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Industry 4.0 and 5.0 topics are emerging fields and have seen rising demand recently. There is a critical need, on the other hand, for improved methods of instructing programming languages since a growing lack of student motivation during the pandemic has had a deleterious influence on the education of programmers. In this context, online/hybrid computer programming courses must be addressed with innovative solutions to support the field with well-educated professionals. In this paper, we present a case study to propose an innovative tailored instructional design for the online/hybrid learning environments for programming courses in engineering faculties. To develop the instructional design, the Kemp Instructional Design Model was followed. The instructional design is a result of the main outputs of the RECOM “Redesigning Introductory Computer Programming Using Innovative Online Modules” project, which aims to bridge the gap between the existing course design in programming courses and the needs of "Covid” and “post-Covid” generation students.

9 Pág., Increasing CO2 air concentration may affect wettability, anatomy and ultra-structure of leaves of Patagonian forest species, evergreen and deciduous plants potentially responding differently to such CO2 increases. In this study, we analysed the wettability, anatomy and ultra-structure of leaves of Nothofagus antarctica (deciduous) and N. betuloides (evergreen) grown under high CO2 concentrations. Leaf wettability was affected by increasing CO2, in different directions depending on species and leaf side. In both species, soluble cuticular lipid concentrations per unit leaf area raised with higher CO2 levels. Stomatal parameters (density, size of guard cells and pores) showed different responses to CO2 increasing depending on the species examined. In both species, leaf tissues showed a general trend to diminish with higher CO2 concentration. Cuticle thickness was modified with higher CO2 concentration in N. betuloides, but not in N. antarctica leaves. In both species, chloroplasts were often damaged with the increase in CO2 concentration. Our results show that several surface and internal leaf parameters can be modified in association with an increase in atmospheric CO2 concentration which may very among plant species., This work was supported by the National Institute of Agricultural Technology (INTA), Argentina.

Previous studies have shown that highly educated women are more likely to realise their fertility aspirations, or experience a faster progression to a higher order birth, compared to lower educated women. This is often explained by improved economic or social resources among the higher educated. However, it is unclear whether educational differences in health behaviours may also contribute to these differential fertility outcomes. In this study, we use data from Waves 1–7 of the UK Longitudinal Household Study, combined with data from the Nurse Health Assessment from Wave 2 to estimate couples’ likelihood of experiencing additional childbirth within six years. A discrete-time event history model is employed to analyse the transition to a higher order birth, while accounting for both partners’ level of education as well as smoking patterns and body mass index. We find that couples in which the female partner is highly educated are more likely to experience childbirth within six years compared to others. In addition, female smoking is negatively associated with the likelihood of childbirth, while no significant effect has been found for male health factors. Female health indicators explain some of the variation in fertility outcomes for women with lower secondary education compared to degree-educated women. However, education remains a significant predictor of the transition to higher order births, also after accounting for male and female health indicators. It is therefore important to consider both socio-economic and health factors in order to understand variations in fertility outcomes.

OBJECTIVES: Dexketoprofen is a non-steroidal analgesic/anti-inflammatory drug and its trometamol salt is extensively preferred in mild or moderate pain due to its rapid onset of relief. A new formulation of 36.9 mg of dexketoprofen trometamol (equivalent to 25 mg dexketoprofen) tablet has been developed and its bioequivalence to the reference product was proven. MATERIALS AND METHODS: An open-label, single-dose, randomized, two-period, and cross-over bioequivalence study was conducted with healthy males under fasting conditions for two different tablet formulations of 25 mg dexketoprofen. To prove the bioequivalence of the test product with the reference product, a comparison study has been performed in compliance with regulations in force under Good Clinical Practice principles. A single-center clinical study was run and blood samples of the participants were withdrawn at specified time points, before and after dosing, to measure the plasma concentrations of dexketoprofen trometamol. A validated analytical method has been developed using an liquid chromatography with tandem mass spectrometry. Instrument to assess the plasma concentrations of the test and reference products. RESULTS: Forty-seven volunteers completed clinical phase of the study. For the test and reference products, the mean ± standard deviations (SD) of C(max) were found 2543.82 ± 655.42 ng/mL and 2539.11 ± 662.57 ng/mL, and the mean ± SD of area under the curve (AUC) from time 0 to the last measurable concentration (AUC(0-tlast)) were found 3483.49 ± 574.42 h.ng/mL and 3560.75 ± 661.83 h.ng/mL, respectively. The primary target variables data demonstrate the bioequivalence of test and reference products with regard to 90% confidence interval for C(max) of 92.45-108.53% and for AUC(0-tlast) of 95.57-100.87%. The geometric mean ratios were found as 100.16% and 98.18% for C(max) and AUC(0-tlast), respectively. There were no serious adverse events or adverse reactions reported throughout the study. CONCLUSION: After statistical evaluation of the analytical results, the test and reference products were considered bioequivalent. Both products were well tolerated and considered as safe.

