1. Modulation of skin androgenesis and sebum production by a dermocosmetic formulation
- Author
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Samara Eberlin, Elisete Isabel Crocco, Michelle Sabrina da Silva, Paula Voltarelli Franco Avelar, Gustavo Henrique da Silva, Ana Lucia Tabarini Alves Pinheiro, Evellin Barbosa Bonifácio, and Gustavo Facchini
- Subjects
Sebaceous gland ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Dermatology ,Sebaceous Glands ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Acne Vulgaris ,medicine ,Humans ,Oil Red O ,Acne ,Testosterone ,Skin ,Chemistry ,Insulin ,Androgen ,medicine.disease ,Sebum ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Dihydrotestosterone ,Androgens ,Intracellular ,medicine.drug - Abstract
Background Excessive androgenesis in the skin promotes sebaceous hyperproduction which is the onset of acne vulgaris pathogenesis. Free fatty acids and lipid accumulation in the glandular infundibulum culminates in microbiota imbalance, triggering inflammatory response and follicular hyperkeratinization. Aims The purpose of this work was to present an alternative cosmetic treatment for acne skin care, focusing on the prevention of sebaceous gland dysregulation. Methods Insulin-stimulated human sebocytes were treated with noncytotoxic concentrations of a DTRW cosmetic formulation. After 6 days of incubation, cell lysates were collected for testosterone, 5α-reductase, and dyhidrotestosterone (DHT) quantitation. In parallel, cells were stained with Oil Red O to measure sebum production. Results Human sebocytes were incubated with insulin to mimic a seborrheic microenvironment with overproduction of intracellular lipids and fatty acids. Concomitant incubation of cell cultures with DRTW was able to promote a 52.97% reduction in intracellular lipid content. The anti-androgenic properties of DRTW had been proved by the reductions of testosterone (↓59.90%), 5α reductase (↓59.34%), and DHT (↓55.98%) levels in sebocyte cultures also stimulated with insulin. Conclusion The results indicate a promising action of DRTW cosmetic formulation in preventing the development of acne lesions by mechanisms involving the modulation of cutaneous androgenesis and consequently the control of sebum overproduction, considered one of the leading causes of acne.
- Published
- 2020