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14 results on '"Pignatello R"'

1. Biological properties of itraconazole-SLNs

Author

Fuochi, V., Carbone, C., Pignatello, R., Petronio Petronio, G., Avola, R., Puglisi, Giovanni, Tibullo, D., Giallongo, C., Puglisi, F., and Furneri, P. M.

Published
2018

7. MAOI activity of thiosemicarbazides and related 2-thiazolylhydrazines

Author

Pignatello R, Mazzone S, Francesco CASTELLI, Mazzone P, Raciti G, and Mazzone G

Subjects
Male, Thiosemicarbazones, Monoamine Oxidase Inhibitors, Calorimetry, Differential Scanning, Chemical Phenomena, Chemistry, Physical, Cell Membrane, Brain, In Vitro Techniques, Lipids, Mitochondria, Rats, Thiazoles, Hydrazines, Spectrometry, Fluorescence, Animals, Female
Abstract

The preparation is described of hydrazides I, thiosemicarbazides II, III, IV and hydrazinothiazoles VIII, which can be considered as "precursors" or "open models" for the synthesized benzoyl-, benzilidene- and benzyl-hydrazinothiazoles V, VI and VII, analogous to 4-methyl and 4-phenyl substituted derivatives A, B and C, described and tested for their MAOI activity in a previous paper. Biochemical assay on the new prepared compounds allowed us to better clarify the structure-activity relationship also of compounds A, B and C of the precedent note. Moreover, on a group of derivatives, which showed a higher activity, a further test was performed to observe the possible correlation between MAOI activity and both their lipophilicity and ability in interacting with liposome bilayers, taken as a model of cell membrane.

9. Biological properties of itraconazole-SLN

Author

Fuochi, V., Carbone, C., Petronio Petronio, G., Avola, R., Tibullo, D., Giallongo, C., fabrizio puglisi, Patamia, I., Pignatello, R., and Furneri, P. M.

Subjects
U937 cell line, Alpha-lipoic acid (ALA), Cationic SLN, Didodecyldimethylammonium bromide (DDAB), Itraconazole (ITZ), Solid lipid nanoparticles (SLN), Biotechnology, Biochemistry, Molecular Medicine, Molecular Biology

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