Keterlibatan seni dalam kehidupan manusia menjadi hal yang fundamental. Bidang keagamaan juga melibatkan seni. Islam dan Katolik memberi tempat bagi seni untuk berpartisipasi untuk menggapai kasih Tuhan. Seni yang memiliki prioritas untuk menciptakan keindahan, mendorong gerak batin manusia untuk lebih mengenal Sang Maha Keindahan yang adalah Tuhan. Tulisan ini melihat makna dan partisipasi seni di dalam agama Islam dan Katolik. Tulisan ini juga bermaksud untuk secara sederhana mengungkapkan peran seni sebagai salah satu upaya membangun sikap toleransi antar umat beragama dalam semangat integritas terbuka. Tulisan mengungkapkan bahwa Islam dan Katolik selalu mengarahkan umat beriman mengenal Tuhan mengajak untuk memandang keseluruhan dunia yang diciptakan-Nya dengan serasi dan indah dalam seni. Melalui seni dari kedua belah pihak, toleransi yang berpusat pada kedamaian bisa semakin menyentuh esensi terdalamnya. Pada akhirnya terlihat dengan jelas bahwa melalui seni umat beriman dijarkan untuk paham bahwa agama itu indah. Keindahan dalam Katolik tidak berseberangan dengan keindahan di dalam agama Islam.

We examined small and long transcriptomics in skeletal muscle and serum-derived extracellular vesicles before and after a single exposure to traditional combined exercise (TRAD) and high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses to TRAD, whereas HITT elicited differential expression of microRNA enriched in brain regions. Follow-up analysis revealed relationships and temporal dynamics across transcript networks, highlighting potential avenues for research into mechanisms of exercise response and adaptation.

There are many management strategies and interventions both preoperative, intraoperative, and postoperative that can be carried out in dealing with postoperative pain. Guidelines for pain management have been prepared by the American Pain Society (APS) with recommendations from the American Society of Anesthesiologists (ASA) where there are many recommendations in postoperative pain management in adults or children by promoting the provision of preoperative education, the use of various modalities both pharmacological and non-pharmacological to the establishment of pain management procedures or policies in each institution. For this reason, the author was interested in examining the comparison of the effectiveness of analgesia between intravenous tramadol and intravenous Paracetamol in minimally invasive Percutaneous Nephrolithotomy (PCNL) postoperative patients at RSUP Dr. M. Djamil Padang. The research was a prospective study with a single-blind randomised controlled trial design. The data used were sourced from clinical trials conducted on post-PCNL patients divided into two subgroups given intravenous tramadol analgetics and others given Paracetamol tablets. In this study, the incidence of Nephrolithiasis was obtained, which was dominated by the male sex, compared to women and suffered a lot at the age of 41-60 years. There was a significant difference in VAS effectiveness between the use of Paracetamol IV and Tramadol IV in post-PCNL patients. The use of Paracetamol may be considered to replace tramadol in the disappearance of acute pain after PCNL postoperative patients in those patients who are allergic to tramadol.

This research was applied to the project learning model of supporting learning materials at high school SMAN 3 Jambi City. The learning model in the 2013 curriculum must fulfill the five steps scientific approach namely Observing, Asking, Experimenting, Collecting data, and Communicating, which is the goal of a learning model like this to make students understand learning well, educational design-based research that adopts the substance of the formative evaluation type with the characteristics of substance experts in procedural assessment, one-on-one evaluation, small group evaluation and field presentation. The concept of formative evaluation can be integrated with research and development method. The Project Based Learning (PjBL) model in Buffer Solution was using a development process type with a hybrid theory-based approach and directing eight-step practice. The theoretical steps are identifying data sources, collecting data and analyzing data, while the practical steps are generating model ideas, describing models, validating concepts and practitioners and formulating recommendations for testing models. The product was validated by a team of experts which includes practitioner validation to see the practicality of using the product being developed. A small group test was carried out to see the application of the product being developed. The results showed that learning chemistry using the PjBL model could increase the activity and results of students' chemistry learning on the concept of buffer solutions. The increase in student chemistry learning outcomes in the buffer solution concept can also be observed based on the value in general of the learning outcomes obtained by students in cycle I of 68.09 increased to 74.81 in cycle II and % completion in the classical way from 39.39 percent increased to 87.88 percent and this fulfills the marker of success is classical completeness reaching 85 percent with Minimum Completeness Criteria of 70.

This study aims to find out the influence of soft skills, hard skills and motivation on employee performance at RBTV Bengkulu City. The population of this study was all RBTV employees numbering 50 people. All of those employees were sampled for research. Data collection techniques with questionnaires and data analysis techniques using regression. The results of this study revealed that soft skills have a significant effect on employee performance, hard skills have a significant effect on employee performance and motivation has a significant effect on employee performance at RBTV Bengkulu City. Keywords: soft skills, hard skills, motivation and performance.

