10 results on '"Papi, Claudio"'
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2. sj-docx-1-tag-10.1177_17562848211072412 ��� Supplemental material for Effectiveness of ustekinumab in patients with refractory Crohn���s disease: a multicentre real-life study in Italy
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Scribano, Maria Lia, Aratari, Annalisa, Neri, Benedetto, Bezzio, Cristina, Balestrieri, Paola, Baccolini, Valentina, Falasco, Giuliano, Camastra, Caterina, Pantanella, Paolo, Monterubbianesi, Rita, Tullio, Alessandro, Saibeni, Simone, Papi, Claudio, Biancone, Livia, Cosintino, Rocco, and Faggiani, Roberto
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FOS: Clinical medicine ,111199 Nutrition and Dietetics not elsewhere classified ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental material, sj-docx-1-tag-10.1177_17562848211072412 for Effectiveness of ustekinumab in patients with refractory Crohn���s disease: a multicentre real-life study in Italy by Maria Lia Scribano, Annalisa Aratari, Benedetto Neri, Cristina Bezzio, Paola Balestrieri, Valentina Baccolini, Giuliano Falasco, Caterina Camastra, Paolo Pantanella, Rita Monterubbianesi, Alessandro Tullio, Simone Saibeni, Claudio Papi, Livia Biancone, Rocco Cosintino and Roberto Faggiani in Therapeutic Advances in Gastroenterology
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- 2022
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3. Safety of treatments for inflammatory bowel disease: Clinical practice guidelines of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Aratari, Annalisa, Bossa, Fabrizio, Cappello, Maria, Cassinotti, Andrea, Chiriatti, Alberto, Fiorino, Gionata, Formica, Vincenzo, Guidi, Luisa, Losco, Alessandra, Mocciaro, Filippo, Onali, Sara, Pastorelli, Luca, Pica, Roberta, Principi, Mariabeatrice, Renna, Sara, Ricci, Chiara, Rispo, Antonio, Rogai, Francesca, Sarmati, Loredana, Scaldaferri, Franco, Spina, Luisa, Tambasco, Rosy, Testa, Anna, Viscido, Angelo, Biancone, Livia, Annese, Vito, Ardizzone, Sandro, Armuzzi, Alessandro, Calabrese, Emma, Caprioli, Flavio, Castiglione, Fabiana, Comberlato, Michele, Cottone, Mario, Danese, Silvio, Daperno, Marco, D'Incà, Renata, Frieri, Giuseppe, Fries, Walter, Gionchetti, Paolo, Kohn, Anna, Latella, Giovanni, Milla, Monica, Orlando, Ambrogio, Papi, Claudio, Petruzziello, Carmelina, Riegler, Gabriele, Rizzello, Fernando, Saibeni, Simone, Scribano, Maria Lia, Vecchi, Maurizio, Vernia, Piero, Meucci, Gianmichele, Rugge, Massimo, Biancone, Livia, Annese, Vito, Ardizzone, Sandro, Armuzzi, Alessandro, Calabrese, Emma, Caprioli, Flavio, Castiglione, Fabiana, Comberlato, Michele, Cottone, Mario, Danese, Silvio, Daperno, Marco, D'Incà, Renata, Frieri, Giuseppe, Fries, Walter, Gionchetti, Paolo, Kohn, Anna, Latella, Giovanni, Milla, Monica, Orlando, Ambrogio, Papi, Claudio, Petruzziello, Carmelina, Riegler, Gabriele, Rizzello, Fernando, Saibeni, Simone, Scribano, Maria Lia, Vecchi, Maurizio, Vernia, Piero, Meucci, Gianmichele, Rugge, Massimo, Aratari, Annalisa, Bossa, Fabrizio, Cappello, Maria, Cassinotti, Andrea, Chiriatti, Alberto, Fiorino, Gionata, Formica, Vincenzo, Guidi, Luisa, Losco, Alessandra, Mocciaro, Filippo, Onali, Sara, Pastorelli, Luca, Pica, Roberta, Principi, Mariabeatrice, Renna, Sara, Ricci, Chiara, Rispo, Antonio, Rogai, Francesca, Sarmati, Loredana, Scaldaferri, Franco, Spina, Luisa, Tambasco, Rosy, Testa, Anna, Viscido, Angelo, Biancone, L, Annese, V, Ardizzone, S, Armuzzi, A, Calabrese, E, Caprioli, F, Castiglione, F, Comberlato, M, Cottone, M, Danese, S, Daperno, M, D'Inca, R, Frieri, G, Fries, W, Gionchetti, P, Kohn, A, Latella, G, Milla, M, Orlando, A, Papi, C, Petruzziello, C, Riegler, G, Rizzello, F, Saibeni, S, Scribano, Ml, Vecchi, M, Vernia, P, and Meucci, G
