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If the neutrino has a large magnetic moment, then a phase effect may appear in its spin-flavor precession inside the supernova. It differs from the ordinary flavor oscillation phase effect in two aspects: It can develop even if there is only one partially adiabatic resonance and it effects a large part of the neutrino energy spectrum. We examine the spin-flavor precession phase effect both analytically and numerically for the Majorana neutrinos in a core collapse supernova. Our analytical approach is based on the assumption that spin-flavor precession and Mikheev-Smirnov-Wolfenstein resonances are completely decoupled. Where this decoupling assumption fails, we present only numerical results. We show that the sensitive phase dependence of the survival probabilities can be treated as an uncertainty which smears the final neutrino energy spectra to be observed at Earth., Comment: 16 pages, 9 figures

We consider the many-body system of neutrinos interacting with each other through neutral current weak force. Emerging many-body effects in such a system could play important roles in some astrophysical sites such as the core collapse supernovae. In the literature this many-body system is usually treated within the mean field approximation which is an effective one-body description based on omitting entangled neutrino states. In this paper, we consider the original many-body system in an effective two flavor mixing scenario under the single angle approximation and present a solution without using the mean field approximation. Our solution is formulated around a special class of many-body eigenstates which do not undergo any level crossings as the neutrino self-interaction rate decreases while the neutrinos radiate from the supernova. In particular, an initial state which consists of electron neutrinos and antineutrinos of an orthogonal flavor can be entirely decomposed in terms of those eigenstates. Assuming that the conditions are perfectly adiabatic so that the evolution of these eigenstates follow their variation with the interaction rate, we show that this initial state develops a spectral split at exactly the same energy predicted by the mean field formulation.

Introduction: Colchicine is the mainstay for the treatment of FMF, which is an auto-inflammatory disease mainly with relapsing polyserositis. Despite daily doses of 2 mg ormore each day, approximately 5% to 10% of the patients continue to suffer from its attacks. In this study, we aimed to investigate the depression and attack features in patients withFMF who have colchicine resistance (CR).Patients e Methods: CR was defined for FMF patients with 2 or more attacks within the last6 months period while using 2 mg/day colchicine. Eighteen patients (9 Female/9 Male) wereenrolled into the CR group and 41 patients were enrolled into the control group (12 Male/29Female). Demographic, clinical e laboratory findings, treatment adherence, and the BeckDepression Inventory (BDI) scores were evaluated. Results: The age of onset of FMF was significantly lower in the CR group (12.3 yrs vs. 16.9 yrs, P = 0.03). Disease duration was longer in the CR group (P = 0.01). Abdominal and leg pain dueto exercise were significantly more frequent in the CR group versus controls (83% vs. 51%;P = 0.02 e 88% vs. 60%; P = 0.04, respectively). Patients with BDI scores over 17 points weremore frequent in the CR group compared to controls (50% vs. 34.1%; P < 0.001).Discussion: We found that: (1) the age of disease onset was lower and (2) the disease durationwas longer in CR group. Pleuritic attacks, hematuria e proteinuria were more frequent in CRpatients. We propose that depression is an important factor to consider in the susceptibilityto CR. © 2014 Elsevier Editora Ltda.

We study the effects of collective neutrino oscillations on $��p$ process nucleosynthesis in proton-rich neutrino-driven winds by including both the multi-angle $3\times3$ flavor mixing and the nucleosynthesis network calculation. The number flux of energetic electron antineutrinos is raised by collective neutrino oscillations in a $1$D supernova model for $40 M_{\odot}$ progenitor. When the gas temperature decreases down to $\sim2-3\times10^{9}$ K, the increased flux of electron antineutrinos promotes $��p$ process more actively, resulting in the enhancement of $p$-nuclei. In the early phase of neutrino-driven wind, blowing at $0.6$ s after core bounce, oscillation effects are prominent in inverted mass hierarchy and $p$-nuclei are synthesized up to $^{106}\mathrm{Cd}$ and $^{108}\mathrm{Cd}$. On the other hand, in the later wind trajectory at $1.1$ s after core bounce, abundances of $p$-nuclei are increased remarkably by $\sim10-10^{4}$ times in normal mass hierarchy and even reaching heavier $p$-nuclei such as $^{124}\mathrm{Xe}$, $^{126}\mathrm{Xe}$ and $^{130}\mathrm{Ba}$. The averaged overproduction factor of $p$-nuclei is dominated by the later wind trajectories. Our results demonstrate that collective neutrino oscillations can strongly influence $��p$ process, which indicates that they should be included in the network calculations in order to obtain precise abundances of $p$-nuclei. The conclusions of this paper depend on the difference of initial neutrino parameters between electron and non-electron antineutrino flavors which is large in our case. Further systematic studies on input neutrino physics and wind trajectories are necessary to draw a robust conclusion. However, this finding would help understand the origin of solar-system isotopic abundances of $p$-nuclei such as $^{92,94}\mathrm{Mo}$ and $^{96,98}\mathrm{Ru}$., 15 pages, 8 figures, accepted for publication in Phys.Rev.D

Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey. This study aimed to provide an overview of TURKBIO data collected by June 2018. Methods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), nonradiographic axial spondyloarthritis (nr-AxSpA), and psoriatic arthritis (PsA). Demographic and clinical features, disease activity markers, and other follow-up parameters, current and previous treatments, and adverse events were registered electronically at each visit using open-source software. The registration of patient-reported outcome measures was carried out electronically by the patients using touch screens. Results: TURKBIO registry included a total of 41,145 treatment series with biologicals. There were 2,588 patients with axSpA (2,459 AS and 129 nr-axSpA), 2,036 with RA, and 428 with PsA. The total number of patients, including those with other diagnoses, was 5,718. In the follow-up period, the number of patients and also visits steadily increased by years. The yearly mean number of visits per patient was found to be 2.3. Significant improvements in disease activity and health assessment parameters were observed following the biological treatments. Biologics were often given in combination with a conventional synthetic disease-modifying antirheumatic drug in patients with RA. Infections were the most commonly seen adverse events, followed by allergic reactions. Tuberculosis was observed in 12 patients, malignancy in 18, and treatment-related mortality in 31. Conclusion: TURKBIO provided a valuable real-life experience with the use of biologics in rheumatic diseases in Turkey