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56 results on '"Otto-von-Guericke-Universität Magdeburg"'

1. Dezentraler IOTA-basierter Industrie-Marktplatz

Author: Otto-von-Guericke-Universität Magdeburg, Christian Diedrich, Hamburg Helmut-Schmidt-Universität, Alaettin Dogan, Holger Köther, and Alexander Belyaev
Published: 2020
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2. Incubating success towards gulf cooperation council (gcc)

Author: Hanadi Mubarak Al-Mubaraki, Holger Schrödl, and Deutschland Otto-von-Guericke-Universität Magdeburg
Subjects: Engineering, Government, Knowledge management, Originality, business.industry, media_common.quotation_subject, Member states, Incubator, Context (language use), Public relations, business, media_common
Abstract: Purpose: This paper aims to identify and assess critical dimension of busi- ness incubation with focus on the Gulf Cooperation Council, which are suitable to measure the effectiveness of business incubation to support startup and entrepre- neurial businesses by providing a number of services and resources to the clients. Design/methodology/approach: The study is a multi-method approach combined of desk-research, interviews, a multi-case study of five incubator organizations in the Gulf Cooperation Council (GCC) member states and a case study in an in- ternational context. Findings: Firstly, a model for measuring the effectiveness of business incubation in a standardized way is developed and secondly, this model is evaluated by a multi-case study and its implications are discussed in the context of an international background. Research limitations/implications: There is little academic research presenting the characteristics of business incubation in the Gulf Cooperation Council (GCC). Originality/value: This model helps practitioners and government parties for fu- ture implementation of incubators program. Furthermore, it adds new knowl- edge for academic literature incubators and economic development to a com- monly agreed model for effectiveness measurement of business incubators.
Published: 2012
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3. Text data mining and data quality management for research information systems in the context of open data and open science

Author: Otmane Azeroual, Gunter Saake, Mohammad Abuosba, Joachim Schöpfel, German Center for Higher Education Research and Science Studies (DZHW), Otto-von-Guericke-Universität Magdeburg, University of Applied Sciences [Berlin] (HTW), Groupe d'Études et de Recherche Interdisciplinaire en Information et COmmunication - ULR 4073 (GERIICO ), Université de Lille, ESI Rabat, and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: FOS: Computer and information sciences, [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Open data, Data quality, Computer Science - Digital Libraries, Databases (cs.DB), Text and data mining, Text analysis, Current research information systems (CRIS), Research information, Standardization, Current research information system, Big data, Data quality management, Computer Science - Databases, Research information systems (RIS), Digital Libraries (cs.DL), Open science, Knowledge discovery database, Data mining
Abstract: International audience; In the implementation and use of research information systems (RIS) in scientific institutions, text data mining and semantic technologies are a key technology for the meaningful use of large amounts of data. It is not the collection of data that is difficult, but the further processing and integration of the data in RIS. Data is usually not uniformly formatted and structured, such as texts and tables that cannot be linked. These include various source systems with their different data formats such as project and publication databases, CERIF and RCD data model, etc. Internal and external data sources continue to develop. On the one hand, they must be constantly synchronized and the results of the data links checked. On the other hand, the texts must be processed in natural language and certain information extracted. Using text data mining, the quality of the metadata is analyzed and this identifies the entities and general keywords. So that the user is supported in the search for interesting research information. The information age makes it easier to store huge amounts of data and increase the number of documents on the internet, in institutions’ intranets, in newswires and blogs is overwhelming. Search engines should help to specifically open up these sources of information and make them usable for administrative and research purposes. Against this backdrop, the aim of this paper is to provide an overview of text data mining techniques and the management of successful data quality for RIS in the context of open data and open science in scientific institutions and libraries, as well as to provide ideas for their application. In particular, solutions for the RIS will be presented.
Published: 2018
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4. Ability of Azathiacyclen Ligands To Stop Cu(Aβ)‐Induced Production of Reactive Oxygen Species: [3N1S] Is the Right Donor Set

Author: Kyangwi P. Malikidogo, Marielle Drommi, Elena Atrián‐Blasco, Jan Hormann, Nora Kulak, Charlène Esmieu, Christelle Hureau, Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Freie Universität Berlin, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), ANR-20-CE07-0009,Copperation,Ligands fluorescents: pour la conception rationnelle de ligands ciblant les ions cuivre dans le cadre de la maladie d'Alzheimer(2020), European Project: 638712,H2020,ERC-2014-STG,aLzINK(2015), Département de Chimie Moléculaire (DCM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Physiochimie des Métaux (PMB), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Instituto de Nanociencia y Materiales de Aragón (INMA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Zaragossa, and Institut für Chemie und Biochemie, Anorganische Chemie, Freie Universität Berlin
Subjects: Oxidative stress, Organic Chemistry, Alzheimer, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [CHIM.COOR]Chemical Sciences/Coordination chemistry, EPR, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, General Chemistry, Alzheimer's disease, Macrocycles, Copper, Catalysis
Abstract: International audience; Alzheimer's disease (AD) is an incurable neurodegenerative disease that leads to the progressive and irreversible loss of mental functions. The amyloid beta (A beta) peptide involved in the disease is responsible for the production of damaging reactive oxygen species (ROS) when bound to Cu ions. A therapeutic approach that consists of removing Cu ions from A beta to alter this deleterious interaction is currently being developed. In this context, we report the ability of five different 12-membered thiaazacyclen ligands to capture Cu from A beta and to redox silence it. We propose that the presence of a sole sulfur atom in the ligand increases the rate of Cu capture and removal from A beta, while the kinetic aspect of the chelation was an issue encountered with the 4N parent ligand. The best ligand for removing Cu from A beta and inhibiting the associated ROS production is the 1-thia-4,7,10-triazacyclododecane [3N1S]. Indeed the replacement of more N by S atoms makes the corresponding Cu complexes easier to reduce and thus able to produce ROS on their own. In addition, the ligand with three sulfur atoms has a weaker affinity for Cu-II than A beta, and is thus unable to remove Cu from CuA beta.
Published: 2023
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5. Minimising the risk of monkeypox virus transmission during faecal microbiota transplantation: recommendations from a European expert panel

Author: Gianluca Ianiro, Benjamin H Mullish, Tariq H Iqbal, Elisabeth M Terveer, Simon Mark Dahl Baunwall, Alexander Link, Harry Sokol, Juozas Kupcinskas, Luca Masucci, Maurizio Sanguinetti, Maria J G T Vehreschild, Christian L Hvas, Josbert J Keller, Antonio Gasbarrini, Ed J Kujiper, Giovanni Cammarota, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Imperial College London, University of Birmingham [Birmingham], Leiden University Medical Center (LUMC), Aarhus University Hospital, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lithuanian University of Health Sciences [Kaunas, Lithuania], Goethe-University Frankfurt am Main, Sokol, Harry, and Imperial College Healthcare NHS Trust- BRC Funding
Subjects: [SDV] Life Sciences [q-bio], Feces, Hepatology, Clostridioides difficile, Settore MED/12 - GASTROENTEROLOGIA, [SDV]Life Sciences [q-bio], Settore MED/09 - MEDICINA INTERNA, Gastroenterology, Humans, Fecal Microbiota Transplantation, Monkeypox virus, faecal microbiota
Abstract: International audience; No abstract available
Published: 2022
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6. Epidemiology of Pierre‐Robin sequence in Europe: A population‐based EUROCAT study

Author: Carmel Mullaney, Mary O'Mahony, Ingeborg Barišić, Nataliia Zymak-Zakutnia, Martin Haeusler, Bruno Schaub, Olatz Mokoroa, Anna Materna-Kiryluk, David Tucker, Anna Pierini, Ljubica Boban, Miriam Gatt, Clara Cavero-Carbonell, Michele Santoro, Anke Rissmann, Jennifer J Kurinczuk, Alessio Coi, Nathalie Lelong, Kari Klungsøyr, Florence Rouget, Silvia Baldacci, Isabelle Perthus, Hermien E. K. de Walle, Monica Lanzoni, Ester Garne, Vera Nelen, Paula Braz, Elisa Ballardini, Karen Luyt, Marie-Claude Addor, Diana Wellesley, Judith Rankin, Hanitra Randrianaivo, Elizabeth S Draper, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Università degli Studi di Ferrara = University of Ferrara (UniFE), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), University of Groningen [Groningen], University of Leicester, Medical University Graz, University of Bergen (UiB), Norwegian Institute of Public Health [Oslo] (NIPH), University of Oxford, Poznan University of Medical Sciences [Poland] (PUMS), Centre de Recherche en Sciences du Sport (EA 1609) (CRESS), Université Paris-Sud - Paris 11 (UP11), University of Bristol [Bristol], CHU Clermont-Ferrand, CHU Sud Saint Pierre [Ile de la Réunion], Newcastle University [Newcastle], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU de la Martinique [Fort de France], Consiglio Nazionale delle Ricerche [Roma] (CNR), Università degli Studi di Ferrara (UniFE), University of Oxford [Oxford], Otto-von-Guericke University [Magdeburg] (OVGU), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), and Reproductive Origins of Adult Health and Disease (ROAHD)
Subjects: medicine.medical_specialty, EUROCAT, Pierre Robin sequence, epidemiology, prevalence, rare congenital anomalies, Epidemiology, [SDV]Life Sciences [q-bio], Pierre Robin Syndrome/epidemiology, Population, Prevalence, Population based, Europe/epidemiology, 03 medical and health sciences, symbols.namesake, Economica, 0302 clinical medicine, Pregnancy, 030225 pediatrics, medicine, Humans, Abnormalities, Multiple, Registries, Poisson regression, education, education.field_of_study, Robin Sequence, LS7_9, 030219 obstetrics & reproductive medicine, Pierre Robin Syndrome, Obstetrics, Potential risk, business.industry, RENAC, Observação em Saúde e Vigilância, Estados de Saúde e de Doença, 3. Good health, Europe, Pediatrics, Perinatology and Child Health, Cohort, symbols, Female, Abnormalities, business, Multiple, Maternal Age
Abstract: Background: Pierre Robin sequence (PRS) is a rare congenital anomaly. Respiratory disorders and feeding difficulties represent the main burden. Objective: The aim of this study was to investigate the epidemiology of PRS using a cohort of cases from EUROCAT, the European network of population-based registries of congenital anomalies. Methods: We analysed cases of PRS born in the period 1998-2017 collected by 29 population-based congenital anomaly registries in 17 different countries. We calculated prevalence estimates, prenatal detection rate, survival up to 1 week, and proportions of associated anomalies. The effect of maternal age was tested using a Poisson regression model. Results: Out of 11 669 155 surveyed births, a total of 1294 cases of PRS were identified. The estimate of the overall prevalence was 12.0 per 100 000 births (95% CI 9.9, 14.5). There was a total of 882 (68.2%) isolated cases, and the prevalence was 7.8 per 100 000 births (95% CI 6.7, 9.2). A total of 250 cases (19.3%) were associated with other structural congenital anomalies, 77 cases (6.0%) were associated with chromosomal anomalies and 77 (6.0%) with genetic syndromes. The prenatal detection rate in isolated cases was 12.0% (95% CI 9.8, 14.5) and increased to 16.0% (95% CI 12.7, 19.7) in the sub-period 2008-2017. The prevalence rate ratio of non-chromosomal cases with maternal age ≥35 was higher than in cases with maternal age
Published: 2021
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7. Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation

Author: Marie-Christine Copin, Christelle Coraux, Isabelle Van Seuningen, Edith Puchelle, Marie-Pierre Buisine, Rodolphe Hajj, Margitta Hinz, Steven L. Brody, Werner Hoffmann, Pierre Lesimple, Dynamique cellulaire et moléculaire de la muqueuse respiratoire, Université de Reims Champagne-Ardenne (URCA)-IFR53-Institut National de la Santé et de la Recherche Médicale (INSERM), Mucines Epitheliales : du Gene a la Fonction, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Institut fur Molekularbiologie und Medizinische Chemie (OVGU), Otto-von-Guericke-Universität Magdeburg, School of Medecine, Washington University in Saint Louis (WUSTL), Birembaut, Philippe, and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Transcription, Genetic, Clinical Biochemistry, Respiratory System, MESH: Mucins, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Mice, 0302 clinical medicine, MESH: Animals, Cells, Cultured, 0303 health sciences, MESH: Peptides, Cilium, MESH: Regeneration, Cell Differentiation, respiratory system, MESH: Gene Expression Regulation, 3. Good health, Cell biology, ErbB Receptors, Protein Transport, medicine.anatomical_structure, MESH: Epithelial Cells, 030220 oncology & carcinogenesis, Female, Trefoil Factor-3, MESH: Cells, Cultured, Signal Transduction, Pulmonary and Respiratory Medicine, MESH: Cell Differentiation, MESH: Protein Transport, MESH: Rats, Transplantation, Heterologous, Mice, Nude, MESH: Receptor, Epidermal Growth Factor, Biology, Epithelial cell migration, 03 medical and health sciences, MESH: Cilia, Ciliogenesis, medicine, MESH: Mice, Nude, Animals, Humans, Regeneration, Cilia, RNA, Messenger, Rats, Wistar, Molecular Biology, MESH: Mice, 030304 developmental biology, MESH: RNA, Messenger, MESH: Humans, Regeneration (biology), Mucin, Mucins, Epithelial Cells, Cell Biology, MESH: Rats, Wistar, In vitro, Epithelium, Rats, Gene Expression Regulation, Immunology, Respiratory epithelium, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Peptides, MESH: Female
Abstract: Human airway surface epithelium is frequently damaged by inhaled factors (viruses, bacteria, xenobiotic substances) as well as by inflammatory mediators that contribute to the shedding of surface epithelial cells. To regain its protective function, the epithelium must rapidly repair and redifferentiate. The Trefoil Factor Family (TFF) peptides are secretory products of many mucous cells. TFF3, the major TFF in the airways, is able to enhance airway epithelial cell migration, but the role of this protein in differentiation has not been defined. To identify the specific role of TFF3 in the differentiation of the human airway surface epithelium, we analyzed the temporal expression pattern of TFF3, MUC5AC, and MUC5B mucins (goblet cells) and ciliated cell markers beta-tubulin (cilia) and FOXJ1 (ciliogenesis) during human airway epithelial regeneration using in vivo humanized airway xenograft and in vitro air-liquid interface (ALI) culture models. We observed that TFF3, MUC5AC, MUC5B, and ciliated cell markers were expressed in well-differentiated airway epithelium. The addition of exogenous recombinant human TFF3 to epithelial cell cultures before the initiation of differentiation resulted in no change in MUC5AC or cytokeratin 13 (CK13, basal cell marker)-positive cells, but induced an increase in the number of FOXJ1-positive cells and in the number of beta-tubulin-positive ciliated cells (P < 0.05). Furthermore, this effect on ciliated cell differentiation could be reversed by specific epidermal growth factor (EGF) receptor (EGF-R) inhibition. These results indicate that TFF3 is able to induce ciliogenesis and to promote airway epithelial ciliated cell differentiation, in part through an EGF-R-dependent pathway.
Published: 2006
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8. Delocalization of dark and bright excitons in flat-band materials and the optical properties of V2O5

