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1. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author

Anttalainen, Ulla, Grote, L., Fietze, I., Riha, R. L., Ryan, S., Staats, R., Hedner, J., Saaresranta, T., Anttalainen, U., Barbe, F., Bonsignore, M. R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I, Esquinas, C., Hayes, L., Joppa, P., Kurki, S., Kvamme, J. A., Tamisier, R., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pepin, J. L., Pretl, M., Roisman, G., Schiza, S. E., Schulz, R., Sliwinski, P., Steiropoulos, P., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vrints, H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R.L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J.A., Tamisier R., Lombardi C., Marrone O., McNicholas W.T., Montserrat J.M., Parati G., Pataka A., Penzel T., Pepin J.L., Pretl M., Roisman G., Schiza S.E., Schulz R., Sliwinski P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Ege Üniversitesi, and ESADA Study Collaborators

Subjects
Adult, Male, medicine.medical_specialty, Insomnia, Neurology, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Nocturnal, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Prevalence, Humans, Medicine, Hypoxia, Sleep Apnea, Obstructive, business.industry, Sleep Breathing Physiology and Disorders • Original Article, Sleep apnea, Middle Aged, Cardiovascular disease, Phenotype, Hypoxia (medical), medicine.disease, Circadian Rhythm, nervous system diseases, Europe, 030228 respiratory system, Otorhinolaryngology, Cardiovascular Diseases, Cohort, Female, Human medicine, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

WOS: 000482433800011, PubMed ID: 30467691, Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m(2)), and ODI (15 vs. 32/h). Conclusion High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms., European Union COST action B26; European Respiratory Society (ERS); ResMed Inc.; Philips Respironics Inc., The ESADA network has received support from the European Union COST action B26. The European Respiratory Society (ERS) supports the ESADA for the second period as a Clinical Research Collaboration (CRC) (2015-2017 and 2018-2020). Unrestricted seeding grants from ResMed Inc. and Philips Respironics Inc. for establishment of the organization and the database are gratefully acknowledged.

Published
2018
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2. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author

Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gunduz, C, Hender, J, and Lepin, J

Subjects
Male, obesity, Databases, Factual, cholesterol, dyslipidemia, hypoxia, obesity, sleep apnoea, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Hypolipidemic Agents, Oxygen saturation (medicine), Sleep Apnea, Obstructive, medicine.diagnostic_test, Sleep apnea, Middle Aged, Europe, Quartile, Cardiovascular Diseases, Cohort, Female, lipids (amino acids, peptides, and proteins), Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, medicine, Humans, Triglycerides, Dyslipidemias, hypoxia, Cholesterol, business.industry, Cholesterol, HDL, dyslipidemia, cholesterol, Cholesterol, LDL, ta3121, medicine.disease, Obesity, nervous system diseases, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, chemistry, Lipid profile, business, sleep apnoea, 030217 neurology & neurosurgery, Dyslipidemia
Abstract

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.

Published
2018
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3. Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA)

Author

Grote L, McNicholas WT, Hedner J, ESADA collaborators (Anttalainen U, Saaresranta T, Basoglu OK, Gunduz C, Tasbakan S, Bouloukaki I, Schiza SE, Bonsignore MR, Marrone O, Petitjean M, Roisman G, Fietze I, Laharnar N, Penzel T, Zou D, Kent BD, Ryan S, Kvamme JA, Bailly S, Pepin J-L, Tamisier R, Lombardi C, Parati G, Pataka A, Plywaczewski R, Sliwinski P, Pretl M, Riha R, Staats R, Steiropoulos P, Joppa P, Verbraecken J, Petiet E, Trakada G, Ludka O, Buskova J, Hein H, Drummond M, van Zeller M, Dogas Z, Galic T, Gouveris H, Mihaicuta S, Randerath W, Herkenrath S, Fanfulla F, Testelmans D, Ege Üniversitesi, Grote L., McNicholas W.T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O.K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S.E., Bonsignore M.R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B.D., Ryan S., Kvamme J.A., Bailly S., Pepin J.-L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, and Testelmans, D

