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2. Kew, O. et al. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296, 356-359

Author

Morris-Glasgow, Victoria, Landaverde, Mauricio, Shaw, Jing, Sutter, Roland, Tambini, Gina, Venczel, Linda, Pedreira, Cristina, Laender, Fernando, Shimizu, Hiroyuki, Yoneyama, Tetsuo, Miyamura, Tatsuo, van Der Avoort, Harrie, Steven Oberste, M., Kilpatrick, David, Pallansch, Mark, de Quadros, Ciro, Burns, Cara, Garib, Zacarías, André, Jean, Blackman, Elizabeth, Jason Freeman, C., Jorba, Jaume, Kew, Olen, and Cochi, Stephen

Abstract

An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.

Published
2002

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