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In order to study the correlation between college students’ sports participation and mental health, this paper compiles a questionnaire based on the situation of college students’ sports participation, “activity and Meter comparison table” and “Chinese college students’ mental health scale”. Taking college students in Henan Province as the survey object, this paper studies the correlation between college students’ mental health and sports participation. It is found that the Pearson correlation coefficient between college students’ mental health and sports participation is 0.659. There are different degrees of correlation between college students’ sports participation and various factors of mental health. There are gender differences between male and female college students. College students who often participate in sports have better mental health.

Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of cancer. This model is based on the idea that CSCs are stem cells with disordered differentiation whose original purpose was to repair damaged tissues. Inflammatory responses and damage repair signals are crucial for the creation and maintenance of CSCs. Normal quiescent stem cells are activated by environmental stimulation, such as an inflammatory response, and undergo cell division and differentiation. In the initial stage of cancer development, stem cell differentiation leads to heteromorphism due to the accumulation of gene mutations, resulting in the development of metaplasia or precancerosis. In the second stage, accumulated mutations induce poor differentiation and lead to cancer development. The monophyletic model illustrates the evolution, biological behavior, and hallmarks of CSCs, proposes a concise understanding of the origin of cancer, and may encourage a novel therapeutic approach. Graphical Abstract

Diagram of crystal growth process for Cd0.95Mg0.05Te ingots. Three large Cd0.95Mg0.05Te ingots with diameter of 30 mm and length of more than 100 mm are successfully grown by the modified vertical Bridgman method under different excess Te conditions.

Compared to 1C towed-streamer (TS) seismic exploration, 4C ocean-bottom seismic (OBS) node exploration has great advantages in complex structure imaging, lithology, and fluid identification using elastic waves. However, sparse spatial sampling of OBS node surveys highlights the problems of the imaging acquisition footprint, poor phase continuity, and low signal-to-noise ratio (S/N) with conventional elastic reverse time migration (ERTM) methods. Therefore, a solution of joint ERTM (J-ERTM) is proposed by combining sparse OBS node data with dense TS data. In the J-ERTM of the hybrid data, a novel weighted boundary condition combined with acoustic-elastic coupling equations and a vector-based crosscorrelation imaging condition are presented to perform PP and PS imaging by receiver-side tensorial extrapolation of TS and OBS node hybrid data. A synthetic example demonstrates that our method can effectively process TS and OBS node hybrid data and improve elastic imaging problems caused by OBS node sparse acquisition. J-ERTM techniques also are applied to an active-source OBS data set from the South China Sea. To improve the imaging quality with limited data, some preprocessing procedures for field TS and OBS node hybrid data sets are necessary, such as denoising, OBS node relocation, OBS node orientation correction, OBS node calibration, and others. After preprocessing, the pressure component and velocity components have a more physical energy relationship, more consistent frequency range and wavelet, and a higher S/N. Finally, the preprocessed hybrid data can be used for J-ERTM. The imaging results demonstrate that our method works well with field data.

Dust aerosols affect the radiative and energy balance at local and global scales by scattering and absorbing sunlight and infrared light. A previous study suggests that dust size distribution is one of the major sources of uncertainty in modeling the dust global distribution. Climate models overestimate the fine dust (≤5 µm) by an order of magnitude, while underestimates of the coarse dust (≥5 µm) range between 0.5 to 1.5 orders of magnitude compared with the global observations. Here we improved the simulated size distribution of dust aerosol using a sectional aerosol model (Community Aerosol and Radiation Model for Atmospheres) coupled with the Community Earth System Model (CESM1/CARMA). Simulated dust mass size distributions peak at around 2–3 µm in diameter and increase by 4 orders of magnitude from 0.1 to 2 µm. Our model demonstrates that North African, Middle Eastern, and Asian dust accounts for ∼ 59.7 %, 12.5 %, and 13.3 % of the global annual mean dust emissions, with the remaining 14.5 % originating from scattered smaller dust sources. The model dust vertical distributions are validated against the NASA Atmospheric Tomography (ATom) field campaign datasets. Both simulations and ATom in situ measurements during the ATom field campaign suggest that dust mass concentrations over the remote ocean drop by 2 to 3 orders of magnitude from the surface to the upper troposphere (200 hPa). Our model suggests that Asian dust contributes to more than 40 % of annual mean dust mass abundances in the global upper troposphere and lower stratosphere (UTLS). The model suggests that Asian dust dominates the dust mass budget in the UTLS of the Asian summer monsoon (ASM) region, with a relative contribution 1–2 orders of magnitude higher than the dust originating from the North African and Middle Eastern deserts.