Congestive Heart Failure (CHF) is a clinical syndrome (a set of signs and symptoms) characterized by shortness of breath and fatigue (at rest or during activities). A professional program aimed at helping CHF patients from cardiac arrest, cardiac surgery and percutaneous coronary intervention (PCI) procedures such as stenting and angioplasty is with cardiac rehabilitation. Phase 1 is an effort that is immediately carried out while the patient is still in the treatment period, the main goal of this phase is to reduce or eliminate the adverse effects of deconditioning due to prolonged bed rest, so that the patient is able to carry out his daily activities independently and safely.To determine the effect of phase 1 cardiac rehabilitation exercise on the quality of life of CHF patients.The research design used in this study was a pre-experimental one-group pretest-posttest design. The quality of life score was assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) with 20 statements. The population in this study were all patients who underwent examination with a diagnosis of CHF, the sample in this study were 23 respondents with exclusion and inclusion criteria. The average age of the respondents is 52 years, most of the respondents are 16 people (69.6%), most of the respondents are highly educated, 17 people (73.9%) and most of the respondents are still actively working as many as 16 people ( 69.6%). The results of the paired T-Test statistical test obtained P value = 0.000. Phase 1 cardiac rehabilitation has a significant effect on the quality of life of Congestive Heart Failure patients. Keywords: CHF, Heart, Quality of Life ABSTRAK Congestive Heart Failure (CHF) adalah sindrom klinis (sekumpulan tanda dan gejala) yang ditandai oleh sesak napas dan fatik (saat istirah atau saat beraktivitas). Sebuah program profesional yang bertujuan membantu pasien CHF dari serangan jantung, operasi jantung dan intervensi koroner perkutan (PCI) prosedur seperti stenting dan angioplasty adalah dengan rehabilitasi jantung. Fase 1 merupakan upaya yang segera dilakukan disaat pasien masih dalam masa perawatan, tujuan utama fase ini adalah mengurangi atau menghilangkan efek buruk dari dekondisi akibat tirah baring lama, agar pasien mampu melakukan aktifitas hariannya secara mandiri dan aman. Untuk mengetahui pengaruh latihan fisik rehabilitasi jantung fase 1 terhadap kualitas hidup pasien CHF. Desain penelitian yang digunakan pada penelitian ini adalah pra experimental one-group pretest-posttes design. Penilaian skor kualitas hidup menggunakan Minnesota Living with Heart Failure Questionnaire (MLHFQ) dengan 20 pernyataan. Populasi pada peneltian ini seluruh pasien yang menjalani pemeriksaan dengan diagnosis CHF, sampel pada penelitian ini yaitu sebanyak 23 responden dengan kriteria eksklusi dan inklusi. Rata-rata usia responden 52 tahun, sebagian besar laki-laki berjumlah 16 orang (69,6%), sebagian besar responden berpendidikan tinggi berjumlah 17 orang (73,9%) dan sebagian besar responden masih aktif bekerja sebanyak 16 orang (69,6%). Hasil uji statistik paired T-Test didapatkan nilai P = 0,000. Rehabilitasi jantung fase 1 berpengaruh signifikan terhadap kualitas hidup pasien CHF Kata Kunci: CHF, Jantung, Kualitas Hidup

O objetivo desse artigo é realizar uma análise interpretativa das Encíclicas papais Pacem in Terris, Laudato Si e Fratelli Tutti a partir dos pressupostos epistemológicos de Paulo Freire e Leonardo Boff e identificar como elas podem contribuir na educação para paz diante do cenário desafiador do século XXI. Para a análise interpretativa foi utilizada a hermenêutica como método e a pesquisa bibliográfica como metodologia, a partir de obras de Ricoeur (1988), Gadamer (1999), Boff (2002; 2003; 2006; 2010; 2012; 2014; 2015; 2021, 2022); Freire (1986; 2016; 2019; 2020; 2021); Francisco (2015, 2020) e João XXIII (1963) entre outros(as). Constatou-se que a proposta de uma educação para a paz, pautada em princípios éticos como a solidariedade universal, o diálogo, a justiça, o cuidado e a cooperação, podem promover uma ecologia integral, permeada pela esperança, e consequentemente uma cultura de paz.

