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Background: In the Montreal classification, L4 Crohn’s disease (CD) is defined as an ileal disease, including L4-esophagogastric duodenum (EGD), L4-jejunum, and L4-proximal ileal involvement. According to the previous studies, the prognosis of L4 disease was worse than that of non-L4 disease. Among L4 diseases, the phenotypes of L4-jejunum and L4-proximal ileum indicated that the risk of abdominal surgery was higher. However, the prognosis of L4-esophagogastroduodenal remains largely elusive. Therefore, we aim to investigate whether the prognosis differs between CD patients with and without esophagogastroduodenal involvement.Methods: In this study, patients with L4-EGD phenotype (n = 74) who underwent gastroscopy, ileocolonoscopy, biopsies, and CTE from 2018 to 2020 were compared with L4 non-EGD controls (n = 148) who were randomly selected at a ratio of 1:2 in the same period. Demographic information inclusive of disease conduct and location, important points of the surgery, and hospitalization have been collected. The distinction between L4-EGD patients and non-L4-EGD patients was identified by way of multivariable logistic regression analysis. The Kaplan–Meier technique was used to consider the possibility of abdominal surgical operation and complications, observed by means of Cox percentage hazard fashions to decide if L4 EGD independently estimated the endpoints inclusive of the abdominal surgery and the occurrences of complications.Results: L4-EGD group (n = 74) had a lower proportion of intestinal fistula than the control group (n = 148) (17.6% versus 34.5%; p = 0.009), and the probabilities of requiring abdominal surgery and multiple abdominal surgeries were also lower (21.6% versus 36.5%; p = 0.025), (6.8% versus 18.9%; p = 0.016), respectively. The frequency of hospitalization was lower in the L4-EGD group than in the control group (3-7 versus 4–9; p = 0.013). L4-EGD phenotype was found to be an independent protective factor for abdominal surgery and intestinal fistula in the Cox regression model, with HRs of 0.536 (95%CI: 0.305–0.940; p = 0.030) and 0.478 (95%CI: 0.259–0.881; p = 0.018), respectively.Conclusion: Our data suggest that the L4-EGD phenotype may have a better prognosis compared to the Non-L4-EGD phenotype. Our data may advocate a revision of the Montreal classification including separate designations for L4-EGD disease.

The tiny neutrino masses can be explained naturally by extending the standard model with right-handed Majorana neutrinos in a low-scale seesaw mechanism, and the CP violation effect induced by the Majorana phase is interesting and worth studying at colliders. In this paper, we investigate the prospects for measuring CP violation in top quark pair production and rare decay via Majorana neutrinos at the LHC. The CP asymmetry stems from the significant interference of contributions from two different Majorana neutrinos and can be appreciable when the two neutrino masses are nearly degenerate. It is found that in the Majorana neutrino mass range of 10 GeV

Melastomataceae have abundant morphological diversity with high economic and ornamental merit in Myrtales. The phylogenetic position of Myrtales is still contested. Here, we report the first chromosome-level genome assembly of Melastoma dodecandrum in Melastomataceae. The assembled genome size was 299.81 Mb with a contig N50 value of 3.00 Mb. Genome evolution analysis indicated that M. dodecandrum, Eucalyptus grandis and Punica granatum were clustered into a clade of Myrtales and formed a sister group with the ancestor of fabids and malvids. We found that M. dodecandrum experienced four whole-genome polyploidization events: the ancient event was shared with most eudicots, one event was shared with Myrtales, and the other two events were unique to M. dodecandrum. Moreover, we identified MADS-box genes and found that the AP1-like genes expanded, and AP3-like genes might have undergone subfunctionalization. We found that the SUAR63-like genes and AG-like genes showed different expression patterns in stamens, which may be associated with heteranthery. In addition, we found that LAZY1-like genes were involved in the negative regulation of stem branching development, which may be related to its creeping features. Our study sheds new light on the evolution of Melastomataceae and Myrtales, which provides a comprehensive genetic resource for future research.

The direct observation of the Yukawa interaction related to Standard Model Higgs and the bottom quark is obtained from the $h\to b\bar{b}$ process recently. The b-tagging becomes an important tool to search for new heavy resonance production at LHC. We use the b-tagging method to investigate the neutral Higgs production in association with a bottom quark pair, and perform the detector simulation for the signal process with the Higgs decaying into $b\bar{b}$ or $\tau^+\tau^-$ together with the dominant backgrounds. Our results show that $b\bar{b}b\bar{b}$ and $b\bar{b}\tau^+\tau^-$ processes will play an important role to search for the exotic heavy Higgs production at LHC and future hadron colliders., Comment: 21 pages, 12 figures

WC-10Co-4Cr cermet coatings were deposited on low carbon steel using the HVOF technique, then heat treated by different process (300 °C × 3 hours, 400 °C × 3 hours, and 500 °C × 3 hours). The influences of heat treatment on microhardness, elasticity modulus of coatings were studied by nanoindentation method in this paper. The results show that the microhardness increased with the heat-treated temperature increasing, but the tendency of elasticity modulus was opposite. In the case of 500 °C × 3 hours heat-treated coating, the microhardness increased by approximately 30% and elasticity modulus decreased by approximately 15% in comparison with that of as-sprayed coating.

WC-10Co-4Cr cermet coatings were deposited on Inconel 718 alloy using the HVOF technique, then were heat treated by isothermal treatment (500°C, 3hours). The influences of isothermal heat treatment on micro-hardness, fracture toughness and abrasive wear resistance of WC coating were studied in this paper. The results show that the micro-hardness and fracture toughness of WC coating decrease after isothermal heat treatment, then the metallic blinder breaks up and the tungsten carbide particles pull out during abrasive wear test. Finally, it was concluded that the abrasive wear resistance of WC-10Co-4Cr coating decreased after isothermal heat treatment (500°C, 3hours).

A study was conducted to investigate the contribution of β-cyanoalanine synthase (CAS) to the botanical metabolism of free cyanide and iron cyanides. Seedlings of rice (Oryza sativa L. cv. XZX 45) were grown hydroponically and then amended with free cyanide (KCN) or ferri-cyanide [K(3)Fe(CN)(6)] into the growth media. Total cyanide, free cyanide, and Fe(3+)/Fe(2+) in aqueous solution were analyzed to identify the speciation of K(3)Fe(CN)(6). Activity of CAS in different parts of the rice seedlings was also assayed in vivo and results indicated that dissociation of K(3)Fe(CN)(6) to free cyanide in solution was negligible. Almost all of the applied KCN was removed by rice seedlings and the metabolic rates were concentration dependent. Phyto-transport of K(3)Fe(CN)(6) was apparent, but appreciable amounts of cyanide were recovered in plant tissues. The metabolic rates of K(3)Fe(CN)(6) were also positively correlated to the concentrations supplied. Rice seedlings exposed to KCN showed a considerable increase in the CAS activity and roots had higher CAS activity than shoots, indicating that CAS plays an important role in the botanical assimilation of KCN. However, no measurable change of CAS activity in different parts of rice seedlings exposed to K(3)Fe(CN)(6) was detected, suggesting that K(3)Fe(CN)(6) is likely metabolized by rice directly through an unknown pathway rather than the β-cyanoalanine pathway.

The centrosymmetric title complex, [Cu(C3H4N2)6]Cl2·4H2O, has a distorted octa­hedral coordination geometry. There is extensive hydrogen bonding involving the cations, anions and water mol­ecules.