The skeleton of lucidumone was constructed through oxidative dearomatization/intramolecular Diels-Alder reaction, Cu-mediated remote C-H hydroxylation, allyl oxidation, acid-promoted dynamic kinetic resolution cyclization, and benzylic oxidation.

Infection caused by bacterial contamination is a critical problem challenging the successful use of medical implants in orthopaedic and dental applications. Consequently, medical implants with antibacterial abilities are in high demand. Tantalum and silver have been previously characterized to have excellent biocompatibility and antibacterial ability, but due to their significantly different properties, it is challenging to manufacture Ta-Ag components via thermal processing methods. Herein, by taking advantage of the unique characteristics of cold spray (CS) technology, an antibacterial Ta-Ag coating was successfully fabricated for the first time. In the CS process, blended Ta-Ag powders with different Ag concentrations were used to fabricate CS Ta-Ag coatings. Their antibacterial ability was preliminary tested and deposition behaviour was systematically investigated. The coating significantly reduced the metabolic activity of S. aureus bacteria, and a better deposition efficiency was obtained by blended Ta-Ag powder. It was found that soft Ag could aggregate in the coating and hard Ta particles were prone to rebound, which induced the peening effect for Ag and mass loss of Ta in the final coating Moreover, the clue of metallurgy bonding between Ta and Ag was detected in the region that experienced severe deformation despite their immiscibility.

Sulphate aerosol in the stratosphere recently became an interactive part of many global climate models and its uncertainties are not yet well constrained. Stratospheric sulphate aerosol is modulated by natural emissions of several sulphur-containing species, including volcanic eruptions, as well as anthropogenic emissions. If not directly injected into the stratosphere by large volcanic eruptions, sulphate aerosols and their precursors are transported into the stratosphere via the tropical tropopause. While there have been some model intercomparison activity for the large volcanic eruptions, the background conditions of sulphur species and in particular the stratospheric aerosol layer have thus far not been addressed at all. Evaluating the background conditions in global models allow to identify modelling issues that are usually masked by larger perturbations such as volcanic eruptions, yet may still be of importance after such a perturbation. Some key factors causing differences between models include different microphysical schemes, chemical schemes, as well as transport and cross-tropopause fluxes. In this work, we use 8 models and available observational data to quantify the full background atmospheric sulphur cycle (burdens, fluxes, and their variability) and investigate its uncertainties within the framework of the Interactive Stratospheric Aerosol Model Intercomparison Project (ISA-MIP). We focus on stratospheric aerosol and its transport with the Brewer-Dobson-Circulation, as well as the influence of the polar vortices. We find significant inter-model variations in the background burden of the major sulphur species. Seasonal cycles agree well in the southern hemisphere, whereas the northern hemisphere shows more inter-model differences due to the individual representations of the northern polar vortex.