Author: Vitaly Gorelov, Lucia Reining, Martin Feneberg, Rüdiger Goldhahn, André Schleife, Walter R. L. Lambrecht, Matteo Gatti, Laboratoire des Solides Irradiés (LSI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), European Theoretical Spectroscopy Facility (ETSF), new, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), University of Illinois at Urbana-Champaign [Urbana], and University of Illinois System
Subjects: [PHYS]Physics [physics], Condensed Matter - Materials Science, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Mechanics of Materials, Modeling and Simulation, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, General Materials Science, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Computational Physics (physics.comp-ph), Physics - Computational Physics, Computer Science Applications
Abstract: The simplest picture of excitons in materials with atomic-like localization of electrons is that of Frenkel excitons, where electrons and holes stay close together, which is associated with a large binding energy. Here, using the example of the layered oxide V2O5, we show how localized charge-transfer excitations combine to form excitons that also have a huge binding energy but, at the same time, a large electron-hole distance, and we explain this seemingly contradictory finding. The anisotropy of the exciton delocalization is determined by the local anisotropy of the structure, whereas the exciton extends orthogonally to the chains formed by the crystal structure. Moreover, we show that the bright exciton goes together with a dark exciton of even larger binding energy and more pronounced anisotropy. These findings are obtained by combining first principles many-body perturbation theory calculations, ellipsometry experiments, and tight binding modelling, leading to very good agreement and a consistent picture. Our explanation is general and can be extended to other materials.
Published: 2022
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9. The challenge of unprecedented floods and droughts in risk management

Author: Heidi Kreibich, Anne F. Van Loon, Kai Schröter, Philip J. Ward, Maurizio Mazzoleni, Nivedita Sairam, Guta Wakbulcho Abeshu, Svetlana Agafonova, Amir AghaKouchak, Hafzullah Aksoy, Camila Alvarez-Garreton, Blanca Aznar, Laila Balkhi, Marlies H. Barendrecht, Sylvain Biancamaria, Liduin Bos-Burgering, Chris Bradley, Yus Budiyono, Wouter Buytaert, Lucinda Capewell, Hayley Carlson, Yonca Cavus, Anaïs Couasnon, Gemma Coxon, Ioannis Daliakopoulos, Marleen C. de Ruiter, Claire Delus, Mathilde Erfurt, Giuseppe Esposito, Didier François, Frédéric Frappart, Jim Freer, Natalia Frolova, Animesh K. Gain, Manolis Grillakis, Jordi Oriol Grima, Diego A. Guzmán, Laurie S. Huning, Monica Ionita, Maxim Kharlamov, Dao Nguyen Khoi, Natalie Kieboom, Maria Kireeva, Aristeidis Koutroulis, Waldo Lavado-Casimiro, Hong-Yi Li, María Carmen LLasat, David Macdonald, Johanna Mård, Hannah Mathew-Richards, Andrew McKenzie, Alfonso Mejia, Eduardo Mario Mendiondo, Marjolein Mens, Shifteh Mobini, Guilherme Samprogna Mohor, Viorica Nagavciuc, Thanh Ngo-Duc, Thi Thao Nguyen Huynh, Pham Thi Thao Nhi, Olga Petrucci, Hong Quan Nguyen, Pere Quintana-Seguí, Saman Razavi, Elena Ridolfi, Jannik Riegel, Md Shibly Sadik, Elisa Savelli, Alexey Sazonov, Sanjib Sharma, Johanna Sörensen, Felipe Augusto Arguello Souza, Kerstin Stahl, Max Steinhausen, Michael Stoelzle, Wiwiana Szalińska, Qiuhong Tang, Fuqiang Tian, Tamara Tokarczyk, Carolina Tovar, Thi Van Thu Tran, Marjolein H. J. Van Huijgevoort, Michelle T. H. van Vliet, Sergiy Vorogushyn, Thorsten Wagener, Yueling Wang, Doris E. Wendt, Elliot Wickham, Long Yang, Mauricio Zambrano-Bigiarini, Günter Blöschl, Giuliano Di Baldassarre, Natural Environment Research Council (NERC), Water and Climate Risk, German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Vrije Universiteit Amsterdam [Amsterdam] (VU), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], University of Houston, Lomonosov Moscow State University (MSU), University of California (UC), Istanbul Technical University (ITÜ), Universidad de la frontera [Chile], Center for Climate and Resilience Research [Conception] ((CR)2), Universidad de Concepción - University of Concepcion [Chile], Operations Department, Barcelona Cicle de l’Aigua, University of Saskatchewan [Saskatoon] (U of S), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Department of Groundwater Management, Deltares, Delft, University of Birmingham [Birmingham], Agency for the Assessment and Application of Technology, Imperial College London, Beykent University [Istanbul], University of Freiburg [Freiburg], University of Bristol [Bristol], Cabot Institute, Hellenic Mediterranean University, Greece, Centre de Recherche en Géographie (LOTERR), Université de Lorraine (UL), Research Institute for Geo-hydrological Protection [Perugia] (IRPI), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Interactions Sol Plante Atmosphère (UMR ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Massachusetts Institute of Technology (MIT), Università Iuav di Venezia = Iuav University of Venice (IUAV), Foundation for Research and Technology - Hellas (FORTH), Pontificia Bolivariana University, Faculty of Civil Engineering [Bucaramanga], California State University [Long Beach] (CSULB ), Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI), Emil Racoviță Institute of Speleology (ERIS), Romanian Academy, University Stefan cel Mare of Suceava (USU), Water Problems Institute of the Russian Academy of Sciences, Russian Academy of Sciences [Moscow] (RAS), University of Sciences [Ho Chi Minh City] (HCMC), Ho Chi Minh City University of Science (HCMUS), ENVIRONMENT AGENCY BRISTOL GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Technical University of Crete [Chania], Servicio Nacional de Meteorología e Hidrología del Perú, University of Barcelona, British Geological Survey [Wallingford], British Geological Survey (BGS), Centre of Natural Hazards and Disaster Science [Uppsala], Uppsala University, Pennsylvania State University (Penn State), Penn State System, Escola de Engenharia de São Carlos (EESC-USP), Universidade de São Paulo = University of São Paulo (USP), Deltares [The Netherlands], Trelleborg municipality, Lund University [Lund], Institute of Environmental Science and Geography [Potsdam], University of Potsdam = Universität Potsdam, Hanoi University of Science and Technology (HUST), Vietnam National University Ho Chi Minh City, University of Technology, Vietnam National University - Ho Chi Minh City (Faculty of Chemical Engineering), Ho Chi Minh City University of Technology (HCMUT), OE OBSERVATORI DE L'EBRE RAMON LLULL UNIVERSITY ROQUETES ESP, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Center for Environmental and Geographic Information Services (CEGIS), Institute of Meteorology and Water Management - National Research Institute (IMGW - PIB), Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China, Tsinghua University [Beijing] (THU), Royal Botanical Gardens Kew [London], KWR Watercycle Research Institute, Utrecht University [Utrecht], University of Nebraska–Lincoln, University of Nebraska System, Nanjing University (NJU), Institute of Hydraulic Engineering and Water Resources Management, Vienna University of Technology (TU Wien), Institute for Water Education (IHE Delft ), and European Project: 01003276
Subjects: General Science & Technology, [SDE.MCG]Environmental Sciences/Global Changes, hydrology, datasets as topic, Oceanografi, hydrologi och vattenresurser, Settore SECS-P/06 - Economia Applicata, risk management, Flood, DISASTER LOSSES, Oceanography, Hydrology and Water Resources, extreme weather, Natural disasters, Canvi climàtic, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, ADAPTATION, humans, Multidisciplinary, Science & Technology, Drought, droughts, HAZARD, Catàstrofes naturals, [SHS.GEO]Humanities and Social Sciences/Geography, Floods, internationality, Climatic change, Multidisciplinary Sciences, SOCIAL VULNERABILITY, climate change, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, floods, Inundacions, ENGENHARIA HIDRÁULICA, Science & Technology - Other Topics, MYRIAD-EU
Abstract: Risk management has reduced vulnerability to floods and droughts globally1,2, yet their impacts are still increasing3. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data4,5. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impacts of floods and droughts but faces difficulties in reducing the impacts of unprecedented events of a magnitude not previously experienced. If the second event was much more hazardous than the first, its impact was almost always higher. This is because management was not designed to deal with such extreme events: for example, they exceeded the design levels of levees and reservoirs. In two success stories, the impact of the second, more hazardous, event was lower, as a result of improved risk management governance and high investment in integrated management. The observed difficulty of managing unprecedented events is alarming, given that more extreme hydrological events are projected owing to climate change3.
Published: 2022
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10. Isotretinoin Laboratory Monitoring in Acne Treatment

Author: Xia, Eric, Han, Jane, Faletsky, Adam, Baldwin, Hilary, Beleznay, Katie, Bettoli, Vincenzo, Dréno, Brigitte, Goh, Chee Leok, Stein Gold, Linda, Gollnick, Harald, Herane, Maria Isabel, Kang, Sewon, Kircik, Leon, Mann, Julianne, Nast, Alexander, Oon, Hazel, See, Jo Ann, Tollefson, Megha, Webster, Guy, Zip, Catherine, Tan, Jerry, Tapper, Elliot, Thiboutot, Diane, Zaenglein, Andrea, Barbieri, John, Mostaghimi, Arash, Harvard Medical School [Boston] (HMS), Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Stritch School of Medicine, Tufts University School of Medicine [Boston], Rutgers Robert Wood Johnson Medical School [New Brunswick, NJ, USA] (Rutgers-New Brunswick), University of British Columbia (UBC), Università degli Studi di Ferrara = University of Ferrara (UniFE), Immunology and New Concepts in ImmunoTherapy (INCIT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre hospitalier universitaire de Nantes (CHU Nantes), National Skin Center [Singapore] (NSC), Henry Ford Health System, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Universidad de los Andes [Santiago] (UANDES), Johns Hopkins University School of Medicine [Baltimore], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Inflammatory Bowel Disease Center [Dartmouth-Hitchcock Medical Center], Dartmouth Hitchcock Medical Center, Humboldt University Of Berlin, Central Sydney Dermatology [Sydney, Australia] (CSD), Mayo Clinic [Rochester], Jefferson (Philadelphia University + Thomas Jefferson University), University of Calgary, University of Western Ontario (UWO), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Pennsylvania State University (Penn State), Penn State System, Children's Hospital of Philadelphia, University of Pennsylvania, and Pecqueret, Valérie
Subjects: [SDV] Life Sciences [q-bio], Delphi Technique, [SDV]Life Sciences [q-bio], education, Acne Vulgaris, Humans, Dermatologic Agents, Dermatology, Isotretinoin, Triglycerides
Abstract: ImportanceAlthough isotretinoin may rarely be associated with laboratory abnormalities such as hypertriglyceridemia, the optimal approach to laboratory monitoring is uncertain, and there is wide variation in clinical practice.ObjectiveTo establish a consensus for isotretinoin laboratory monitoring among a diverse, international cohort of clinical and research experts in acne.Design, Setting, and ParticipantsUsing a modified electronic Delphi process, 4 rounds of anonymous electronic surveys were administered from 2021 to 2022. For laboratory tests reaching consensus (≥70% agreement) for inclusion, questions regarding more time-specific monitoring throughout isotretinoin therapy were asked in subsequent rounds. The participants were international board-certified dermatologist acne experts who were selected on a voluntary basis based on involvement in acne-related professional organizations and research.Main Outcomes and MeasuresThe primary outcome measured was whether participants could reach consensus on key isotretinoin laboratory monitoring parameters.ResultsThe 22 participants from 5 continents had a mean (SD) time in practice of 23.7 (11.6) years and represented a variety of practice settings. Throughout the 4-round study, participation rates ranged from 90% to 100%. Consensus was achieved for the following: check alanine aminotransferase within a month prior to initiation (89.5%) and at peak dose (89.5%) but not monthly (76.2%) or after treatment completion (73.7%); check triglycerides within a month prior to initiation (89.5%) and at peak dose (78.9%) but not monthly (84.2%) or after treatment completion (73.7%); do not check complete blood cell count or basic metabolic panel parameters at any point during isotretinoin treatment (all >70%); do not check gamma-glutamyl transferase (78.9%), bilirubin (81.0%), albumin (72.7%), total protein (72.7%), low-density lipoprotein (73.7%), high-density lipoprotein (73.7%), or C-reactive protein (77.3%).Conclusions and RelevanceThis Delphi study identified a core set of laboratory tests that should be evaluated prior to and during treatment with isotretinoin. These results provide valuable data to guide clinical practice and clinical guideline development to optimize laboratory monitoring in patients treated with isotretinoin.
Published: 2022
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11. Visual analysis of density and velocity profiles in dense 3D granular gases

Author: Yves Garrabos, Dmitry Puzyrev, Nicolas Vandewalle, Eric Opsomer, C. Lecoutre, Fabien Palencia, Raúl Cruz Hidalgo, Ralf Stannarius, Martial Noirhomme, Torsten Trittel, David Fischer, Kirsten Harth, Eric Falcon, Otto-von-Guericke University [Magdeburg] (OVGU), Universidad de Navarra [Pamplona] (UNAV), Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Group for Research and Applications in Statistical Physics (GRASP), Université de Liège, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ESA Topical Team Space Grains, European Project: 4000103461,Space Grains, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Matière et Systèmes Complexes (MSC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and GDR 2799 Micropesanteur Fondamentale & Appliquée
Subjects: Science, Density, Imaging techniques, Tracking (particle physics), 01 natural sciences, Leidenfrost effect, Granular gases, Article, 010305 fluids & plasmas, 0103 physical sciences, Statistical physics, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Statistical physics, thermodynamics and nonlinear dynamics, 010306 general physics, Cluster analysis, Physics, Ground truth, Multidisciplinary, Basis (linear algebra), Nonlinear phenomena, Low volume, Container (abstract data type), Medicine, Visual analysis, Particle, Velocity profiles, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]
Abstract: Granular multiparticle ensembles are of interest from fundamental statistical viewpoints as well as for the understanding of collective processes in industry and in nature. Extraction of physical data from optical observations of three-dimensional (3D) granular ensembles poses considerable problems. Particle-based tracking is possible only at low volume fractions, not in clusters. We apply shadow-based and feature-tracking methods to analyze the dynamics of granular gases in a container with vibrating side walls under microgravity. In order to validate the reliability of these optical analysis methods, we perform numerical simulations of ensembles similar to the experiment. The simulation output is graphically rendered to mimic the experimentally obtained images. We validate the output of the optical analysis methods on the basis of this ground truth information. This approach provides insight in two interconnected problems: the confirmation of the accuracy of the simulations and the test of the applicability of the visual analysis. The proposed approach can be used for further investigations of dynamical properties of such media, including the granular Leidenfrost effect, granular cooling, and gas-clustering transitions.
Published: 2021
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12. Total variation distance for discretely observed Lévy processes: A Gaussian approximation of the small jumps

