36 results on '"Patrizia Ferrero"'
Search Results
2. ATXN2 intermediate repeat expansions influence the clinical phenotype in frontotemporal dementia
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Innocenzo Rainero, Marina Ferrone, Cecilia Mancini, Annalisa Gai, Milena Zucca, Alessandro Vacca, Silvia Boschi, Maria Teresa Giordana, Elisa Rubino, Flora Govone, Stefano Bianca, Lorenzo Pinessi, Laura Orsi, Patrizia Ferrero, and Alfredo Brusco more...
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0301 basic medicine ,Oncology ,Male ,Aging ,medicine.medical_specialty ,Locus (genetics) ,Disease ,Frontotemporal lobar degeneration ,03 medical and health sciences ,SCA2 ,0302 clinical medicine ,Intermediate expansions ,Risk Factors ,Internal medicine ,mental disorders ,medicine ,Humans ,Amyotrophic lateral sclerosis ,Clinical phenotype ,Genetic Association Studies ,Aged ,Ataxin-2 ,Neuroscience (all) ,polyQ repeats ,business.industry ,General Neuroscience ,Parkinsonism ,ATXN2 ,Neurology (clinical) ,Developmental Biology ,Geriatrics and Gerontology ,medicine.disease ,Phenotype ,nervous system diseases ,030104 developmental biology ,Frontotemporal Dementia ,Female ,business ,Trinucleotide Repeat Expansion ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
Common genetic risk factors are associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Intermediate repeat expansions at the Ataxin-2 locus (ATXN2) are a risk factor for ALS and influence the phenotype. We assessed whether ATXN2 is a risk factor for FTD or modify clinical features in a data set of Italian patients. Three hundred sixty-eight unrelated FTD cases and 342 controls were enrolled. The frequency of intermediate CAG repeats in ATXN2 gene was not different comparing patients and controls. CAG repeats were interrupted by CAA in all patients carrying intermediate repeats. Interestingly, patients with an increased number of CAG repeats had an earlier onset of the disease than those without expansions (p = 0.011), and presented more frequently with parkinsonism (p = 0.010), and psychotic symptoms (p = 0.013) at disease onset. Our study does not support a major role of ATXN2 intermediate CAG expansions in predisposing to FTD but suggests that ATXN2 may act as a phenotype modifier. more...
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- 2018
Catalog
3. Late onset bipolar disorder and frontotemporal dementia with mutation in progranulin gene: a case report
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Patrizia Ferrero, Flora Govone, Elisa Rubino, Annalisa Gai, Milena Zucca, Alessandro Vacca, Innocenzo Rainero, Salvatore Gallone, P Fenoglio, and Maria Teresa Giordana
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Male ,medicine.medical_specialty ,Pediatrics ,Neurology ,Bipolar Disorder ,Bipolar disorder type 1 ,Late onset ,medicine.disease_cause ,behavioral disciplines and activities ,Polymorphism, Single Nucleotide ,Late Onset Disorders ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Progranulins ,mental disorders ,medicine ,Mood state ,Humans ,Genetic Predisposition to Disease ,Bipolar disorder ,Amyotrophic lateral sclerosis ,Psychiatry ,Gene ,Aged ,Mutation ,Bipolar disorder type 1, frontotemporal dementia, progranulin gene, Neurology, Neurology (clinical) ,medicine.disease ,nervous system diseases ,030227 psychiatry ,progranulin gene ,Frontotemporal Dementia ,Intercellular Signaling Peptides and Proteins ,Neurology (clinical) ,Psychology ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
Bipolar disorder is a chronic psychiatric illness characterised by fluctuation in mood state, with a relapsing and remitting course. Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous syndrome, with the most frequent phenotype being behavioural variant frontotemporal dementia (bvFTD). Here, we report the case of an Italian male presenting with late-onset bipolar disorder that developed into bvFTD over time, carrying a mutation in the GRN gene. Interestingly, the patient carried the c.1639 C T variant in the GRN gene, resulting in a R547C substitution. Our case report further corroborates the notion that, in addition to FTD, progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations. more...
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- 2017
4. Standardized Semi-Quantitative Evaluation of [123I]FP-CIT SPECT in a Multicenter Study
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Gabriela Mariam Delgado Yabar, Baldassarre O. Elia, Paola Filippi, Michela Zotta, Francesca Dazzara, Giancarlo Castellano, Maurizio Zibetti, Riccardo Emanuele Pellerito, Matteo Manfredi, Andrea Skanjeti, Marco Iudicello, Valerio Podio, and Patrizia Ferrero more...
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Patient population ,Qualitative analysis ,Multicenter study ,123I-FP-CIT ,business.industry ,Multicenter trial ,Area under the curve ,Medicine ,Mean age ,General Medicine ,business ,Nuclear medicine ,Semi quantitative - Abstract
To the best of our knowledge no multicenter studies have been published using standardized semi-quantitative evaluation of [123I]FP-CIT scan (DAT-SPECT). The aims of this study were: 1) to cross-compare semi-quantitative software-assisted evaluations of DAT-SPECTs performed in three centers with different equipments; 2) to assess the accuracy of semi-quantitative evaluations of DAT-SPECT and 3) to identify the threshold with the best accuracy, sensitivity and specificity in a patient population with suspected parkinsonian syndrome. Materials and Methods: Two hundred twenty patients (mean age at the time of SPECT acquisition, 67.4 ± 9.5 yy) acquired in three centers (Ospedale San Luigi Gonzaga; Ospedale San Giovanni Battista Molinette; Ospedale Mauriziano Umberto I) were included. All of them underwent DAT-SPECT from January 2006 to July 2010. All exams were analyzed with the freely available software BASGAN and semi-quantitative data were used to predict disease. In particular, analyses were based on the values from the most deteriorated putamen and caudate, normalized for age and corrected for equipment. ROC analysis was performed and area under the curve (AUC) was estimated. Results: Analysis showed high AUCs (0.898, 0.864, 0.900 and 0.891 for each center and for the multicenter setting, respectively) confirming the very good accuracies reached. The best cut-off were 0.72 and 0.82 for putamen and caudate respectively. These thresholds allowed sensitivities and specificities in each center and in the multicenter setting of 76% and 96%, 91% and 82%, 93% and 90%, 86% and 89% respectively. No significant differences were observed between sensibility and specificity in each center. Conclusion: A unique threshold useful for all centers with high and similar sensitivities and specificities is possible after correction for age and equipments. The high accuracy reached in this multicenter trial by the semi-quantitative analysis seems similar to accuracies from qualitative analysis in other multicenter studies. more...
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- 2013
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5. Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review
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Anna Montuschi, Alessia Pellerino, Patrizia Ferrero, Maria Teresa Giordana, Andrea Naldi, and Silvia Grifoni
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medicine.medical_specialty ,Neurology ,ALS ,FTLD ,genetics ,neuropathology ,neuropsychology ,Behavioral Symptoms ,Dermatology ,Neuropathology ,Disease ,Neuroimaging ,medicine ,Humans ,Dementia ,Amyotrophic lateral sclerosis ,Amyotrophic Lateral Sclerosis ,Neuropsychology ,Cognition ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Neurology (clinical) ,Cognition Disorders ,Psychology ,Neuroscience - Abstract
Amyotrophic lateral sclerosis (ALS) is generally considered to be a paradigm of pure motor neuron disorder; nevertheless, the possible occurrence of cognitive impairment up to a frank dementia in patients affected by ALS is recognized. The appraisal of the cognitive impairment in ALS patients is crucial not only to the therapeutic trials of this incurable disease, but also to the planning of care, compliance to interventions, the end-of-life decisions. The cognitive/behavioral changes of ALS patients are consistent with frontotemporal dysfunctions; the overlap of neuropathological features of ALS and frontotemporal lobe degeneration (FTLD) supports, in addition, the putative spectrum of ALS and FTD. In the present review, the pertinent clinical, genetic, neuropathological, neuropsychological and neuroimaging data of the literature are comprehensively and critically discussed. The distinct and overlapping features of ALS and FTD are pointed out, as well as the undisclosed questions deserving additional studies. more...