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Guidelines ,Inflammatory bowel disease ,Medical treatments ,Safety ,Adrenal Cortex Hormones ,Aminosalicylic Acid ,Anti-Bacterial Agents ,Antibodies, Monoclonal, Humanized ,Cyclosporine ,Drug Therapy, Combination ,Female ,Humans ,Inflammatory Bowel Diseases ,Italy ,Mercaptopurine ,Methotrexate ,Pregnancy ,Randomized Controlled Trials as Topic ,Treatment Outcome ,Tumor Necrosis Factor-alpha ,Evidence-Based Medicine ,Hepatology ,Gastroenterology ,Disease ,Guideline ,Adrenal Cortex Hormone ,chemistry.chemical_compound ,0302 clinical medicine ,Monoclonal ,030212 general & internal medicine ,Humanized ,Settore MED/12 - Gastroenterologia ,Ulcerative colitis ,Combination ,030211 gastroenterology & hepatology ,Human ,medicine.drug ,medicine.medical_specialty ,Antibodies ,Vedolizumab ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,Anti-Bacterial Agent ,medicine ,Intensive care medicine ,business.industry ,medicine.disease ,digestive system diseases ,Rifaximin ,Metronidazole ,chemistry ,Etiology ,business ,Medical treatment - Abstract
Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a growing incidence and prevalence in several countries, including Italy. Although the etiology of Crohn's disease and ulcerative colitis is unknown, due to the current knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines are available regarding the efficacy and safety of available drug treatments for inflammatory bowel diseases. Nevertheless, national guidelines provide additional information adapted to local feasibility, costs and legal issues related to the use of the same drugs. These observations prompted the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) to establish Italian guidelines on the safety of currently available treatments for Crohn's disease and ulcerative colitis. These guidelines discuss the use of aminosalicylates, systemic and low bioavailability corticosteroids, antibiotics (metronidazole, ciprofloxacin, rifaximin), thiopurines, methotrexate, cyclosporine A, TNFα antagonists, vedolizumab, and combination therapies. These guidelines are based on current knowledge derived from evidence-based medicine coupled with clinical experience of a national working group.
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- 2017
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4. Supplemental material for Early-onset versus late-onset Crohn's disease: An Italian cohort study
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Cantoro, Laura, Lenti, Marco Vincenzo, Monterubbianesi, Rita, Cicala, Michele, Giannarelli, Diana, Papi, Claudio, Kohn, Anna, and Sabatino, Antonio Di
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FOS: Clinical medicine ,FOS: Biological sciences ,111199 Nutrition and Dietetics not elsewhere classified ,FOS: Health sciences ,110308 Geriatrics and Gerontology ,69999 Biological Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental Material for Early-onset versus late-onset Crohn's disease: An Italian cohort study by Laura Cantoro, Marco Vincenzo Lenti, Rita Monterubbianesi, Michele Cicala, Diana Giannarelli, Claudio Papi# Anna Kohn#Antonio Di Sabatino in United European Gastroenterology Journal
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- 2019
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5. Anti-TNF Therapy in Elderly People in IBD: An Italian Multicentre Survey
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Cottone, Mario, Kohn, Anna, Daperno, Marco, Armuzzi, Alessandro, Guidi, Luisa, Renata D'Incà, Bossa, Fabrizio, Biancone, Livia, Gionchetti, Paolo, Ardizzone, Sandro, Papi, Claudio, Fries, Walter, Danese, Silvio, Cappello, Maria, Castiglione, Fabiana, and Orlando, Ambrogio
6. Early Post-Operative Endoscopic Recurrence in Crohn's Disease in an Italian Multicentric Cohort
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Orlando, Ambrogio, Scimeca, Daniela, Mocciaro, Filippo, Testa, Anna, Aratari, Annalisa, Bossa, Fabrizio, Tambasco, Rosy, Angelucci, Erika, Onali, Sara, Cappello, Maria, Fries, Walter, Renata D'Incà, Castiglione, Fabiana, Papi, Claudio, Annese, Vito, Gionchetti, Paolo, Vernia, Piero, Biancone, Livia, and Cottone, Mario