Author: Céline Duval, Alexandra Carpentier, Ester Mariucci, Duval, Céline, Institut für Mathematische Stochastik, Fakultät für Mathematik, Otto-von-Guericke-Universität Magdeburg, Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), and Institut für Mathematik, Universität Potsdam.
Subjects: Statistics and Probability, [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], Gaussian, Gaussian approximation, Mathematics - Statistics Theory, 01 natural sciences, Measure (mathematics), Lévy process, 010104 statistics & probability, Total variation, symbols.namesake, Total variation distance, Statistical physics, 0101 mathematics, Statistical hypothesis testing, Mathematics, [STAT.TH] Statistics [stat]/Statistics Theory [stat.TH], 010102 general mathematics, Statistical model, [STAT.TH]Statistics [stat]/Statistics Theory [stat.TH], 60G51, 62M99 (Primary), 60E99 (Secondary), [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Distribution (mathematics), Lévy processes, Small jumps, Metric (mathematics), symbols, Statistics, Probability and Uncertainty, Statistical test, Mathematics - Probability
Abstract: It is common practice to treat small jumps of L\'evy processes as Wiener noise and thus to approximate its marginals by a Gaussian distribution. However, results that allow to quantify the goodness of this approximation according to a given metric are rare. In this paper, we clarify what happens when the chosen metric is the total variation distance. Such a choice is motivated by its statistical interpretation. If the total variation distance between two statistical models converges to zero, then no tests can be constructed to distinguish the two models which are therefore equivalent, statistically speaking. We elaborate a fine analysis of a Gaussian approximation for the small jumps of L\'evy processes with infinite L\'evy measure in total variation distance. Non asymptotic bounds for the total variation distance between $n$ discrete observations of small jumps of a L\'evy process and the corresponding Gaussian distribution is presented and extensively discussed. As a byproduct, new upper bounds for the total variation distance between discrete observations of L\'evy processes are provided. The theory is illustrated by concrete examples., Comment: Important and necessary changes have been made in this new version, this version supersedes version 1
Published: 2021
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13. Simulation of the FDA nozzle benchmark: A lattice Boltzmann study

Author: Feng Huang, Romain Noël, Philipp Berg, Seyed Ali Hosseini, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Statistical Inference for Structural Health Monitoring (I4S), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Département Composants et Systèmes (COSYS), Université Gustave Eiffel-Université Gustave Eiffel, and Department of Mechanical and Process Engineering [Zürich] (D-MAVT)
Subjects: [PHYS.PHYS.PHYS-COMP-PH]Physics [physics]/Physics [physics]/Computational Physics [physics.comp-ph], Physics::Fluid Dynamics, Benchmarking, Hemodynamics, Fluid Dynamics (physics.flu-dyn), FOS: Physical sciences, Computer Simulation, Health Informatics, Physics - Fluid Dynamics, Rheology, Software, Computer Science Applications
Abstract: International audience; Background and objective: Contrary to flows in small intracranial vessels, many blood flow configurations such as thosefound in aortic vessels and aneurysms involve larger Reynolds numbers and, therefore, transitional or turbulent conditions. Dealing with such systems require both robust and efficient numerical methods.Methods: We assess here the performance of a lattice Boltzmann solver with full Hermite expansion of the equilibriumand central Hermite moments collision operator at higher Reynolds numbers, especially for under-resolved simulations.To that end the food and drug administration’s benchmark nozzle is considered at three different Reynolds numberscovering all regimes: 1) laminar at a Reynolds number of 500, 2) transitional at a Reynolds number of 3500, and 3)low-level turbulence at a Reynolds number of 6500.Results: The lattice Boltzmann results are compared with previously published inter-laboratory experimental data obtained by particle image velocimetry. Our results show good agreement with the experimental measurements throughout the nozzle, demonstrating the good performance of the solver even in under-resolved simulations.Conclusion: In this manner, fast but sufficiently accurate numerical predictions can be achieved for flow configurationsof practical interest regarding medical applications.
Published: 2022
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14. Multiscale criticality measures as general-purpose gauges of proper brain function

Author: Hermann Hinrichs, Tomer Fekete, Jacobo D. Sitt, Hans-Jochen Heinze, Oren Shriki, Ben-Gurion University of the Negev (BGU), Leibniz-Institut für Neurobiologie (LIN), Leibniz Association, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), HAL-SU, Gestionnaire, Otto-von-Guericke University [Magdeburg] (OVGU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Computer science, computer.software_genre, Behavioral or, 0302 clinical medicine, Dynamical systems, Cognitive impairment, Network model, 0303 health sciences, Brain Mapping, Multidisciplinary, Hierarchy (mathematics), Information processing, Brain, Cognition, Criticality, Schizophrenia, Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Dynamical systems theory, Consciousness, Schizophrenia (object-oriented programming), Science, Models, Neurological, Dementia, Computational neuroscience, Network models, Epilepsy, Disorders of consciousness, Deviance (statistics), Machine learning, Article, 03 medical and health sciences, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030304 developmental biology, Structure (mathematical logic), business.industry, medicine.disease, 030104 developmental biology, Artificial intelligence, Scale (map), business, computer, 030217 neurology & neurosurgery
Abstract: The brain is universally regarded as a system for processing information. If so, any behavioral or cognitive dysfunction should lend itself to depiction in terms of information processing deficiencies. Information is characterized by recursive, hierarchical complexity. The brain accommodates this complexity by a hierarchy of large/slow and small/fast spatiotemporal loops of activity. Thus, successful information processing hinges upon tightly regulating the spatiotemporal makeup of activity, to optimally match the underlying multiscale delay structure of such hierarchical networks. Reduced capacity for information processing will then be expressed as deviance from this requisite multiscale character of spatiotemporal activity. This deviance is captured by a general family of multiscale criticality measures (MsCr). MsCr measures reflect the behavior of conventional criticality measures (such as the branching parameter) across temporal scale. We applied MsCr to MEG and EEG data in several telling degraded information processing scenarios. Consistently with our previous modeling work, MsCr measures systematically varied with information processing capacity: MsCr fingerprints showed deviance in the four states of compromised information processing examined in this study, disorders of consciousness, mild cognitive impairment, schizophrenia and even during pre-ictal activity. MsCr measures might thus be able to serve as general gauges of information processing capacity and, therefore, as normative measures of brain health.
Published: 2021
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15. Verfassungsgesetzgebung als historisches Ereignis der Verkörperung von Vernunft. Zur Verbindung von Demokratie Und menschenrechten

Author: Lohmann, Georg, Gensler, Marek, Gralińska-Toborek, Agnieszka, Kazimierska-Jerzyk, Wioletta, Kędziora, Krzysztof, Miksa, Joanna, and Professor Emeritus. Otto-von-Guericke-Universität Magdeburg
Subjects: de-democratization, human rights, Julius Froebel, constitution-making
Abstract: Based on three open questions, which Habermas poses at the end of his two-volume book “Also a History of Philosophy”, the national constitution-making of a people is reconstructed as an answer to the first question, following Julius Froebel. Already the elements of a public opinion formation answer the third question, in which the constitution- making can already establish the egalitarian universalism of the human rights, which then become constituted basic and human rights in the general will-making. However, the open questions and ambivalent solutions of the national constitutional formulations, such as the promotion of capitalist economy or political de-democratizations, make it clear that the answer to the second question in international human rights must remain open and require morally unbound efforts.
Published: 2021
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16. Benchmarking Quality-Dependent and Cost-Sensitive Score-Level Multimodal Biometric Fusion Algorithms

Author: Bernadette Dorizzi, Fernando Alonso-Fernandez, L. Allano, Albert Ali Salah, Tobias Scheidat, Norman Poh, Javier Ortega-Garcia, Donald E. Maurer, Julian Fierrez, John P. Baker, O. Fatukasi, Harald Ganster, Thirimachos Bourlai, Josef Kittler, Claus Vielhauer, Onkar Ambekar, UAM. Departamento de Ingeniería Informática, Análisis y Tratamiento de Voz y Señales Biométricas (ING EPS-002), Centre for Vision, Speech and Signal Processing (CVSSP), University of Surrey (UNIS), Lane Department of Computer Science and Electrical Engineering [Virginia] (LCSEE), West Virginia University [Morgantown], Département Electronique et Physique (EPH), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Biometric Recognition Group (Universidad Autonoma de Madrid) (ATVS), Centrum Wiskunde & Informatica (CWI), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Institute of Digital Image Processing (Joanneum Research) (DIP), Intelligent Systems Lab Amsterdam - Intelligent Sensory Information Systems (University of Amsterdam) (ISLA-ISIS), Department of Informatics and Media (University of Applied Sciences Brandenburg), Institut für Technische und Betriebliche Informationssysteme (Otto-von-Guericke-Universität Magdeburg) (ITI), Signals and Images, and Département Electronique et Physique (TSP - EPH)
Subjects: FOS: Computer and information sciences, Computer Science - Cryptography and Security, Biometrics, Computer Networks and Communications, Computer science, Computer Vision and Pattern Recognition (cs.CV), Data_MISCELLANEOUS, Computer Science - Computer Vision and Pattern Recognition, Access control, Signalbehandling, 02 engineering and technology, [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], Software, Cost-sensitive fusion, 0202 electrical engineering, electronic engineering, information engineering, Biometric database, Safety, Risk, Reliability and Quality, Quality-based fusion, Informática, Authentication, business.industry, Fingerprint (computing), Multimodal biometric authentication, 020206 networking & telecommunications, Benchmarking, Security controls, Signal Processing, Benchmark (computing), 020201 artificial intelligence & image processing, business, Algorithm, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Cryptography and Security (cs.CR)
Abstract: Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works., Automatically verifying the identity of a person by means of biometrics (e.g., face and fingerprint) is an important application in our day-to-day activities such as accessing banking services and security control in airports. To increase the system reliability, several biometric devices are often used. Such a combined system is known as a multimodal biometric system. This paper reports a benchmarking study carried out within the framework of the BioSecure DS2 (Access Control) evaluation campaign organized by the University of Surrey, involving face, fingerprint, and iris biometrics for person authentication, targeting the application of physical access control in a medium-size establishment with some 500 persons. While multimodal biometrics is a well-investigated subject in the literature, there exists no benchmark for a fusion algorithm comparison. Working towards this goal, we designed two sets of experiments: quality-dependent and cost-sensitive evaluation. The quality-dependent evaluation aims at assessing how well fusion algorithms can perform under changing quality of raw biometric images principally due to change of devices. The cost-sensitive evaluation, on the other hand, investigates how well a fusion algorithm can perform given restricted computation and in the presence of software and hardware failures, resulting in errors such as failure-to-acquire and failure-to-match. Since multiple capturing devices are available, a fusion algorithm should be able to handle this nonideal but nevertheless realistic scenario. In both evaluations, each fusion algorithm is provided with scores from each biometric comparison subsystem as well as the quality measures of both the template and the query data. The response to the call of the evaluation campaign proved very encouraging, with the submission of 22 fusion systems. To the best of our knowledge, this campaign is the first attempt to benchmark quality-based multimodal fusion algorithms. In the presence of changing - - image quality which may be due to a change of acquisition devices and/or device capturing configurations, we observe that the top performing fusion algorithms are those that exploit automatically derived quality measurements. Our evaluation also suggests that while using all the available biometric sensors can definitely increase the fusion performance, this comes at the expense of increased cost in terms of acquisition time, computation time, the physical cost of hardware, and its maintenance cost. As demonstrated in our experiments, a promising solution which minimizes the composite cost is sequential fusion, where a fusion algorithm sequentially uses match scores until a desired confidence is reached, or until all the match scores are exhausted, before outputting the final combined score., This evaluation was made possible thanks to the EU funding from the following projects: BioSecure (www.biosecure.info) and Mobio (www.mobioproject.org). The participating teams are supported by their respective national fund bodies: the Dutch BSIK/BRICKS project and the Spanish project TEC2006-13141-C03-03.
Published: 2021
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17. Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells

Author: Patricia Gintschel, Pauline Formaglio, Michael Meyer-Hermann, Andreas Müller, Burkhart Schraven, Philippe Robert, Anne Dudeck, Anna Krone, Juliane Mohr, Sascha Kahlfuß, Sahamoddin Khailaie, Juliane Handschuh, Sandrina Heyde, Yan Fu, Anja Schröder, Gang Zhao, Sebastian Binder, Jochen Huehn, Lars Philipsen, Gerald F. Späth, Anastasios Siokis, Ina Sauerland, Juliane Stettin, Philippe Bousso, Jessica Bertrand, Mohamad Alabdullah, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Helmholtz Centre for Infection Research (HZI), University of Oslo (UiO), Parasitologie moléculaire et Signalisation / Molecular Parasitology and Signaling, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Dynamiques des Réponses immunes - Dynamics of Immune Responses, Hannover Medical School [Hannover] (MHH), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], This work was supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (StG ImmProDynamics, grant agreement 714233 to A.J.M.), the German Research Foundation (DFG) (SFB854-Z01, SFB854-B31, MU 3744/2-1, MU3744/4-1, and SPP2225 [MU3744/5-1] to A.J.M. and KA 4514/2-1 to S. Kahlfuß), and the federal state of Saxony-Anhalt and the European Regional Development Fund (project NeutrEat to A.J.M.)., Otto-von-Guericke University [Magdeburg] (OVGU), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Ricard Andraos, Christel, and BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.
Subjects: Phagocyte, Intravital Microscopy, [SDV]Life Sciences [q-bio], chemistry.chemical_compound, Mice, 0302 clinical medicine, Cell Movement, Immunology and Allergy, Leishmania major, Pathogen, Leishmaniasis, Leishmania, 0303 health sciences, biology, Effector, intracellular pathogen, phagocyte, Cell biology, [SDV] Life Sciences [q-bio], iNOS, Infectious Diseases, medicine.anatomical_structure, Host-Pathogen Interactions, monocyte, medicine.symptom, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Immunology, Inflammation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cell Growth Processes, Nitric Oxide, biosensor, Article, Nitric oxide, 03 medical and health sciences, nitric oxide, medicine, Animals, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, 030304 developmental biology, Cell Proliferation, 2-photon microscopy, Monocyte, Intracellular parasite, Macrophages, Models, Theoretical, biology.organism_classification, Mice, Inbred C57BL, Disease Models, Animal, chemistry, inflammation, 030215 immunology
Abstract: Summary Nitric oxide (NO) is an important antimicrobial effector but also prevents unnecessary tissue damage by shutting down the recruitment of monocyte-derived phagocytes. Intracellular pathogens such as Leishmania major can hijack these cells as a niche for replication. Thus, NO might exert containment by restricting the availability of the cellular niche required for efficient pathogen proliferation. However, such indirect modes of action remain to be established. By combining mathematical modeling with intravital 2-photon biosensors of pathogen viability and proliferation, we show that low L. major proliferation results not from direct NO impact on the pathogen but from reduced availability of proliferation-permissive host cells. Although inhibiting NO production increases recruitment of these cells, and thus pathogen proliferation, blocking cell recruitment uncouples the NO effect from pathogen proliferation. Therefore, NO fulfills two distinct functions for L. major containment: permitting direct killing and restricting the supply of proliferation-permissive host cells., Graphical abstract, Highlights • Direct killing of L. major by NO occurs only during the peak of the immune response • Efficient L. major proliferation requires newly recruited monocyte-derived cells • Loss of NO production increases both pathogen proliferation and monocyte recruitment • NO dampens L. major proliferation indirectly, limiting the pathogen’s cellular niche, Besides direct antimicrobial activity, nitric oxide (NO) can inhibit the entry of inflammatory cells into infected tissues. Intracellular pathogens can hijack such cells as niches for proliferation. Formaglio et al. show that restriction of proliferation-permissive host cell recruitment by NO represents a mechanism that controls Leishmania major infection.
Published: 2020
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18. Preserved Contextual Cueing in Realistic Scenes in Patients with Age-Related Macular Degeneration