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- 2010
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6. Contents Vol. 27, 2009
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Carlo Caltagirone, Ladson Hinton, M. Quintana, Brynjar Fure, Björn Hultberg, S. de Sola, Walter Valfrè, Elisa Rubino, Ronald E. Gangnon, Massimo Musicco, Mary N. Haan, Giuseppina D’Amico, Giuseppe Gambina, Jane E. Mahoney, Leiv Sandvik, Laurel A. Beckett, Douglas Hinerfeld, Serena Mosti, Jørgen Wagle, Peter St George-Hyslop, Lorenzo Pinessi, Brynhild Stensrød, G. Sánchez-Benavides, Patrizia Ferrero, Yan Li, Salvatore Gallone, Carey E. Gleason, Richard J. Caselli, Giuseppe Moretto, Yolanda Hagar, J. Peña-Casanova, Denisa Baci, Giovanna Vaula, L Ulizzi, Stephen P. Baker, Ekaterina Rogaeva, Renato Scacchi, Giorgetta Cappa, Karin Nilsson, Barbara L. Fischer, Lars Gustafson, Keith A. Josephs, Ping-Yiu Yik, Eugenia Rota, Knut Engedal, R.M. Manero, Bradley F. Boeve, Barbara A. Evans, Leung-Wing Chu, S. Quiñones-Úbeda, Rosa Maria Corbo, Torgeir Bruun Wyller, Luca Cravello, Zhong Li, Preben Bo Mortensen, Concetta Di Lorenzo, Innocenzo Rainero, Alexander Kurz, Lars Vedel Kessing, James E. Evans, Katie Palmer, Majaz Moonis, Kevin J. Kane, Thien Kieu Thi Phung, Kjell Flekkøy, Kristin L. Eiklid, Brendan J. Kelley, Hector M. González, Giovanna Salamone, Joan M. Swearer, You-Qiang Song, Horst Bickel, Nancy West, Gunhild Waldemar, Daniel A. Pollen, P Fenoglio, Federica Lupo, Lasse Farner, Birgitte Bo Andersen, and Dan M Mungas more...
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Psychiatry and Mental health ,Cognitive Neuroscience ,Geriatrics and Gerontology - Published
- 2009
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7. Absence of TARDBP Gene Mutations in an Italian Series of Patients with Frontotemporal Lobar Degeneration
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Maria Grazia Maniaci, Michela Zotta, Elisa Rubino, Silvia Grifoni, Innocenzo Rainero, Maria Teresa Giordana, Silvia Peletto, Elio Scarpini, Pier Luigi Acutis, Patrizia Ferrero, P Fenoglio, Lorenzo Pinessi, Eliana Venturelli, Daniela Galimberti, and Salvatore Gallone more...
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Genetics ,Mutation ,Pathology ,medicine.medical_specialty ,Cognitive Neuroscience ,Binding protein ,TAR DNA-Binding Protein 43 ,Frontotemporal lobar degeneration ,Gene mutation ,Biology ,medicine.disease_cause ,medicine.disease ,Psychiatry and Mental health ,Degenerative disease ,Polymorphism (computer science) ,medicine ,Dementia ,Geriatrics and Gerontology - Abstract
Background/Aim: Recent studies showed that TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a major pathological protein in both sporadic and familial frontotemporal lobar degeneration (FTLD). The aim of this study was to search for mutations of the TARDBP gene in the disease. Methods: We sequenced the TARDBP gene in 172 unrelated FTLD patients recruited from 2 Italian memory clinics. Results: We identified 3 different variants of the TARDBP gene in 12 FTLD patients. Three patients showed a silent variant, Ala66Ala (c.332T → C) in exon 2. A novel heterozygous mutation was found in intron 4 (c.543 + 51A → G) in 1 patient, which is not located at the splicing site. Finally, a c.208C → T variant in the 3′ untranslated region was detected in 8 probands. None of the aforementioned variants were predicted to affect TDP-43. Hence, pathogenic mutations were not identified in any of the FTLD cases. Conclusion: Our study, in accord with previous studies in different populations, found no evidence for a major genetic role of the TARDBP gene in FTLD. more...
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- 2009
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8. Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients
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Eugenia Rota, Bruno Bergamasco, Graziella Bellone, Paola Rocca, Giorgio Emanuelli, and Patrizia Ferrero
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Dermatology ,Transforming Growth Factor beta1 ,Pathogenesis ,Interferon-gamma ,Cerebrospinal fluid ,Alzheimer Disease ,Predictive Value of Tests ,Transforming Growth Factor beta ,Normal pressure hydrocephalus ,Internal medicine ,medicine ,Humans ,Dementia ,Vascular dementia ,Aged ,Cerebrospinal Fluid ,business.industry ,Dementia, Vascular ,Brain ,Interleukin ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,Interleukin-12 ,Hydrocephalus, Normal Pressure ,Interleukin-10 ,Up-Regulation ,Psychiatry and Mental health ,Interleukin 10 ,Cytokine ,Endocrinology ,Disease Progression ,Encephalitis ,Female ,Neurology (clinical) ,business ,Biomarkers - Abstract
An inflammatory response has been hypothesised to be involved in the pathogenesis of primary dementias, above all Alzheimer's disease (AD). This study was aimed at evaluating interleukin (IL)-12 and a panel of related cytokine levels in paired CSF and sera of demented patients. IL-12 (p70 heterodimer and total IL-12 p40 chain), interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta1 levels were measured in 30 patients with probable Alzheimer's disease (PrAD), 57 patients with other dementing disorders, including probable vascular dementia (PrVD), Parkinson's disease (PD) and normal pressure hydrocephalus (NPH), and 25 cognitively normal control subjects. In the presence of unchanged concentrations of IL-12, IFN-gamma and IL-10, the mean CSF level of TGF-beta1 and the correspondent TGF-beta1 index, but not the serum level, were significantly increased in PrAD compared to controls and PrVD, whereas no difference was found vs. NPH and PD. Our results support the pathophysiological role of TGF-beta1 system in AD. more...
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- 2006
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9. A case of multiple sclerosis with pure, massive superficial demyelination
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Laura Orsi, Orso Bugiani, Giorgio Giaccone, Patrizia Ferrero, and Fabrizio Tagliavini
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Cerebral Cortex ,Male ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,business.industry ,Multiple sclerosis ,Middle Aged ,Spinal cord ,medicine.disease ,White matter ,Myelin ,Fatal Outcome ,medicine.anatomical_structure ,Spinal Cord ,Cortex (anatomy) ,medicine ,Spastic ,Humans ,Neurology (clinical) ,Neurologic disease ,business ,Paraplegia ,Myelin Sheath - Abstract
Although multiple sclerosis (MS) has been classically regarded as a primarily white matter disorder, recent histopathologic studies have shown that the gray matter may be also heavily affected. Subpial demyelination appears as large bands of myelin loss extending from the surface of the cortex into its deeper layers.1 In vivo this change can only be visualized by ultra-high-fields MRI.2 We describe a patient presenting a neurologic disease that rapidly led to spastic paraplegia and death. Plaques of demyelination were absent in the white matter of the brain, but the neuropathologic diagnosis was MS, based on severe and widespread loss of myelin in the spinal cord. Extensive subpial demyelination involved the … more...
