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2. Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey

Author

Akira, Yoshida, Minchul, Kim, Masataka, Kuwana, R, Naveen, Ashima, Makol, Parikshit, Sen, James B, Lilleker, Vishwesh, Agarwal, Sinan, Kardes, Jessica, Day, Marcin, Milchert, Mrudula, Joshi, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham, Edgar Gracia-Ramos, Ioannis, Parodis, Albert Selva, O'Callaghan, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn, Tan, Arvind, Nune, Lorenzo, Cavagna, Miguel A, Saavedra, Samuel Katsuyuki, Shinjo, Nelly, Ziade, Johannes, Knitza, Oliver, Distler, Hector, Chinoy, Vikas, Agarwal, Rohit, Aggarwal, and Latika, Gupta

Subjects
Rheumatology, Pharmacology (medical)
Abstract

Objectives The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P Conclusion Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.

Published
2022
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3. COVID-19 vaccine safety during the antenatal period in women with idiopathic inflammatory myopathies

Author

Andreoli, Laura, Parikshit, Sen, Lini, Daniele, Melinda Nagy Vincze, Karen, Schreiber, COVAD Study Group, Vikas, Agarwal, Rohit, Aggarwal, Latika Gupta The COVAD study group includes: Naveen, R, Mrudula, Joshi, Sreoshy, Saha, Kshitij, Jagtap, Lilleker, James B., Vishwesh, Agarwal, Sinan, Kardes, Jessica, Day, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Ioannis, Parodis, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn Tan, Lorenzo, Cavagna, Saavedra, Miguel A., Samuel Katsuyuki Shinjo, Nelly, Ziade, Johannes, Knitza, Masataka, Kuwana, Arvind, Nune, Oliver, Distler, Hector, Chinoy, Ashima, Makol, Dzifa, Dey, Carlos Enrique Toro Gutie´rrez, Carlo Vinicio Caballero-Uribe, Bhupen, Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Pandya, Sapan C., Rakesh Kumar Pilania, Aman, Sharma, Manesh, Manoj, Vikas, Gupta, Kavadichanda, Chengappa G., Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Pande, Arunkumar R., Kunal, Chandwar, Akanksha, Ghodke, Zoha Zahid Fazal, Do¨ndu¨ U¨ sku¨ dar Cansu, Res¸it, Yıldırım, Aarat, Patel, Pauling, John D., Chris, Wincup, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Silvia, Grignaschi, Alessandro, Giollo, Alessia, Alluno, Florenzo, Ioannone, Marco, Fornaro, Lisa, S Traboco, Syahrul Sazliyana Shaharir, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garc ıa-De La Torre, Colunga-Pedrazza, Iris J., Javier Merayo Chalico, Jesu´, s Loarce-Martos, Sergio Prieto-Gonza´ lez, Raquel Aranega Gonzalez, Leonardo Santos Hoff, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Takahisa, Gono, Stylianos, Tomaras, Fabian Nikolai Proft, Marie-Therese, Holzer, Russka, Shumnalieva, Margarita Aleksandrovna Gromova, Aharonov, Or, Zolta´n, Griger, Ihsane, Hmamouchi, Imane El bouchti, Zineb, Baba, Margherita, Giannini, Franc¸ois, Maurier, Julien, Campagne, Alain, Meyer, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Oce´ane, Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, ´ lvaro Arbela´ez, A, Javier, Cajas, Jose´ Anto´nio Pereira Silva, Jo~ao Eurico Fonseca, Olena, Zimba, Doskaliuk, Bohdana, Uyi, Ima-Edomwonyi, Ibukunoluwa, Dedeke, Emorinken, Airenakho, Nwankwo Henry Madu, Abubakar, Yerima, Hakeem, Olaosebikan, Okwara Celestine Chibuzo, Becky, Adugna, Oruma Devi Koussougbo, Elisa, Palalane, Ho, So, Manuel Francisco Ugarte-Gil, Lyn, Chinchay, Jose´ Proa~no Bernaola, Victorio, Pimentel, Tanveer Hasan, A. T. M., Binit, Vaidya, Hanan Mohammed Fathi, Mohammed, Reem Hamdy A., Yi-Ming, Chen, Ghita, Harifi, Lina El Kibbi, Hussein Mohammed Halabi, Akawatcharangura, P., Wanruchada, Katchamart, Yuril ıs Fuentes-Silva, Karoll, Cabriza, Jonathan, Losanto, Nelly, Colaman, Antonio, Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Rau´, l Gonza´ lez, Lilith Stange Nunez, Cristian Vergara, M, Jossiell Then Ba´ez, Hugo, Alonzo, Carlos Benito Santiago Pastelin, Rodrigo Garc ıa Salinas, Alejandro Qui~no´nez Obiols, Nilmo, Cha´vez, Andrea Bran Ordo´ ~nez, Sandra, Argueta, Gil Alberto Reyes Llerena, Radames, Sierra-Zorita, Dina, Arrieta, Eduardo Romero Hidalgo, Ricardo, Saenz, Idania Escalante, M, Roberto, Morales, Wendy, Calapaqui, Ivonne, Quezada, and Gabriela, Arredondo