Faeces produced by marine vertebrates and macro-invertebrates contain sufficient organic matter to represent a usable food source for a wide array of macroscopic animals. In some extant marine environments, coprophagy even represents a crucial trophic interaction in food webs. In ancient ecosystems, coprophagy by macroscopic animals is occasionally exemplified by coprolites that exhibit biting traces or burrows. Here, we report Gnathichnus pentax on an exquisitely preserved vertebrate-bitten vertebrate coprolite from the marine calcareous deposits of the Pietra leccese (Miocene, southern Italy). This unusual occurrence is interpreted as evidence of the feeding activity of a regular echinoid; in particular, it may represent either exploratory coprophagy or the browsing of an algal (microbial) film that locally developed on the exterior of the faeces. Strengthening the former interpretation, the development of microbial communities on submerged faeces often leads to their destruction; furthermore, some extant Antarctic echinoderms are well known to ordinarily feed on vertebrate faeces, and coprophagy is believed to be fairly widespread among sea urchins. Supporting the algal browsing hypothesis, in turn, only a limited area of the external surface of the faeces was subject to grazing, and the resulting trace is neatly defined, which suggest that the feeding sea urchin targeted a precise location on the dung's exterior when the latter was already rather firm. To our knowledge, the G. pentax specimen studied here represents the first published record of this ichnotaxon on a coprolite.

One of the common complications of diabetes is diabetic foot problems such as deformities. Foot deformity is a risk factor for foot ulcers in diabetic patients. Diabetic foot complications such as diabetic ulcers and amputations will harm the quality of life of diabetic patients. This study aims to explain the relationship between wearing footwear and the incidence of foot deformity in people with type 2 diabetes. The research method was a quantitative study with a cross-sectional study design. The sample in this study consisted of 55 people with an accidental sampling technique. Data were collected through interviews and observations at the feet of the respondents. The types of foot deformities found in the respondents were hallux valgus 7.3%, hallux limitus 3.6%, hallux rigidus 3.6%, flat foot 5.5%, verruca plantaris 1.8%, and callus 7.3%. The results of this study were there is a relationship between the use of footwear and the incidence of foot deformity as evidenced by the Chi-Square statistical test results with a P value of 0.000 (P value < alpha). The results of the study found that the use of poor footwear can affect the shape of the feet, especially in patients with diabetes mellitus.

BackgroundMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer, associated with a worse prognosis. The Immune Checkpoint Inhibitors (ICIs) avelumab and pembrolizumab have been recently approved as first-line treatment in metastatic MCC (mMCC). The clinical observation of improved outcomes in obese patients following treatment with ICIs, known as the “obesity paradox”, has been studied across many types of tumors. Probably due to the rarity of this tumor, data on mMMC patients are lacking.Patients and methodsThis is an observational, hospital-based, study to investigate the role of Body Mass Index (BMI) as predictive biomarker of ICI response in mMCC patients treated with avelumab as first-line treatment. The study population included the patients treated from February 2019 to October 2022 in an Italian referral center for rare tumors. Clinico-pathological characteristics, BMI, laboratory parameters (NLR and platelet count), and response to avelumab were analyzed from a MCC System database prospectively collected.ResultsThirty-two (32) patients were included. Notably, the presence of pre-treatment BMI ≥ 30 was significantly associated with longer PFS [BMI < 30 Group: median PFS, 4 months (95% CI: 2.5-5.4); BMI ≥ 30 Group: median PFS, not reached; pConclusionTo our knowledge, this is the first study that investigates the predictive role of BMI in MCC patients. Our data were consistent with the clinical observation of improved outcomes in obese patients across other tumor types. Thus, advanced age, a weakened immune system, and the obesity-associated “inflammaging”, are key factors that could impact the cancer immune responses of mMCC patients.

BACKGROUND: Interspecific competition in insect parasitoids is an important ecological phenomenon that has relevant implications for biological pest control. To date, interspecific intrinsic (=larval) competition has been intensively studied, while investigations on extrinsic (=adult) competition have often lagged behind. In this study we examined the role played by parasitoid reproductive traits and host clutch size on the outcome of extrinsic competition between Trissolcus basalis (Wollaston) and Ooencyrtus telenomicida (Vassiliev), two egg parasitoids of the pest Nezara viridula (L). Laboratory experiments were conducted by allowing both parasitoid species to exploit an egg mass made of 10, 20, 30, or 40 hosts through single or simultaneous releases. Furthermore, under field conditions, egg masses consisting of 10 or 40 hosts were exposed in a tomato crop in order to validate laboratory investigation. RESULTS: The results show that the egg mass size is an important predictor of extrinsic competition in our study system as a higher proportion of T. basalis emerged from large egg masses, while O. telenomicida dominated in small egg masses. Analysis of reproductive traits of parasitoid species indicates that T. basalis has superior abilities in host exploitation compared with O. telenomicida. CONCLUSIONS: We found that contrasting reproductive traits of two competing egg parasitoid species facilitate coexistence on a shared stink bug host. This work also highlights the importance to consider extrinsic competitive interactions between parasitoid species in a biological control perspective. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