7. Early Post-Operative Endoscopic Recurrence in Crohn's Disease Patients: Data From a Large Prospective Italian Multicenter Cohort
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Orlando, Ambrogio, Mocciaro, Filippo, Scimeca, Daniela, Rispo, Antonio, Scribano, Maria Lia, Testa, Anna, Aratari, Annalisa, Bossa, Fabrizio, Tambasco, Rosy, Angelucci, Erika, Onali, Sara, Cappello, Maria, Fries, Walter, Renata D'Incà, Martinato, Matteo, Castiglione, Fabiana, Papi, Claudio, Annese, Vito, Gionchetti, Paolo, Rizzello, Fernando, Vernia, Piero, Biancone, Livia, Kohn, Anna, and Cottone, Mario
8. CHARACTERIZATION OF INCIDENT CASES OF CANCER IN INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE MULTICENTER NESTED CASE-CONTROL IG-IBD STUDY
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Biancone, Livia, Armuzzi, Alessandro, Lia, Scribano Maria, Renata D'Incà, Papi, Claudio, Spina, Luisa, Ruffa, Alessandra, Petruzziello, Carmelina, Guidi, Luisa, Kohn, Anna, Calabrese, Emma, Mocciaro, Filippo, Alvisi, Patrizia, Angelucci, Erika, Monterubbianesi, Rita, Fries, Walter, Riegler, Gabriele, Castiglione, Fabiana, Margagnoni, Giovanna, Renna, Sara, Di Mitri, Roberto, Meucci, Gianmichele, Rogai, Francesca, Ardizzone, Sandro, Rossi, Alessandra, Orlando, Ambrogio, and Pallone, Francesco
9. Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis
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Michele Martino, Catherine Klersy, Antonietta D'Errico, Giovanni Monteleone, G. Solina, Claudia Mescoli, Massimo Rugge, Livia Biancone, Gino Roberto Corazza, Francesco Tonelli, Flavio Caprioli, Gessica Lobascio, Fernando Rizzello, Augusto Orlandi, Vincenzo Villanacci, Stefano Ferrero, Roberto Caronna, Giovanni Arpa, Laura Cantoro, Antonio Di Sabatino, Roberto Fiocca, Enrico Solcia, Maria Cristina Macciomei, Fausto Sessa, Sandro Ardizzone, Claudio Papi, Paolo Giuffrida, Gianluca M. Sampietro, Deborah Malvi, Gilberto Poggioli, Federica Grillo, Gabriella Nesi, Barbara Oreggia, Marco Paulli, Giovanni Latella, Antonio Ciardi, Marco Vincenzo Lenti, Alessandro Vanoli, Ombretta Luinetti, Paolo Fociani, Maurizio Vecchi, Renata D'Incà, Aroldo Rizzo, Arpa, Giovanni, Grillo, Federica, Giuffrida, Paolo, Nesi, Gabriella, Klersy, Catherine, Mescoli, Claudia, Lenti, Marco Vincenzo, Lobascio, Gessica, Martino, Michele, Latella, Giovanni, Malvi, Deborah, Macciomei, Maria Cristina, Fociani, Paolo, Villanacci, Vincenzo, Rizzo, Aroldo, Ferrero, Stefano, Sessa, Fausto, Orlandi, Augusto, Monteleone, Giovanni, Biancone, Livia, Cantoro, Laura, Tonelli, Francesco, Ciardi, Antonio, Poggioli, Gilberto, Rizzello, Fernando, Ardizzone, Sandro, Sampietro, Gianluca, Solina, Gaspare, Oreggia, Barbara, Papi, Claudio, D'Incà, Renata, Vecchi, Maurizio, Caprioli, Flavio, Caronna, Roberto, D'Errico, Antonietta, Fiocca, Roberto, Rugge, Massimo, Corazza, Gino Roberto, Luinetti, Ombretta, Paulli, Marco, Solcia, Enrico, Di Sabatino, Antonio, and Vanoli, Alessandro
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Male ,medicine.medical_specialty ,Colorectal cancer ,tumor budding ,Settore MED/08 - Anatomia Patologica ,Adenocarcinoma ,adenocarcinoma ,grading ,poorly differentiated cluster ,Gastroenterology ,tumour budding ,Diagnosis, Differential ,Crohn Disease ,Tumor budding ,Internal medicine ,Intestinal Neoplasms ,Intestine, Small ,Prevalence ,medicine ,Carcinoma ,Humans ,Neoplasm Invasiveness ,Grading (tumors) ,Neoplasm Staging ,Retrospective Studies ,Cancer staging ,Settore MED/12 - Gastroenterologia ,Crohn's disease ,business.industry ,Patient Selection ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Italy ,Female ,Histopathology ,Neoplasm Grading ,business - Abstract
Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.