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Databases, Factual, Polysomnography, medicine.medical_treatment, Pneumonia, Viral, Personnel Staffing and Scheduling, Disease, Covid, sleep laboratory, Betacoronavirus, 03 medical and health sciences, Sleep Apnea Syndrome, Sleep Apnea Syndromes, 0302 clinical medicine, Surveys and Questionnaires, mental disorders, Research Letter, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Continuous positive airway pressure, Pandemics, Sleep Medicine Specialty, Continuous Positive Airway Pressure, medicine.diagnostic_test, Coronavirus Infection, SARS-CoV-2, business.industry, Sleep apnea, COVID-19, Atrial fibrillation, medicine.disease, Comorbidity, Obesity, Telemedicine, Europe, 030228 respiratory system, Heart failure, Coronavirus Infections, business, Delivery of Health Care, management
Abstract

Sleep disordered breathing (SDB) is highly prevalent with a male to female predominance of two to one, and is more common in middle-aged and elderly subjects [1]. Affected patients often present with comorbidities such as obesity, cardiovascular disease (systemic hypertension, heart failure, atrial fibrillation), and diabetes mellitus Type II [2]. The strong overlap between the profile for SDB patients and the identified risk factors for adverse outcomes of COVID-19 infection that include age, male gender, and cardio-metabolic comorbidity [3] suggest that SDB patients may benefit from effective therapy if confronted with COVID-19 infection [4].

Published
2020
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4. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author

Pataka, Athanasia, Bonsignore, Maria R., Ryan, Silke, Riha, Renata L., Pepin, Jean-Louis, Schiza, Sofia, Basoglu, Ozen K., Sliwinski, Pawel, Ludka, Ondrej, Steiropoulos, Paschalis, Anttalainen, Ulla, McNicholas, Walter T., Hedner, Jan, Grote, Ludger, Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I., Penzel, T., Ludka, O., Rodenstein, D., Masa, J. F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Grote, L., Hedner, J., Pepin, J-L., Levy, P., Lavie, L., Lavie, P., Hein, H., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Safarik, P. J., Tkacova, R., Staats, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M. R., Marrone, O., Escourrou, P., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Sliwinski, P., Plywaczewski, R., Bielicki, P., ESADA Study Grp, Pataka A., Bonsignore M.R., Ryan S., Riha R.L., Pepin J.-L., Schiza S., Basoglu O.K., Sliwinski P., Ludka O., Steiropoulos P., Anttalainen U., McNicholas W.T., Hedner J., Grote L., Aristotle University of Thessaloniki, Università degli studi di Palermo - University of Palermo, University College Dublin [Dublin] (UCD), Royal Infirmary of Edinburgh, Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), University of Crete [Heraklion] (UOC), Ege university, National Institute of Tuberculosis and Lung Diseases, St. Anne’s University Hospital [Brno], Democritus University of Thrace (DUTH), University of Turku, Sahlgrenska University Hospital [Gothenburg], University of Gothenburg (GU), ESADA study group: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, O Ludka, D Rodenstein, J F Masa, I Bouloukaki, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, L Grote, J Hedner, J L Pepin, P Levy, L Lavie, P Lavie, H Hein, O K Basoglu, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, R Staats, F Barbe, C Lombardi, G Parati, M Drummond, M van Zeller, M R Bonsignore, O Marrone, P Escourrou, G Roisman, M Pretl, A Vitols, Z Dogas, T Galic, A Pataka, U Anttalainen, T Saaresranta, P Sliwinski, R Plywaczewski, P Bielicki, and SALAS, Danielle

