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We examine the parameter space region of the inverse seesaw model that is consistent with neutrino oscillation data. We focus on the correlation between the current limits from the search of the $\mu\to e\gamma$ lepton flavour violating decay and the non-standard effects associated with the presence of new heavy neutrino states. Unlike what we would expect from an inverse seesaw model, we have found a parametrization for the mass matrices in which the rates of charged lepton flavour-violating processes are negligible. Additionally, we provide a model where the inverse seesaw is obtained naturally, and the mass matrices get this structure with negligible violation of the lepton flavour., Comment: 20 pages, 3 figures and 3 tables

Este artigo tem como objetivo apresentar as possibilidades administrativas e pedagógicas na utilização de um sistema informatizado na gestão escolar com foco na inclusão do aluno com necessidade especial. Nesse sentido, a Secretaria de Estado de Educação e Desporto (SEDUC/AM) desenvolveu e implantou o Sistema Integrado de Gestão Educacional do Amazonas (Sigeam), que traz, dentre outros serviços, um módulo chamado Especial. Esse módulo é composto de serviços e relatórios gerenciais que têm por finalidade subsidiar a gestão escolar e a macrogestão da SEDUC/AM, nas tomadas de decisão sobre o público-alvo da educação especial. É importante destacar que o interesse neste tema surgiu a partir de formações ministradas por esta pesquisadora aos gestores escolares, nas quais foram constatadas que estes, não só, não tinham acesso a todos os serviços deste módulo, como sequer conheciam, na íntegra, aqueles aos quais tinham acesso. Assim sendo, considerando esses fatores como condicionantes para o pleno uso do sistema, pondera-se que não basta ter um sistema informatizado, como também é fundamental que se conheçam as possibilidades administrativas e pedagógicas a ele pertinentes, além de possibilitar acesso pleno aos gestores. No que concerne à pesquisa, utilizou-se metodologia de natureza qualitativa exploratória e descritiva, sendo embasada por estudos bibliográficos da temática educação especial, no uso das NTICs e das possibilidades advindas da utilização de sistemas. Destarte, os achados dessa pesquisa trouxeram informações que podem possibilitar à SEDUC/AM ser mais assertiva nas políticas implementadas na área da educação inclusiva. Palavras-chave: educação especial; Sigeam; gestão escolar.

Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEEP < 10, (II) PaO2/FiO2 ≥ 150 at PEEP ≥ 10, (III) PaO2/FiO2 < 150 at PEEP < 10, and (IV) PaO2/FiO2 < 150 at PEEP ≥ 10. Primary outcome was death in the ICU. Results: ICU mortalities were similar in the testing and confirmatory cohorts (375/1000, 37.5% vs. 112/303, 37.0%, respectively). At baseline, most patients from the testing cohort (n = 792/1000, 79.2%) had a PaO2/FiO2 < 150, with similar mortality among the four subsets (p = 0.23). When assessed at 24 h, ICU mortality increased with an advance in the subset: 17.9%, 22.8%, 40.0%, and 49.3% (p < 0.0001). The findings were replicated in the confirmatory cohort (p < 0.0001). However, independent of the PEEP levels, patients with PaO2/FiO2 < 150 at 24 h followed a distinct 30-day ICU survival compared with patients with PaO2/FiO2 ≥ 150 (hazard ratio 2.8, 95% CI 2.2–3.5, p < 0.0001). Conclusions: Subsets based on PaO2/FiO2 thresholds of 150 mm Hg assessed after 24 h of moderate/severe ARDS diagnosis are clinically relevant for establishing prognosis, and are helpful for selecting adjunctive therapies for hypoxemia and for enrolling patients into therapeutic trials.

We present a realistic, simple and natural model of strongly-interacting dark matter based on the neutrino-portal paradigm. The strong interactions at small velocities are generated by the exchange of dark photons, and produce the observed core-like DM distribution in galactic centers; this effect could be spoiled by the formation of DM bound states (also due to dark-photon effects), which we avoid by requiring the DM candidates to be light, with masses below O(10 GeV). The mixing of the dark photon with the Z and ordinary photon is strongly suppressed by introducing a softly-broken discrete symmetry similar to charge conjugation, which also ensures that the dark photon life-time is short enough to avoid restrictions derived form big-bang nucleosynthesis and large-scale structure formation. Other constraints are accommodated without the need of fine tuning, in particular nucleon scattering occurs only at one loop, so direct detection cross sections are naturally suppressed. Neutrino masses are generated through the inverse see saw., Comment: 23 pages, 13 figures

Objectives: Incomplete or ambiguous evidence for identifying high-risk patients with acute respiratory distress syndrome for enrollment into randomized controlled trials has come at the cost of an unreasonable number of negative trials. We examined a set of selected variables early in acute respiratory distress syndrome to determine accurate prognostic predictors for selecting high-risk patients for randomized controlled trials. Design: A training and testing study using a secondary analysis of data from four prospective, multicenter, observational studies. Setting: A network of multidisciplinary ICUs. Patients: We studied 1,200 patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. Interventions: None. Measurements and Main Results: We evaluated different thresholds for patient's age, Pao 2 /Fio 2, plateau pressure, and number of extrapulmonary organ failures to predict ICU outcome at 24 hours of acute respiratory distress syndrome diagnosis. We generated 1,000 random scenarios as training (n = 900, 75% of population) and testing (n = 300, 25% of population) datasets and averaged the logistic coefficients for each scenario. Thresholds for age (< 50, 50-70, > 70 yr), Pao 2 /Fio 2 (= 100, 101-150, > 150 mm Hg), plateau pressure (< 29, 29-30, > 30 cm H2O), and number of extrapulmonary organ failure (< 2, 2, > 2) stratified accurately acute respiratory distress syndrome patients into categories of risk. The model that included all four variables proved best to identify patients with the highest or lowest risk of death (area under the receiver operating characteristic curve, 0.86; 95% CI, 0.84-0.88). Decision tree analyses confirmed the accuracy and robustness of this enrichment model. Conclusions: Combined thresholds for patient's age, Pao 2 / Fio 2, plateau pressure, and extrapulmonary organ failure provides prognostic enrichment accuracy for stratifying and selecting acute respiratory distress syndrome patients for randomized controlled trials.