Author: Stefanie Linnhoff, Stefan Pollmann, Eleonora Porracin, Franziska Geringswald, Katja Renner, Lisa Rosenblum, Michael B. Hoffmann, Anne Herbik, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Capital Normal University [Beijing], Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and DFG-Grant PO548/14-2
Subjects: Visual search, macular degeneration, visual search, genetic structures, Working memory, vision loss, incidental learning, media_common.quotation_subject, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Eye movement, Context (language use), applied_psychology, Article, eye diseases, Memorization, lcsh:RC321-571, Foveal, Explicit memory, Contrast (vision), Psychology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, fovea, media_common, Cognitive psychology
Abstract: International audience; Foveal vision loss has been shown to reduce efficient visual search guidance due to contextual cueing by incidentally learned contexts. However, previous studies used artificial (T- among L-shape) search paradigms that prevent the memorization of a target in a semantically meaningful scene. Here, we investigated contextual cueing in real-life scenes that allow explicit memory of target locations in semantically rich scenes. In contrast to the contextual cueing deficits in artificial scenes, contextual cueing in patients with age-related macular degeneration (AMD) did not differ from age-matched normal-sighted controls. We discuss this in the context of visuospatial working-memory demands for which both eye movement control in the presence of central vision loss and memory-guided search may compete. Memory-guided search in semantically rich scenes may depend less on visuospatial working memory than search in abstract displays, potentially explaining intact contextual cueing in the former but not the latter. In a practical sense, our findings may indicate that patients with AMD are less deficient than expected after previous lab experiments. This shows the usefulness of realistic stimuli in experimental clinical research.
Published: 2020
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19. Partial sleep deprivation affects endurance performance and psychophysiological responses during 12-minute self-paced running exercise

Author: Achraf Ammar, Mohamed Ayachi, Wajdi Souissi, Mohamed Naceur Souissi, Amir Khcharem, Tarak Driss, Omar Hammouda, Giovanni de Marco, Laboratoire Interdisciplinaire en Neurosciences, Physiologie et psychologie (LINP2), Université Paris Nanterre (UPN), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), and Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], Physical Exertion, Experimental and Cognitive Psychology, Bedtime, Running, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Oxygen Consumption, Heart Rate, Internal medicine, Heart rate, Medicine, Humans, Exercise, Self paced, Rating of perceived exertion, business.industry, 030229 sport sciences, Oxygen uptake, Sleep deprivation, Mood, Cardiology, Exercise Test, Physical Endurance, Sleep Deprivation, medicine.symptom, business, 030217 neurology & neurosurgery, Respiratory minute volume
Abstract: Purpose This study aimed to investigate the effects of partial sleep deprivation (PSD) on physical performance and psychophysiological responses during 12-minute self-paced running exercise. Methods Twenty runners (20.8±1.1 years, 70.6±4.9 kg, 175.1±3.9 cm) performed, in a randomized order, two running self-paced field exercises after a normal sleep night (CONT, bedtime from 22:30 h to 06:30 h) and one night of PSD (bedtime from 00:30 h to 04:30 h). Core temperature and motivation were recorded before exercise. Speed, covered distance, heart rate (HR), rating of perceived exertion (RPE) and respiratory parameters (i.e., minute ventilation (VE), oxygen uptake (VO2) and carbon dioxide production (VCO2)) were assessed during exercise. Blood lactate concentration [La] was assessed 2 min after exercise. Simple reaction time (SRT), mood and barrage test (BT) were assessed before and after exercise. Results Higher RPE (p=0.01, d=0.90) and lower physical performance (i.e., p=0.001, d=0.59 for running speed and p=0.01, d=0.7 and Δ (%)=-6% for covered distance), following PSD, were obtained compared to CONT. Similarly, PSD attenuated core temperature (p=0.01, d=0.84), HR (p=0.006, ɳp2=0.45), VE (p=0.001, ɳp2=0.73), VO2 (p=0.001, ɳp2=0.96), BT (p Conclusion The decrease of running performance and the increase of physical discomfort after PSD could be the origin of the lower cardio-respiratory responses to the 12-minute self-paced exercise. Effective strategies should be introduced to overcome the deterioration of physical performance and physiological responses after PSD.
Published: 2020
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20. Changes in the management of acne: 2009-2019

Author: Harald Gollnick, Valerie Sanders, Marie Jose Rueda, Diane Thiboutot, Brigitte Dréno, Malbec, Odile, Pennsylvania State University (Penn State), Penn State System, Nantes Université (Nantes Univ), Sanders Medical Writing [Pueblo West, CO, USA] (SMW), Eli Lilly and Company [Indianapolis], and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Male, medicine.medical_specialty, antibiotic resistance, Time Factors, [SDV]Life Sciences [q-bio], Dermatology, Spironolactone, Severity of Illness Index, Drug Administration Schedule, Antimicrobial Stewardship, Sex Hormone-Binding Globulin, Acne Vulgaris, Drug Resistance, Bacterial, medicine, Humans, guidelines, Isotretinoin, acne, ComputingMilieux_MISCELLANEOUS, Acne, Benzoyl Peroxide, business.industry, medicine.disease, Anti-Bacterial Agents, [SDV] Life Sciences [q-bio], Practice Guidelines as Topic, Female, business, Contraceptives, Oral
Abstract: International audience; No abstract available
Published: 2020
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21. Fludarabine/busulfan versus fludarabine/total-body-irradiation (2 Gy) as conditioning prior to allogeneic stem cell transplantation in patients (>= 60 years) with acute myelogenous leukemia: a study of the acute leukemia working party of the EBMT

Author: Didier Blaise, Uwe Platzbecker, Arnon Nagler, Nicolaas Schaap, Gwendolyn Van Gorkom, Jan J. Cornelissen, Jürgen Kuball, Mohamad Mohty, Emmanuelle Polge, Dietger Niederwieser, Myriam Labopin, Henrik Sengeløv, Bipin N. Savani, Thomas Heinicke, Victoria Potter, Goda Choi, Franciane Paul, Hematology, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University Hospital Leipzig, Rigshospitalet [Copenhagen], Copenhagen University Hospital, University Medical Center Groningen [Groningen] (UMCG), Erasmus University Medical Center [Rotterdam] (Erasmus MC), University Medical Center [Utrecht], School for Oncology and Developmental Biology [Maastricht] (GROW), Maastricht University [Maastricht]-Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Radboud University Medical Center [Nijmegen], King's College Hospital (KCH), Hôpital Lapeyronie [Montpellier] (CHU), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], Chaim Sheba Medical Center, Promovendi ODB, Interne Geneeskunde, MUMC+: MA Hematologie (9), and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Subjects: Transplantation Conditioning, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Graft vs Host Disease, COMPLETE REMISSION, Gastroenterology, HEMATOLOGIC MALIGNANCIES, 0302 clinical medicine, hemic and lymphatic diseases, VERSUS-HOST-DISEASE, UNRELATED DONORS, Medicine, ComputingMilieux_MISCELLANEOUS, MYELODYSPLASTIC SYNDROME, Acute leukemia, Incidence (epidemiology), ANTITHYMOCYTE GLOBULIN, Hematopoietic Stem Cell Transplantation, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Total body irradiation, 3. Good health, Fludarabine, ANTI-THYMOCYTE GLOBULIN, Leukemia, Myeloid, Acute, Leukemia, 030220 oncology & carcinogenesis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Vidarabine, CLINICAL-TRIALS, medicine.drug, medicine.medical_specialty, ACUTE MYELOID-LEUKEMIA, 03 medical and health sciences, Myelogenous, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Humans, MESH: Aged, Busulfan, Aged, Retrospective Studies, Transplantation, business.industry, medicine.disease, BONE-MARROW-TRANSPLANTATION, MESH: Humans, Leukemia, Myeloid, Acute / therapy, Vidarabine / analogs & derivatives, business, 030215 immunology
Abstract: International audience; Nonmyeloablative (NMA) conditioning regimens facilitate allogeneic stem cell transplantation (alloSCT) in elderly patients and/or in those with comorbidities. The acute leukemia working party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT) compared the outcomes of patients ≥60 years with AML in first complete remission (CR1), that had received an alloSCT following NMA conditioning, i.e. either fludarabine/busulfan (FB2) or fludarabine/total-body-irradiation-2Gy (FluTBI2Gy). A total of 1088 patients were included (median age 65 years). Donors were matched siblings (MSD) and matched unrelated donors (MUD) in 47% and 53%, respectively. In vivo T-cell depletion (TCD) was applied to 79% and none (0%) of patients in the FB2 and FluTBI2Gy groups, respectively. In the MSD group we found a trend for less extensive cGVHD in patients receiving FB2 with in vivo TCD, HR: 0.49, p = 0.08, and in those without worse NRM, HR: 2.14, p = 0.04, and a trend for more total cGVHD, HR: 1.61, p = 0.09. Patients transplanted from MUDs had a significantly higher incidence of total cGVHD, extensive cGVHD and a worse GRFS with FluTBI2Gy in comparison to FB2, HR: 2.44; p < 0.0001; HR 4.59; p < 0.00001 and HR: 1.35; p = 0.03, respectively. No differences were observed with respect to LFS, OS, RI, NRM, and aGVHD.
Published: 2020
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22. Kernel-Based Reinforcement Learning: A Finite-Time Analysis

Author: Domingues, Omar, Ménard, Pierre, Pirotta, Matteo, Kaufmann, Emilie, Valko, Michal, Scool (Scool), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Facebook AI Research [Paris] (FAIR), Facebook, Centre National de la Recherche Scientifique (CNRS), DeepMind [Paris], The research presented was supported by European CHISTERA project DELTA, French Ministry of Higher Education and Research, Nord-Pas-de-Calais Regional Council, and by French National Research Agency as part of the 'Investissements d’avenir' program, reference ANR-19-P3IA-0001 (PRAIRIE 3IA Institute) and the project BOLD, reference ANR-19-CE23-0026-04., ANR-19-CE23-0026,BOLD,Au delà de l'apprentissage séquentiel pour de meilleures prises de décisions(2019), ANR-19-P3IA-0001,PRAIRIE,PaRis Artificial Intelligence Research InstitutE(2019), European Project, and Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Computer Science::Machine Learning, FOS: Computer and information sciences, Computer Science - Machine Learning, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Statistics - Machine Learning, Machine Learning (stat.ML), Machine Learning (cs.LG)
Abstract: We consider the exploration-exploitation dilemma in finite-horizon reinforcement learning problems whose state-action space is endowed with a metric. We introduce Kernel-UCBVI, a model-based optimistic algorithm that leverages the smoothness of the MDP and a non-parametric kernel estimator of the rewards and transitions to efficiently balance exploration and exploitation. For problems with $K$ episodes and horizon $H$, we provide a regret bound of $\widetilde{O}\left( H^3 K^{\frac{2d}{2d+1}}\right)$, where $d$ is the covering dimension of the joint state-action space. This is the first regret bound for kernel-based RL using smoothing kernels, which requires very weak assumptions on the MDP and has been previously applied to a wide range of tasks. We empirically validate our approach in continuous MDPs with sparse rewards., Comment: Update following the publication in ICML 2021, including fixed typos
Published: 2020
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23. A Kernel-Based Approach to Non-Stationary Reinforcement Learning in Metric Spaces

Author: Domingues, Omar, Ménard, Pierre, Pirotta, Matteo, Kaufmann, Emilie, Valko, Michal, Scool (Scool), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Facebook AI Research [Paris] (FAIR), Facebook, DeepMind [Paris], European Project, Otto-von-Guericke University [Magdeburg] (OVGU), Centre National de la Recherche Scientifique (CNRS), Valko, Michal, and CHISTERA DELTA - INCOMING
Subjects: Computer Science::Machine Learning, FOS: Computer and information sciences, Computer Science - Machine Learning, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Statistics - Machine Learning, Machine Learning (stat.ML), ComputingMethodologies_ARTIFICIALINTELLIGENCE, [STAT.ML] Statistics [stat]/Machine Learning [stat.ML], Machine Learning (cs.LG)
Abstract: In this work, we propose KeRNS: an algorithm for episodic reinforcement learning in non-stationary Markov Decision Processes (MDPs) whose state-action set is endowed with a metric. Using a non-parametric model of the MDP built with time-dependent kernels, we prove a regret bound that scales with the covering dimension of the state-action space and the total variation of the MDP with time, which quantifies its level of non-stationarity. Our method generalizes previous approaches based on sliding windows and exponential discounting used to handle changing environments. We further propose a practical implementation of KeRNS, we analyze its regret and validate it experimentally., Comment: Update following the publication in AISTATS 2021. Fixed typos and lemma about runtime
Published: 2020
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24. EEG-Based Hypo-vigilance Detection Using Convolutional Neural Network

Author: Siwar Chaabene, Amal Boudaya, Bassem Bouaziz, Lotfi Chaari, Anita Hökelmann, Achraf Ammar, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Digital Research Center of Sfax (TUNISIA), Otto Von Guericke Universität Magdeburg - OVGU (GERMANY), Institut de Recherche en Informatique de Toulouse - IRIT (Toulouse, France), Multimedia, InfoRmation systems and Advanced Computing Laboratory (MIRACL), Faculté des Sciences Economiques et de Gestion de Sfax (FSEG Sfax), Université de Sfax - University of Sfax-Université de Sfax - University of Sfax, Centre de Recherche en Numérique de Sfax (CRNS), Traitement et Compréhension d’Images (IRIT-TCI), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Institut National Polytechnique (Toulouse) (Toulouse INP), and Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Research areas, Computer science, media_common.quotation_subject, Headset, 02 engineering and technology, Electroencephalography, Convolutional neural network, Article, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 0202 electrical engineering, electronic engineering, information engineering, medicine, Traitement du signal et de l'image, EEG, media_common, medicine.diagnostic_test, business.industry, Biomedical signal, 020206 networking & telecommunications, Pattern recognition, Eeg classification, Hypo-vigilance detection, 020201 artificial intelligence & image processing, Artificial intelligence, business, CNN, Vigilance (psychology)
Abstract: National audience; Hypo-vigilance detection is becoming an important active research areas in the biomedical signal processing field. For this purpose, electroencephalogram (EEG) is one of the most common modalities in drowsiness and awakeness detection. In this context, we propose a new EEG classification method for detecting fatigue state. Our method makes use of a and awakeness detection. In this context, we propose a new EEG classification method for detecting fatigue state. Our method makes use of a Convolutional Neural Network (CNN) architecture. We define an experimental protocol using the Emotiv EPOC+ headset. After that, we evaluate our proposed method on a recorded and annotated dataset. The reported results demonstrate high detection accuracy (93%) and indicate that the proposed method is an efficient alternative for hypo-vigilance detection as compared with other methods.
Published: 2020
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25. Interspecies conservation of organisation and function between nonhomologous regional centromeres

