1. The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the Cornea Donor Study
- Author
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Writing Committee for the Cornea Donor Study Research Group, Mannis, Mark J, Holland, Edward J, Gal, Robin L, Dontchev, Mariya, Kollman, Craig, Raghinaru, Dan, Dunn, Steven P, Schultze, Robert L, Verdier, David D, Lass, Jonathan H, Raber, Irving M, Sugar, Joel, Gorovoy, Mark S, Sugar, Alan, Stulting, R Doyle, Montoya, Monty M, Penta, Jeffrey G, Benetz, Beth Ann, and Beck, Roy W
- Subjects
Adult ,Male ,Aging ,Adolescent ,Clinical Trials and Supportive Activities ,Clinical Sciences ,Eye Banks ,Eye ,Ophthalmology & Optometry ,Writing Committee for the Cornea Donor Study Research Group ,Young Adult ,Penetrating ,Double-Blind Method ,Clinical Research ,Opthalmology and Optometry ,Humans ,Registries ,Prospective Studies ,Child ,Eye Disease and Disorders of Vision ,Aged ,Transplantation ,Fuchs' Endothelial Dystrophy ,Corneal Edema ,Graft Survival ,Age Factors ,Middle Aged ,Tissue Donors ,Keratoplasty ,Public Health and Health Services ,Female ,Follow-Up Studies - Abstract
ObjectiveTo determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.DesignMulticenter, prospective, double-masked clinical trial.ParticipantsA total of 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs' dystrophy (62%), pseudophakic/aphakic corneal edema (34%), or another corneal endothelial disorder (4%) and followed for up to 12 years.MethodsForty-three eye banks provided corneas from donors aged 12 to 75 years, using a randomized approach to assign donor corneas to study participants without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines.Main outcome measuresGraft failure defined as a regraft or, in the absence of a regraft, a cloudy cornea that was sufficiently opaque to compromise vision for 3 consecutive months.ResultsIn the primary analysis, the 10-year success rate was 77% for 707 corneas from donors aged 12 to 65 years compared with 71% for 383 donors aged 66 to 75 years (difference, +6%; 95% confidence interval, -1 to +12; P = 0.11). When analyzed as a continuous variable, higher donor age was associated with lower graft success beyond the first 5 years (P
- Published
- 2013