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- 2012
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10. Guidelines for the diagnosis of dementia and Alzheimer's disease
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Nicola Pugliese, Laura Bracco, Alessandro Padovani, Vincenzo Mascia, Francesco Valluzzi, Francesco Iemolo, Sandro Sorbi, Roberto Gallassi, Giorgio Giaccone, Pasquale Alfieri, Andrea Stracciari, Graziella D'Achille, Francesco Redi, Gabriella Marcon, M. Gasparini, S. Latorraca, Rudolf Schoenuber, Rosa Maria Ruggieri, Gilberto Pizzolato, Roberta Pantieri, Bruno Bergamasco, Bernardino Ghetti, Massimo Musicco, Antonio Daniele, Carlo Piccolini, Antonietta Citterio, Patrizia Ferrero, Antonio Carolei, Michela Morbin, Serena Amici, Guido Gainotti, Silvia Piacentini, Lucilla Parnetti, Biancamaria Guarnieri, Orso Bugiani, Vito Toso, Serenella Grioli, Margherita Alberoni, E. Farina, Stefano Grottoli, Antonella Bartoli, Claudio Mariani, Federico Piccoli, Ildebrando Appollonio, Emanuela Galante, Paolo Gabriele, Bruno Passerella, Simonetta Mearelli, Luigi Grimaldi, Luciana Ciannella, Maria Caterina Silveri, Stefano Avanzi, Maria Morante, Carla Pettenati, Amalia C. Bruni, Daniele Durante, Carlo Caltagirone, Giuseppe Sorrentino, Anna De Rosa, Marco Paganini, Ettore Nardelli, Paolo Forleo, Massimo Tabaton, Francesco Le Pira, Marco Saetta, Pietro Parisen, Gian Luigi Lenzi, Leandro Provinciali, Paolo Frigio Nichelli, Sebastiano Lorusso, Patrizia Sucapane, Grazia Dell'Agnello, Giuseppe Del Curatolo, Daniele Antana, Fabrizio Tagliavini, Umberto Ruggiero, Paolo Caffarra, Floriano Girotti, Virgilio Gallai, Sorbi, S, Alberoni, M, Alfieri, P, Amici, S, Antana, D, Appollonio, I, Avanzi, S, Bartoli, A, Bergamasco, B, Bracco, L, Bruni, A, Bugiani, O, Caffarra, P, Caltagirone, C, Carolei, A, Rosa, A, Ciannella, L, Citterio, A, Daniele, A, D'Achille, G, Del Curatolo, G, Dell'Agnello, G, Durante, D, Farina, E, Ferrero, P, Forleo, P, Gainotti, G, Gabriele, P, Galante, E, Gallai, V, Gallassi, R, Gasparini, M, Ghetti, B, Giaccone, G, Girotti, F, Grimaldi, L, Grioli, S, Guarnieri, B, Grottoli, S, Iemolo, F, Latorraca, S, Le Pira, F, Lenzi, G, Lorusso, S, Mariani, C, Marcon, G, Mascia, V, Mearelli, S, Morante, M, Morbin, M, Musicco, M, Nardelli, E, Nichelli, P, Padovani, A, Paganini, M, Pantieri, R, Parisen, P, Parnetti, L, Passerella, B, Pettenati, C, Piacentini, S, Piccoli, F, Piccolini, C, Pizzolato, G, Provinciali, L, Pugliese, N, Redi, F, Ruggieri, R, Ruggiero, U, Saetta, M, Schoenuber, R, Silveri, M, Sorrentino, G, Sucapane, P, Stracciari, A, Tabaton, M, Tagliavini, F, Toso, V, and Valluzzi, F more...
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MED/26 - NEUROLOGIA ,Psychiatry and Mental health ,media_common.quotation_subject ,Neurology (clinical) ,Dermatology ,General Medicine ,Art ,MED/09 - MEDICINA INTERNA ,M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA ,Humanities ,Guideline, dementia, Alzheimer's disease, diagnosis ,media_common - Abstract
SIN DOCUMENT*The Dementia Study Group is co-ordinated by Sandro Sorbi andincludes: Margherita Alberoni, Milan; Pasquale Alfieri, SommaVesuviana (NA); Serena Amici, Perugia; Daniele Antana, Rome;Ildebrando Appollonio, Monza (MI); Stefano Avanzi,Castelgoffredo (MN); Antonella Bartoli, Pescara; BrunoBergamasco, Turin; Laura Bracco, Florence; Amalia Bruni,Lamezia Terme (CZ); Orso Bugiani, Milan; Paolo Caffarra, Parma;Carlo Caltagirone, Rome; Antonio Carolei, L’Aquila; Anna RosaCasini, Rome; Luciana Ciannella, Benevento; Antonietta Citterio,Pavia; Antonio Daniele, Rome; Graziella D’Achille, Isernia;Giuseppe Del Curatolo, Grosseto; Grazia Dell’Agnello, Pisa;Daniele Durante, Parma; Elisabetta Farina, Milan; Patrizia Ferrero,Turin; Paolo Forleo, Florence; Guido Gainotti, Rome; PaoloGabriele, Cassino (FR); Emanuela Galante, Castelgoffredo (MN);Virgilio Gallai, Perugia; Roberto Gallassi, Bologna; MaddalenaGasparini, Milan; Bernardino Ghetti, Indianapolis (USA); GiorgioGiaccone, Milan; Floriano Girotti, Milan; Luigi Grimaldi, Milanand Caltanisetta; Serenella Grioli, Catania; Bianca MariaGuarnieri, Pescara; Stefano Grottoli, Fossombrone (PS); FrancescoIemolo, Ragusa; Stefania Latorraca, Florence; Francesco Le Pira,Catania; Gian Luigi Lenzi, Rome; Sebastiano Lorusso, Rimini;Claudio Mariani, Milan; Gabriella Marcon, Udine; VincenzoMascia, Carbonia (CA); Simonetta Mearelli, L’Aquila; MariaMorante, Senigallia (AN); Michela Morbin, Milan; MassimoMusicco, Segrate (MI); Ettore Nardelli, Verona; Paolo Nichelli,Modena; Alessandro Padovani, Brescia; Marco Paganini, Florence;Roberta Pantieri, Bologna; Pietro Parisen, Vicenza; LucillaParnetti, Perugia; Bruno Passerella, Brindisi; Carla Pettenati, Rho(MI); Silvia Piacentini, Florence; Federico Piccoli, Palermo; CarloPiccolini, Perugia; Gilberto Pizzolato, Padova; LeandroProvinciali, Ancona; Nicola Pugliese, Salerno; Francesco Redi,Arezzo; Rosa Maria Ruggieri, Palermo; Umberto Ruggiero,Naples; Marco Saetta, Siracusa; Rudolf Schoenuber, Bolzano;Maria Caterina Silveri, Rome; Sandro Sorbi, Florence; GiuseppeSorrentino, Naples; Patrizia Sucapane, L’Aquila; Andrea Stracciari,Bologna; Massimo Tabaton, Genova; Fabrizio Tagliavini, Milan;Vito Toso, Vicenza; Francesco Valluzzi, Putignano Noci (BA)S. Sorbi ( )Department of Neurological and Psychiatric SciencesUniversity of FlorenceViale Morgagni 85, I-50131 Florence, Italy more...
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- 2000
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11. Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder
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Carola Eva, Filippo Bogetto, A.M. Beoni, Paola Rocca, Giuseppe Maina, Patrizia Ferrero, and Luigi Ravizza
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Adult ,Male ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Transcription, Genetic ,medicine.drug_class ,Lymphocyte ,behavioral disciplines and activities ,Obsessive compulsive ,Internal medicine ,mental disorders ,Gene expression ,medicine ,Humans ,Pharmacology (medical) ,Lymphocytes ,RNA, Messenger ,Receptor ,Biological Psychiatry ,Pharmacology ,Analysis of Variance ,Messenger RNA ,Benzodiazepine ,business.industry ,Isoquinolines ,Receptors, GABA-A ,humanities ,Peripheral ,Psychiatry and Mental health ,medicine.anatomical_structure ,Endocrinology ,Neurology ,Immunology ,Female ,Neurology (clinical) ,Analysis of variance ,business - Abstract
The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients (n=8) as compared to controls (n=10), whereas no significant changes were observed in episodic OCD patients (n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD. more...