12 p.-7 fig.-1 schem.-1 graph. abst., Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by well-defined ligands to boost innate and adaptive immune responses. Monophosphoryl lipid A (MPLA), a detoxified analogue of lipid A, is a clinically approved adjuvant that stimulates toll-like receptor 4 (TLR4). The synthesis of MPLA poses manufacturing and quality assessment challenges. Bridging this gap, we report here the development and preclinical testing of chemically simplified TLR4 agonists that could sustainably be produced in high purity and on a large scale. Underpinned by computational and biological experiments, we show that synthetic monosaccharide-based molecules (FP compounds) bind to the TLR4/MD-2 dimer with submicromolar affinities stabilizing the active receptor conformation. This results in the activation of MyD88- and TRIF-dependent TLR4 signaling and the NLRP3 inflammasome. FP compounds lack in vivo toxicity and exhibit adjuvant activity by stimulating antibody responses with a potency comparable to MPLA., The support from European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 860325 (www.BactiVax.eu), Italian Ministry grant PRIN 2017, no. 2017E44A9P (BacHounds:Supramolecular nanostructures for bacteria detection), and the Spanish Ministry for Science and Innovation (grants CTQ2017-88353-R and PRE2018-086249) is acknowledged.

Purpose Hyponatremia is the most frequent electrolytic disorder in clinical practice. In addition to neurological symptoms, hyponatremia, even when mild/moderate and chronic, has been related to other manifestations, such as bone demineralization and increased risk of fractures. To better elucidate tissue alterations associated with reduced serum sodium concentration [Na+], we developed an in vivo model of hyponatremia secondary to the Syndrome of Inappropriate Antidiuresis. Methods and results Hyponatremia was induced in Foxn1nu/nu mice by subcutaneous infusion of the vasopressin analog 1-deamino [8-D-arginine] vasopressin (dDAVP) for 14 days via osmotic mini-pumps. Mice in the control group were infused with isotonic saline solution. Serum [Na+] progressively decreased, with a nadir of 123.4 ± 2.3 mEq/L (mean ± SD, dDAVP 0.3 ng/h) and 111.6 ± 4.7 mEq/L (mean ± SD, dDAVP 0.5 ng/h). Evident signs of liver steatofibrosis were observed at histology in hyponatremic mice. Accordingly, the expression of proteins involved in lipid metabolism (SREBP-1, PPARα and PPARγ) and in myofibroblast formation (αSMA and CTGF) significantly increased. Furthermore, heme oxygenase 1 expression was up-regulated in Kupffer and hepatic stellate cells in the liver of hyponatremic mice. Testis alterations were also observed. In particular, the thickness of the seminiferous epithelium appeared reduced. The expression levels of PCNA and PTMA, which are involved in DNA replication and germ cells maturation, were markedly reduced in the testis of hyponatremic mice. Conclusion Overall, these findings shed new light on the possible consequences of chronic hyponatremia and prompt a more thorough evaluation of hyponatremic patients.

This paper investigates how psychological needs spurring self-determined motivation relate to collective efficacy for flourishing in online learning communities. Self-determination theory posits individuals experience intrinsic motivation to flourish at educational tasks because of targeted satisfaction of the three psychological needs: autonomy, relatedness, and competence. However, studies conducted to investigate collective, technology-assisted learning processes suggest competence and relatedness may play a pivotal role in online community engagement and knowledge-sharing. Moreover, informal gaming experiences may mirror the collaborative skills needed in online educational/professional communities. These insights suggest confidence in one’s abilities to contribute to a community, the perception of a strong, supportive social culture in the online classroom, and informal online experiences may lead to self-determined motivation enabling agents in distributed, technology-assisted classrooms to collectively flourish. Little work has been done to examine effects of need satisfaction on collective efficacy in using online technologies. To fill this research gap, we used structural equation modelling to investigate perceptions of 636 undergraduate students enrolled in classes within an education department at a midwestern university employing weekly asynchronous blogging. Our results suggest students’ experience with multiplayer gaming, and need satisfaction towards competence and relatedness correlate with higher collective efficacy in technology-assisted classrooms employing discussion forums. Implications for practice or policy: For instructors, student usership and design can spur motivation in online classrooms. For researchers, understanding student perceptions of collaboration using technology can help understand how to design better technology-assisted classrooms. The design of collaborative online educational communities should focus on creating positive social cultures and fostering competence for students.

Increased PSA levels can be caused by prostate cancer, prostate infection, and BPH. Several studies report that the use of antibiotics can affect PSA levels. This study aims to determine the effect of ciprofloxacin administration in patients with prostate-specific antigen values ??of 4-10 ng/mL. This was an analytical study with a prospective cohort design. This study was conducted at Dr. M. Djamil Hospital, Padang starting from July 2022 until October 2022. The sampling technique used non-probability sampling with consecutive sampling method. The patient was given the antibiotic ciprofloxacin 2x500 mg for 2 weeks. PSA measurements were carried out before and after administration of antibiotics. There were 20 subject with an average age of 62.65 years (52-79). The mean of initial PSA value was 6.53 ng/mL and the final PSA value was 5.76 ng/mL. There was a significant difference between PSA levels before and after administration of ciprofloxacin (p=0.000). The use of antibiotics in patients with PSA levels of 4-10 ng/ml can reduce PSA levels.