Subjects
Rheumatology, Pharmacology (medical)
Published
2022
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4. COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and tolerance in rheumatoid arthritis

Author

Naveen, R, Ioannis, Parodis, Mrudula, Joshi, Parikshit, Sen, Julius, Lindblom, Vishwesh, Agarwal, James, B Lilleker, Ai Lyn Tan, Arvind, Nune, Samuel Katsuyuki Shinjo, Babur, Salim, Nelly, Ziade, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Miguel, A Saavedra, Jessica, Day, Ashima, Makol, Oliver, Distler, Hector, Chinoy, COVAD Study Group, Vikas Agarwal, Rohit Aggarwal, Latika, Gupta, Elena Nikiphorou The COVAD study group collaborators are: Bhupen Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Pandya, Sapan C., Rakesh Kumar Pilania, Aman, Sharma, Manoj, M, Vikas, Gupta, Kavadichanda, Chengappa G., Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Pandey, Arun Kumar R., Kunal, Chandwar, Sinan, Kardes¸, Do¨ndu¨ U¨ sku¨ dar Cansu, Minchul, Kim, Tulika, Chatterjee, Pauling, John D., Chris, Wincup, Lorenzo, Cavagna, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Marcin, Milchert, Traboco, Lisa S., Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garc ıa-De La Torre, Jesu´, s Loarce-Martos, Sergio Prieto-Gonza´ lez, Albert, Gil-Vila, Raquel Aranega Gonzalez, Masataka, Kuwana, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Johannes, Knitza, Stylianos, Tomaras, Margarita Aleksandrovna Gromova, Aharonov, Or, Gheita, Tamer A., Ihsane, Hmamouchi, Leonardo Santos Hoff, Margherita, Giannini, Franc¸ois, Maurier, Julien, Campagne, Alain, Meyer, Melinda, Nagy-Vincze, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Oce´ane, Landon-Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, Jose´ Anto´ nio Pereira Silva, Jo~ao Eurico Fonseca, and Olena, Zimba.

Subjects
rheumatoid arthritis, Adverse effects, COVID-19, autoimmune diseases, vaccination, Rheumatology, Pharmacology (medical)
Abstract