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- 2000
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12. Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients
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Carola Eva, A.M. Beoni, Luigi Ravizza, Patrizia Ferrero, Paola Rocca, and E. Zanalda
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Adult ,Male ,medicine.medical_specialty ,Generalized anxiety disorder ,medicine.drug_class ,Lymphocyte ,Nordazepam ,Polymerase Chain Reaction ,Peripheral blood mononuclear cell ,Benzodiazepines ,Internal medicine ,medicine ,Humans ,Lymphocytes ,RNA, Messenger ,Receptor ,Biological Psychiatry ,Benzodiazepine ,Messenger RNA ,business.industry ,Middle Aged ,Receptors, GABA-A ,medicine.disease ,Anxiety Disorders ,Endocrinology ,medicine.anatomical_structure ,Anti-Anxiety Agents ,Anxiety ,Female ,medicine.symptom ,business ,Anxiety disorder ,Follow-Up Studies - Abstract
Background: The aim of this study was to assess whether the decrease of peripheral benzodiazepine receptor (pBR) number in peripheral blood mononuclear cells (PBMC), previously observed in patients with generalized anxiety disorder, is paralleled by changes in the relative content of messenger RNA (mRNA) encoding pBR. Methods: Eight patients with a DSM-III-R diagnosis of generalized anxiety disorder were examined before, during, and after 2′-chloro-N-desmethyl-diazepam treatment. Eight healthy subjects were analyzed in parallel. The relative content of pBR mRNA was determined by reverse-transcriptase-polymerase chain reaction, using β -actin as internal standard. Kinetic binding properties of pBR were measured using 3 H-PK11195 as a ligand. Results: pBR and pBR mRNA were significantly decreased in untreated generalized anxiety disorder patients as compared to controls (by 45% and 70%, respectively). Both pBR density and mRNA levels returned to control values during treatment or after withdrawal, which also coincided with recovery from anxiety. Conclusions: These results suggest that the turnover rate of pBR is reduced in PBMC of generalized anxiety disorder patients, and that this change occurs at the transcriptional level. more...
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- 1998
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13. Spatially-resolved dust properties of the GRB 980425 host galaxy
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Darach Watson, S. D. Vergani, Stefano Covino, Dong Xu, Silvia Piranomonte, Maarten Baes, J. Juul Rasmussen, Gianfranco Gentile, Andrea Rossi, Eliana Palazzi, Michał J. Michałowski, A. de Ugarte Postigo, Valerio D'Elia, S. Berta, Nial R. Tanvir, E. Le Floc'h, Diego Götz, Patrizia Ferrero, D. Malesani, Leslie K. Hunt, Jesper Sollerman, P. van der Werf, Jens Hjorth, D. Burlon, Sandra Savaglio, Simone Bianchi, J. M. Castro Cerón, D. Le Borgne, M. P. Koprowski, S. Basa, Tara Murphy, Jean-Gabriel Cuby, Elena Pian, Ghent University [Belgium] (UGENT), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), European Project: 322307,EC:FP7:PEOPLE,FP7-PEOPLE-2012-CIG,HETRANSIENTS(2012), Universiteit Gent = Ghent University [Belgium] (UGENT), Astrophysics, Astronomy and Astrophysics Research Group, Universiteit Gent = Ghent University (UGENT), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) more...
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HERSCHEL REFERENCE SURVEY ,submillimeter: galaxies ,galaxies: individual: ESO 184-G82 ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,Stellar population ,MASS-METALLICITY RELATION ,Metallicity ,Astrophysics::High Energy Astrophysical Phenomena ,individual: ESO 184-G82 [galaxies] ,galaxies [submillimeter] ,gamma-ray burst: individual: 980425 ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,GAMMA-RAY BURST ,CORE-COLLAPSE SUPERNOVAE ,COMPACT DWARF GALAXIES ,STAR-FORMING GALAXIES ,Astrophysics::Solar and Stellar Astrophysics ,NEARBY GALAXIES ,Astrophysics::Galaxy Astrophysics ,SPITZER-SPACE-TELESCOPE ,Dwarf galaxy ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,GRB 980425 ,ISM [galaxies] ,extinction ,Star formation ,Astronomy and Astrophysics ,Atacama Large Millimeter Array ,Galaxy ,SPECTRAL ENERGY-DISTRIBUTION ,Physics and Astronomy ,13. Climate action ,Space and Planetary Science ,galaxies: star formation ,individual: 980425 [gamma-ray burst] ,LARGE-MAGELLANIC-CLOUD ,dust, extinction ,dust ,Astrophysics::Earth and Planetary Astrophysics ,star formation [galaxies] ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Gamma-ray burst ,galaxies: ISM ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Gamma-ray bursts (GRBs) have been proposed as a tool for studying star formation in the Universe, so it is crucial to investigate whether their host galaxies and immediate environments are in any way special compared with other star-forming galaxies. Here we present spatially resolved maps of dust emission of the host galaxy of the closest known GRB 980425 at z=0.0085 using our new high-resolution observations from Herschel, Atacama Pathfinder Experiment (APEX), Atacama Large Millimeter Array (ALMA) and Australia Telescope Compact Array (ATCA). We modelled the spectral energy distributions of the host and of the star-forming region displaying the Wolf-Rayet signatures in the spectrum (WR region), located 800 pc from the GRB position. The host is characterised by low dust content and a high fraction of UV-visible star formation, similar to other dwarf galaxies. These galaxies are abundant in the local universe, so it is not surprising to find a GRB in one of them, assuming the correspondence between the GRB rate and star formation. The WR region contributes substantially to the host emission at the far-infrared, millimetre, and radio wavelengths and we propose that this is a consequence of its high gas density. If dense environments are also found close to the positions of other GRBs, then the ISM density should also be considered, along with metallicity, an important factor influencing whether a given stellar population can produce a GRB., Comment: Accepted by A&A. 14 pages, 7 figures, 2 tables. V2: minor updates to match the published version more...
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- 2013
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14. An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis
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Patrizia Ferrero, Paola Rocca, Paolo Benna, E. Montalenti, Bruno Bergamasco, C. De Leo, and Luigi Ravizza
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Adult ,medicine.medical_specialty ,Multiple Sclerosis ,Peripheral type ,Neurology ,GABAA receptor ,business.industry ,General Neuroscience ,Multiple sclerosis ,Cell Membrane ,Pharmacology ,Isoquinolines ,Receptors, GABA-A ,medicine.disease ,Peripheral blood mononuclear cell ,Monocytes ,Kinetics ,Drug withdrawal ,Steroid therapy ,medicine ,Humans ,Steroids ,Neurology (clinical) ,Receptor ,business - Abstract
We report here a study of peripheral type benzodiazepine receptors (pBZr) in mononuclear cells (MNC) from blood of patients with multiple sclerosis (MS) during periods of stable and active disease and from normal controls. Most active MS patients were retested in a longitudinal study, both during a treatment with high dose steroids and while medication free. Active MS produces a significant decrease of receptor density compared with the controls whereas remission of the disease shows no effect. Four weeks of steroid treatment restore binding density to normal levels, and two weeks of drug withdrawal result in a small, but significant increase in number of the binding sites compared with the control value. We suggest that the number of pBZr in blood MNC might change during the clinical course and steroid therapy of MS. more...