Introduction Physical activity (PA) in older people is associated with improved morbidity and mortality outcomes. Increasing numbers of older people are choosing to live in retirement villages, many of which promote themselves as providing opportunities for activity. Aim To explore the characteristics of PA village residents were undertaking and the associated individual and village factors. Methods Health, functional and wellbeing information was collected from 577 residents recruited from 34 villages in Auckland, New Zealand, using an International Resident Assessment Instrument and customised survey tools containing items on self-reported PA. Managers from villages completed a survey on village characteristics and facilities. Results The mean age (s.d.) of village residents was 82 (7) years, and 325 (56%) reporting doing one or more hours of PA in the 3 days prior to assessment. Moderate exercise was performed by 240 (42%) village residents, for a mean (s.d.) of 2.7 (3.4) h per week. The most common activities provided by villages included: bowls/petanque (22, 65%) and exercise classes (22, 65%), and walking was the most common activity undertaken (348, 60%). Factors independently associated with PA included individual factors (gender, fatigue, constipation, self-reported health, number of medications, moving to village for safety and security, utilising village fitness programme, use of the internet, and satisfaction with opportunities to be active) and village-related factors (access to unit, and ownership model). Discussion PA uptake is determined by many factors at both personal (physical and psychosocial) and environmental levels. Clinicians should focus on individualised PA promotion in those with identified risk factors for low levels of PA.

AIM: To verify the added value of respiratory function monitor (RFM) to assess ventilation and the heart rate (HR) changes during stabilization of preterm infants.METHODS: Preterm infants 100 bpm; T2 the delivery of the last PPV). For each inflation, PIP, PEEP, MAP, expired tidal volume/kg (Vte/kg), and mean dynamic compliance (Cdyn) were analyzed.RESULTS: PIP and MAP values were significantly higher at T1 (27.09 ± 5.37 and 17.47 ± 3.85 cmH2 O) and at T2 (24.7 ± 3.86 and 15.2 ± 3.78 cmH2 O) compared to T0 (24.05 ± 2.27 and 15.85 ± 2.77 cmH2 O). PEEP at T1 was significantly higher (6.27 ± 2.17 cmH2 O) compared to T2 (5.61 ± 1.50 cmH2 O). Vte/kg showed significantly lower T0 values (3.57 ± 2.14 ml/kg) compared to T1 (6.18 ± 2.51 ml/kg) and T2 (6.89 ± 2.40 ml/kg). There was a significant effect of time on Cdyn.CONCLUSIONS: A clear correspondence between HR rise and adequate Vte/kg during stabilization of very preterm infants was highlighted. RFM might be useful to tailor ventilation, following real-time changes of lung compliance.

In 2020 and 2021, the eleventh and twelfth seasons of excavations at the Late Bronze Age city of Hala Sultan Tekke were carried out in the cemetery of Area A. Based on indications provided by a large-scale magnetometer survey, two tombs exposed by intensive farming were located, Tombs RR and SS. The excavation of Tomb RR, which had started in 2018, was concluded. The total minimum number (MNI) of skeletons in this tomb, of which most were incomplete and disarticulated, is estimated at 137. In addition to clay figurines, seals and scarabs, objects of ivory, as well as jewellery of gold, silver, bronze, faience and carnelian, the inhumations are associated with more than 100 intact or complete ceramic vessels, many of them imported from the Mycenaean, Minoan, Hittite and Levantine spheres of culture. The pottery indicates a LC II(A/)B–C1 date of the inhumations, i.e., covering the 14th and the beginning of the 13th centuries BC. The excavations of the adjacent Tomb SS began in 2020 and has been concluded in May 2022. It contained a minimum of eleven inhumations, most of them (almost) complete and articulated, and large deposits of Cypriot and imported pottery, in total over 300 vessels mainly from the LC (I–)IIB, i.e., from the 16th/15th to mainly the 14th centuries BC. These contexts not only offer an insight into the complex Late Cypriot mortuary practices and funerary rituals but also reflect the urban élites with far-reaching inter-cultural connections.

Technological developments, electronic components and circuits have resulted in a direct voltage supply system that is produced by converting the input DC voltage to another form of DC voltage with a higher output utilizing a boost converter circuit, using a low source voltage where the output voltage can be changed according to user requirements. To anticipate the voltage drop on the output side which is affected by changes in the resistance value of the load and changes in the value of the source voltage, a voltage control is needed that can regulate the output stability of the boost converter. One of the voltage control techniques used is integral proportional controller (PI). This study uses the Ziggler – Nichols oscillation method which is applied to the integral proportional controller (PI) in the boost converter circuit by using the Arduino Mega2650 as a controller circuit which is programmed with Matlab Simulink and a voltage sensor that functions to detect output on the boost converter as well as feedback from the Proportional Integral (PI) controller which will later be compared with the desired setpoint to produce the appropriate Pulse width Modulation (PWM) signal. The test results show that the PI controller works well in accordance with the purpose of adjusting the output voltage on the boost converter. This can be seen in the output of the boost converter which is in accordance with the reference voltage of 15 volts, 20 volts, and 24 volts with an output voltage of 15.36 volts, 20.52 volts, 24.82 volts