Sentiment analysis has recently gained popularity in the financial domain thanks to its capability to predict the stock market based on the wisdom of the crowds. Nevertheless, current sentiment indicators are still silos that cannot be combined to get better insight about the mood of different communities. In this article we propose a Linked Data approach for modelling sentiment and emotions about financial entities. We aim at integrating sentiment information from different communities or providers, and complements existing initiatives such as FIBO. The ap- proach has been validated in the semantic annotation of tweets of several stocks in the Spanish stock market, including its sentiment information.

We propose a realistic A4 extension of the Standard Model involving a particular quark-lepton mass relation, namely that the ratio of the third family mass to the geometric mean of the first and second family masses are equal for down-type quarks and charged leptons. This relation, which is approximately renormalization group invariant, is usually regarded as arising from the Georgi-Jarlskog relations, but in the present model there is no unification group or supersymmetry. In the neutrino sector we propose a simple modification of the so called Zee-Wolfenstein mass matrix pattern which allows an acceptable reactor angle along with a deviation of the atmospheric and solar angles from their bi-maximal values. Quark masses, mixing angles and CP violation are well described by a numerical fit., Comment: 9 pages, 3 figures, version published in Phys. Lett. B

These are the proceedings of the 2nd Workshop on Flavor Symmetries and Consequences in Accelerators and Cosmology, held 30 June 2012 - 4 July 2012, Dortmund, Germany., Comment: Order 400 pages, several figures including the group picture v2: corrected author list and contribution

Recently T2K gives hint in favor of large reactor angle. Most of the models, with tri-bimaximal mixing at the leading order, can not reproduce such a large mixing angle since they predict typically corrections for the reactor angle of the order of the Cabibbo angle. In this letter, we discuss the possibility to have large reactor angle within the T2K region with maximal atmospheric mixing angle and trimaximal solar mixing angle, through the deviation from tri-bimaximal. We derive the structure of neutrino mass matrix that leads to the large reactor angle leaving maximal atmospheric angle and trimaximal solar angle. It is shown that such a structure of neutrino mass matrix can arise in a model with S4 flavor symmetry., Comment: 7 pages, 2 figures, some references added and text improved

We study a model based on the dihedral group D4 in which the dark matter is stabilized by the interplay between a remnant Z2 symmetry, of the same spontaneously broken non-abelian group, and an auxiliary Z2 introduced to eliminate unwanted couplings in the scalar potential. In the lepton sector the model is compatible with normal hierarchy only and predicts a vanishing reactor mixing angle. Since m1=0, we also have a simple prediction for the effective mass in terms of the solar angle. There also exists a large portion of the model parameter space where the upper bounds on lepton flavor violating processes are not violated. We incorporate quarks in the same scheme finding that a description of the CKM mixing matrix is possible and that semileptonic K and D decays mediated by flavour changing neutral currents are under control., Comment: 12 pages, model slightly modified adding one scalar field. Neutrino phenomenology unchanged, quark mixings in much better agreement with the data

Hematocrits of 131 cerebral infarction cases were correlated with the outcome at 2 weeks. Bivariate analysis showed that cases with more intense admission deficit had lower admission hematocrit and that cases with poorer outcome had lower Day 2 and 4 hematocrits. However, multivariate analysis of several prognostic factors (including hematocrit, glycemia, blood pressure, age, and sex) showed that hematocrit was not independently related to outcome. Higher hematocrit thus is not indicative of less favorable short-term outcome.

Coherent elastic neutrino-nucleus scattering (CE$\nu$NS) is a process in which neutrinos scatter on a nucleus which acts as a single particle. Though the total cross section is large by neutrino standards, CE$\nu$NS has long proven difficult to detect, since the deposited energy into the nucleus is $\sim$ keV. In 2017, the COHERENT collaboration announced the detection of CE$\nu$NS using a stopped-pion source with CsI detectors, followed up the detection of CE$\nu$NS using an Ar target. The detection of CE$\nu$NS has spawned a flurry of activities in high-energy physics, inspiring new constraints on beyond the Standard Model (BSM) physics, and new experimental methods. The CE$\nu$NS process has important implications for not only high-energy physics, but also astrophysics, nuclear physics, and beyond. This whitepaper discusses the scientific importance of CE$\nu$NS, highlighting how present experiments such as COHERENT are informing theory, and also how future experiments will provide a wealth of information across the aforementioned fields of physics., Comment: contribution to Snowmasss 2021. Contact authors: P. S. Barbeau, R. Strauss, L. E. Strigari

In the light of the recent Daya Bay result the reactor angle is about 9 degrees, we reconsider the model presented in arXiv:1005.3482 showing that, when all neutrino oscillation parameters are taken at their best fit values of Schwetz et al and the reactor angle to be the central value of Daya Bay, the predicted value of the CP phase is approximately 45 degrees.

We present an extension of the Standard Model (SM) based on the discrete flavor symmetry S3 which gives a neutrino mass matrix with two-zero texture of Fritzsch-type and nearly diagonal charged lepton mass matrix. The model is compatible with the normal hierarchy only and predicts the sine squared of the reactor angle to be 0.01 at the best fit values of solar and atmospheric parameters and maximal leptonic CP violation., Comment: 14 pages and 3 figures. Final version to appear in J. Phys G