (CCGHR) released a set of six equity-centred principles and critically reflective questions. These principles offered a platform for identifying equity implications and choices about theories, methods, approaches, partnerships, or practices in global and public health. In 2022, as questions of how to unsettle systems of power and move beyond rhetorical efforts to advance equity action continue to grow, Canada's global public health research community is turning a critically reflexive gaze at our own practices and ways of working, recognizing excellence as necessarily integrating equity in research pursuits, processes, and outcomes. In this commentary, we reflect on the contexts that led to the evolution of the CCGHR Principles for Global Health Research and highlight their current reach and impact, including their integration in the Canadian Institutes Framework for Action on Global Health Research. We invite others to embrace a lifelong commitment to equity work as an act of solidarity and investment in our collective futures.RéSUMé: La participation canadienne à la santé mondiale et publique est depuis longtemps centrée sur les questions d’équité dans les pratiques, les politiques et la recherche. En 2015, au moyen d’une série de dialogues délibératifs sur les normes éthiques qui devraient guider la façon dont les gens participent à la recherche en santé mondiale, la Coalition canadienne pour la recherche en santé mondiale (CCRSM) a publié six principes et questions de réflexion critique centrés sur l’équité. Ces principes ont constitué une plateforme pour déterminer les répercussions de théories, de méthodes, d’approches, de partenariats ou de pratiques en santé mondiale et publique sur l’équité – et les choix à faire. En 2022, alors qu’il se pose de plus en plus de questions sur la façon d’ébranler les systèmes de pouvoir et d’aller au-delà des efforts rhétoriques pour faire avancer les mesures d’équité, la communauté de recherche en santé publique mondiale du Canada porte un regard critique et réflexif sur ses propres pratiques et façons de travailler, en reconnaissant l’excellence comme intégrant nécessairement l’équité dans les activités, les processus et les résultats de recherche. Dans ce commentaire, nous réfléchissons aux contextes qui ont fait évoluer les Principes de recherche en santé mondiale CCRSM et nous soulignons leur portée et leurs effets actuels, y compris leur intégration dans le Cadre d’action pour la recherche en santé mondiale des Instituts de recherche en santé du Canada. Nous lançons à d’autres l’invitation d’adopter un engagement à vie en faveur de l’équité, par solidarité et pour investir dans notre avenir collectif.

Representation of the optimization process to automate the development of mortar mixes for robotic 3D printing with the aim to reduce the required workload while generating mixture compositions with improved properties by following an optimum trend.

Fabrication of thin-wall components using the laser powder bed fusion (LPBF) additive manufacturing (AM) technology was investigated for two “hard-to-weld” high gamma prime Ni-based superalloys RENE 65 (R65) and RENE 108 (R108). Simple block parts with wall thicknesses of 0.25 mm, 1.00 mm, and 5.00 mm are printed using a bidirectional laser scanning strategy without layer-wise rotation. Parts with walls thinner than 5 mm fail before reaching the designated build height. Results indicate that reduction of limiting build height (LBH) corresponds to the reduction of part thickness and is unaffected by alloy composition. On the contrary, the number of internal micro-cracks along columnar grain boundaries in the build direction (BD) increases with part thickness and is significantly higher in R108 than R65. These findings suggest that reduced LBH in parts with thinner walls is not caused by internal micro-crack formation. Fractography and finite element analysis (FEA) of the in-process thermal stresses show that the LBH trend is not explained by the conventional cracking mechanism. Simulations suggest that part thickness affects stress distribution leading to more substantial distortion and consequent failure to add layers for continued fabrication of thinner parts.

This article presents a proof-of-concept to recycle microbrewery waste as a carbon source for synthesizing carbon dots (CDs). A simple method has been developed to synthesize water-soluble CDs based on microwave irradiation of brewery spent grain. The structures and optical properties of the CDs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, photoluminescence spectroscopy (PL), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy. The effects of reaction time, temperature and pH on the properties of carbon dots were studied. These CDs were found to be spherical with an average diameter of 5.3 nm, N-doped, containing many functional groups (hydroxyl, ethers, esters, carboxyl and amino groups), and to exhibit good photoluminescence with a fluorescent quantum yield of 14%. Finally, the interaction between carbon dots and metal ions was investigated towards developing CDs as a sensing technology for water treatment, food quality and safety detection.

We generalize the perfectly clustering words of Simpson and Puglisi and relate them to band bricks over certain gentle algebras. This allows us to prove a generalization of a conjecture by the second author on perfectly clustering words., Comment: 37 pages

Objectives The aim of this study was to explore the experiences of faculty teaching in programs designed to support internationally educated nurses’ transition to nursing practice in Canada. Methods This was a qualitative study that gathered data through semi-structured interviews. Results Four themes were developed from the data: learning the learner, feeling moral unrest in my role, inviting reciprocal relationships, and finding our way. Conclusions There is an urgent need to ensure that faculty are well prepared for their role and that the needs of internationally educated nurses, both personal and pedagogical, are central. Despite the challenges experienced by faculty, they also describe great growth as a result of their new role. Implications for an International Audience Findings from this study are particularly relevant for those in high income countries seeking to support internationally educated nurses. Faculty preparedness and holistic support for students are critical for ethical, high-quality education.