Objectives The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA patients. Methods An online self-reported questionnaire (March–December 2021) was used to capture data related to COVID-19 vaccination-related AEs in RA, other autoimmune rheumatic diseases (AIRDs) (excluding RA and inflammatory myositis), non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs). Descriptive and multivariable regression analyses were performed. Results Of the 9462 complete respondents, 14.2% (n = 1347) had been diagnosed with RA; they had a mean (s.d.) age of 50.7 (13.7) years, 74.2% were women and 49.3% were Caucasian. In total, 76.9% and 4.2% of patients with RA reported minor and major AEs, respectively. Patients with active and inactive RA had similar AE and hospitalization frequencies. Overall, AEs were reported more frequently by BNT162b2 and mRNA-1273 recipients and less frequently by BBV152 recipients compared with the rest. Major AE and hospitalization frequencies were similar across recipients of different vaccines. Patients receiving methotrexate and hydroxychloroquine reported fewer minor AEs than those patients not on them. Compared with HCs and patients with other AIRDs, patients with RA reported similar total AEs, overall minor AEs, and hospitalizations. Compared with nrAIDs, patients with RA reported lower frequencies of overall AEs, minor AEs (both odds ratio [OR] = 0.7; 95% CI: 0.5, 0.9), and injection site pain (OR = 0.6; 95% CI: 0.5, 0.8) with similar major AE and hospitalization frequencies. Conclusion Despite the differences in AE frequency across different COVID-19 vaccines, all were well tolerated in patients with RA and were comparable to HCs, providing reassurance as to the safety of COVID-19 vaccination.

Published
2022
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5. Pain in idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and healthy controls: A report from the COVAD study

Author

Leonardo Santos Hoff, Samuel Katsuyuki Shinjo, Minchul Kim, Rafael Giovani Missé, Naveen R, Jessica Day, Rafael Alves Cordeiro, Jucier Gonçalves Júnior, Tulika Chatterjee, Parikshit Sen, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O’Callaghan, Elena Nikiphorou, Ashima Makol, Ai Lyn Tan, Lorenzo Cavagna, Miguel A Saavedra, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Arvind Nune, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, and COVAD Study Group

Published
2022
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6. COVID-19 severity and vaccine breakthrough infections in idiopathic inflammatory myopathies, other systemic autoimmune and inflammatory diseases, and healthy individuals: results from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study

Author

Leonardo Santos Hoff, Samuel Katsuyuki Shinjo, Naveen R, Jessica Day, Parikshit Sen, Jucier Gonçalves Junior, James B. Lilleker, Mrudula Joshi, Vishwesh Agarwal, Sinan Kardes, Minchul Kim, Marcin Milchert, Ashima Makol, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O’Callaghan, Elena Nikiphorou, Ai Lyn Tan, Tulika Chatterjee, Lorenzo Cavagna, Miguel A Saavedra, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Arvind Nune, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, and COVAD Study Group

Published
2022
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7. COVID-19: Symphony or Cacophony of Immunology

Author

Neelam Makwana, Binita Goswami, and Parikshit Sen

Subjects
Innate immune system, Coronavirus disease 2019 (COVID-19), business.industry, Immunology, Pandemic, Symphony, Medicine, General Medicine, Acquired immune system, business, Cytokine storm, medicine.disease
Published
2020
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8. Autoimmune multimorbidity and fatigue in women with idiopathic inflammatory myopathies: an international, patient-reported, e-survey

Author

Akira Yoshida, Minchul Kim, Masataka Kuwana, Naveen Ravichandran, Ashima Makol, Parikshit Sen, James B Lilleker, Vishwesh Agarwal, Abraham Edgar Gracia-Ramos, Albert Selva O'Callaghan, Ai Lyn Tan, Lorenzo Cavagna, Miguel A Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, and Latika Gupta

Subjects
Rheumatology, Immunology, Immunology and Allergy
Published
2022
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9. COVID-19 vaccination-related adverse events among autoimmune disease patients: results from the COVAD study