Supervolcanic eruptions induced abrupt global cooling (roughly at a rate of ~1ºC/year lasting for years to decades), such as the prehistoric Yellowstone eruption released, by some estimates, SO2 about 100 times higher than the 1991 Mt. Pinatubo eruption. An abrupt global cooling of several ºC, even if only lasting a few years, would present immediate and drastic stress on biodiversity and food production - posing a global catastrophic risk to human society. Using a simple climate model, this paper discusses the possibility of counteracting supervolcanic cooling with the intentional release of greenhouse gases. Although well-known longer-lived compounds such as CO2 and CH₄ are found to be unsuitable for this purpose, select fluorinated gases (F-gases), either individually or in combinations, may be released at gigaton scale to offset most of the supervolcanic cooling. We identify candidate F-gases (viz. C4F6 and CH3F) and derive radiative and chemical properties of ‘ideal’ compounds matching specific cooling events. Geophysical constraints on manufacturing and stockpiling due to mineral availability are considered alongside technical and economic implications based on present-day market assumptions. The consequences of F-gas release in perturbing atmospheric chemistry are discussed in the context of those due to the supervolcanic eruption itself. The conceptual analysis here suggests the possibility of mitigating certain global catastrophic risks via intentional intervention.

We implemented the Community Aerosol and Radiation Model for Atmospheres (CARMA) in both the high and low-top model versions of the Community Earth System Model Version 2 (CESM2). CARMA is a sectional microphysical model, which we use for aerosol in both the troposphere and stratosphere. CARMA is fully coupled to chemistry, clouds, radiation, and transport routines in CESM2. This development enables the comparison of simulations with a sectional (CARMA) and a modal (MAM4) aerosol microphysical model in the same modeling framework. The new implementation of CARMA has been adopted from previous work with some additions that align with the current CESM2 MAM4 implementation. The main updates include an interactive secondary organic aerosol description in CARMA using the volatility basis set (VBS) approach, updated wet removal, and the use of transient emissions of aerosols and trace gases. In addition, we implemented an alternative aerosol nucleation scheme in CARMA, which is also used in MAM4. Detailed comparisons of stratospheric aerosol properties after the Mt Pinatubo eruption reveal the importance of prescribing sulfur injections in a larger region rather than in a single column to better represent the observed evolution of aerosols. Both CARMA and MAM4 in CESM2 are able to represent stratospheric and tropospheric aerosol properties reasonably well compared to observations. Several differences in the performance of the two aerosol models show, in general, an improved representation of aerosols using the sectional aerosol model in CESM2. These include a better representation of the aerosol size distribution after the Mt Pinatubo volcanic eruption in CARMA compared to MAM4. MAM4 produces on average smaller aerosols and less removal than CARMA, which results in a larger total mass. Both CARMA and MAM4 reproduce stratospheric Aerosol Optical Depth (AOD) within the errorbar of the observations between 2001 and 2020, except for recent larger volcanic eruptions that are overestimated by both model configurations. The CARMA background surface area density and aerosol size distribution in the stratosphere and troposphere compare well to observations, with some underestimation of the Aitken-mode size range. MAM4 shows shortcomings in reproducing coarse-mode aerosol distributions in the stratosphere and troposphere. This work outlines additional development needs for CESM2 CARMA to improve the model compared to observations in both the troposphere and stratosphere.

S1. Frequency of Pan-IN lesion types in KC versus KCC mice. S2. Re-expression of Ch25h in PDAC cell lines. S3. Presence of exogenous lipids diminishes effect of Ch25h re-expression in PDAC. S4. Re-expression of Ch25h does not affect Ras localization. S5. CH25H decreases autophagic flux in PDAC cells. S6. Ch25h slows PDAC tumor growth.