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- 1992
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15. Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degeneration
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Patrizia Ferrero, P Fenoglio, Walter Valfrè, Giuseppina D’Amico, Denisa Baci, Elisa Rubino, Innocenzo Rainero, Giorgetta Cappa, Giovanna Vaula, Salvatore Gallone, Eugenia Rota, and Lorenzo Pinessi
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Male ,Pathology ,medicine.medical_specialty ,Genotype ,Cognitive Neuroscience ,medicine.medical_treatment ,Frontotemporal lobar degeneration ,Polymorphism, Single Nucleotide ,Pathogenesis ,Interleukin-1 alpha ,Apolipoproteins E ,Polymorphism (computer science) ,medicine ,Dementia ,Humans ,Age of Onset ,Interleukin 6 ,Alleles ,Aged ,Inflammation ,biology ,business.industry ,Interleukin-1 beta ,Interleukin-6 ,Tumor necrosis factor-alpha ,Tumor Necrosis Factor-alpha ,Interleukins ,Interleukin ,DNA ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Cytokine ,Italy ,Case-Control Studies ,Immunology ,biology.protein ,Disease Progression ,Cytokines ,Female ,Geriatrics and Gerontology ,business - Abstract
Background/Aims: Recent studies suggested a role for pro-inflammatory mediators in frontotemporal lobar degeneration (FTLD). The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease. Methods: Using a case-control study, we compared allelic and genotypic frequencies of several polymorphisms in the interleukin (IL)-1α, interleukin (IL)-1β, interleukin (IL)-6 and tumor necrosis factor (TNF)-α genes between 110 FTLD patients and 119 healthy controls. Results: No significant association between the examined polymorphisms and the disease was found. However, in comparison with remaining genotypes, patients carrying the T/T genotype of the IL-1β gene showed a significantly lower age at onset of the disease. In addition, scores of the Frontal Assessment Battery were significantly modified by the IL-6 –174G>C polymorphism. Conclusion: Our findings support a role for pro-inflammatory cytokine genes in the pathogenesis of frontotemporal lobar degeneration. more...
- Published
- 2009
16. A study of 3H-PK 11 195 binding to 'peripheral-type' benzodiazepine receptors on human lymphocytes
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F. Enrichens, Olivero G, Luigi Ravizza, Paola Rocca, Paolo Benna, A. Gualerzi, Mao P, Bruno Bergamasco, and Patrizia Ferrero
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medicine.medical_specialty ,Cirrhosis ,GABAA receptor ,Lymphocyte ,Encephalopathy ,Biology ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Neurology ,Internal medicine ,Muscarinic acetylcholine receptor ,medicine ,Neurology (clinical) ,Binding site ,Receptor ,Hepatic encephalopathy - Abstract
In an attempt to assess the involvement of the "peripheral-type" benzodiazepine receptors (pBDZR) in hepatic encephalopathy (HE), we examined the binding of the isoquinoline carboxamide derivative 3 H-PK 11 195 to lymphocyte membranes from a group of patients with liver cirrhosis with or without clinical signs of HE and normal controls. Lymphocyte 3 H-PK 11 195 binding is saturable, with high affinity and presents the pharmacological specificity corresponding to pBDZR. A significant 40% decrease in the number of 3 H-PK 11 195 binding sites, without a concomitant change in the apparent affinity, is observed in the group with HE as compared to the controls, but not in that with liver diseases without HE. The decrease in binding capacity correlates significantly with the clinical grading of HE, but not with age, sex, aetiology of cirrhosis or presence of surgical shunt. In contrast to the reduction of pBDZR, 3 H-N-methylscopolamine binding to lymphocyte muscarinic receptors is not affected in HE. These findings are consistent with a role for pBDZR in HE and may stimulate studies of endogenous modulators and pharmacological agents for these receptors in the disease. more...
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- 1991
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17. Dark bursts in the Swift era
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Andrea Rossi, David Alexander Kann, Steve Schulze, Patrizia Ferrero, Robert Filgas, Sylvio Klose, Christian Clemens, Aybüke Küpcü Yoldaş, Thomas Krühler, Abdullah Yoldaş, Jochen Greiner, M. Galassi, David Palmer, and Ed Fenimore more...
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Swift ,Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Dark matter ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,law.invention ,Telescope ,law ,Astrophysics::Earth and Planetary Astrophysics ,Gamma-ray burst ,computer ,computer.programming_language - Abstract
The nature of the dark bursts is still not fully understood. Here, we report on some of our recent studies on Swift dark bursts. Thereby, we pay particular attention to GRB 050717, for which we obtained a deep imaging of the X‐ray error circle with the newly commissioned GROND camera mounted at the 2.2 m telescope on La Silla. more...
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- 2008
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18. GRB 060605: multi-wavelength analysis of the first GRB observed using integral field spectroscopy
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Patrizia Ferrero, P. Böhm, Lorenzo Amati, Jochen Greiner, David Alexander Kann, Martin Roth, S. D. Barthelmy, Sebastián F. Sánchez, Sylvio Klose, Samantha Oates, Steve Schulze, D. Malesani, Sandra Savaglio, Eliana Palazzi, E. Maiorano, Javier Gorosabel, N. Masetti, Jens Hjorth, and Dirk Grupe more...
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Collimated light ,Galaxy ,Redshift ,Afterglow ,law.invention ,Telescope ,Lorentz factor ,symbols.namesake ,Space and Planetary Science ,law ,symbols ,Gamma-ray burst ,Energy (signal processing) - Abstract
The long and relatively faint gamma-ray burst GRB 060605 detected by \emph{Swift}/BAT lasted about 20 sec. Its afterglow could be observed with \emph{Swift}/XRT for nearly 1 day, while \emph{Swift}/UVOT could detect the afterglow during the first 6 hours after the event. Here, we report on integral field spectroscopy of its afterglow performed with PMAS/PPak mounted at the Calar Alto 3.5 m telescope. In addition, we report on a detailed analysis of XRT and UVOT data and on the results of deep late-time VLT observations that reveal the GRB host galaxy. We find that the burst occurred at a redshift of $z$=3.773, possibly associated with a faint, $R_C=26.4 \pm 0.3$ host. Based on the optical and X-ray data, we deduce information on the SED of the afterglow, the position of the cooling frequency in the SED, the nature of the circumburst environment, its collimation factor, and its energetics. We find that the GRB fireball was expanding into a constant-density medium and that the explosion was collimated with a narrow half-opening angle of about 2.4 degrees. The initial Lorentz factor of the fireball was about 250; however, its beaming-corrected energy release in the gamma-ray band was comparably low. The optical, X-ray afterglow, on the other hand, was rather luminous. Finally, we find that the data are consistent within the error bars with an achromatic evolution of the afterglow during the suspected jet break time at about 0.27 days after the burst., Comment: accepted in A&A; changed title, major reviews after referee's report; 15 pages and 14 figures more...
- Published
- 2008
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19. Optical observations of GRB 060218/SN 2006aj and its host galaxy
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Elena Pian, Eliana Palazzi, Sandra Savaglio, and Patrizia Ferrero
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Physics ,Supernova ,Astrophysics (astro-ph) ,FOS: Physical sciences ,Astrophysics ,Spectroscopy ,Gamma-ray burst ,Galaxy ,Dwarf galaxy - Abstract
The supernova SN 2006aj associated with GRB 060218 is the second-closest GRB-SN observed to date ($z$=0.033) and is the clearest example of a SN associated with a Swift GRB with the earliest optical spectroscopy. Its optical data showed that this is the fastest evolving and among the least luminous GRB-SNe (70% as luminous as SN1998bw). However, its expansion velocity and a comparison with other stripped-envelope SNe suggest that SN2006aj is an intermediate object between Type Ic GRB-SNe and those not accompained by a GRB. High-resolution optical spectroscopy together with SDSS pre-burst observations revealed that the host galaxy of SN2006aj is a low-luminosity, metal-poor star-forming dwarf galaxy., Comment: To appear in conf. proc. of "The Multicoloured Landscape of Compact Objects and their Explosive Progenitors: Theory vs Observations", a conference held in Cefalu, Sicily, June 11-24, 2006 more...