We obtain a multiplication formula for cluster characters on (stably) 2-Calabi-Yau (Frobenius or) triangulated categories. This formula generalizes those known for arbitrary pairs of objects and for Auslander-Reiten triangles. As an application, we show that for cluster algebras of acyclic types, specialization of a cluster variable to 1 sends all cluster variables to elements of a cluster algebra of smaller rank. We also obtain application to the reduction of friezes of acyclic type., Comment: 18 pages, v2 updated references

This meta-analysis tested maternal responsivity as a mediator of the association between socioeconomic risk and children's preschool language abilities. The search included studies up to 2017 and meta-analytic structural equation modeling, allowed us to examine the magnitude of the indirect effect across 17 studies (k = 19). The meta-analysis included 6433 predominantly White, English speaking children (Mage = 36 months; 50% female) from Western, industrialized countries. All paths in the model were statistically significant, notably, the indirect effect was significant (b = -.052), showing that maternal responsivity may be a proximal intervening variable between socioeconomic risk and children's language development. Moderator analyses found that the indirect effect was stronger for sensitive parenting than warmth and when parenting was assessed in the family home.

The negative environmental impacts of Portland cement as a binder in the construction industry have created a growing impetus to develop sustainable alternative binders. Various types of clay have been considered as potential cement replacements. The impact of clays as cement replacement depends on the dosage and treatment methods. This paper presents a comprehensive review to determine the effects of different types of clay on the fresh and hardened properties of concrete mixtures by analyzing the experimental database reported by the literature, including raw, calcined, modified, nano, and organo. This study intends to show the process of optimizing the use of clay in concrete, the reason behind converting raw clay to modified types, and research gaps through a comparison study between different types of clays. The present review study shows that clay-based concrete mixtures have higher thixotropy and yield stress values, improving shape stability. This results in lower early-age shrinkage of the concrete. However, the high floc strength of clay-based concrete causes a reduction in flowability. Treatment methods of raw clay, such as calcination and nano-sized clay particles, improve concrete compressive strength. General results of the previous studies highlight that all types of clay investigated positively affect the resistance of concrete to environmental attack.

This work reports for the first time a straightforward and efficient approach to covalent surface functionalization of a sustainable graphene-like nanomaterial with abundant carboxylic acid groups. This approach results in an efficient and robust chelatant platform for anchoring highly dispersed ultrasmall palladium particles with excellent catalytic activity in the reduction of both cationic (methylene blue, MB) and anionic (eosin-Y, Eo-Y) toxic organic dyes. The large-specific-surface-area (SBET = 266.94 m2/g) graphene-like nanomaterial (GHN) was prepared through a green and cost-effective pyrolysis process from saccharose using layered bentonite clay as a template. To introduce a high density of carboxylic acid functions, GHN was first doubly functionalized by successive grafting reaction using two different strategies: (i) in the first case, GHN was first grafted by (3-glycidyloxypropyl) trimethoxysilane (GPTMS) and then bifunctionalized by chemical grafting of tris(4-hydroxyphenyl)methane triglycidyl ether (TGE). In the second case, the grafting order of the two molecules has been reversed. GHN-GPTMS-TGE provided the highest number of grafted reactive epoxy groups, and it was selected for further functionalization with carboxylic acid functions via a ring-opening reaction through a two-step hydrolysis (H2SO4)/oxidation (KMnO4) approach. The GHN nanomaterial bearing carboxylic acid groups was then treated with sodium hydroxide to produce a deprotonated carboxylic acid-rich platform. Finally, due to a high density of accessible chelatant carboxylic acid groups, GHN-COO- binds strongly a great amount of Pd2+ ions to form stable complexes which after reduction by NaBH4 leads to highly dispersed, densely anchored, and uniformly distributed nanoscale Pd particles (d ∼ 4.5 nm) on the surface of the functionalized GHN. The GHN-COO-@PdNPs nanohybrid proved to be highly efficient for dye reduction by NaBH4 in aqueous solution at room temperature. Moreover, because of the high stability of the as-prepared graphene-like supported PdNPs, it exhibited very good reusability and could be recycled up to eight times without any significant loss in activity.

Music therapy (MT) has been used in health care settings for a wide variety of treatment goals. Many inpatients with neurologic impairments struggle with low mood and pain for which MT may be a novel adjunct treatment. The aims of this study were to: (1) evaluate change in mood and pain following a single MT session; (2) explore the impact of an MT program on mood, pain and satisfaction from the perspective of the patient, family and staff. A mixed-methods study was conducted. Forty participants completed pre/post MT surveys evaluating mood, pain and satisfaction. Individual semi-structured interviews and focus groups were conducted with 14 MT program participants (inpatients), 5 family members of participants and 16 staff. There was significant improvement in mood (p < 0.001) and decrease in pain (p < 0.05) from pre-to-post MT with 74% reporting being “very satisfied” with the session. “Benefits of MT” was the overarching theme of the qualitative data. Subthemes were emotional regulation, pain management, effects on self-concept, enjoyment, and social connectedness. Improvements in mood and pain were reported from pre-to-post MT session and in interviews. Further evaluation of MT effectiveness against standard of care rehabilitation and cost implications is required.Implications for RehabilitationMusic therapy (MT) is delivered by accredited music therapists (MTAs) in health care settings, including rehabilitation units, as an individual, group or co-treatment therapy.MT can be used for a range of health outcomes, including the treatment of mood and pain, in addition to improving inpatient satisfaction.Early evidence using pre/post MT surveys suggests an improvement in mood and pain following a single therapy session.Qualitative data suggest overall benefit of offering MT services in addition to standard neurorehabilitation therapy, including improvements to emotional regulation, pain management, self-concept, enjoyment, and social connectedness. Music therapy (MT) is delivered by accredited music therapists (MTAs) in health care settings, including rehabilitation units, as an individual, group or co-treatment therapy. MT can be used for a range of health outcomes, including the treatment of mood and pain, in addition to improving inpatient satisfaction. Early evidence using pre/post MT surveys suggests an improvement in mood and pain following a single therapy session. Qualitative data suggest overall benefit of offering MT services in addition to standard neurorehabilitation therapy, including improvements to emotional regulation, pain management, self-concept, enjoyment, and social connectedness.