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Supplemental Material, Appendix for Does the Talkable programme improve caregiver knowledge and confidence in assisting their child’s language learning? A pilot study by Karen Nitsche, Suze Leitão and Richard Parsons in Australasian Journal of Early Childhood

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Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyses the methylation of nicotinamide to form N′-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases, suggesting a role for the enzyme as a therapeutic target beyond its previously ascribed metabolic function in detoxification. We here describe the systematic development of NNMT inhibitors derived from the structures of the substrates involved in the methylation reaction. By covalently linking fragments of the NNMT substrates a diverse library of bisubstrate-like compounds was prepared. The ability of these compounds to inhibit NNMT was evaluated providing valuable insights into the structural tolerances of the enzyme active site. These studies led to the identification of new NNMT inhibitors that mimic the transition state of the methylation reaction and inhibit the enzyme with activity on par with established methyltransferase inhibitors.

The effect of planar flow casting parameters on the microstructural development and soft magnetic properties of Fe-metalloid nanocrystalline materials with a high saturation magnetisation has been investigated. Furthermore, the size and potential origin of a field induced anisotropy for this class of materials has also been examined. Fe-metalloid nanocrystalline magnetically soft materials, such as the Fe-B-(Si)-Cu alloy system, can offer the unique combination of a large saturation magnetisation while still maintaining relatively low core-losses. However, the nanocrystallisation process is known to be strongly influenced by the microstructure present in the precursor materials, which may differ considerably between batches due to the natural variability in the planar flow casting process used for its production. This work therefore investigates the origin of this variability and the effect that different processing parameters have on the final microstructure and magnetic softness for a nanocrystalline Fe₈₂.₅B₁₄Si₂Cu₁.₅ alloy. It is found that the ribbon geometry and the casting substrate speed both strongly influence the magnetic softness after nanocrystallisation and that by closely controlling these parameters the variability between batches may be reduced. Furthermore, these findings also suggest that variations in the ribbon-substrate contact and ribbon geometry may lead to significant fluctuations in the cooling rate experienced by different regions within an as-cast ribbon and that this might lead to an inhomogeneous microstructure. Therefore, these findings suggest that by tailoring the substrate speed and ribbon geometry for a given composition, it may be possible to achieve a far larger and more consistent cooling rate than that currently achievable by planar flow casting. It is known that a substantial field induced anisotropy has the potential to degrade magnetic softness in nanocrystalline materials at small grain sizes. Therefore, the size and origin of a field induced anisotropy located within the crystalline phase of an Fe-rich, Si-poor Fe-metalloid nanocrystalline alloy is also investigated. It is seen that a substantial field induced anisotropy exists within the crystalline phase of a Fe-B-(Si)-Cu alloy system and that this may negatively impact its magnetic softness. It is also found that a small uniaxial lattice distortion exists within the crystalline phase after field annealing for nanocrystalline Fe₉₄₋ₓNb₆Bₓ (x = 10, 12 and 14). The size of this lattice distortion is shown to agree well with predictions made by the magnetoelastic model and that this is the likely origin of the field induced anisotropy seen to exist in Si-free Fe-metalloid nanocrystalline alloys. Therefore, with this new understanding it may now be possible to develop novel methods for the control or removal of field induced anisotropies from nanocrystalline Fe-rich materials which may potentially improve their soft magnetic properties.

Curso de Matemáticas para superar el examen IGCSE (International General Certificate of Secondary Education) según la especificación A de Edexcel. Contiene: estudio de los números, álgebra, secuencias, funciones y gráficos, formas, vectores y transformaciones, geometría y estadística. Incluye ejercicios de respuesta múltiple en cada apartado y al término de cada capítulo, con soluciones disponibles al final del libro para comprobar el nivel de los conocimientos adquiridos, y un resumen de las fórmulas más importantes que se pueden necesitar durante el examen. SC Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel. +34917748000; biblioteca@mecd.es GBR

