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Fragestellung: Vergleich zwischen Farbdopplersonographie und Portographie zur Nachsorge von TIPSS-Patienten. Material und Methoden: In einer prospektiven Studie wurde bei 40 konsekutiven TIPSS-Patienten im Rahmen der Nachsorge eine venose Portographie und am selben Tag eine Farbdopplersonographie durchgefuhrt. Innerhalb des TIPSS wurden Fluswerte am Einflustrakt (portales Segment) und Ausflustrakt (Lebervenensegment) gemessen. Ergebnisse: Bei 28 Patienten mit unauffalligem Shunt lag die Flusgeschwindigkeit im Einflustrakt zwischen 30–120 cm/s (Median 60 cm/s), im Ausflustrakt zwischen 60–155 cm/s (Median 82 cm/s). Im Ausflustrakt war die Flusgeschwindigkeit signifikant hoher als im Einflustrakt (p

We report the case of a 52 year old male with diabetes mellitus and long standing evidence of hepatic iron excess. Initially considered to have haemochromatosis, this patient was reevaluated when hepatic iron stores were found to be unaffected by a prolonged course of weekly phlebotomy. The development of neurological disease prompted diagnostic consideration of aceruloplasminaemia, which we confirmed by demonstration of a novel frameshift mutation in the ceruloplasmin gene. Our inability to resolve the patient's iron overload by regular phlebotomy is consistent with recent animal studies indicating an essential role for ceruloplasmin in cellular iron efflux. Evaluation of this case underscores the clinical relevance of aceruloplasminaemia in the differential diagnosis of hepatic iron overload and provides insight into the pathogenetic mechanisms of hepatocellular iron storage and efflux. Keywords: aceruloplasminaemia; ceruloplasmin; diabetes; haemochromatosis; iron

widely neglected. Only a few studies have been performed to assess the presence and expansion of pathoBackground. Prolonged peritoneal dialysis and frequent episodes of peritonitis lead to structural changes logical processes such as abdominal tumours [1], tuberculous [2] or meconium [3] peritonitis, and to and thickening of the peritoneum. Ultrasonography investigations may provide the opportunity to detect investigate anatomical structures such as ligaments or recessus [4,5]. The interest in morphology and function morphological changes early, but no systematic investigations have been performed yet. of the peritoneum has increased since chronic ambulatory peritoneal dialysis (CAPD) has become a routine Methods. Normal values of peritoneal thickness were obtained by systematically examining 131 healthy chil- procedure for the treatment of patients with terminal renal failure [6‐10]. The peritoneum has frequently dren (0‐15 years) by ultrasound. Parietal peritoneal thickness was best measured at the sternal‐umbical been studied by histological and histomorphometrical methods [11‐15] to understand the morphological and line distal from the xiphoid. Growth charts with 95% intervals were prepared.The data of 26 patients with physiological changes, but systematic ultrasound studies are missing. end-stage renal failure (5‐18 years) were compared to those of the normal children. The aim of this study was to determine whether ultrasonography of the peritoneum can be performed Results. The variation coeYcient for the consecutive measurements was only 5%, interobserver error was in a reliable and reproducible fashion. In addition, it was ascertained whether the thickness of the peritonapproximately 7%. Whereas gender did not have any influence, peritoneal thickness was significantly correl- eum depends on age, gender, and body size, and whether patients on CAPD and haemodialysis show ated to age, weight and most obviously to height (r= 0.81; P

In an attempt to overcome the inherent disadvantage of narcotic antitussive therapy, three basic alkoxy-alkyl esters of phenothiazine-10-carboxylic acid were synthesized and tested for pharmacological activity. These compounds possessed antitussive activity in the cat in the range of activity of codeine. Dimethyl-amino-ethoxy-ethyl phenothiazine-10-carboxylate was chosen, on the basis of strong antitussive activity coupled with low acute toxicity and low antispasmodic activity, for chronic toxicity studies and clinical trial. This compound is devoid of central depressant or analgesic properties and possesses a moderate local anaesthetic action.