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5 results on '"Pierattelli R."'

1. NMR in the SPINE Structural Proteomics project

Author

AB, E., Atkinson, A.R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., Diercks, T., Doetsch, V, Engelke, F., Folkers, G.E., Griesinger, C., Gronwald, W., Gunther, U., Habeck, M., de Jong, R.N., Kalbitzer, H.R., Kieffer, B., Leeflang, B.R., Loss, S., Luchinat, C., Marquardsen, T., Moskau, D., Neidig, K.P., Nilges, M., Piccioli, M., Pierattelli, R., Rieping, W., Schippmann, T., Schwalbe, H., Travé, G., Trenner, J., Wöhnert, J., Zweckstetter, M., Kaptein, R., Chemie van glyco-conjugaten, NMR-spectroscopie, and Dep Scheikunde

Published
2006

5. Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II)

Author

M. Passerotto, Giuseppe Bruno, S. Petruso, M. Motta, G. C. Stocco, Simona Rubino, G. Gulì, L. Steardo, E. Del Giudice, Roberta Pierattelli, RUBINO S, PETRUSO S, PIERATTELLI R, BRUNO G, STOCCO G, STEARDO L, MOTTA M, PASSEROTTO M, DEL GIUDICE E, and GULI G

Subjects
2-BenzoylpyrroleCopper(II) and platinum(II) complexesCytotoxicity, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Cell Survival, Molecular Conformation, chemistry.chemical_element, Antineoplastic Agents, Crystal structure, Crystallography, X-Ray, Ligands, Biochemistry, Jurkat cells, Inorganic Chemistry, Jurkat Cells, Organometallic Compounds, Humans, Pyrroles, Cytotoxicity, Coordination geometry, Platinum, Formazans, Cell Death, Dose-Response Relationship, Drug, Molecular Structure, X-ray, Hydrogen Bonding, 2-benzoylpyrrole, copper(ii) and platinum(ii) complexes, cytotoxicity, Carbon-13 NMR, Flow Cytometry, Copper, Crystallography, chemistry, xray cristallogrphy, Indicators and Reagents
Abstract

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1 H and 1 3 C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu I I (2-BZP) 2 ] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu I I (2-BZP) 2 ] and [Pt I I (2-BZP) 2 ] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 μM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 μM. While the Pt I I complexes may have damaged DNA to induce cell death. treatment with the Cull complex did not induce Jurkat cell death.

Published
2004

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