- Published
- 2007
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20. Subject Index Vol. 27, 2009
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Massimo Musicco, Richard J. Caselli, G. Sánchez-Benavides, Giuseppina D’Amico, Yolanda Hagar, Federica Lupo, Denisa Baci, Giuseppe Gambina, Jane E. Mahoney, M. Quintana, Joan M. Swearer, Giorgetta Cappa, Ekaterina Rogaeva, Leiv Sandvik, Laurel A. Beckett, You-Qiang Song, Birgitte Bo Andersen, Katie Palmer, Mary N. Haan, Walter Valfrè, Luca Cravello, Horst Bickel, James E. Evans, R.M. Manero, Thien Kieu Thi Phung, Nancy West, Salvatore Gallone, Rosa Maria Corbo, Lasse Farner, Majaz Moonis, Kevin J. Kane, Serena Mosti, Ping-Yiu Yik, Brynjar Fure, Barbara L. Fischer, Brendan J. Kelley, Concetta Di Lorenzo, Torgeir Bruun Wyller, Carlo Caltagirone, Ladson Hinton, Leung-Wing Chu, Björn Hultberg, Hector M. González, Lars Vedel Kessing, Zhong Li, P Fenoglio, Dan M Mungas, Carey E. Gleason, Innocenzo Rainero, Alexander Kurz, Karin Nilsson, Eugenia Rota, Jørgen Wagle, Kjell Flekkøy, Preben Bo Mortensen, S. Quiñones-Úbeda, Gunhild Waldemar, Peter St George-Hyslop, Brynhild Stensrød, Daniel A. Pollen, J. Peña-Casanova, Knut Engedal, Barbara A. Evans, Yan Li, Elisa Rubino, Kristin L. Eiklid, Lars Gustafson, Patrizia Ferrero, Bradley F. Boeve, Douglas Hinerfeld, S. de Sola, Ronald E. Gangnon, Lorenzo Pinessi, L Ulizzi, Stephen P. Baker, Keith A. Josephs, Giuseppe Moretto, Giovanna Vaula, Giovanna Salamone, and Renato Scacchi more...
- Subjects
Psychiatry and Mental health ,Index (economics) ,Cognitive Neuroscience ,Statistics ,Subject (documents) ,Geriatrics and Gerontology ,Mathematics - Published
- 2009
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21. GRB 081007 AND GRB 090424: THE SURROUNDING MEDIUM, OUTFLOWS, AND SUPERNOVAE
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Aaron P. LaCluyze, Johan P. U. Fynbo, Robert J. Smith, Silvia Piranomonte, P. D'Avanzo, Stefano Valenti, Stefano Covino, Zhi-Ping Jin, Zach Cano, Ruben Salvaterra, C. Guidorzi, Shiho Kobayashi, Sergio Campana, Carole Mundell, Emma S. Walker, Patrizia Ferrero, Javier Gorosabel, Thomas Vestrand, D. Malesani, Elena Pian, J. B. Haislip, Gianpiero Tagliaferri, Gianni Marconi, Massimo Della Valle, A. J. Castro-Tirado, P. R. Wozniak, Andreja Gomboc, Daniel E. Reichart, Paolo A. Mazzali, Iain A. Steele, Jens Hjorth, S. D. Vergani, Dino Fugazza, R. Sanchez-Ramirez, A. Melandri, Nial R. Tanvir, and D. Bersier more...
- Subjects
Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,01 natural sciences ,Luminosity ,symbols.namesake ,0103 physical sciences ,Astrophysics::Solar and Stellar Astrophysics ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,QB ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Gamma rays: bursts ,Physics ,Photosphere ,010308 nuclear & particles physics ,Supernova: individual (SN 2008hw) ,Astronomy and Astrophysics ,ISM: jets and outflows ,Galaxy ,Afterglow ,Interstellar medium ,Supernova ,Lorentz factor ,13. Climate action ,Space and Planetary Science ,symbols ,Astrophysics - High Energy Astrophysical Phenomena ,Gamma-ray burst - Abstract
We discuss the results of the analysis of multi-wavelength data for the afterglows of GRB 081007 and GRB 090424, two bursts detected by Swift. One of them, GRB 081007, also shows a spectroscopically confirmed supernova, SN 2008hw, which resembles SN 1998bw in its absorption features, while the maximum luminosity is only about half as large as that of SN 1998bw. Bright optical flashes have been detected in both events, which allows us to derive solid constraints on the circumburst-matter density profile. This is particularly interesting in the case of GRB 081007, whose afterglow is found to be propagating into a constant-density medium, yielding yet another example of a GRB clearly associated with a massive star progenitor which did not sculpt the surroundings with its stellar wind. There is no supernova component detected in the afterglow of GRB 090424, likely due to the brightness of the host galaxy, comparable to the Milky Way. We show that the afterglow data are consistent with the presence of both forward- and reverse-shock emission powered by relativistic outflows expanding into the interstellar medium. The absence of optical peaks due to the forward shock strongly suggests that the reverse shock regions should be mildly magnetized. The initial Lorentz factor of outflow of GRB 081007 is estimated to be \Gamma ~ 200, while for GRB 090424 a lower limit of \Gamma > 170 is derived. We also discuss the prompt emission of GRB 081007, which consists of just a single pulse. We argue that neither the external forward-shock model nor the shock-breakout model can account for the prompt emission data and suggest that the single-pulse-like prompt emission may be due to magnetic energy dissipation of a Poynting-flux dominated outflow or to a dissipative photosphere., Comment: 15 pages, 8 figures, accepted for publication in the Astrophysical Journal more...
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- 2013
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22. The circumburst density profile around GRB progenitors: a statistical study
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Gunnlaugur Björnsson, Steve Schulze, Patrizia Ferrero, Thomas Krühler, David Alexander Kann, Pall Jakobsson, Jochen Greiner, Andrea Rossi, and Sylvio Klose
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Physics ,Coalescence (physics) ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,Young stellar object ,FOS: Physical sciences ,Astronomy and Astrophysics ,Radius ,Astrophysics ,Light curve ,Afterglow ,Stars ,Wind profile power law ,Space and Planetary Science ,Gamma-ray burst ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
According to our present understanding, long GRBs originate from the collapse of massive stars while short bursts are due to the coalescence of compact stellar objects. Since the afterglow evolution is determined by the circumburst density profile, n(r), traversed by the fireball, it can be used to distinguish between a so-called ISM profile, n(r) = const., and a free stellar wind, $n(r) \propto r^{-2}$. Our goal is to derive the most probable circumburst density profile for a large number of Swift-detected bursts using well-sampled afterglow light curves in the optical and X-ray bands. We combined all publicly available optical and Swift/X-ray afterglow data from June 2005 to September 2009 to find the best-sampled late-time afterglow light curves. After applying several selection criteria, our final sample consists of 27 bursts, including one short burst. The afterglow evolution was then studied within the framework of the fireball model. We find that the majority (18) of the 27 afterglow light curves are compatible with a constant density medium (ISM case). Only 6 of the 27 afterglows show evidence for a wind profile at late times. In particular, we set upper limits on the wind termination-shock radius, $R_T$, for GRB fireballs which are propagating into an ISM profile and lower limits on $R_T$ for those which were found to propagate through a wind medium. Observational evidence for ISM profiles dominates in GRB afterglow studies, implying that most GRB progenitors might have relatively small wind termination-shock radii. A smaller group of progenitors, however, seems to be characterised by notably more extended wind regions., Comment: A&A, accepted (Oct 26, 2010); 20 pages in journal format; 6 pages main text, 13 pages Appendix, 1 page references, 6 tables and 2 figures; included comments by the referee and language editor; removed grey colouring of the tables more...