Technology-based entrepreneurial (Technoprenuer) trainings aim at increasing the interest of students and university graduates to become Technoprenuer actors as part of reducing the number of educated unemployment rate. On the other hand, based on the continuously development of transportation technology, smart transportation utilizing the Internet of Things (IoT) is expected to help many parties in the field of supervision and enforcementas as well as the community as it can improve safety and reduce the level of accidents on the road. Therefore, this training provided material on technoprenership and IoT implementation to gain those two benefits. The training was held for 2 weeks, 2 days of which were synchronous and the rest were asynchronous. The trainees consisted of 15 UPI students and they were expected to be able to build prototypes in the end of the training. As the result, 60% of the participants were able to realize their business ideas until the prototype stage.

VRP (vehicle routing problem) belongs to the problem of NP-hard. It makes the computation time becoming longer as the number of data increases. This statement is in accordance with previous research which solved the VRP for the rice distribution system in Bandung which consisted of 40 demand points in the form of traditional markets using the optimal method. The computational time required is 167 hours 52 minutes 38 seconds. Therefore, a heuristic method is needed to solve VRP with a more efficient computation time and an acceptable solution. The purpose of this paper is to complete the VRP by using an annealing simulation to design a rice distribution system in Bandung. Simulated annealing (SA) is a local search algorithm (meta-heuristic) that is able to get out of the local optimum. Its ease of implementation, the use of hill-climbing motions to avoid local optimal, and the convergent nature, have made SA a popular technique over the past two decades. After comparing the results to the ILP model, the computational experiments show what the SA algorithm developed in this paper is able to produce a relatively small gap in terms of total transportation cost, which is 1.26%. This paper has also succeeded in improving the previous paper by reducing the computation time to 19 seconds using the developed SA algorithm.

Purpose Hyponatremia occurs in about 30% of patients with pneumonia, including those with SARS-CoV-2 (COVID-19) infection. Hyponatremia predicts a worse outcome in several pathologic conditions and in COVID-19 has been associated with a higher risk of non-invasive ventilation, ICU transfer and death. The main objective of this study was to determine whether early hyponatremia is also a predictor of long-term sequelae at follow-up. Methods In this observational study, we collected 6-month follow-up data from 189 laboratory-confirmed COVID-19 patients previously admitted to a University Hospital. About 25% of the patients (n = 47) had hyponatremia at the time of hospital admission. Results Serum [Na+] was significantly increased in the whole group of 189 patients at 6 months, compared to the value at hospital admission (141.4 ± 2.2 vs 137 ± 3.5 mEq/L, p 2/FiO2 increased. Accordingly, pulmonary involvement, evaluated at the chest X-ray by the RALE score, decreased. However, in patients with hyponatremia at hospital admission, higher levels of LDH, fibrinogen, troponin T and NT-ProBNP were detected at follow-up, compared to patients with normonatremia at admission. In addition, hyponatremia at admission was associated with worse echocardiography parameters related to right ventricular function, together with a higher RALE score. Conclusion These results suggest that early hyponatremia in COVID-19 patients is associated with the presence of laboratory and imaging parameters indicating a greater pulmonary and right-sided heart involvement at follow-up.

We engineered an ultrasensitive reporter of p16 INK4a , a biomarker of cellular senescence. Our reporter detected p16 INK4a -expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16 INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16 INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16 INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.

L'infermiere di triage assume un ruolo fondamentale all'interno dell'attività in pronto soccorso in quanto può influenzare la qualità dei processi, oltre ad avere importanti implicazioni in termini di responsabilità e rischio clinico. Nel dipartimento d'emergenza e accettazione dell'Ospedale Misericordia di Grosseto nel 2018 si è introdotta una modalità di valutazione della qualità del triage con l'obiettivo di migliorare la performance complessiva del gruppo dei professionisti.

In this study, we prepared a fine-grained, aluminum-reinforced alumina support matrix of the active mass of catalysts, which showed activity in heterogeneous catalytic reactions stimulated by electromagnetic radiation in the microwave range. The support absorbed microwave radiation of 2.45 GHz. We compared the textural characteristics of samples of Аl/Аl2О3 supports obtained by conventional heat treatment to those synthesized by heat treatment in a microwave field. We found several advantages of heat treating potential supports of the active mass by using microwave radiation. Using the examples of joint deep oxidation of n-butane and carbon monoxide, dealkylation of toluene with water vapor into benzene, and acidylation of diethyl amine with m-toluic acid, we found that after exposure to microwave radiation, the fine-grained aluminum powder-reinforced Аl/Аl2О3 support can be used for preparing catalysts that can be used in reactions stimulated by a microwave electromagnetic field.