Supplementary Table 1: List of oligonucleotides used for qPCR

Cholesterol dependence is an essential characteristic of pancreatic ductal adenocarcinoma (PDAC). Cholesterol 25-hydroxylase (CH25H) catalyzes monooxygenation of cholesterol into 25-hydroxycholesterol, which is implicated in inhibiting cholesterol biosynthesis and in cholesterol depletion. Here, we show that, within PDAC cells, accumulation of cholesterol was facilitated by the loss of CH25H. Methylation of the CH25H gene and decreased levels of CH25H expression occurred in human pancreatic cancers and was associated with poor prognosis. Knockout of Ch25h in mice accelerated progression of Kras-driven pancreatic intraepithelial neoplasia. Conversely, restoration of CH25H expression in human and mouse PDAC cells decreased their viability under conditions of cholesterol deficit, and decelerated tumor growth in immune competent hosts. Mechanistically, the loss of CH25H promoted autophagy resulting in downregulation of MHC-I and decreased CD8+ T-cell tumor infiltration. Re-expression of CH25H in PDAC cells combined with immune checkpoint inhibitors notably inhibited tumor growth. We discuss additional benefits that PDAC cells might gain from inactivation of CH25H and the potential translational importance of these findings for therapeutic approaches to PDAC.Implications:Loss of CH25H by pancreatic cancer cells may stimulate tumor progression and interfere with immunotherapies.

This paper proposes a two-person multi-stage zero-sum game model considering the confrontation between cascading failures and control strategies in an AC/DC hybrid system to solve the blocking problem of DC systems caused by successive failures at the receiving end of an AC/DC system. A game model is established between an attacker (power grid failure) and a defender (dispatch side). From the attacker’s perspective, this study mainly investigates the problem of system line failures caused by AC or DC blockages. From the perspective of dispatch-side defense, the multiple-feed short-circuit ratio constraint method, output adjustment measures of the energy storage system, sensitivity control, and distance third-segment protection adjustment are used as strategies to reduce system losses. Using as many line return data as possible as samples, the deep Q-network (DQN), a deep reinforcement learning algorithm, is used to obtain the Nash equilibrium of the game model. The corresponding optimal dispatch and defense strategies are also obtained while obtaining the optimal sequence of tripping failures for AC/DC hybrid system cascading failures. Using the improved IEEE 39-node system as an example, the simulation results verify the appropriateness of the two-stage dynamic zero-sum game model to schedule online defense strategies and the effectiveness and superiority of the energy storage system participating in defense adjustment.

Background In gastric cancer, there is a controversial finding regarding the high recurrence rate after neoadjuvant therapy. The use of ctDNA detection for minimal residual disease (MRD) with plasma genotyping has shown higher sensitivity and specificity compared to imaging and serum markers for predicting recurrence. Therefore, we aim to investigate the perioperative dynamic changes in ctDNA in surgical II-III GS patients and assess the efficacy of neoadjuvant chemotherapy. Methods In detail, we will collect blood samples from each patient before neoadjuvant chemotherapy (NAC), after NAC, and one month after surgery. We will also collect tumor tissue before and after NAC. Gene mutations will be detected using a 733-gene NGS panel, and DNA concentrations will be measured. To evaluate the effectiveness of the treatment, we will use RECIST Version 1.1 (RECIST 1.1). Discussion This study aims to assess the correlation between perioperative changes in ctDNA levels and the response to chemotherapy in patients with gastric cancer. It will provide evidence that perioperative ctDNA detection may predict early recurrence, highlighting the potential clinical utility of ctDNA in guiding therapeutic decision-making. Compared to tumor tissue biopsy, ctDNA can non-invasively detect more comprehensive genomic information from a limited amount of plasma. Trial registration: Registered prospectively in the Chinese Clinical Trials Registry with registration number ChiCTR2200060842 on June 12st, 2022.