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- 2019
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10. Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular, and Prognostic Features. A Study From the Small Bowel Cancer Italian Consortium
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Claudia Mescoli, Michele Martino, Fausto Sessa, Massimo Rugge, Ombretta Luinetti, Gabriella Nesi, Vincenzo Canzonieri, Alessandro Vanoli, Luca Reggiani Bonetti, Ada Maria Florena, Giovanni Monteleone, Daniela Furlan, Umberto Volta, Paolo Fociani, Vincenzo Villanacci, Antonino Giulio Giannone, Marco Silano, Antonio Di Sabatino, Antonio Maccioni, Paolo Usai, G. Solina, Vittorio Perfetti, Federica Grillo, Maria Cristina Macciomei, Rachele Manca, Stefano Ferrero, Renato Cannizzaro, Aroldo Rizzo, Livia Biancone, Luca Elli, Claudio Papi, Giacomo Caio, Giovanni Latella, Antonio Calabrò, Roberta Cerutti, Marianna Salemme, Paolo Giuffrida, Gianluca M. Sampietro, Gino Roberto Corazza, Paola Migliora, Donatella Santini, Sandro Ardizzone, Augusto Orlandi, Francesco Tonelli, Antonio Ciardi, Catherine Klersy, Carolina Ciacci, Davide Trapani, Renata D'Incà, Francesco Paolo D'Armiento, Marco Paulli, Marco Astegiano, Roberto Caronna, Roberto Fiocca, Luigi Michele Coppola, Paola Alberizzi, Enrico Solcia, Giuseppe Santeusanio, G. Sandri, Roberta Riboni, Vanoli, Alessandro, Sabatino, Antonio Di, Furlan, Daniela, Klersy, Catherine, Grillo, Federica, Fiocca, Roberto, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Fociani, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Luinetti, Ombretta, Calabrò, Antonio, Tonelli, Francesco, Volta, Umberto, Santini, Donatella, Caio, Giacomo, Giuffrida, Paolo, Elli, Luca, Ferrero, Stefano, Latella, Giovanni, Ciardi, Antonio, Caronna, Roberto, Solina, Gaspare, Rizzo, Aroldo, Ciacci, Carolina, D'Armiento, FRANCESCO PAOLO, Salemme, Marianna, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Bonetti, Luca Reggiani, Biancone, Livia, Monteleone, Giovanni, Orlandi, Augusto, Santeusanio, Giuseppe, Macciomei, Maria C, D'Incà, Renata, Perfetti, Vittorio, Sandri, Giancarlo, Silano, Marco, Florena, Ada M, Giannone, Antonino G, Papi, Claudio, Coppola, Luigi, Usai, Paolo, Maccioni, Antonio, Astegiano, Marco, Migliora, Paola, Manca, Rachele, Martino, Michele, Trapani, Davide, Cerutti, Roberta, Alberizzi, Paola, Riboni, Roberta, Sessa, Fausto, Paulli, Marco, Solcia, Enrico, Corazza, Gino R., Di Sabatino, Antonio, D’Armiento, Francesco P., Reggiani Bonetti, Luca, Macciomei, Maria C., D’Incà, Renata, Florena, Ada M., Giannone, Antonino G., Vanoli A., Di Sabatino A., Furlan D., Klersy C., Grillo F., Fiocca R., Mescoli C., Rugge M., Nesi G., Fociani P., Sampietro G., Ardizzone S., Luinetti O., Calabro A., Tonelli F., Volta U., Santini D., Caio G., Giuffrida P., Elli L., Ferrero S., Latella G., Ciardi A., Caronna R., Solina G., Rizzo A., Ciacci C., D'Armiento F.P., Salemme M., Villanacci V., Cannizzaro R., Canzonieri V., Bonetti L.R., Biancone L., Monteleone G., Orlandi A., Santeusanio G., Macciomei M.C., D'Inca R., Perfetti V., Sandri G., Silano M., Florena A.M., Giannone A.G., Papi C., Coppola L., Usai P., Maccioni A., Astegiano M., Migliora P., Manca R., Martino M., Trapani D., Cerutti R., Alberizzi P., Riboni R., Sessa F., Paulli M., Solcia E., and Corazza G.R.