Background: To evaluate the technical results of an arterial repair, a variety of intraoperative imaging and assessment techniques can be used during carotid endarterectomy (CEA). The aim of the study was to evaluate the usefulness of intraoperative ultrasound flow measurement as a quality control after primary CEA in a teaching hospital setting. Methods: Over 36 months, 107 consecutive CEAs were performed at our institution. Retrospectively acquired demographics, intraoperative flow measurements, duplex results, revisions, and surgical outcomes were reviewed. Postoperative 30-day transient ischemic attack (TIA), stroke, and death rates were analyzed. Results were compared with ultrasound flow measurement and duplex ultrasonography. Results: From March 2012 to March 2015, 107 primary consecutive CEAs were performed in 107 patients (71% male, 29% female), whose age ranged from 51 to 81 years with a mean age of 68 ± 4 years. Associated risk factors included diabetes for 89 (83%), smoking for 92 (86%), hypertension for 94 (87.8%), chronic renal insufficiency for 71 (66%), and coronary artery disease for 57 (53%) of the patients. Early postoperative duplex scans in all 107 patients showed no significant changes from intraoperative findings. The ipsilateral stroke and death rate in this study was 0 (0/107) and the 30-day death and stroke rate was also 0 (0/107), with no significant difference between trainees and senior surgeons. Three patients (2.8%) had flow < 100 mL/Min and two of them were revised after completion of contrast angiography. Conclusions: The findings of this study indicate that the intraoperative flow measurement is an alternative method for detecting technical errors and a tool for quality-control imaging. Especially for trainees, it makes sense to ensure effectiveness of the procedure upon its completion and to assess the technical adequacy of CEA.

We sought to describe global patterns in achievement of risk factor control for primary prevention in patients with T2D and explore the association of country's GNI/capita with risk factor control.The DISCOVER study is a prospective, observational study of patients with T2D from 38 countries enrolled at initiation of second-line glucose-lowering therapy. We examined achievement of risk factor control (glycosylated hemoglobin7%, blood pressure140/90 mmHg, prescription of a statin) at 3 years among those without optimal control at baseline. Countries were stratified by gross national income (GNI)/capita, from 2017). We examined the impact of country GNI/capita with achievement of risk factor control.Our cohort included 9613 patients with T2D and without baseline cardiovascular disease (mean age 57.2 ± 8.7 years, 47.9% women). At baseline, 6354/7646 patients (83.1%) had suboptimal glucose control, 3449/9200 patients (37.5%) had suboptimal BP control, and 2800/4221 patients (66.7%) were not on an appropriate statin (sample sizes differed due to missing covariate data). Optimal control at 3 years of follow-up was achieved in 41% (glucose), 56% (blood pressure), and 29% (statins) of patients. There was significant variability in achievement of risk factor control across countries but no association between country GNI/capita with achievement of risk factor control (p 0.08 for all).In a global, prospective study of patients with T2D, we found that cardiovascular risk factor control achievement was suboptimal despite 3 years of follow-up in specialized health care systems. Neither country-level nor patient-level socioeconomic factors fully explained this finding.

This study was conducted to solve of applying the learning model to skills and scientific process results in Buffer Solution learning materials in senior high school (SMA). In the early stages, the researchers designed scaffolding by linking the PjBL Flipped Classroom model, KPS, and buffer solution material. Then, these two products were validated by a team of experts involving scaffolding design validation, flow validation, learning design validation, and material validation to see the suitability of the scaffolding assistance at each stage of the PjBL Flipped Classroom model and the feasibility of the products developed and required to adopt the products produced to the principles set found in learning design. After completing the validation stage, the practitioner validation stage is continued to see the practicality of using the product being developed. Then a small group test is carried out to see the application of the product being developed. The results showed that learning chemistry using the Scaffolding Flow in the PJBL Flipped Classroom model could increase students' chemistry learning activities and outcomes on the concept of buffer solutions.

Wireless Sensor Networks (WSNs) represent a key component in emerging distributed computing paradigms such as IoT, Ambient Intelligence, and Smart Cities. In these contexts, the difficulty of testing, verifying, and monitoring applications in their intended scenarios ranges from challenging to impractical. Current simulators can only be used to investigate correctness at source code level and with limited accuracy. This paper proposes a system and a methodology to model and verify symbolic distributed applications running on WSNs. The approach allows to complement the distributed application code at a high level of abstraction in order to test and reprogram it, directly, on deployed network devices. The proposed intelligent architecture enables the execution of distributed applications and the verification of the supplied correctness conditions. This paper shows the feasibility of the proposed approach and its effectiveness even when networks include resource-constrained nodes with some sample applications and quantitative experiments measuring the overhead introduced by the monitoring operations.