- Published
- 2010
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23. Simultaneous polarization monitoring of supernovae SN 2008D/XT 080109 and SN 2007uy: isolating geometry from dust
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Patrizia Ferrero, I. Agudo, A. de Ugarte Postigo, M. Bremer, S. Leon, J. P. U. Fynbo, D. A. Kann, A. J. Castro-Tirado, A. Llorente, Martin Jelínek, A. M. Rossi, Michał J. Michałowski, J. M. Winters, Javier Gorosabel, Datao Xu, S. Klose, T. Augusteijn, Jens Hjorth, and J. P. Madrid more...
- Subjects
Physics ,Linear polarization ,media_common.quotation_subject ,Astrophysics (astro-ph) ,Rotational symmetry ,FOS: Physical sciences ,Astronomy and Astrophysics ,Optical polarization ,Astrophysics ,Polarization (waves) ,Coincidence ,Supernova ,Space and Planetary Science ,Sky ,Hypernova ,media_common - Abstract
The possible existence of a continuum encompassing the diversity of explosive stellar deaths,ranging from ordinary SNe to relativistic hypernovae associated with long duration GRBs, is under intense debate. In this context, SN2008D associated with XT080109 could represent a paradigmatic case, since it might exemplify a potential borderline event. The main aim is to infer geometric information of SN2008D through the evolution of its linear optical polarization. We also report the polarization evolution of SN2007uy, and discuss the properties of the host ISM towards the XT. The final goal is to compare the polarization properties, and hence the geometries of both SNe, which shone contemporaneously in NGC2770. This fortunate coincidence brought us the opportunity to observe both SNe simultaneously, and most importantly, with identical instrumental setups. The observations span 74.9 days, starting 3.6 days after the XT and are distributed in 11 visits. In addition we performed observations in the mm range in order to identify the dominant polarization. We report positive linear polarization detections at several epochs for SN2008D at a level of ~1% and at ~1.5% for SN2007uy. SN2007uy shows constant polarization, which could be described by the host interstellar polarization plus a constant eccentricity expansion on the sky plane. A statistical analysis of the distribution of the SN2008D Stokes parametres suggests that it could show an intrinsic variable polarization component. Assuming the SN2007uy polarization is constant, we find that the evolution of the intrinsic SN2008D polarization could be explained by an aspherical axisymmetric expansion with variable eccentricity. We come to the same result even if we make no assumption on SN2007uy, although at a lower significance level. We suggest that at least the projected, if not the intrinsic, geometries of both SNe could differ., 10 pages, 3 figures, accepted for publication in A&A more...
- Published
- 2010
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24. Associated polyneuropathy and demyelinating disease. Case report
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Patrizia Ferrero, W. Troni, Bruno Bergamasco, N. Rebaudengo, and C. Bianco
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Male ,medicine.medical_specialty ,Pathology ,Neurology ,Adolescent ,Polyradiculoneuropathy ,Dermatology ,Cerebrospinal fluid ,Demyelinating disease ,medicine ,Evoked Potentials, Auditory, Brain Stem ,Reaction Time ,Humans ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Acoustic Stimulation ,Etiology ,Evoked Potentials, Visual ,Neurology (clinical) ,Neurosurgery ,business ,Polyneuropathy ,Photic Stimulation ,Demyelinating Diseases - Abstract
We report a case in which an acute Guillain-Barre-like syndrome was quickly followed by a central demyelinating disease, documented by the clinical findings as well as by magnetic resonance imaging (MRI), electrophysiological and cerebrospinal fluid examinations. The close follow-on of the clinical signs seems to exclude a simple coincidence of two separate diseases and it may constitute further evidence for a possible etiological link between central and peripheral myelin damage. We discuss the possibility of a common pathogenic factor underlying central and peripheral demyelination. more...
- Published
- 1992
25. Peripheral-type benzodiazepine receptors in anxiety disorders
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Bruno Bergamasco, Paola Rocca, E. Zanalda, Giuseppe Maina, A. Gualerzi, Luigi Ravizza, and Patrizia Ferrero
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medicine.medical_specialty ,Obsessive-Compulsive Disorder ,Generalized anxiety disorder ,medicine.drug_class ,Scopolamine Derivatives ,Radioligand Assay ,Internal medicine ,medicine ,Humans ,Lymphocytes ,Receptor ,Benzodiazepine ,GABAA receptor ,Panic disorder ,Panic ,Parasympatholytics ,N-Methylscopolamine ,medicine.disease ,Isoquinolines ,Receptors, GABA-A ,Anxiety Disorders ,Long-Term Care ,Receptors, Muscarinic ,Psychiatry and Mental health ,Endocrinology ,Anti-Anxiety Agents ,Anxiety ,medicine.symptom ,Psychology ,Anxiety disorder ,Clinical psychology - Abstract
Peripheral benzodiazepine receptors (pBDZr) were analyzed in lymphocyte membranes from patients with anxiety disorders (generalized anxiety disorder (GAD), n = 15; panic disorder (PD), n = 10; obsessive-compulsive disorder (OCD), n = 18), other mental disorders (n = 40) and 50 healthy controls, by the specific binding of 3H-PK11195. The number of binding sites (Bmax) was significantly decreased in groups with both GAD and OCD as compared with age-matched controls, by 45% and 25% respectively, whereas the binding affinity (Kd) was the same in all disorder and control groups. Conversely, no changes in binding capacity was observed in the other disorder groups and particularly in the one with PD. The abnormality in pBDZr observed in patients with GAD was restored to a normal value after long-term treatment with 2'-chloro-N-desmethyldiazepam, which also coincided with their recovery from anxiety. Our data suggest that the clinical heterogeneity in anxiety disorders might be related to different biological mechanisms and that lymphocyte pBDZr might be useful in demonstrating these differences. more...
- Published
- 1991
26. In vitro and in vivo effects of anxiety and benzodiazepines on immune parameters and lymphocyte benzodiazepine receptor mRNA
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Paola Rocca, A.M. Beoni, Carola Eva, Luigi Ravizza, and Patrizia Ferrero
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Pharmacology ,Benzodiazepine ,business.industry ,medicine.drug_class ,Lymphocyte ,In vitro ,Psychiatry and Mental health ,Immune system ,medicine.anatomical_structure ,Neurology ,In vivo ,Receptor mrna ,Immunology ,Medicine ,Anxiety ,Pharmacology (medical) ,Neurology (clinical) ,medicine.symptom ,business ,Biological Psychiatry - Published
- 1996
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27. Carbamazepine antiproliferative action in human lymphocytes: a possible role of peripheral benzodiazepine receptors
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Paola Rocca, Patrizia Ferrero, M. Giubertoni, Bruno Bergamasco, Luigi Ravizza, and E. Montalenti
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Pharmacology ,GABAA receptor ,Chemistry ,Carbamazepine ,Lymphocyte proliferation ,Peripheral ,Psychiatry and Mental health ,Neurology ,Action (philosophy) ,medicine ,Pharmacology (medical) ,Neurology (clinical) ,Biological Psychiatry ,medicine.drug - Published
- 1993
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28. 3H-PK11195 binding to human blood mononuclear cells during the menstrual cycle
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Luigi Ravizza, E. Montalenti, Paola Rocca, Patrizia Ferrero, and Bruno Bergamasco
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Pharmacology ,medicine.medical_specialty ,Human blood ,business.industry ,media_common.quotation_subject ,Peripheral blood mononuclear cell ,Psychiatry and Mental health ,Endocrinology ,Neurology ,Internal medicine ,Medicine ,Pharmacology (medical) ,Neurology (clinical) ,business ,Biological Psychiatry ,Menstrual cycle ,media_common - Published
- 1992
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29. Stress modulation of peripheral benzodiazepine mRNA in humans: Relationship with some immunological parameters
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Patrizia Ferrero, A.M. Beonl, Carola Eva, Paola Rocca, and Luigi Ravizza
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Messenger RNA ,Benzodiazepine ,medicine.drug_class ,business.industry ,medicine ,Pharmacology ,business ,Biological Psychiatry ,Peripheral - Published