Background:Although inactivated COVID-19 vaccines are proven to be safe and effective in the general population, the dynamic response and duration of antibodies after vaccination in the real world should be further assessed.Methods:We enrolled 1067 volunteers who had been vaccinated with one or two doses of CoronaVac in Zhejiang Province, China. Another 90 healthy adults without previous vaccinations were recruited and vaccinated with three doses of CoronaVac, 28 days and 6 months apart. Serum samples were collected from multiple timepoints and analyzed for specific IgM/IgG and neutralizing antibodies (NAbs) for immunogenicity evaluation. Antibody responses to the Delta and Omicron variants were measured by pseudovirus-based neutralization tests.Results:Our results revealed that binding antibody IgM peaked 14–28 days after one dose of CoronaVac, while IgG and NAbs peaked approximately 1 month after the second dose then declined slightly over time. Antibody responses had waned by month 6 after vaccination and became undetectable in the majority of individuals at 12 months. Levels of NAbs to live SARS-CoV-2 were correlated with anti-SARS-CoV-2 IgG and NAbs to pseudovirus, but not IgM. Homologous booster around 6 months after primary vaccination activated anamnestic immunity and raised NAbs 25.5-fold. The neutralized fraction subsequently rose to 36.0% for Delta (p=0.03) and 4.3% for Omicron (p=0.004), and the response rate for Omicron rose from 7.9% (7/89)–17.8% (16/90).Conclusions:Two doses of CoronaVac vaccine resulted in limited protection over a short duration. The inactivated vaccine booster can reverse the decrease of antibody levels to prime strain, but it does not elicit potent neutralization against Omicron; therefore, the optimization of booster procedures is vital.Funding:Key Research and Development Program of Zhejiang Province; Key Program of Health Commission of Zhejiang Province/ Science Foundation of National Health Commission; Major Program of Zhejiang Municipal Natural Science Foundation; Explorer Program of Zhejiang Municipal Natural Science Foundation.

Background The incidence and mortality of gastric cancer ranks fifth and fourth worldwide among all malignancies, respectively. Accumulating evidences have revealed the close relationship between mitochondrial dysfunction and the initiation and progression of stomach cancer. However, rare prognostic models for mitochondrial-related gene risk have been built up in stomach cancer. Methods In current study, the expression and prognostic value of mitochondrial-related genes in stomach adenocarcinoma (STAD) patients were systematically analyzed to establish a mitochondrial-related risk model based on available TCGA and GEO databases. The tumor microenvironment (TME), immune cell infiltration, tumor mutation burden, and drug sensitivity of gastric adenocarcinoma patients were also investigated using R language, GraphPad Prism 8 and online databases. Results We established a mitochondrial-related risk prognostic model including NOX4, ALDH3A2, FKBP10 and MAOA and validated its predictive power. This risk model indicated that the immune cell infiltration in high-risk group was significantly different from that in the low-risk group. Besides, the risk score was closely related to TME signature genes and immune checkpoint molecules, suggesting that the immunosuppressive tumor microenvironment might lead to poor prognosis in high-risk groups. Moreover, TIDE analysis demonstrated that combined analysis of risk score and immune score, or stromal score, or microsatellite status could more effectively predict the benefit of immunotherapy in STAD patients with different stratifications. Finally, rapamycin, PD-0325901 and dasatinib were found to be more effective for patients in the high-risk group, whereas AZD7762, CEP-701 and methotrexate were predicted to be more effective for patients in the low-risk group. Conclusions Our results suggest that the mitochondrial-related risk model could be a reliable prognostic biomarker for personalized treatment of STAD patients.