Author

Parikshit, Sen, Naveen, Ravichandran, Arvind, Nune, James B, Lilleker, Vishwesh, Agarwal, Sinan, Kardes, Minchul, Kim, Jessica, Day, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar, Gracia-Ramos, Ioannis, Parodis, Albert, Selva O'Callaghan, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn, Tan, Lorenzo, Cavagna, Miguel A, Saavedra, Samuel Katsuyuki, Shinjo, Nelly, Ziade, Johannes, Knitza, Masataka, Kuwana, Oliver, Distler, Hector, Chinoy, Vikas, Agarwal, Rohit, Aggarwal, Latika, Gupta, and Olena, Zimba

Subjects
Rheumatology, Pharmacology (medical)
Abstract

Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination-related adverse events (AEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed in the COVAD study, a patient self-reported cross-sectional survey. Methods The survey was circulated in early 2021 by >110 collaborators (94 countries) to collect SAID details, COVID-19 vaccination details and 7-day vaccine AEs, irrespective of respondent vaccination status. Analysis was performed based on data distribution and variable type. Results Ten thousand nine hundred respondents [median (interquartile range) age 42 (30–55) years, 74% females and 45% Caucasians] were analysed; 5867 patients (54%) with SAIDs were compared with 5033 HCs. Seventy-nine percent had minor and only 3% had major vaccine AEs requiring urgent medical attention (but not hospital admission) overall. Headache [SAIDs = 26%, HCs = 24%; odds ratio (OR) = 1.1 (95% CI: 1.03, 1.3); P = 0.014], abdominal pain [SAIDs = 2.6%, HCs = 1.4%; OR = 1.5 (95% CI: 1.1, 2.3); P = 0.011], and dizziness [SAIDs = 6%, HCs = 4%; OR = 1.3 (95% CI: 1.07, 1.6); P = 0.011], were slightly more frequent in SAIDs. Overall, major AEs [SAIDs = 4%, HCs = 2%; OR = 1.9 (95% CI: 1.6, 2.2); P Conclusion Vaccination against COVID-19 is safe in SAID patients. SAIDs were at a higher risk of major AEs than HCs, though absolute risk was small. There are small differences in minor AEs between vaccine types in SAID patients.

Published
2022
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10. ASSESSMENT OF THE EFFECT OF SOCIAL MEDIA USAGE AND COVID-19 PANDEMIC NEWS UPDATES ON THE MENTAL WELL-BEING OF STUDENTS DURING THE LOCKDOWN IN INDIA

Author

Vatsala Khurana, Binita Goswami, Nikhil Gupta, Surajeet Kumar Patra, and Parikshit Sen

Subjects
Coronavirus disease 2019 (COVID-19), business.industry, Mental well-being, Pandemic, Social media, Public relations, business, Psychology
Abstract

As a result of the Lockdown imposed by the Government of India, social media usage has considerably increased among students. A constant urge to keep oneself updated with the news regarding the pandemic has also been observed, which has inevitably led to students getting exposed to a constant stream of negative news. To investigate the effect of the time spent on social media and the time spent self-updating on news related to the COVID-19 pandemic on the mental well-being of 138 undergraduate college students, aged 18 to 24. A voluntary online questionnaire using the Affectometer 2 scale was used during the 5th week of the lockdown. We found a strong negative correlation between the time spent on social media and the mental well-being of students, while no statistically significant correlation between the time spent self-updating on COVID-19 related news and mental well-being was found. It is important that students use social media in moderation and find alternative avenues for recreation, to prevent unnecessary stress and potential adverse effects on their mental health, and thus maintain their psychological well-being.

Published
2021
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13. Abstract 167: COVID-19 vaccine side effects in Type 1 diabetes mellitus patients as compared to healthy controls: Results from the COVAD study

Author

Tulika Chatterjee, R Naveen, AbrahamEdgar Gracia-Ramos, Bhupen Barman, Parikshit Sen, Mrudula Joshi, Sreoshy Saha, Arvind Nune, Arunkumar Pande, Tsvetelina Velikova, Ioannis Parodis, AiLyn Tan, SamuelKatsuyuki Shinjo, Hiya Boro, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, and null COVAD Study Group

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
2022
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