Subjects
Male, obesity, Letter, Databases, Factual, Download, [SDV]Life Sciences [q-bio], cigarette smoking, Polysomnography, cancer risk, disease burden, apnea hypopnea index, sleep disordered breathing, study design, 0302 clinical medicine, polysomnography, Risk Factors, Nothing, cancer diagnosis, Neoplasms, middle aged, gender, Prevalence, 030212 general & internal medicine, Sleep study, obstructive sleep apnea, Sleep Apnea, Obstructive, education.field_of_study, anthropometry, quantitative analysis, medicine.diagnostic_test, adult, risk assessment, clinical trial, cohort analysis, prostate cancer, pulse oximetry, [SDV] Life Sciences [q-bio], Europe, not available, comorbidity, aged, female, waist hip ratio, colon cancer, priority journal, risk factor, factual database, disease severity, cerebrovascular accident, Pulmonary and Respiratory Medicine, medicine.medical_specialty, alcohol consumption, intermittent hypoxia, Population, MEDLINE, lymphoma, Settore MED/10 - Malattie Dell'Apparato Respiratorio, malignant neoplasm, cancer growth, 03 medical and health sciences, melanoma, medicine, cancer, cross-sectional study, Humans, controlled study, human, education, Cancer prevalence, hypoxia, business.industry, statistical model, Conflict of interest, prediction, major clinical study, body mass, oxygen saturation, lung cancer, multicenter study, Cross-Sectional Studies, Logistic Models, age, 030228 respiratory system, disease severity assessment, Family medicine, oxygen desaturation index, head and neck cancer, Human medicine, business, neoplasm
Abstract

[No abstract available], ResMed Foundation; Philips; European Respiratory Society, ERS; Fondation Air Liquide, Conflict of interest: A. Pataka has nothing to disclose. M.R. Bonsignore has nothing to disclose. S. Ryan has nothing to disclose. R.L. Riha has nothing to disclose. J-L. Pepin reports grants and research funds from Air Liquide Foundation, Agiradom, AstraZeneca, Fisher and Paykel, Mutualia, Philips, Resmed and Vitalaire, personal fees from Agiradom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed and Sefam. S. Schiza has nothing to disclose. O.K. Basoglu has nothing to disclose. P. Sliwinski has nothing to disclose. O. Ludka has nothing to disclose. P. Steiropoulos has nothing to disclose. U. Anttalainen has nothing to disclose. W.T. McNicholas has nothing to disclose. J. Hedner reports grants from ResMed Foundation, Philips Respironics and the European Respiratory Society, for start-up and conduct of the study. L. Grote reports grants from Resmed Foundation and Respironics Foundation, during the conduct of the study; personal fees for lecturing from Resmed, Philips and Itamar, grants from Resmed, other (equipment) from Itamar, outside the submitted work; in addition, L. Grote has a patent for sleep apnoea treatment pending., Support statement: The ESADA network has received support from the European Union COST action B26 and is currently a Clinical Research Collaboration funded by the European Respiratory Society. Additionally, the ESADA study group has received unrestricted seeding grants from the ResMed and the Philips Respironics Foundation for the establishment of the database in 2007 and 2011. The ESADA has an ongoing collaboration with Bayer AG. Non-financial support was provided by the European Sleep Research Society and the European Respiratory Society for communication, meetings and data presentations for the ESADA collaborators.

Published
2019
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5. THE REFERENCE SITE COLLABORATIVE NETWORK OF THE EUROPEAN INNOVATION PARTNERSHIP ON ACTIVE AND HEALTHY AGEING