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Male ,0301 basic medicine ,Neuroblastoma RAS viral oncogene homolog ,Oncology ,Survival ,Receptor, ErbB-2 ,Colorectal cancer ,medicine.disease_cause ,Inflammatory bowel disease ,tumour-infiltrating lymphocyte ,ErbB-2 ,0302 clinical medicine ,Crohn Disease ,Retrospective Studie ,Risk Factors ,80 and over ,Child ,Class I Phosphatidylinositol 3-Kinase ,Aged, 80 and over ,Colonic Neoplasm ,Settore MED/12 - Gastroenterologia ,Crohn's disease ,MLH1 methylation ,Tumour-infiltrating lymphocytes ,Gastroenterology ,General Medicine ,Middle Aged ,Prognosis ,Microsatellite instability ,MLH1 promoter methylation ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Survival Analysi ,KRAS ,Human ,Receptor ,Adult ,Proto-Oncogene Proteins B-raf ,medicine.medical_specialty ,Prognosi ,Class I Phosphatidylinositol 3-Kinases ,Settore MED/08 - Anatomia Patologica ,NO ,Proto-Oncogene Proteins p21(ras) ,Young Adult ,03 medical and health sciences ,Internal medicine ,medicine ,Carcinoma ,Humans ,inflammatory bowel disease ,microsatellite instability ,survival ,tumour-infiltrating lymphocytes ,neoplasms ,Aged ,Retrospective Studies ,Celiac Disease ,Microsatellite Instability ,Survival Analysis ,Tumor Suppressor Protein p53 ,business.industry ,Tumour-infiltrating lymphocyte ,Risk Factor ,Cancer ,medicine.disease ,eye diseases ,digestive system diseases ,030104 developmental biology ,business - Abstract
Background and aims An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-associated SBC [CrD-SBC] in comparison with sporadic SBC [spo-SBC]. Methods A total of 76 patients undergoing surgical resection for non-familial SBC [26 CD-SBC, 25 CrD-SBC, 25 spo-SBC] were retrospectively enrolled to investigate patients' survival and histological and molecular features including microsatellite instability [MSI] and KRAS/NRAS, BRAF, PIK3CA, TP53, HER2 gene alterations. Results CD-SBC showed a significantly better sex-, age-, and stage-adjusted overall and cancer-specific survival than CrD-SBC, whereas no significant difference was found between spo-SBC and either CD-SBC or CrD-SBC. CD-SBC exhibited a significantly higher rate of MSI and median tumour-infiltrating lymphocytes [TIL] than CrD-SBC and spo-SBC. Among the whole SBC series, both MSI─which was the result of MLH1 promoter methylation in all but one cases─and high TIL density were associated with improved survival at univariable and stage-inclusive multivariable analysis. However, only TILs retained prognostic power when clinical subgroups were added to the multivariable model. KRAS mutation and HER2 amplification were detected in 30% and 7% of cases, respectively, without prognostic implications. Conclusions In comparison with CrD-SBC, CD-SBC patients harbour MSI and high TILs more frequently and show better outcome. This seems mainly due to their higher TIL density, which at multivariable analysis showed an independent prognostic value. MSI/TIL status, KRAS mutations and HER2 amplification might help in stratifying patients for targeted anti-cancer therapy.
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- 2017
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