Background Excessive oxidative stress plays a critical role in the progression of various diseases, including intervertebral disk degeneration (IVDD). Recent studies have found that anemonin (ANE) possesses antioxidant and anti-inflammatory effects. However, the role of ANE in IVDD is still unclear. Therefore, this study investigated the effect and mechanism of ANE on H2O2 induced degeneration of nucleus pulposus cells (NPCs). Methods NPCs were pretreated with ANE, and then treated with H2O2. NOX4 was upregulated by transfection of pcDNA-NOX4 into NPCs. Cytotoxicity was detected by MTT, oxidative stress-related indicators and inflammatory factors were measured by ELISA, mRNA expression was assessed by RT-PCR, and protein expression was tested by western blot. Results ANE attenuated H2O2-induced inhibition of NPCs activity. H2O2 enhanced oxidative stress, namely, increased ROS and MDA levels and decreased SOD level. However, these were suppressed and pretreated by ANE. ANE treatment repressed the expression of inflammatory factors (IL-6, IL-1β and TNF-α) in H2O2-induced NPCs. ANE treatment also prevented the degradation of extracellular matrix induced by H2O2, showing the downregulation of MMP-3, 13 and ADAMTS-4, 5 and the upregulation of collagen II. NOX4 is a key factor regulating oxidative stress. Our study confirmed that ANE could restrain NOX4 and p-NF-κB. In addition, overexpression of NOX4 counteracted the antioxidant and anti-inflammatory activities of ANE in H2O2-induced NPCs, and the inhibition of the degradation of extracellular matrix induced by ANE was also reversed by overexpression of NOX4. Conclusion ANE repressed oxidative stress, inflammation and extracellular matrix degradation in H2O2-induced NPCs by inhibiting NOX4/NF-κB pathway. Our study indicated that ANE might be a candidate drug for the treatment of IVDD.

Evasion of antitumor immunity and resistance to therapies in solid tumors are aided by an immunosuppressive tumor microenvironment (TME). We found that TME factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IFNAR1 on CD8

The restart process of waxy crude pipelines is an unsteady thermo-hydraulic coupling process, which mainly includes two modes of the constant flow and constant pressure in industry. However, some parameters involved in the restart process have obvious uncertainties, such as the operating parameters, physical parameters of crude oil, environmental parameters, and pipeline parameters, resulting in the traditional deterministic method that cannot scientifically describe the safety of the pipeline restart process. To do this, this study introduces the reliability-based limit state method and interference principle into the safety evaluation of waxy crude pipelines during the restart process. Considering the random fluctuation characteristics of the mentioned parameters, the restart physical process, the flow and heat transfer mathematical model, and the restart failure limit state function were established. On this basis, the failure probability during the restart process for one waxy crude pipeline under constant flow was determined. This research has realized the quantitative evaluation of restart safety of waxy crude pipelines.

Background: Currently, there is a lack of effective strategy for the prevention of peritoneal metastasis(PM) from locally advanced gastric cancer (AGC). This randomized controlled study aimed to evaluate the outcome of D2 radical resection with hyperthermic intraperitoneal chemotherapy (HIPEC) plus systemic chemotherapy versus systemic chemotherapy alone in locally AGC patients. Methods: All patients enrolled were randomly assigned to receive HIPEC plus systemic chemotherapy (HIPEC group) or systemic chemotherapy alone (non-HIPEC group) after radical gastrectomy. HIPEC was performed intraperitoneally with cisplatin (40 mg/m2) within 72h after surgery, while systemic chemotherapy based on SOX regimen (S-1 combined with oxaliplatin) was administered 4-6 weeks after radical surgery. Patterns of recurrence, adverse events, 3-year disease-free survival (DFS) and overall survival (OS) were analyzed. Results: A total of 134 patients were enrolled in the present study. The 3-year DFS rate was 73.8% in the HIPEC group, which was significantly higher than that in the non-HIPEC group (61.2%, P=0.031). The 3-year OS rate was 73.9% in the HIPEC group and 77.6% in the non-HIPEC group, with no significant difference (P = 0.737). PM was the most common distant metastasis in both groups. The occurrence rate of PM in the HIPEC group was statistically lower than that in the non-HIPEC group (20.9% vs. 40.3%, P=0.015). Grade 3 or 4 adverse events were occurred in 19 (14.2%) patients, and there was no statistic difference between the two groups. Conclusion: Radical surgery followed by HIPEC combined with systemic chemotherapy is a safe and feasible strategy for locally AGC patients and could effectively improve the DFS and reduce the occurrence of PM. However, more prospective randomized studies with a large sample size are warranted. Trial registration: This study was registered with www.medresman.org.cn as ChiCTR2200055966 on 30/01/2022.