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3. N-nitrosomelatonin

Author

Turjanski, Adrián, Chaia, Zulema Débora, Doctorovich, Fabio, Estrin, Dario, Rosenstein, Ruth, and Piro, Oscar Enrique

Subjects
Física, Cristalografía, General Medicine, General Biochemistry, Genetics and Molecular Biology
Abstract

The title compound, N-[2-(5-methoxy-1-nitroso-1H-indol-3-yl)ethyl]acetamide, C13H15N3O3, an N-nitroso derivative of melatonin, crystallizes in the monoclinic C2/c space group. The molecules are arranged in such a way that the aromatic rings are in a planar conformation, with the alkylamide side chains in a different plane, at a dihedral angle of 108.60 (6)°. The alkylamide chains are interconnected by hydrogen bonds, constituting an infinite array. Facultad de Ciencias Exactas

Published
1999

4. Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Author

Paola Hernández, Fabiana Blanco, Hugo Cerecetto, Oscar E. Piro, Mercedes González, Homero Rubbo, Gloria V. López, Ana M. Ferreira, Carlos Batthyány, López Gloria V., Blanco Fabiana, Hernández Paola, Ferreira Ana, Piro Oscar E., Batthyány Carlos, González Mercedes, Rubbo Homero, and Cerecetto Hugo

Subjects
Stereochemistry, Vasodilator Agents, alpha-Tocopherol, Clinical Biochemistry, Pharmaceutical Science, Aorta, Thoracic, Nitric Oxide, Rats, Inbred WKY, Biochemistry, Chemical synthesis, Antioxidants, Nitric oxide, Mice, chemistry.chemical_compound, X-Ray Diffraction, Drug Discovery, Animals, Vitamin E, Nitric Oxide Donors, Phenols, Tocopherol, Molecular Biology, Cell Proliferation, Oxadiazoles, Molecular Structure, Macrophages, Organic Chemistry, Furoxan, Biological activity, Combinatorial chemistry, In vitro, Rats, Vasodilation, chemistry, Molecular Medicine, NO donor, Antioxidant, LDL oxidation
Abstract

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Published
2007

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