Author

Bousquet, J., Illario, M., Farrell, J., Batey, N., Carriazo, A. M., Malva, J., Hajjam, J., Colgan, E., Guldemond, N., Perala-Heape, M., Onorato, G. L., Bedbrook, A., Leonardini, L., Stroetman, V., Birov, S., Abreu, C., Abrunhosa, A., Agrimi, A., Alalaakkola, T., Allegretti, N., Alonso-Trujillo, F., Alvarez-Benito, M., Angioli, S., Apostolo, J., Armitage, G., Arnavielhe, S., Baena-Parejo, M., Bamidis, P. D., Balenovic, A., Barbolini, M., Baroni, I., Blain, H., Bernard, P. L., Bersani, M., Berti, E., Bogatyrchuk, L., Bourret, R., Brehm, J., Brussino, L., Buhr, D., Bultje, D., Cabeza, E., Cano, A., Capitani, C., Carantona, E., Cardoso, A., Coll Clavero, J., Combe, B., Conforti, D., Coppola, L., Corti, F., Coscioni, E., Costa, E., Crooks, G., Cunha, A., Daien, C., Dantas, Darpon Sierra, J., Davoli, M., Dedeu Baraldes, A., Luca, V., Nardi, L., Di Ciano, M., Dozet, A., Ekinci, B., Erve, S., Espinoza Almendro, J. M., Fait, A., Fensli, R., Fernandez Nocelo, S., Galvez-Daza, P., Gamez-Paya, J., Garcia Saez, M., Garcia Sanchez, I., Gemicioglu, B., Goetzke, W., Goossens, E., Geurdens, M., Gutter, Z., Hansen, H., Hartman, S., Hegendorfer, G., Heikka, H., Henderson, D., Heran, D., Hirvonen, S., Iaccarino, G., Jansson, N., Kallasvaara, H., Kalyoncu, F., Kirchmayer, U., Kokko, J. A., Korpelainen, J., Kostka, T., Kuna, P., Lajarin Ortega, T., Lama, C. M., Laune, D., Lauri, D., Ledroit, V., Levato, G., Lewis, L., Liotta, G., Lundgren, L., Lupianez-Villanueva, F., Mc Garry, P., Maggio, M., Manuel Keenoy, E., Martinez, C., Martinez-Domene, M., Martinez-Lozano Aranaga, B., Massimilliano, M., Maurizio, A., Mayora, O., Melle, C., Mendez-Zorilla, A., Mengon, H., Mercier, G., Mercier, J., Meyer, I., Millet Pi-Figueras, A., Mitsias, P., Molloy, D. W., Monti, R., Moro, M. L., Muranko, H., Nalin, M., Nobili, A., Nogues, M., O Caoimh, R., Pais, S., Papini, D., Parkkila, P., Pattichis, C., Pavlickova, A., Peiponen, A., Pereira, S., Pepin, J. L., Piera Jimenez, J., Portheine, P., Potel, L., Pozzi, A. C., Quinonez, P., Lauritsen, Ramirez X., Ramos, M. J., Rannali-Kontturi, A., Risino, A., Robalo-Cordeiro, C., Rolla, G., Roller, R., Romano, M., Romano, V., Ruiz-Fernandez, J., Saccavini, C., Sachinopoulou, A., Sanchez Rubio, M. J., Santos, L., simonetta scalvini, Scopetani, E., Smedberg, D., Solana-Lara, R., Soltysik, B., Sorlini, M., Stericker, S., Badiale, Stramba M., Taillieu, I., Tervahauta, M., Teixeira, A., Tikanmaki, H., Todo-Bom, A., Tooley, A., Tuulonen, A., Tziraki, C., Ussai, S., Veen, S., Venchiarutti, A., Verdoy-Berastegi, D., Verissimo, M., Visconti, L., Vollenbroek-Hutten, M., Weinzerl, K., Wozniak, L., Yorgancioglu, A., Zavagli, V., Zurkuhlen, A. J., Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Department of Hydraulic and Environmental Engineering, University of Pavia, Department of Geriatrics - Efficiency and Deficiency Laboratory, Università degli Studi di Firenze [Firenze], Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), Mineralogisch-Petrographisches Institut (MPI), Mineralogisch-Petrographisches Institut, University of Coimbra [Portugal] (UC), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Laboratoire d'océanographie de Villefranche (LOV), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Istituto di Astrofisica Spaziale, Hôpital Lapeyronie [Montpellier] (CHU), Centre d’Expertise National des Technologies de l’Information et de la Communication pour l’autonomie - CENTICH (FRANCE), Center for Turbulence Research (CTR), Stanford University [Stanford], Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Station de