Author: Tong, P, Pidoux, A, Toda, N, Ard, R, Berger, H, Shukla, M, Torres-Garcia, J, Müller, C, Nieduszynski, C, Allshire, R, Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Center for Pneumology, Donaustauf Hospital, Centre for Genetics and Genomics, and University of Nottingham, UK (UON)
Subjects: Centromeres, Histone variants, Science, [SDV]Life Sciences [q-bio], [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], lcsh:Q, Epigenetics, macromolecular substances, [SDV.BID]Life Sciences [q-bio]/Biodiversity, lcsh:Science, Evolutionary genetics
Abstract: Despite the conserved essential function of centromeres, centromeric DNA itself is not conserved. The histone-H3 variant, CENP-A, is the epigenetic mark that specifies centromere identity. Paradoxically, CENP-A normally assembles on particular sequences at specific genomic locations. To gain insight into the specification of complex centromeres, here we take an evolutionary approach, fully assembling genomes and centromeres of related fission yeasts.Centromere domain organization, but not sequence, is conserved between Schizosaccharomyces pombe, S. octosporus and S. cryophilus with a central CENP-ACnp1 domain flanked by heterochromatic outer-repeat regions. Conserved syntenic clusters of tRNA genes and 5S-rRNA genes occur across the centromeres of S. octosporus and S. cryophilus, suggesting conserved function. Interestingly, nonhomologous centromere central-core sequences from S. octosporus and S. cryophilus are recognized in S. pombe, resulting in crossspecies establishment of CENP-ACnp1 chromatin and functional kinetochores. Therefore, despite the lack of sequence conservation, Schizosaccharomyces centromere DNA possesses intrinsic conserved properties that promote assembly of CENP-A chromatin.
Published: 2019
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26. Computer experiments with functional inputs and scalar outputs by a norm-based approach

Author: Jana Fruth, Thomas Muehlenstaedt, Olivier Roustant, Technische Universität Dortmund [Dortmund] (TU), Otto-von-Guericke University [Magdeburg] (OVGU), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Méthodes d'Analyse Stochastique des Codes et Traitements Numériques (GdR MASCOT-NUM), Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Institut Henri Fayol, and Breuil, Florent
Subjects: FOS: Computer and information sciences, Statistics and Probability, Mathematical optimization, Scalar (mathematics), 0211 other engineering and technologies, 02 engineering and technology, 01 natural sciences, Theoretical Computer Science, Methodology (stat.ME), 010104 statistics & probability, symbols.namesake, Kriging, 0101 mathematics, Gaussian process, Statistics - Methodology, Mathematics, 021103 operations research, Other Statistics (stat.OT), space-filling design, Computer experiment, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Metamodeling, Statistics - Other Statistics, Maximin design, Computational Theory and Mathematics, Latin hypercube sampling, Norm (mathematics), symbols, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, Hypercube, Statistics, Probability and Uncertainty
Abstract: A framework for designing and analyzing computer experiments is presented, which is constructed for dealing with functional and real number inputs and real number outputs. For designing experiments with both functional and real number inputs a two stage approach is suggested. The first stage consists of constructing a candidate set for each functional input and during the second stage an optimal combination of the found candidate sets and a Latin hypercube for the real number inputs is searched for. The resulting designs can be considered to be generalizations of Latin hypercubes. GP models are explored as metamodel. The functional inputs are incorporated into the kriging model by applying norms in order to define distances between two functional inputs. In order to make the calculation of these norms computationally feasible, the use of B-splines is promoted.
Published: 2016
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27. Mesure des attitudes environnementales : analyse structurale d’une version française de la NEPS (Dunlap et al., 2000)

Author: Michel Piolat, Heidi Ittner, Alexandra Schleyer-Lindenmann, Bruno Dauvier, Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Psychologie de la Connaissance, du Langage et de l'Émotion (PsyCLÉ), Aix Marseille Université (AMU), Otto-von-Guericke University [Magdeburg] (OVGU), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: New Ecological Paradigm, Dunlap, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, 05 social sciences, [SHS.PSY]Humanities and Social Sciences/Psychology, 050301 education, 050109 social psychology, attitudes environnementales, Nouveau Paradigme Ecologique, environmental attitudes, NEPS, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, NEP Scale, 0501 psychology and cognitive sciences, France, 0503 education, ComputingMilieux_MISCELLANEOUS, General Psychology
Abstract: Resume La mesure des attitudes a l’egard de la nature constitue un domaine bien developpe de la psychologie de l’environnement. Parmi les instruments les plus utilises figure l’echelle « Nouveau Paradigme Ecologique » (« New Ecological Paradigm Scale » – NEPS) de Dunlap, Van Liere, Mertig, et Jones (2000). Notre objectif est de proposer une version francaise de cette echelle et d’en analyser la structure. D’abord, nous presentons le paradigme et l’echelle originale, puis la version francaise de l’echelle et l’etude de sa structure par des analyses factorielles exploratoires et la confrontation de plusieurs modeles structuraux ajustes par equations structurales. Dans une premiere etude avec un echantillon de 251 etudiants et salaries, les analyses factorielles exploratoires montrent une structure en deux facteurs independants. Une deuxieme etude aupres d’un echantillon de 182 etudiants montre que ce resultat est attribuable a un artefact d’acquiescement. Les resultats de la deuxieme etude permettent de confirmer une structure en quatre facteurs. Ces analyses montrent qu’un modele hierarchique en quatre facteurs avec un facteur de second ordre est le mieux ajuste aux donnees. Les resultats suggerent que la NEPS est utilisable aupres d’un public francophone, mais que sa structure doit etre verifiee aupres de chaque echantillon. Basees sur ces resultats, les dimensions psychologiques de la NEPS sont discutees.
Published: 2016
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28. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Author: Tom Mikkelsen, Rogier Versteeg, Christelle Dufour, Jens Schittenhelm, Umut H. Toprak, Eleonora Aronica, Sariah Allen, Stefan M. Pfister, Arie Perry, Dominique Figarella-Branger, David T.W. Jones, Stephan Wolf, Irene Slavc, Christian Mawrin, Pieter Wesseling, Nada Jabado, Cynthia Cowdrey, David W. Ellison, Andreas von Deimling, Jörg Felsberg, Michael A. Grotzer, Pascale Varlet, Michael C. Frühwald, Volker Hovestadt, Timothy E. Van Meter, Gnanaprakash Balasubramanian, V. Peter Collins, Wolfram Scheurlen, Christian Hagel, Volkmar Hans, Johannes Gojo, Irina Leis, Michael D. Taylor, Catherine Keohane, Marco Prinz, Rachid Drissi, Maria Łastowska, Istvan Vajtai, Anne Jouvet, Sonika Dahiya, Marietta Wolter, Matthias Schlesner, Till Milde, Chris Jones, Pascal Johann, Kristian W. Pajtler, Anna Maria Buccoliero, Marina Ryzhova, David Scheie, Kenneth Aldape, Matija Snuderl, Martin Ebinger, Bret C. Mobley, Sebastian Brabetz, Joanna J. Phillips, Tarek Shalaby, Silvia Hofer, Christian Koelsche, Christel Herold-Mende, Barbara C. Worst, Martin U. Schuhmann, Jüri Reimand, Walter Berger, Stephan Frank, Diana Carvalho, Daniela Lötsch, Christof M. Kramm, Amar Gajjar, David Capper, Peter van Sluis, Ivo Buchhalter, Christine Haberler, Katja von Hoff, Stefan Rutkowski, Roland Eils, Martin Hasselblatt, Ulrich Schüller, Maryam Fouladi, Jochen Rößler, Guido Reifenberger, Brent A. Orr, Andrew S. Moore, Alan Mackay, Marc Remke, André O. von Bueren, Felix Sahm, Jan Koster, Karel Zitterbart, Dominik Sturm, Paul A. Northcott, Peter Lichter, Matthias A. Karajannis, Stefan Holm, Martin Sill, Wiesława Grajkowska, Stéphanie Puget, Felice Giangaspero, Marcel Kool, Reinhard Schneppenheim, Lynn Ann Forrester, Mariarita Santi, Torsten Pietsch, Camelia M. Monoranu, Richard Volckmann, Iris Fried, Matthew Schniederjan, Andrey Korshunov, Elke Pfaff, Rainer Grobholz, Jacques Grill, Pathology, CCA - Cancer biology, Heidelberg University Hospital [Heidelberg], St Jude Children's Research Hospital, Department of Neuropathology, Institute of Pathology, NN Burdenko Neurosurgical Institute (NNBNI), University of Toronto, The Institute of Cancer Research, Royal Cancer Hospital, University of California [San Francisco] (UC San Francisco), University of California (UC), Children's Hospital Medical Center, Children's Hospital Medical Center Cincinnatri, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), The Children's Memorial Health Institute, Cnopf’sche Kinderklinik, Universität Bonn = University of Bonn, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Medizinische Universität Wien = Medical University of Vienna, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Karolinska Institutet [Stockholm], Luzerner Kantonsspital, University of Freiburg [Freiburg], Cork University Hospital, Hadassah Hebrew University Medical Center [Jerusalem], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Vanderbilt University [Nashville], Children’s Healthcare of Atlanta, Children’s Hospital of Philadelphia (CHOP ), Università degli Studi di Firenze = University of Florence (UniFI), Washington University in Saint Louis (WUSTL), University Medical Center Göttingen (UMG), Klinikum Augsburg, University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Radboud University Medical Center [Nijmegen], Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Tübingen University Hospital [Germany], University Hospital Basel [Basel], Hirslanden Medical Center, University Hospital Berne, Medical Center Bielefeld, Masaryk University [Brno] (MUNI), Department of Pathology, University of Cambridge [UK] (CAM), University of Amsterdam [Amsterdam] (UvA), Hôpital d'Instruction des Armées Sainte Anne, Service de Santé des Armées, Institut Gustave Roussy (IGR), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), University hospital of Zurich [Zurich], Virginia Commonwealth University (VCU), Biocenter University of Würzburg = Biozentrum der Universität Würzburg, Julius-Maximilians-Universität Würzburg (JMU), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU), VU University Medical Center [Amsterdam], Henry Ford Hospital, The University of Texas M.D. Anderson Cancer Center [Houston], University of Queensland [Brisbane], McGill University = Université McGill [Montréal, Canada], Cellular and Computational Neuroscience (SILS, FNWI), University of California [San Francisco] (UCSF), University of California, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Bonn, Otto-von-Guericke University [Magdeburg] (OVGU), Anna Meyer Children's Hospital and University of Florence, Freiburg University Medical Center, Masaryk University and University Hospital Brno, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), ANS - Cellular & Molecular Mechanisms, APH - Amsterdam Public Health, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Oncogenomics, and Other departments
Subjects: Pathology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Astroblastoma, Neuroectodermal Tumors, Repressor Proteins / genetics, CNS-PNETs, Biochemistry, Central Nervous System Neoplasms, 0302 clinical medicine, Neuroectodermal Tumors / diagnosis, Central Nervous System Neoplasms / classification, Central Nervous System Neoplasms / genetics, Non-U.S. Gov't, Child, Tumor Suppressor Proteins / genetics, Central Nervous System Neoplasms / pathology, Research Support, Non-U.S. Gov't, food and beverages, Forkhead Transcription Factors, genetics and molecular biology, neuroectodermal tumors, central nervous system, 3. Good health, Gene Expression Regulation, Neoplastic, Neuroepithelial cell, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Sarcoma, Signal Transduction, tumor, Repressor Proteins / chemistry, medicine.medical_specialty, Molecular Sequence Data, Central nervous system, Brain tumor, [SDV.CAN]Life Sciences [q-bio]/Cancer, Neuroectodermal Tumors / genetics, Neuroectodermal Tumors / pathology, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Biology, Research Support, General Biochemistry, Genetics and Molecular Biology, N.I.H, 03 medical and health sciences, Research Support, N.I.H., Extramural, Forkhead Transcription Factors / genetics, Proto-Oncogene Proteins, Neuroblastoma, Journal Article, medicine, Humans, Amino Acid Sequence, Neuroectodermal Tumors / classification, Proto-Oncogene Proteins / genetics, Medulloblastoma, Biochemistry, Genetics and Molecular Biology(all), Tumor Suppressor Proteins, Gene Expression Profiling, Extramural, DNA Methylation, medicine.disease, Proto-Oncogene Proteins / chemistry, Repressor Proteins, Gene expression profiling, Immunology, Trans-Activators, Central Nervous System Neoplasms / diagnosis, ddc:004, 030217 neurology & neurosurgery, Genetics and Molecular Biology(all)
Abstract: Item does not contain fulltext Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
Published: 2016
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29. MNE: Software for Acquiring, Processing, and Visualizing MEG/EEG Data