- 1997
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30. Downregulation of peripheral benzodiazepine receptors and their mRNA in peripheral blood mononuclear cells from anxious patients
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A Beoni, Luigi Ravizza, E. Zanalda, P Rocca, Patrizia Ferrero, and Carola Eva
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Pharmacology ,Psychiatry and Mental health ,medicine.medical_specialty ,Messenger RNA ,Endocrinology ,Downregulation and upregulation ,business.industry ,GABAA receptor ,Internal medicine ,Medicine ,business ,Peripheral blood mononuclear cell ,Peripheral - Published
- 1995
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31. EVIDENCE OF TWO SUBTYPES OF OBSESSIVE-COMPULSIVE DISORDER
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Patrizia Ferrero, Luigi Ravizza, G. Maina, Paola Rocca, and Filippo Bogetto
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Pharmacology ,Obsessive compulsive ,Pharmacology (medical) ,Neurology (clinical) ,Clinical psychology - Published
- 1992
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32. MODULATION OF A LYMPHOCYTE PERIPHERAL TYPE BENZODIAZEPINE RECEPTORS (pBZr) BY METHYL-PREDNISOLONE
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Paola Rocca, Bruno Bergamasco, Luigi Ravizza, E. Montalenti, and Patrizia Ferrero
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Pharmacology ,Methyl prednisolone ,medicine.anatomical_structure ,Peripheral type ,GABAA receptor ,Chemistry ,Lymphocyte ,Immunology ,medicine ,Pharmacology (medical) ,Neurology (clinical) - Published
- 1992
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33. Neonatal Hypoxia and Epileptic Risk: A Clinical Prospective Study
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Patrizia Ferrero, Bruno Bergamasco, Paolo Benna, and Roberto Gavinelli
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Male ,Pediatrics ,medicine.medical_specialty ,Population ,Neurological disorder ,Fetal Hypoxia ,Epilepsy ,Pregnancy ,medicine ,Humans ,Prospective cohort study ,education ,Asphyxia Neonatorum ,Fetus ,education.field_of_study ,business.industry ,Infant, Newborn ,Hypoxia (medical) ,medicine.disease ,Neurology ,Etiology ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
A historical cohort study was undertaken to determine the risk of epilepsy in a population of 371 newborns with an acute neurological disorder related to fetal and/or neonatal hypoxia compared with a control population of 362 normal newborns. The results showed that the risk of epilepsy was 5.1 times higher in the group of subjects affected at birth by a hypoxia-related acute neurological syndrome than in the control group. (Although the incidence of epilepsy is higher in the first year of life, epileptic seizures connected to perinatal hypoxia may occur in early childhood or later on.) Also, there were frequently persistent neuropsychiatric disorders in children with perinatal hypoxia (5.4%). There was no difference in the two groups regarding the incidence of febrile convulsions. The data show that perinatal hypoxia plays a role in the etiology of epilepsy, although at birth the hypoxia might result in only a modest and oftentimes completely reversible neurological syndrome. more...
- Published
- 1984
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34. [3H]N-methylscopolamine binding to muscarinic receptors in human peripheral blood lymphocytes: Characterization, localization on T-lymphocyte subsets and age-dependent changes
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Ada Funaro, Luigi Ravizza, Paola Rocca, E. Genazzani, Patrizia Ferrero, Bruno Bergamasco, and Carola Eva
- Subjects
Adult ,Aging ,medicine.medical_specialty ,T-Lymphocytes ,Scopolamine Derivatives ,In Vitro Techniques ,Biology ,Peripheral blood mononuclear cell ,Cellular and Molecular Neuroscience ,Internal medicine ,Muscarinic acetylcholine receptor ,medicine ,Animals ,Humans ,Binding site ,Pharmacology ,B-Lymphocytes ,Sheep ,Cell Membrane ,Parasympatholytics ,T lymphocyte ,Muscarinic acetylcholine receptor M1 ,N-Methylscopolamine ,Receptors, Muscarinic ,Pirenzepine ,Molecular biology ,In vitro ,Quinuclidinyl Benzilate ,Endocrinology ,medicine.drug - Abstract
The properties of the binding of the muscarinic receptor ligands, [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) in human mononuclear cells were compared. The binding of [3H]QNB showed a high, non-specific component and lack of saturability in both intact mononuclear cells and preparations of lysed mononuclear cell membranes. Conversely the specific binding of [3H]NMS had a high affinity and was saturable at concentrations greater than 30 nM in both intact and broken cells. Classical muscarinic receptor antagonists displaced specific binding of [3H]NMS binding according to the law of mass action, while displacement curves for pirenzepine and muscarinic agonists were very shallow (nH less than 1), suggesting the presence of more than one subtype of muscarinic receptor on mononuclear cell membranes. Binding studies with [3H]NMS to purified mononuclear cell subpopulations demonstrated that muscarinic binding sites were mainly localized on thymus-derived (T) lymphocytes and large granule lymphocytes. Moreover evidence is presented of an age-dependent increase of the density of muscarinic binding sites on T-lymphocytes. The results are discussed in terms of the usefulness of the binding of [3H]NMS in studying the physiological function of muscarinic receptors on human T-lymphocytes and their possible changes in patients with neurological diseases. more...
- Published
- 1989
- Full Text
- View/download PDF
35. Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in human CSF
- Author
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L. Tarenzi, L. Bergamini, Bruno Bergamasco, Gianfranco Baggio, Paolo Costa, Patrizia Ferrero, and Paolo Benna
- Subjects
medicine.medical_specialty ,Parkinson's disease ,business.industry ,Multiple sclerosis ,Human brain ,medicine.disease ,Olivopontocerebellar atrophy ,medicine.anatomical_structure ,Cerebrospinal fluid ,Endocrinology ,Neurology ,Normal pressure hydrocephalus ,Internal medicine ,medicine ,Neurology (clinical) ,business ,Diazepam binding inhibitor ,CSF albumin - Abstract
Cerebrospinal fluid (CSF) levels of the anxiogenic neuropeptide diazepam binding inhibitor (DBI) were determined by radioimmunoassay in 281 patients who underwent evaluation for neurological problems. Serial dilution curves and reverse-phase high pressure liquid chromatography showed that the immunoreactive material in CSF behaved just as authentic DBI extracted from human brain. Furthermore in the assay there was no evidence of interference from CSF samples deprived of DBI by immunoaffinity. In 82 patients with no evidence of major lesions in the central nervous system, who acted as controls, the CSF DBI content was shown to be age- and sex-related. No correlation was observed with the CSF protein concentration. In patients with different types of dementia, the levels of CSF DBI were significantly increased in a group with normal pressure hydrocephalus. No significant differences were found between Alzheimer's disease, multi-infarct dementia, or dementia with Parkinson's disease and controls. In non-demented patients with Parkinson's disease the levels of DBI were increased in a subgroup with depressive disturbances whereas no differences was observed in the non-depressed cases. The content of DBI was markedly reduced in 5 cases with olivopontocerebellar atrophy and in 4 with spinocerebellar ataxia. In all the other disorders studied the levels of DBI were similar to or slightly lower (multiple sclerosis) than those of the controls. The origin of DBI in cerebrospinal fluid is uncertain; a number of various possibilities are discussed concerning the proposed role of DBI as modulator of brain GABAergic transmission. more...
- Published
- 1988
- Full Text
- View/download PDF
36. 3H-N-methylscopolamine binding to human lymphocytes. A model to study cholinergic dysfunction in Alzheimer's disease
- Author
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Patrizia Ferrero, E. Genazzani, Paola Rocca, Luigi Ravizza, Bruno Bergamasco, and Carola Eva
- Subjects
Pharmacology ,medicine.medical_specialty ,Endocrinology ,N-Methylscopolamine ,Chemistry ,Internal medicine ,medicine ,Cholinergic ,Disease - Published
- 1988
- Full Text
- View/download PDF
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