Palavas, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de magnétisme et d'optique de Versailles (LMOV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Grenoble] (CHU), Epidemiology Unit, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Istituto Nazionale di Geofisica e Vulcanologia, Sezione di Palermo, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ethics, Law & Medical humanities, APH - Aging & Later Life, Bousquet, J, Illario, M, Farrell, J, Batey, N, Carriazo, A M, Malva, J, Hajjam, J, Colgan, E, Guldemond, N, Perälä-Heape, M, Onorato, G L, Bedbrook, A, Leonardini, L, Stroetman, V, Birov, S, Abreu, C, Abrunhosa, A, Agrimi, A, Alalääkkölä, T, Allegretti, N, Alonso-Trujillo, F, Álvarez-Benito, M, Angioli, S, Apóstolo, J, Armitage, G, Arnavielhe, S, Baena-ParejoI, M, Bamidis, P D, Balenović, A, Barbolini, M, Baroni, I, Blain, H, Bernard, P L, Bersani, M, Berti, E, Bogatyrchuk, L, Bourret, R, Brehm, J, Brussino, L, Buhr, D, Bultje, D, Cabeza, E, Cano, A, De Capitani, C, Carantoña, E, Cardoso, A, Coll Clavero, J I, Combe, B, Conforti, D, Coppola, L, Corti, F, Coscioni, E, Costa, E, Crooks, G, Cunha, A, Daien, C, Dantas, Null, Darpón Sierra, J, Davoli, M, Dedeu Baraldes, A, De Luca, V, De Nardi, L, Di Ciano, M, Dozet, A, Ekinci, B, Erve, S, Espinoza Almendro, J M, Fait, A, Fensli, R, Fernandez Nocelo, S, Gálvez-Daza, P, Gámez-Payá, J, García Sáez, M, Garcia Sanchez, I, Gemicioğlu, B, Goetzke, W, Goossens, E, Geurdens, M, Gütter, Z, Hansen, H, Hartman, S, Hegendörfer, G, Heikka, H, Henderson, D, Héran, D, Hirvonen, S, Iaccarino, G, Jansson, N, Kallasvaara, H, Kalyoncu, F, Kirchmayer, U, Kokko, J A, Korpelainen, J, Kostka, T, Kuna, P, Lajarín Ortega, T, Lama, C M, Laune, D, Lauri, D, Ledroit, V, Levato, G, Lewis, L, Liotta, G, Lundgren, L, Lupiañez-Villanueva, F, Mc Garry, P, Maggio, M, Manuel de Keenoy, E, Martinez, C, Martínez-Domene, M, Martínez-Lozano Aranaga, B, Massimilliano, M, Maurizio, A, Mayora, O, Melle, C, Mendez-Zorilla, A, Mengon, H, Mercier, G, Mercier, J, Meyer, I, Millet Pi-Figueras, A, Mitsias, P, Molloy, D W, Monti, R, Moro, M L, Muranko, H, Nalin, M, Nobili, A, Noguès, M, O'Caoimh, R, Pais, S, Papini, D, Parkkila, P, Pattichis, C, Pavlickova, A, Peiponen, A, Pereira, S, Pépin, J L, Piera Jiménez, J, Portheine, P, Potel, L, Pozzi, A C, Quiñonez, P, Ramirez Lauritsen, X, Ramos, M J, Rännäli-Kontturi, A, Risino, A, Robalo-Cordeiro, C, Rolla, G, Roller, R, Romano, M, Romano, V, Ruiz-Fernández, J, Saccavini, C, Sachinopoulou, A, Sánchez Rubio, M J, Santos, L, Scalvini, S, Scopetani, E, Smedberg, D, Solana-Lara, R, Sołtysik, B, Sorlini, M, Stericker, S, Stramba Badiale, M, Taillieu, I, Tervahauta, M, Teixeira, A, Tikanmäki, H, Todo-Bom, A, Tooley, A, Tuulonen, A, Tziraki, C, Ussai, S, Van der Veen, S, Venchiarutti, A, Verdoy-Berastegi, D, Verissimo, M, Visconti, L, Vollenbroek-Hutten, M, Weinzerl, K, Wozniak, L, Yorgancıoğlu, A, Zavagli, V, Zurkuhlen, A J, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Università degli Studi di Pavia = University of Pavia (UNIPV), Università degli Studi di Firenze = University of Florence (UniFI), Center for Turbulence Research [Stanford] (CTR), Stanford University, KYomed INNOV, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Active and healthy ageing, DG CONNECT, DG Santé, EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Allergic Rhinitis, Operational Definition, Program, Turkey, DG Sante, [SDV]Life Sciences [q-bio], Eip, Diseases, Articles, 03 medical and health sciences, 0302 clinical medicine, Synergies, 030228 respiratory system, Aha, Settore MED/42, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs.