Author: Eric Larson, Denis A. Engemann, Sheraz Khan, Alexandre Gramfort, Lorenz Esch, Christoph Dinh, Mainak Jas, Matti Hämäläinen, Boston Children's Hospital, Technische Universität Ilmenau (TU ), Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Otto-von-Guericke University [Magdeburg] (OVGU), University of Washington [Seattle], Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Centre de Mathématiques Appliquées - Ecole Polytechnique (CMAP), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Harvard Medical School [Boston] (HMS), Karolinska Institutet [Stockholm], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Signal processing, Computer science, [SDV]Life Sciences [q-bio], Electroencephalography, Open-Source, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Software, Real-time analysis, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, medicine, Magnetoencephalography (MEG), Use case, Electroencephalography (EEG), Set (psychology), 030304 developmental biology, [STAT.AP]Statistics [stat]/Applications [stat.AP], 0303 health sciences, medicine.diagnostic_test, business.industry, Software development, Analysis tools, Cognition, Magnetoencephalography, Data science, Variety (cybernetics), business, 030217 neurology & neurosurgery
Abstract: International audience; The methods for acquiring, processing, and visualizing magnetoencephalography (MEG) and electroencephalography (EEG) data are rapidly evolving. Advancements in hardware and software development offer new opportunities for cognitive and clinical neuroscientists but at the same time introduce new challenges as well. In recent years the MEG/EEG community has developed a variety of software tools to overcome these challenges and cater to individual research needs. As part of this endeavor, the MNE software project, which includes MNE-C, MNE-Python, MNE-CPP, and MNE-MATLAB as its subprojects, offers an efficient set of tools addressing certain common needs. Even more importantly, the MNE software family covers diverse use case scenarios. Here, we present the landscape of the MNE project and discuss how it will evolve to address the current and emerging needs of the MEG/EEG community.
Published: 2019
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30. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Author: Sandra E. Black, M. Arfan Ikram, Charlotte Cordonnier, Sudha Seshadri, Paul M. Matthews, Vladimir Hachinski, Luciano A. Sposato, Jennifer Linn, Martin Dichgans, Robert J. van Oostenbrugge, Aad van der Lugt, David J. Werring, Anand Viswanathan, Joanna M. Wardlaw, François De Guio, Christophe Tzourio, Carol Brayne, Reinhold Schmidt, Richard H. Swartz, Leonardo Pantoni, Frank A. Wollenweber, Marco Duering, Bernard Mazoyer, Emrah Düzel, Fergus N. Doubal, Perminder S. Sachdev, Meike W. Vernooij, Franz Fazekas, John T. O'Brien, Blossom C. M. Stephan, Eric E. Smith, Carole Dufouil, Eric Jouvent, Hugues Chabriat, Geert J. Biessels, Vincent Mok, Bo Norrving, Stefan Ropele, Mark A. van Buchem, Christopher Chen, Frank Eric De Leeuw, De Guio, François, Génétique et Physiopathologie des Maladies Cérébro-Vasculaires (U1161 / UMR_S 1161), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), DHU NeuroVasc Sorbonne Paris-Cité, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [Lariboisière], AP-HP Groupe Hospitalier Lariboisière, Department of Neurology, VU University Medical Center [Amsterdam], Department of Medicine (Neurology), University of Toronto, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Pharmacology [Singapour], National University of Singapore (NUS)-Yong Loo Lin School of Medicine [Singapore], Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Neurology [Nijmegen], Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen]-Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen], Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), Munich Center for Systems Neurology (SyNergy), University of Edinburgh, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cognitive Neurology and Dementia Research [Magdeburg, Germany], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)-Department of Cognitive Neurology and Dementia Research, Department of Neurology [Austria], Medical University Graz, Department of Clinical Neurological Sciences [London, Canada], University of Western Ontario (UWO), Departments of Radiology and of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Neurology [Rotterdam], Department of Neuroradiology [Munich], Klinikum Großhadern Munich - Hospital [Munich, Germany], Division of Brain Sciences [London], Imperial College London, Groupe d'Imagerie Neurofonctionnelle (GIN - UMR 5296), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Medicine and Therapeutics [Hong Kong], The Chinese University of Hong Kong [Hong Kong], Department of Clinical Sciences & Neurology [Lund, Sweden], Lund University [Lund], Department of Psychiatry [Cambridge, UK], NEUROFARBA Department [Firenze, Italy], Università degli Studi di Firenze = University of Florence (UniFI), Centre for Healthy Brain Ageing [Sydney], The University of Sydney, School of Computer Science [Manchester], University of Manchester [Manchester], Department of Neurology [Boston, USA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU)-Boston University [Boston] (BU), Department of Clinical Neurosciences and Hotchkiss Brain Institute [Calgary, Canada], University of Calgary, Institute of Health and Society [Newcastle, UK], Newcastle University, Campus for Aging and Vitality [Newcastle, UK], Department of Radiology [Leiden, The Netherlands], Leids Universitair Medisch Centrum [Leiden, The Netherlands], Department of Neurology [Maastricht, The Netherlands], Maastricht University Medical Centre - MUMC [Maastricht, The Netherlands], Glaucoma Research Unit [London], Moorfields Eye Hospital [London], Stroke Research Group [London, UK] (Department of Brain Repair and Rehabilitation), University of London - UCL [London, UK], Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), University of Edinburgh-Medical Research Council (MRC), CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U1171, Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Radboud University Medical Center [Nijmegen]-Donders Institute for Brain, Cognition and Behaviour, Radboud university [Nijmegen]-Radboud university [Nijmegen], Otto-von-Guericke University [Magdeburg] (OVGU)-Department of Cognitive Neurology and Dementia Research, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Lund University [Lund, Sweden], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Medical Research Council (MRC), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Epidemiology, Neurology, and Radiology & Nuclear Medicine
Subjects: Pathology, Neurology, [SDV]Life Sciences [q-bio], brain volume, Review, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Image Processing, Computer-Assisted, RATING-SCALE, Review Articles, WHITE-MATTER HYPERINTENSITY, reproducibility, lacunes, microbleeds, white matter hyperintensities, atrophy, marker, cerebral small vessel disease, Magnetic resonance imaging, repeatability, variability, perivascular spaces, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Brain, Hematology, MULTIPLE-SCLEROSIS, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], 3. Good health, ALZHEIMERS-DISEASE, [SDV] Life Sciences [q-bio], VIRCHOW-ROBIN SPACES, Brain size, Radiology, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, Clinical Neurology, MEASURING BRAIN ATROPHY, SURFACE-BASED ANALYSIS, 1102 Cardiovascular Medicine And Haematology, Endocrinology & Metabolism, 03 medical and health sciences, VOLUME CHANGES, Neuroimaging, medicine, Journal Article, Humans, GRADIENT NONLINEARITY CORRECTION, VASCULAR DEMENTIA, Vascular dementia, Reproducibility, Science & Technology, Neurology & Neurosurgery, business.industry, Multiple sclerosis, Neurosciences, Reproducibility of Results, 1103 Clinical Sciences, medicine.disease, Hyperintensity, Cerebral Small Vessel Diseases, Microvessels, Neurosciences & Neurology, Neurology (clinical), 1109 Neurosciences, business, Biomarkers, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Item does not contain fulltext Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
Published: 2016
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31. A minimax near-optimal algorithm for adaptive rejection sampling

Author: Achdou, Juliette, Lam, Joseph C., Carpentier, Alexandra, Blanchard, Gilles, Laboratoire de Mathématiques d'Orsay (LMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Understanding the Shape of Data (DATASHAPE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria), Institut für Mathematik [Potsdam], University of Potsdam = Universität Potsdam, numberly (1000mercis Group), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Aurélien Garivier, Satyen Kale, Universität Potsdam, and Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Active learning, 62D05, 62L12, 62G05 (Primary) 62L05, 62G07 (Secondary), I.2.6, G.3, Machine Learning (stat.ML), Minimax rates, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], Machine Learning (cs.LG), [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Statistics - Machine Learning, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Adaptive rejection sampling, Monte-Carlo
Abstract: Rejection Sampling is a fundamental Monte-Carlo method. It is used to sample from distributions admitting a probability density function which can be evaluated exactly at any given point, albeit at a high computational cost. However, without proper tuning, this technique implies a high rejection rate. Several methods have been explored to cope with this problem, based on the principle of adaptively estimating the density by a simpler function, using the information of the previous samples. Most of them either rely on strong assumptions on the form of the density, or do not offer any theoretical performance guarantee. We give the first theoretical lower bound for the problem of adaptive rejection sampling and introduce a new algorithm which guarantees a near-optimal rejection rate in a minimax sense., Comment: 32 pages, 4 figures. Submitted to ALT 2019
Published: 2018
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32. Estimating minimum effect with outlier selection

Author: Alexandra Carpentier, Sylvain Delattre, Nicolas Verzelen, Etienne Roquain, Verzelen, Nicolas, Otto-von-Guericke-Universität Magdeburg, Sorbonne Université (SU), Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie (MISTEA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), Otto-von-Guericke University [Magdeburg] (OVGU), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), ANR-16-CE40-0019,SansSouci,Approches post hoc pour les tests multiples à grande échelle(2016), and ANR-17-CE40-0001,BASICS,Bayésien non-paramétrique, quantification de l'incertitude et structures aléatoires(2017)
Subjects: Statistics and Probability, False discovery rate, FOS: Computer and information sciences, minimax rate, selective inference, equicorrelation, moment matching, Mathematics - Statistics Theory, Statistics Theory (math.ST), 01 natural sciences, Methodology (stat.ME), 010104 statistics & probability, Contamination, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], 0502 economics and business, Convergence (routing), Statistics, FOS: Mathematics, [MATH]Mathematics [math], 0101 mathematics, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST], Selection (genetic algorithm), Statistics - Methodology, 050205 econometrics, Mathematics, Hermite polynomials, 62C20, multiple testing, sparsity, 05 social sciences, Estimator, Minimax, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Multiple comparisons problem, Outlier, false discovery rate, Statistics, Probability and Uncertainty, Null hypothesis, post hoc, 62G10
Abstract: We introduce one-sided versions of Huber's contamination model, in which corrupted samples tend to take larger values than uncorrupted ones. Two intertwined problems are addressed: estimation of the mean of uncorrupted samples (minimum effect) and selection of corrupted samples (outliers). Regarding the minimum effect estimation, we derive the minimax risks and introduce adaptive estimators to the unknown number of contaminations. Interestingly, the optimal convergence rate highly differs from that in classical Huber's contamination model. Also, our analysis uncovers the effect of particular structural assumptions on the distribution of the contaminated samples. As for the problem of selecting the outliers, we formulate the problem in a multiple testing framework for which the location/scaling of the null hypotheses are unknown. We rigorously prove how estimating the null hypothesis is possible while maintaining a theoretical guarantee on the amount of the falsely selected outliers, both through false discovery rate (FDR) or post hoc bounds. As a by-product, we address a long-standing open issue on FDR control under equi-correlation, which reinforces the interest of removing dependency when making multiple testing., Comment: 70 pages; 7 figures
Published: 2018
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33. Conformation-Controlled Sorption Properties and Breathing of the Aliphatic Al-MOF [Al(OH)(CDC)]

Author: Helge Reinsch, Alexis S. Munn, Stefan Kaskel, Philip L. Llewellyn, Richard I. Walton, Ivo Zizak, Jeroen Lannoeye, Alexandra Lieb, Guillaume Maurin, Norbert Stock, Dirk De Vos, Felicitas Niekiel, Andreas Heerwig, Christian-Albrechts-Universität zu Kiel (CAU), University of Warwick [Coventry], Fachrichtung Chemie und Lebensmittelchemie, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Department of Inorganic Chemistry, Center for Surface Chemistry and Catalysis, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratoire Chimie Provence (LCP), Université de Provence - Aix-Marseille 1-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institute of Simulation and Graphics [Magdeburg], Otto-von-Guericke University [Magdeburg] (OVGU), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Isothermal microcalorimetry, Chemistry, Inorganic chemistry, Molecular Conformation, Sorption, Carbon Dioxide, Xylenes, Synchrotron, law.invention, Inorganic Chemistry, chemistry.chemical_compound, Adsorption, law, Thermodynamics, Molecule, Physical chemistry, Density functional theory, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Physical and Theoretical Chemistry, Mesitylene, Powder Diffraction, ComputingMilieux_MISCELLANEOUS, Powder diffraction, Aluminum
Abstract: The Al-MOF CAU-13 ([Al(OH)(trans-CDC)]; trans-H2CDC = trans-1,4-cyclohexanedicarboxylic acid) is structurally related to the MIL-53 compounds that are well-known for their "breathing" behavior, i.e., the framework flexibility upon external stimuli such as the presence of adsorbate molecules. The adsorption properties of CAU-13 were investigated in detail. The sorption isotherms of N2, H2, CH4, CO, CO2, and water were recorded, and the adsorption enthalpies for the gases were determined by microcalorimetry. The structural changes upon adsorption of CO2 were followed with in situ synchrotron powder X-ray diffraction (PXRD). The patterns were analyzed by parametric unit cell refinement, and the preferential arrangement of the CO2 molecules was modeled by density functional theory calculations. The adsorption and separation of mixtures of o-, m-, and p-xylene from mesitylene showed a preferred adsorption of o-xylene. The structures of o/m/p-xylene-loaded CAU-13 were determined from PXRD data. The adsorption of xylene isomers induces a larger pore opening than that in the thermal activation of CAU-13. In the crystal structure of the activated sample CAU-13(empty pore), half of the linkers adopt the a,a confirmation and the other half the e,e conformation, and the presence of a,a-CDC(2-) ions hampers the structural flexibility of CAU-13. However, after the adsorption of xylene, all linkers are present in the e,e conformation, allowing for a wider pore opening by this new type of "breathing".
Published: 2014
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34. The wearable cardioverter-defibrillator: current technology and evolving indications

Author: Fauchier, Laurent, Clementy, Nicolas, Bisson, Arnaud, Stamboul, Karim, Ivanes, Fabrice, Angoulvant, Denis, Babuty, Dominique, Lip, Gregory, Reek, Sven, Burri, Haran, Roberts, Paul, Perings, Christian, Epstein, Andrew, Klein, Helmut, Gorenek, Bulent, Sticherling, Christian, Goette, Andreas, Jung, Werner, Vos, Marc, Brignole, Michele, Elsner, Christian, Dan, Gheorghe-Andrei, Marin, Francisco, Boriani, Giuseppe, Lane, Deirdre, Blomström-Lundqvist, Carina, Savelieva, Irina, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), Service de Cardiologie (CHU Trousseau, Tours), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Bourgogne (UB), Service de Cardiologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Cellules Dendritiques, Immunomodulation et Greffes, Service de Cardiologie B, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Cardiology, Birmingham City Hospital, Hôpitaux Universitaires de Genève (HUG), University Hospital Southampton, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Department of Cardiology [Lavagna, Italy], Ospedali del Tigullio, Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Universidad de Murcia, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University of Liverpool, and Uppsala Universitet [Uppsala]
Subjects: Life vest, Cost-Benefit Analysis, Electric Countershock, Wearable computer, Arrhythmias, 030204 cardiovascular system & hematology, External defibrillation, Sudden cardiac death, Ventricular arrhythmias, Wearable cardioverter-defibrillator, Cardiology and Cardiovascular Medicine, Physiology (medical), Implantable defibrillators, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, ddc:616, Cardiac/prevention & control, Arrhythmic risk, business.industry, Arrhythmias, Cardiac, Equipment Design, Health Care Costs, medicine.disease, Sudden, Death, Cardiac/economics/mortality/physiopathology/therapy, Death, Sudden, Cardiac, Treatment Outcome, Defibrillators/economics, Patient Satisfaction, Patient Compliance, Current technology, Electric Countershock/adverse effects/economics/instrumentation/mortality, Medical emergency, Diffusion of Innovation, business, Wearable cardioverter defibrillator, Defibrillators
Abstract: The wearable cardioverter-defibrillator has been available for over a decade and now is frequently prescribed for patients deemed at high arrhythmic risk in whom the underlying pathology is potentially reversible or who are awaiting an implantable cardioverter-defibrillator. The use of the wearable cardioverter-defibrillator is included in the new 2015 ESC guidelines for the management of ventricular arrhythmias and prevention of sudden cardiac death. The present review provides insight into the current technology and an overview of this approach.
Published: 2016
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35. Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury

Author: Peter R. Mertens, Jean-Claude Dussaule, Ute Raffetseder, Monique Kerroch, Clemens D. Cohen, Annemarie Dittrich, Sonja Djudjaj, Sabine Brandt, Cheng Zhu, Maja T. Lindenmeyer, Dominique Guerrot, Jürgen Floege, Peter Boor, Christos Chatziantoniou, Lydia Hanssen, Tammo Ostendorf, Department of Nephrology and Immunology, Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University [Magdeburg] (OVGU), Remodelage et Reparation du Tissu Renal, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pathology, Institute of Molecular Biomedicine, Comenius University in Bratislava, Department of Medical Microbiology, Division of nephrology and Institute of Physiology, Universität Zürich [Zürich] = University of Zurich (UZH), This work was supported by fellowship grants from the ERA-ETDA (to S.D.), DFG SFB 854 project 01 (to P.R.M.) and DFG Sachbeihilfeantrag 1365/7-1 (to P.R.M.). C.C. received INSERM funding. U.R was funded by the Else-Kröner-Fresenius- Stiftung., Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: MESH: Signal Transduction, MESH: Inflammation, Pathology, Receptor expression, Nephron, 030204 cardiovascular system & hematology, MESH: Receptor, Notch1, MESH: Mice, Knockout, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Biopsy, 0302 clinical medicine, MESH: Up-Regulation, MESH: Animals, chemotaxis, Receptor, 0303 health sciences, Kidney, Kidney diseases, 3. Good health, tubular cells, medicine.anatomical_structure, MESH: Fibrosis, MESH: Membrane Proteins, medicine.symptom, MESH: Nephritis, Interstitial, medicine.medical_specialty, MESH: Rats, proliferation, Notch signaling pathway, Inflammation, Biology, Pathology and Forensic Medicine, 03 medical and health sciences, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, medicine, MESH: Intercellular Signaling Peptides and Proteins, MESH: Mice, MESH: Transforming Growth Factor beta, 030304 developmental biology, MESH: Humans, urogenital system, fibrosis, Kidney metabolism, MESH: Kidney, medicine.disease, MESH: Cell Line, inflammation, Notch receptors, MESH: Ureteral Obstruction, MESH: Disease Models, Animal, MESH: Receptors, Notch, MESH: Female, Kidney disease
Abstract: International audience; Kidney diseases impart a vast burden on affected individuals and the overall health care system. Progressive loss of renal parenchymal cells and functional decline following injury are often observed. Notch-1 and -2 receptors are crucially involved in nephron development and contribute to inflammatory kidney diseases. We specifically determined the participation of receptor Notch-3 following tubulointerstitial injury and in inflammatory responses. Here we show by heat map analyses that Notch-3 transcripts are up-regulated in human kidney diseases. A similar response was corroborated with kidney cells following TGF-β exposure in vitro. The murine unilateral ureteral obstruction (UUO) model mirrors hallmarks of tubulointerstitial injury and damage. A subset of tubular and interstitial cells demonstrated up-regulated Notch-3 receptor expression in diseased animals. We hypothesized a relevance of Notch-3 receptors for the chemotactic response. To address this question, animals with genetic ablation of receptor Notch-3 were analysed following UUO. As a result, we found that Notch-3-deficient animals are protected from tubular injury and cell loss with significantly reduced interstitial collagen deposition. Monocytic cell infiltration was significantly reduced and retarded, likely due to abrogated chemokine synthesis. A cell model was set up that mimics enhanced receptor Notch-3 expression and activation. Here a pro-mitogenic response was seen with activated signalling in tubular cells and fibroblasts. In conclusion, Notch-3 receptor fulfils non-redundant roles in the inflamed kidney that may not be replaced by other Notch receptor family members. Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease.
Published: 2012
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36. The Double-Stranded RNA Bluetongue Virus Induces Type I Interferon in Plasmacytoid Dendritic Cells via a MYD88-Dependent TLR7/8-Independent Signaling Pathway

Author: Jamila Elhmouzi-Younes, Emilie Chauveau, Stéphan Zientara, Polly Roy, Florentina Pascale, Céline Urien, Peter P. C. Mertens, Stéphanie Dabo, Haru Takamatsu, Bernard Charley, Jayne Hope, Michel Bonneau, Behzad Hemati, Meredith Stewart, Isabelle Schwartz-Cornil, Suzana Ruscanu, Damien Vitour, Eliane F. Meurs, Corinne Sailleau, Mickael Bourge, Gilles Meyer, Emmanuel Bréard, Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Institut des sciences du végétal (ISV), Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Imagerie Interventionnelle (CR2I), Institute for Animal Health (IAH), Biotechnology and Biological Sciences Research Council, Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University [Magdeburg] (OVGU), Ecole Vétérinaire de Toulouse, Hépacivirus et immunité innée, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Biotechnology and Biological Sciences Research Council (BBSRC), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Subjects: MESH: Signal Transduction, MESH: Interferon Type I, viruses, MESH: Membrane Glycoproteins, MESH: Bluetongue virus, Interferon, MESH: Animals, Cells, Cultured, 0303 health sciences, MESH: Cytokines, Membrane Glycoproteins, biology, MESH: Dendritic Cells, 030302 biochemistry & molecular biology, hemic and immune systems, MESH: Toll-Like Receptor 8, 3. Good health, MESH: Toll-Like Receptor 7, Virus-Cell Interactions, Interferon Type I, Cytokines, MESH: Immunity, Innate, Female, medicine.drug, MESH: Myeloid Differentiation Factor 88, MESH: Cells, Cultured, Signal Transduction, Immunology, MESH: Sheep, MESH: Receptors, Interleukin-1, Microbiology, Bluetongue, Virus, 03 medical and health sciences, Virology, medicine, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Animals, MESH: Bluetongue, 030304 developmental biology, Innate immune system, Sheep, Receptors, Interleukin-1, RNA virus, TLR7, Dendritic Cells, biology.organism_classification, Protein kinase R, Molecular biology, Immunity, Innate, Viral replication, Toll-Like Receptor 7, Toll-Like Receptor 8, Insect Science, Myeloid Differentiation Factor 88, MESH: Female, Interferon type I, Bluetongue virus
Abstract: Dendritic cells (DCs), especially plasmacytoid DCs (pDCs), produce large amounts of alpha/beta interferon (IFN-α/β) upon infection with DNA or RNA viruses, which has impacts on the physiopathology of the viral infections and on the quality of the adaptive immunity. However, little is known about the IFN-α/β production by DCs during infections by double-stranded RNA (dsRNA) viruses. We present here novel information about the production of IFN-α/β induced by bluetongue virus (BTV), a vector-borne dsRNA Orbivirus of ruminants, in sheep primary DCs. We found that BTV induced IFN-α/β in skin lymph and in blood in vivo . Although BTV replicated in a substantial fraction of the conventional DCs (cDCs) and pDCs in vitro , only pDCs responded to BTV by producing a significant amount of IFN-α/β. BTV replication in pDCs was not mandatory for IFN-α/β production since it was still induced by UV-inactivated BTV (UV-BTV). Other inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and IL-12p40, were also induced by UV-BTV in primary pDCs. The induction of IFN-α/β required endo-/lysosomal acidification and maturation. However, despite being an RNA virus, UV-BTV did not signal through Toll-like receptor 7 (TLR7) for IFN-α/β induction. In contrast, pathways involving the MyD88 adaptor and kinases dsRNA-activated protein kinase (PKR) and stress-activated protein kinase (SAPK)/Jun N-terminal protein kinase (JNK) were implicated. This work highlights the importance of pDCs for the production of innate immunity cytokines induced by a dsRNA virus, and it shows that a dsRNA virus can induce IFN-α/β in pDCs via a novel TLR-independent and Myd88-dependent pathway. These findings have implications for the design of efficient vaccines against dsRNA viruses.
Published: 2012
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37. A new class of monomial bent functions

Author: Pascale Charpin, Gohar M. Kyureghyan, Anne Canteaut, Security, Cryptology and Transmissions (SECRET), Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Otto-von-Guericke University [Magdeburg] (OVGU), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Monomial, Bent function, Parity function, Cubic function, Dimension (graph theory), Bent molecular geometry, Derivatives of Boolean functions, 0102 computer and information sciences, 02 engineering and technology, Characterization (mathematics), 01 natural sciences, Theoretical Computer Science, Combinatorics, [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], Boolean function, 0202 electrical engineering, electronic engineering, information engineering, Boolean expression, Monomial function, Engineering(all), Mathematics, Discrete mathematics, Algebra and Number Theory, Applied Mathematics, General Engineering, [MATH.MATH-IT]Mathematics [math]/Information Theory [math.IT], 020206 networking & telecommunications, Quadratic function, 010201 computation theory & mathematics, [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Function composition, Stone's representation theorem for Boolean algebras, Permutation polynomials, Vector space
Abstract: International audience; We study the Boolean functions fλ :F2n →F2, n = 6r, of the form f (x) = Tr(λxd ) with d = 22r + 2r + 1 and λ ∈ F2n . Our main result is the characterization of those λ for which fλ are bent. We show also that the set of these cubic bent functions contains a subset, which with the constantly zero function forms a vector space of dimension 2r over F2. Further we determine the Walsh spectra of some related quadratic functions, the derivatives of the functions fλ.
Published: 2008
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38. Deletion of the LIME adaptor protein minimally affects T and B cell development and function

Author: Pavla Angelisova, Amandine Sansoni, Marie Malissen, Sylvie Richelme, Claude Grégoire, Dirk Reinhold, Luca Simeoni, Anja Schmidt-Giese, Vaclav Horejsi, Bernard Malissen, Burkhart Schraven, Ying Wang, Šárka Šímová, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institute of Molecular Genetics of the Czech Academy of Sciences (IMG / CAS), Czech Academy of Sciences [Prague] (CAS), Institute for Immunology, Otto-von-Guericke University [Magdeburg] (OVGU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: MESH: Cell Differentiation, MESH: Mice, Transgenic, T-Lymphocytes, Blotting, Western, Immunology, Autoimmunity, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, MESH: Flow Cytometry, Biology, engineering.material, Lymphocyte Activation, complex mixtures, Mice, 03 medical and health sciences, Interleukin 21, 0302 clinical medicine, MESH: Reverse Transcriptase Polymerase Chain Reaction, MESH: B-Lymphocytes, MESH: Autoimmunity, medicine, Animals, MESH: Blotting, Western, Immunology and Allergy, MESH: Animals, IL-2 receptor, MESH: Lymphocyte Activation, MESH: Mice, B cell, 030304 developmental biology, Lime, B-Lymphocytes, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, ZAP70, MESH: Enzyme-Linked Immunosorbent Assay, Signal transducing adaptor protein, Cell Differentiation, MESH: Adaptor Proteins, Vesicular Transport, Flow Cytometry, Cell biology, Adaptor Proteins, Vesicular Transport, MESH: T-Lymphocytes, medicine.anatomical_structure, engineering, [SDV.IMM]Life Sciences [q-bio]/Immunology, Tyrosine kinase, 030215 immunology, Proto-oncogene tyrosine-protein kinase Src
Abstract: International audience; LIME (Lck-interacting membrane protein) is a transmembrane adaptor that associates with the Lck and Fyn protein tyrosine kinases and with the C-terminal Src kinase (Csk). To delineate the role of LIME in vivo, LIME-deficient mice were generated. Although Lime transcripts were expressed in immature and mature B and T cells, the absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence of T cells. Therefore, our in vivo results refute all the previous roles postulated for LIME on the basis of studies of transformed B and T cells and demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors.
Published: 2007
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39. RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation

Author: Theresia E. B. Stradal, Stefanie Kliche, Gaël Ménasché, Gary A. Koretzky, Burkhart Schraven, Emily J. H. Chen, Ménasché, Gaël, Signal of Transduction Program [Philadelphia, PA, USA] (Abramson Family Cancer Research Institute), University of Pennsylvania School of Veterinary Medicine, Institute of Molecular and Clinical Immunology [Magdeburg, Germany], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Signaling and Motility Group [Braunschweig, Germany] (HZI), Helmholtz Center for Infection Research [Braunschweig, Germany] (HZI), Department of Pathology and Laboratory Medicine [Philadelphia, PA, USA] (Perelman School of Medicine), University of Pennsylvania, and This work was supported by long-term postdoctoral fellowships from the European Molecular Biology Organization (G.M.), by Deutsche Forschungsgemeinschaft grants KL1292/5-1 and GRK1167 (S.K. and B.S.), and by the U.S. National Institutes of Health (G.K.).
Subjects: Integrins, [SDV.IMM] Life Sciences [q-bio]/Immunology, Recombinant Fusion Proteins, T-Lymphocytes, [SDV]Life Sciences [q-bio], Integrin, Receptors, Antigen, T-Cell, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Cell Line, Mice, Cell Adhesion, Animals, Humans, Small GTPase, Cell adhesion, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Adaptor Proteins, Signal Transducing, T-cell receptor, Membrane Proteins, rap1 GTP-Binding Proteins, Signal transducing adaptor protein, Articles, Cell Biology, Phosphoproteins, Cell biology, [SDV] Life Sciences [q-bio], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Rap1, Signal transduction, Protein Binding, Signal Transduction, Proto-oncogene tyrosine-protein kinase Src
Abstract: International audience; One outcome of T-cell receptor (TCR) signaling is increased affinity and avidity of integrins for their ligands. This occurs through a process known as inside-out signaling, which has been shown to require several molecular components including the adapter proteins ADAP (adhesion and degranulation-promoting adapter protein) and SKAP-55 (55-kDa src kinase-associated phosphoprotein) and the small GTPase Rap1. Herein, we provide evidence linking ADAP and SKAP-55 to RIAM, a recently described adapter protein that binds selectively to active Rap1. We identified RIAM as a key component linking the ADAP/SKAP-55 module to the small GTPase Rap1, facilitating TCR-mediated integrin activation. We show that RIAM constitutively interacts with SKAP-55 in both a heterologous transfection system and primary T cells and map the region essential for this interaction. Additionally, we find that the SKAP-55/RIAM complex is essential both for TCR-mediated adhesion and for efficient conjugate formation between T cells and antigen-presenting cells. Mechanistic studies revealed that the ADAP/SKAP-55 module relocalized RIAM and Rap1 to the plasma membrane following TCR activation to facilitate integrin activation. These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation.
Published: 2007
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40. Discontinuous and continuous separation of the monomeric and dimeric forms of human bone morphogenetic protein-2 from renaturation batches

Author: L. Gueorguieva, Luis Felipe Vallejo, Ursula Rinas, Andreas Seidel-Morgenstern, and Otto-von-Guericke-Universität Magdeburg, Institut für Verfahrenstechnik, PO Box 4120, D-39106 Magdeburg, Germany.
Subjects: Stereochemistry, Dimer, Protein Renaturation, Bone Morphogenetic Protein 2, Bone morphogenetic protein, Biochemistry, Bone morphogenetic protein 2, Inclusion bodies, Analytical Chemistry, chemistry.chemical_compound, Transforming Growth Factor beta, Escherichia coli, Polyacrylamide gel electrophoresis, Chromatography, Heparin, Chemistry, Organic Chemistry, General Medicine, Recombinant Proteins, Monomer, Bone Morphogenetic Proteins, Electrophoresis, Polyacrylamide Gel, Spectrophotometry, Ultraviolet, Simulated moving bed, Dimerization, Chromatography, Liquid
Abstract: Bone morphogenetic protein-2 (BMP-2) is one of the most interesting of the approximately 14 BMPs which belong to the transforming-growth-factor-beta (TGF-beta) superfamily. BMP-2 induces bone formation and thus plays an important role as a pharmaceutical protein. Recently, rhBMP-2 has been produced in form of inactive inclusion bodies in Escherichia coli. After solubilization and renaturation the biologically active dimeric form of rhBMP-2 can be generated. However, inactive monomers of BMP-2 are also formed during the renaturation process which must be separated from the active dimeric BMP-2. The purpose of this paper is to present: (a) results of an experimental study of a chromatographic separation of the monomeric and dimeric forms; and (b) a concept for a continuous counter-current simulated moving bed (SMB) process. The capacity of heparin as stationary phase was estimated for different salt concentrations in the mobile phase. A simulation study of a three-zone SMB process was performed applying a two step salt gradient. The results reveal the potential of the process for the purification of the dimeric BMP-2.
Published: 2006
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41. Back-propagating action potential