Background Nursing students’ positive attitudes towards ageing and older people are central to developing person-centred care. Perceptions about older people are influenced by social and generational values and beliefs, including a general understanding that older people need to be cared for. Nursing students often undertake early clinical placements in aged care settings, where residents’ needs are complex, yet the nursing experience is often considered ‘basic’ care. Illustrating that older people have rich personal histories and are valuable contributors to society can balance students’ perceptions and expectations and outcomes of clinical placements. Educational interventions using photo-elicitation and in-depth dialogue may surface students’ assumptions and challenge their misperceptions of older people before the first clinical placement. Aim To examine the impact of the innovative Depth of Field: Exploring Ageing © (DOF) resource as preparation for nursing students’ clinical placement in residential aged care facilities. Methods Mixed methods, block randomised controlled study with first year students. Students attending clinical laboratory groups received either usual preparation (control, n = 108) or DOF plus usual preparation (intervention, n = 99). Pre/post surveys included: Geriatric Attitudes Scale (GAS) and demographics. Eight students from the intervention group participated in focus groups post-clinical. Findings Groups were similar at baseline. There were statistically significant changes following the intervention (p ≤ .05) for 9/13 individual GAS items and difference in overall mean scores (intervention group: M = 0.26; SD = 0.27; control group: M = 0.01; SD = 0.27). Focus group themes included: preconceptions toward older people; feelings of being emotionally unprepared; and perceptions of the DOF intervention in preparing students to connect with the older person. Discussion The DOF vignette provided opportunity for students to preflect on ageing. Translation to practice was evidenced with students seeing beyond residents’ physical care requirements to the value of connecting with the older person’s story to facilitate person-centred care. Conclusions The DOF intervention assisted students to adopt positive attitudes and a broader perspective of older people, as preparation for placement in residential aged care facilities.

Our study measures effects of the Spirometry Learning Module (SLM) on health-care professionals’ knowledge of spirometry test quality and perceived confidence, experience, and understanding of spirometry measurements and interpretation. Professionals from both primary and hospital-based settings enrolled in the SLM, a training model focusing on spirometry test performance and interpretation, including an online interactive learning component and a face-to-face workshop. Participants were asked to submit patient spirometry assessment worksheets for feedback on quality and interpretation. Data were collected at baseline, SLM completion (20 weeks), and 12 months after SLM completion. Knowledge of spirometry test quality was evaluated with questions relating to five case-based assessments of common spirometric patterns. Perceived confidence, experience, and knowledge in test performance were measured using a 7-point Likert scale. The Friedman test combined with post hoc analyses were used to analyse differences between baseline, 20-week, and 12-month post completion. Qualitative interviews were performed to assess reasons for non-completion. Of the 90 participants enrolled in the SLM and consented to research, 48 completed the 20-week measurement and 11 completed the 12-month measurement. Statistically significant improvements were detected in all outcomes in participants who completed the SLM to 20-week and 12-month follow-up assessments (all p values