7. Nmmlck: A Key Player In Intermittent Hypoxia-Induced Inflammatory Vascular Remodeling?

Author

Arnaud, C., Recoquillon, R., Bouyon, S., Cachot, S., Lemarié, E., Toral, M., M Carmen Martinez, Andriantsitohaina, R., Pepin, J. L., Stress Oxydant et Pathologies Métaboliques (SOPAM), and Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

12. Methodological issues in a cost-of-dementia study in Belgium: the NAtional Dementia Economic Study (NADES)

Author

Kurz, X., Broers, M., Scuvée-Moreau, J., Eric Salmon, Ventura, M., Pepin, J. L., Dom, R., Franck, G., and Dresse, A.

Subjects
Male, Psychological Tests, Cohort Studies, Belgium, Caregivers, Cost of Illness, Socioeconomic Factors, Quality of Life, Humans, Mass Screening, Dementia, Ethics, Medical, Female, Prospective Studies, Cognition Disorders, Algorithms, Aged
Abstract

The NAtional Dementia Economic Study (NADES) is an on-going prospective, one-year cohort study developed in Belgium to assess the socio-economic consequences of dementia in a group of patients and their caregivers (n = 400). Comparison is made with a group of subjects with cognitive impairment and no dementia (n = 100) and a group of subjects without any cognitive impairment (n = 100). Recruitment of subjects is based on screening of warning signs of dementia by general practitioners, followed by a Cambridge Mental Disorders of the Elderly Examination (CAMDEX) performed at home. This paper presents an overview of the study protocol and the rationale for basic design options, such as the choice of study population, screening strategy, and methods used for the case validation. It also presents preliminary results on the prevalence of dementia in general practice, the sensitivity and specificity of the warning signs as a screening test of dementia, and the validity of a computerised case ascertainment algorithm based on DSM-III-R criteria.

15. Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view

Author

Sonya Craig, Jean-Louis Pépin, Winfried Randerath, Christian Caussé, Johan Verbraecken, Jerryll Asin, Ferran Barbé, Maria R. Bonsignore, University of Liverpool, Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), University of Cologne, Bioprojet Pharma [Paris], Laboratoire Pharmaceutique Bioprojet Pharma [Paris], Antwerp University Hospital [Edegem] (UZA), University of Antwerp (UA), Università degli studi di Palermo - University of Palermo, Craig S., Pepin J.-L., Randerath W., Causse C., Verbraecken J., Asin J., Barbe F., and Bonsignore M.R.

Subjects
Pulmonary and Respiratory Medicine, Sleep Apnea, Obstructive, Sleepiness, Reproducibility of Results, Síndromes d'apnea del son, Disorders of Excessive Somnolence, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Epworth Sleepiness Scale, Obstructive sleep apnea, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, maintenance of wakefulness test, Humans, wake promoting agents, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, Wakefulness, Son--Pacients
Abstract

International audience; Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, with disorders such as insufficient sleep and depression commonly associated. Subjective EDS can be evaluated using the Epworth Sleepiness Scale, in which the patient reports the probability of dozing in certain situations; however, its reliability has been challenged. Objective tests such as the multiple sleep latency test or the maintenance of wakefulness test are not commonly used in patients with OSA, since they require nocturnal polysomnography, daytime testing and are expensive. Drugs for EDS are available in the United States but were discontinued in Europe some time ago. For European respiratory physicians, treatment of EDS with medication is new and they may lack experience in pharmacological treatment of EDS, while novel wake-promoting drugs have been recently developed and approved for clinical use in OSA patients in the USA and Europe. This review will discuss 1) the potential prognostic significance of EDS in OSA patients at diagnosis, 2) the prevalence and predictors of residual EDS in treated OSA patients, and 3) the evolution of therapy for EDS specifically for Europe.

Published
2022
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