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Background:. Intracerebral hemorrhage (ICH) is one of the most severe complications during veno-venous extracorporeal membrane oxygenation (VV-ECMO). This study aimed to determine the risk factors for ICH and mortality in such patients. Methods:. We analyzed the clinical data of 77 patients who received VV-ECMO due to severe respiratory failure from July 2013 to May 2019 at China-Japan Friendship Hospital. Demographical data, laboratory indices, imaging characteristics, and other clinical information were collected. Multivariable logistic regression analyses were performed to identify risk factors for ICH and mortality. Results:. Of 77 patients, 11 (14.3%) suffered from ICH, and 36 (46.8%) survived. The survival rate was significantly lower (18.2% [2/11] vs. 51.5% [34/66], P = 0.040) in patients with ICH than in those without ICH. Multivariable analysis revealed that factors independently associated with ICH were diabetes mellitus (adjusted odds ratio [aOR]: 12.848, 95% confidence interval [CI]: 1.129–146.188, P = 0.040) and minimum fibrinogen during ECMO (aOR: 2.557, 95% CI: 1.244–5.252, P = 0.011). Multivariable analysis showed that factors independently associated with mortality were acute hepatic failure during ECMO (aOR: 9.205, 95% CI: 1.375–61.604, P = 0.022), CO2 retention before ECMO (aOR: 7.602, 95% CI: 1.514–38.188, P = 0.014), and minimum platelet concentration during ECMO (aOR: 0.130, 95% CI: 0.029–0.577, P = 0.007). Conclusions:. Diabetes mellitus and minimum fibrinogen concentration during ECMO are risk factors for ICH in patients with severe respiratory failure managed using VV-ECMO. This indicated that anticoagulants use and nervous system monitoring should be performed more carefully in patients with diabetes when treated with VV-ECMO due to severe respiratory failure.

To observe the long-term safety and performance of Nurotron cochlear implant system. To analyze the auditory and speech rehabilitation characteristic of pediatric deafened patients after cochlear implantation.To analyze 3 years results of pediatric deafened patients with Nurotron® Venus™ cochlear implants. From April to June 2011, sixty deaf children received domestic cochlear implant. All subjects were switched on after 3 to 4 weeks of surgery, and were assessed the auditory rehabilitation on 3 months, 12 months, 24 months and 36 months after switching on. To evaluate the rehabilitation results by Aided Hearing Thresholds, AuditoryVerbal Ability Test and IT-MAIS Questionnaire. Meanwhile, the safety and performance of cochlear implant system were followed-up. Before surgery, all the recipients in this study were 12 to 71 months of age with the average hearing threshold higher than 90 dBHL.Sixty cases of deaf children were implanted successfully. All the recipients used their devices every day, and all of their devices worked well. No complication or side effect related to implantation were found. The sound field aided hearing thresholds, vowels, consonants, monosyllabic words and two-syllable words test, as well as Ling's test, and IT-MAIS Questionnaire of all recipients were improved significantly with prolonged use of CI device. The results of grammatical competence, understanding, communication and presentation skills tests also get significantly promotion in 3 years follow up.With prolonged use of CI device, the hearing and language tests of children recipients could obtain significantly improvement. The Nurotron® Venus™ CI system works safely and effectively.