Fundamentals of Business (2016) is an openly licensed (CC BY NC SA 3.0) textbook designed for use in Virginia Tech’s Pamplin College of Business introductory level business course, MGT1104 Foundations of Business. A new version of this book was released in August 2018. See http://hdl.handle.net/10919/84848 for more details. If you are an instructor reviewing, adopting, or adapting this textbook, please help us understand a little more about your use by filling out this form http://bit.ly/business-interest. Share and find ancillary resources for this book at OER Commons. Questions? Comments? Did you adopt this book? Please contact the project manager at openeducation@vt.edu. A testbank is now available by request for this book. The testbank is available to any instructor who has adopted Fundamentals of Business in their course. This work is a project of University Libraries and the Pamplin College of Business, Virginia Tech. Lead: Stephen J. Skripak (adapter) Contributors: Richard Parsons, Anastasia Cortes, Anita Walz Layout: Anastasia Cortes Selected graphics: Brian Craig http://bcraigdesign.com Cover design: Trevor Finney Student Reviewers: Jonathan De Pena, Nina Lindsay, Sachi Soni Project Manager: Anita Walz Editable files are available in MSWord in the .zip folder. Please view the README.txt file within this zipped collection. Print-on-demand softcover versions of this work are available at the cost of manufacturing and shipping from Lulu Press: color | black & white. Selected graphics produced by Brian Craig are available CC BY 4.0 via WikimediaCommons. ISBN: (B&W): 978-0-9979201-1-6 ISBN: (Color): 978-0-9979201-0-9 TABLE OF CONTENTS Preface: Teamwork in Business Chapter 1: The Foundations of Business Chapter 2: Economics and Business Chapter 3: Ethics and Social Responsibility Chapter 4: Business in a Global Environment Chapter 5: Forms of Business Ownership Chapter 6: Entrepreneurship: Starting a Business Chapter 7: Management and Leadership Chapter 8: Structuring Organizations Chapter 9: Operations Management Chapter 10: Motivating Employees Chapter 11: Managing Human Resources Chapter 12: Union/Management Issues Chapter 13: Marketing: Providing Value to Customers Chapter 14: Pricing Strategy Chapter 15: Hospitality and Tourism Chapter 16: Accounting and Financial Information Chapter 17: Personal Finances To request access to the permissions files, please contact vtechworks@vt.edu. TABLE OF CONTENTS Preface: Teamwork in Business Chapter 1: The Foundations of Business Chapter 2: Economics and Business Chapter 3: Ethics and Social Responsibility Chapter 4: Business in a Global Environment Chapter 5: Forms of Business Ownership Chapter 6: Entrepreneurship: Starting a Business Chapter 7: Management and Leadership Chapter 8: Structuring Organizations Chapter 9: Operations Management Chapter 10: Motivating Employees Chapter 11: Managing Human Resources Chapter 12: Union/Management Issues Chapter 13: Marketing: Providing Value to Customers Chapter 14: Pricing Strategy Chapter 15: Hospitality and Tourism Chapter 16: Accounting and Financial Information Chapter 17: Personal Finances Chapter 15 is licensed CC BY 4.0 https://creativecommons.org/licenses/by/4.0 and was adapted by Richard Parsons from https://opentextbc.ca/introtourism Introduction to Tourism and Hospitality in BC. All other chapters are licensed with a Creative Commons Attribution Non-Commercial Share Alike License 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0 and were adapted by Stephen J. Skripak from http://www.saylor.org/site/textbooks/Exploring%20Business.pdf. Lead Author: Stephen J. Skripak with Richard Parsons Project Manager: Anita Walz Graphic Design: Brian Craig http://bcraigdesign.com Layout: Anastasia Cortes Student Reviewers: Jonathan De Pena, Sachi Soni, Nina Lindsay This work is a project of University Libraries and the Pamplin College of Business, Virginia Tech May 2016 This book is dedicated to reducing the cost of education in business. – S. Skripak Contains front cover (PDF/A and MS Word), full text (PDF/A and MS Word), and compressed PDF (which contains the front cover and the full text). Included are both the final published version of this textbook, as well as an editable version of the textbook that can be downloaded as a Word document.

High levels of injection prescribing were reported in Mongolia. Understanding the factors influencing the injection prescribing is essential to reduce their inappropriate use. The study evaluated the views, experiences and attitudes of community members associated with the prescribing of injections in Mongolia. A structured questionnaire focusing on respondents' characteristics, experiences and views about injections was developed and administered face-to-face to community members in Ulaanbaatar, Mongolia. Standard descriptive statistics were used to summarize demographic data and responses to the questionnaires. Dependent variables were compared using Kruskal-Wallis Tests for independence. Statistical analyses were performed using SPSS Version 21.0. Six hundred participants were approached and the response rate was 79% (n = 474). Almost half of the respondents were aged between 31 and 50 (n = 228, 48.1%) and 40.9% of respondents were male (n = 194). Most respondents were from Ulaanbaatar city (n = 407, 85.7%). All respondents had received injections in the past and 268 (56.5%) had received injection in the past year. The most common reason for having an injection in the past year was reported as treatment of a disease (n = 163, 60.8%), or for administration of vitamins (n = 70, 26.1%). Injections were prescribed by a doctor (n = 353, 74.9%), dispensed by a pharmacist (n = 283, 59.7%) and administered by a nurse (n = 277, 54.9%). Only 16% of all respondents had the expectation of receiving injections when they visited a doctor (n = 77). An important perception regarding injections was that they hastened the recovery process (n = 269, 56.8%). When asked their opinion about therapeutic injections, 40% of all respondents agreed that injections were a better medicine (n = 190) than oral medications, with older respondents strongly agreeing (p