Author: Volkmar Lessmann, Nicola Kuczewski, Christophe Porcher, Jean-Luc Gaiarsa, Igor Medina, Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Institute of Physiology, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Tyzio, Roman, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Brain-derived neurotrophic factor, biology, Mechanism (biology), [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Peptide secretion, Article Addendum, medicine.anatomical_structure, nervous system, Neuromodulation, Synaptic plasticity, medicine, biology.protein, Premovement neuronal activity, Secretion, General Agricultural and Biological Sciences, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Neuroscience, Neurotrophin
Abstract: International audience; Brain derived neurotrophic factor (BDNF) is crucial for the formation of appropriate synaptic connections during development and for learning and memory in adults. Secretion of this neurotrophin is under activity-dependent control. Understanding which patterns of physiological activity regulate BDNF secretion is therefore an important step in the comprehension of its role. We have recently shown that back propagation of action potentials (bAPs) is the principal triggering mechanism of dendritic BDNF secretion occurring during ongoing neuronal activity in neuronal cultures. In the present addendum we discuss possible implications of bAPs-induced BDNF secretion on the construction and reorganization of neuronal networks.
Published: 2008
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42. On sets determining the differential spectrum of mappings

Author: Gohar M. Kyureghyan, Pascale Charpin, Security, Cryptology and Transmissions (SECRET), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Otto-von-Guericke University [Magdeburg] (OVGU), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: bent function, Monomial, Bent function, Binomial (polynomial), APN mappings, 0102 computer and information sciences, 02 engineering and technology, permutation, 01 natural sciences, binomial, Combinatorics, hyperplane, Permutation, Boolean function, 0202 electrical engineering, electronic engineering, information engineering, monomial, [MATH]Mathematics [math], cryptographic criteria, Mathematics, Discrete mathematics, Differential uniformity, Multiplicative function, differential uniformity, General Engineering, 020206 networking & telecommunications, Hyperplane, 010201 computation theory & mathematics
Abstract: Special issue on the honor of Gerard Cohen; International audience; The differential uniformity of a mapping $F : F 2 n → F 2 n$ is defined as the maximum number of solutions $x$ for equations $F (x+a)+F (x) = b$ when $a ̸ = 0$ and $b$ run over $F 2 n$. In this paper we study the question whether it is possible to determine the differential uniformity of a mapping by considering not all elements $a ̸ = 0$, but only those from a special proper subset of $F 2 n \ {0}$. We show that the answer is " yes " , when $F$ has differential uniformity 2, that is if $F$ is APN. In this case it is enough to take $a ̸ = 0$ on a hyperplane in $F 2 n$. Further we show that also for a large family of mappings F of a special shape, it is enough to consider a from a suitable multiplicative subgroup of $F 2 n$ .
Published: 2017
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43. Estimation of consistent parameter sets for continuous-time nonlinear systems using occupation measures and LMI relaxations

Author: Philipp Rumschinski, Didier Henrion, Stefan Streif, Rolf Findeisen, Otto-von-Guericke University [Magdeburg] (OVGU), Équipe Méthodes et Algorithmes en Commande (LAAS-MAC), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Institute for Automation Engineering (IFAT), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), and Université de Toulouse (UT)
Subjects: 0303 health sciences, 0209 industrial biotechnology, Mathematical optimization, Polynomial, Linear programming, Estimation theory, 02 engineering and technology, Decision problem, 03 medical and health sciences, Nonlinear system, 020901 industrial engineering & automation, Optimization and Control (math.OC), FOS: Mathematics, Initial value problem, Relaxation (approximation), [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Multidimensional systems, Mathematics - Optimization and Control, 030304 developmental biology, Mathematics
Abstract: International audience; Obtaining initial conditions and parameterizations leading to a model consistent with available measurements or safety specifications is important for many applications. Examples include model (in-)validation, prediction, fault diagnosis, and controller design. We present an approach to determine inner- and outer-approximations of the set containing all consistent initial conditions/parameterizations for nonlinear continuous-time systems. These approximations are found by occupation measures that encode the system dynamics and measurements, and give rise to an infinite-dimensional linear program. We exploit the flexibility and linearity of the decision problem to incorporate uncertain-but-bounded and pointwise-in-time state and output constraints, a feature which was not addressed in previous works. The infinite-dimensional linear program is relaxed by a hierarchy of LMI problems that provide certificates in case no consistent initial condition/parameterization exists. Furthermore, the applied LMI relaxation guarantees that the approximations converge (almost uniformly) to the true consistent set. We illustrate the approach with a biochemical reaction network involving unknown initial conditions and parameters.
Published: 2013
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44. Berufliche Rehabilitation: Fakten - Analysen - Entwicklungstendenzen; Evaluation von Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben; Zwischenbericht

Author: Schattat, Bettina, Dony, Elke, Gruber, Stefan, Jasim, Alaa, Rauch, Angela, Schmelzer, Paul, Schneider, Andreas, Titze, Nancy, Thomsen, Ulrich, Zapfel, Stefan, Zimmermann, Ralf, Sommer, Jörn, Gericke, Thomas, Frank, Wilma, Matthes, Stephanie, Ekert, Stefan, Thomsen, Stephan L., Bundesministerium für Arbeit und Soziales, Institut für Arbeitsmarkt- und Berufsforschung der Bundesagentur für Arbeit (IAB), Otto-von-Guericke-Universität Magdeburg, Fak. für Humanwissenschaften, Institut für Erziehungswissenschaft, Lehrstuhl für Soziale und Berufliche Rehabilitation, Niedersächsisches Institut für Wirtschaftsforschung e.V. -NIW, and InterVal GmbH
Subjects: gainful employment, Sozialleistung, Economics, social benefits, self-determination, Labor Market Policy, Federal Republic of Germany, Sozialpolitik, Social Security, social policy, Erwerbstätigkeit, physical disability, vocational rehabilitation, ddc:330, handicapped, equal treatment, participation, soziale Sicherung, Partizipation, Evaluation, Social sciences, sociology, anthropology, berufliche Integration, Chancengleichheit, equal opportunity, Förderungsmaßnahme, Sozialwissenschaften, Soziologie, Körperbehinderung, Wirtschaft, occupational integration, Selbstbestimmung, Arbeitsmarktpolitik, Bundesrepublik Deutschland, Behinderter, mental disability, geistige Behinderung, promotional measure, ddc:300, berufliche Rehabilitation, Gleichbehandlung
Abstract: Die Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben in den Bereichen der Arbeitsförderung und der Grundsicherung für Arbeitsuchende sind eine bedeutende Komponente der Arbeitsmarktpolitik. Mit der mehrstufig angelegten Evaluation von Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben sollen Ansatzpunkte für die Optimierung der praktischen Umsetzung und die Fortentwicklung des rechtlichen Rahmens dieser Leistungen ermittelt werden. Bislang wurden drei Forschungsmodule durchgeführt. Deren Ergebnisse werden mit dem hier vorliegenden Bericht veröffentlicht. Inhaltsverzeichnis: Teil A: Basisstudie zur Evaluation von Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben; Zusammenfassender Bericht. Teil B: Implementationsstudie 1 zur Evaluation von Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben; Zusammenfassender Bericht. Teil C: Beratung zu wirkungsanalytischen Ansätzen für die Evaluation von Leistungen zur Teilhabe behinderter Menschen am Arbeitsleben: Zusammenfassender Bericht.
Published: 2012

45. Endogenous Timing in General Rent‐Seeking and Conflict Models

Author: Rota-Graziosi, Grégoire, Hoffmann, Magnus, Etudes & Documents - Publications, CERDI, Centre d'Études et de Recherches sur le Développement International (CERDI), Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Department of Economics (Department of Economics), Otto-von-Guericke University [Magdeburg] (OVGU), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: Contests, Endogenous timing, JEL: D - Microeconomics/D.D3 - Distribution/D.D3.D30 - General, Contests,Endogenous timing,Endogenous prize, JEL: C - Mathematical and Quantitative Methods/C.C7 - Game Theory and Bargaining Theory/C.C7.C72 - Noncooperative Games, JEL: D - Microeconomics/D.D2 - Production and Organizations/D.D2.D23 - Organizational Behavior • Transaction Costs • Property Rights, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Endogenous prize, [SHS.ECO] Humanities and Social Sciences/Economics and Finance
Abstract: This paper examines simultaneous versus sequential choice of effort in a twoplayer contest with a general contest success function. The timing of moves, determined in a pre‐play stage prior to the contest‐subgame, as well as the value of the prize is allowed to be endogenous. Contrary to endogenous timing models with an exogenously fixed prize the present paper finds the following. (1) Players may decide to choose their effort simultaneously in the subgame perfect equilibrium (SPE) of the extended game, (2) the SPE does not need to be unique, (3) in particular, there is no unique SPE with sequential moves if costs of effort are exclusively endogenously determined, (4) if the unique SPE is sequential play, the win probability in the NE is in no way crucial for the determination of an endogenous leadership, (5) and symmetry among players does not rule out incentives for precommitment to effort locally away from the Nash‐Cournot level
Published: 2011

46. Weak solutions to the continuous coagulation equation with multiple fragmentation

Author: Gerald Warnecke, Ankik Kumar Giri, Philippe Laurençot, Institute for Applied Mathematics, Montan University Leoben, University of Leoben (MU), Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institute for Analysis and Numerics, Otto-von-Guericke University Magdeburg, Otto-von-Guericke University [Magdeburg] (OVGU), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: genetic structures, information science, Existence, 01 natural sciences, Article, Singularity, Mathematics - Analysis of PDEs, Weak compactness, FOS: Mathematics, Coagulation (water treatment), [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], natural sciences, 0101 mathematics, 45K05, 82C21, Nuclear Experiment, Physics::Atmospheric and Oceanic Physics, Mathematics, Coagulation, Applied Mathematics, 010102 general mathematics, Mathematical analysis, digestive, oral, and skin physiology, Fragmentation (computing), food and beverages, Multiple fragmentation, 010101 applied mathematics, Unbounded kernels, Kernel (statistics), Astrophysics::Earth and Planetary Astrophysics, Analysis, Analysis of PDEs (math.AP)
Abstract: The existence of weak solutions to the continuous coagulation equation with multiple fragmentation is shown for a class of unbounded coagulation and fragmentation kernels, the fragmentation kernel having possibly a singularity at the origin. This result extends previous ones where either boundedness of the coagulation kernel or no singularity at the origin for the fragmentation kernel were assumed.
Published: 2011
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47. Quality of life after successful treatment of early-stage Hodgkin's lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial

Author: Heutte, Natacha, Flechtner, Henning H., Mounier, Nicolas, Mellink, Wilhelmina A. M., Meerwaldt, Jacobus H., Eghbali, Houchingue, van't Veer, Mars B., Noordijk, Evert M., Kluin-Nelemans, Johanna C., Lampka, Elzbieta, Thomas, Jose, Lugtenburg, Pieternella J., Viterbo, Luisa, Carde, Patrice, Hagenbeek, Anton, van der Maazen, Richard W.M., Smit, Wilma G.J.M., Brice, Pauline, van Kooy, Marinus Marwijk, Baars, Johanna W., Poortmans, Philip, Tirelli, Umberto, Leeksma, Onno C., Tomsic, Radka, Feugier, Pierre, Salles, Gilles, Gabarre, Jean, Kersten, Marie Jose, Van Den Neste, Eric, Creemers, Geert-Jan M., Gaillard, Isabelle, Meijnders, Paul, Tertian, Gerard, Reman, Oumedaly, Muller, Hein P., Troncy, Jacques, Blanc, Michel, Voogt, Paul J., Wijermans, Pierre, Rieux, Chantal, Ferme, Christophe, Henry-Amar, Michel, Schroyens, Wilfried, EORTC-GELA H8 Trial Group, Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Curie [Paris], Service d'Hématologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Laboratoire de Biologie Moléculaire de la Cellule (LBMC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cliniques Universitaires Saint-Luc [Bruxelles], Université Pierre Mendès France - Grenoble 2 (UPMF), Middelheim Hospital, Hématologie, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Henri Mondor [Créteil], École polytechnique (X), Unité de Recherche clinique [Caen], Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Calvados Cancer Registry, Otto-von-Guericke University [Magdeburg] (OVGU), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Service d'Hématologie clinique [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Henri Mondor, Hematology, CCA -Cancer Center Amsterdam, Clinical Haematology, AII - Amsterdam institute for Infection and Immunity, and EORTC-GELA H8 Trial Group
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, [SDV]Life Sciences [q-bio], MEDLINE, [SDV.CAN]Life Sciences [q-bio]/Cancer, Logistic regression, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Quality of life, SDG 3 - Good Health and Well-being, law, Translational research [ONCOL 3], medicine, Humans, 030212 general & internal medicine, Cognitive skill, Stage (cooking), ComputingMilieux_MISCELLANEOUS, Aged, business.industry, Odds ratio, Middle Aged, Hodgkin's lymphoma, medicine.disease, Hodgkin Disease, humanities, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Physical therapy, Quality of Life, Female, Human medicine, business, Follow-Up Studies
Abstract: Background Little is known about the longitudinal course of health-related quality of life (HRQoL) in patients with Hodgkin's lymphoma during their post-treatment follow-up and re-adaptation to normal life. We report on the HRQoL of patients treated in the randomised H8 trial of the European Organisation for Research and Treatment of Cancer (EORTC) Lymphoma Group and the Groupe d'Études des Lymphomes de l'Adulte (GELA). We aimed to assess HRQoL and fatigue following treatment, to analyse relations with treatment, and to identify factors that predict persistent fatigue. Methods Patients received HRQoL questionnaires at the end of primary therapy and during follow-up. The EORTC QLQ-C30 was used to assess HRQoL, and the Multidimensional Fatigue Inventory (MFI-20) was used to assess fatigue. Changes of mean HRQoL scores over time were analysed with mixed models. Multiple polytomic nominal logistic regression was done to identify independent baseline predictors of fatigue within MFI-20 dimensions. Analyses were done on an intention-to-treat basis. This study is registered with www.ClinicalTrials.gov, number NCT00379041. Findings 2666 assessments from 935 patients were analysed. Mean follow-up was 90 months (range 52118). Age affected all functioning and symptom scores except emotional functioning, with younger age associated with higher functioning and lower severity of symptoms; improvement with time showed similar patterns between age groups. Women reported lower HRQoL and higher symptom scores than did men. Overall, 3·2% (14/439 for role functioning) to 9·7% (43/442 for social functioning) and 5·8% (29/498 for reduced motivation) to 9·9% (49/498 for general fatigue) of patients reported impairments of 10 points or more (on a 0100 scale) in QLQ-C30 and MFI-20 scores, respectively, independent of age and sex. Emotional domains were more affected than physical ones. There was no relation between HRQoL outcome and type of treatment. Fatigue (MFI-20 scores) at the end of treatment was the only predictive variable for persistent fatigue, with odds ratios varying from 2·58 (95% CI 1·006·67) to 41·51 (12·02143·33; p≤0·0001). Sensitivity analyses adjusting for missing data were much the same as the main results. Interpretation HRQoL data after treatment for early-stage Hodgkin's lymphoma show that patients experience strain and limitations in all subdomains apart from cognitive functioning (QLQ-C30), and also have reduced motivation (MFI-20). Differences in HRQoL improvement with time were linked to age and sex, but not type of treatment. Fatigue status at the end of treatment seems to predict subsequent HRQoL. Abstract: Background little is known about the longitudinal course of health-related quality of life (HRQoL) in patients with Hodgkin's lymphoma during their post-treatment follow-up and re-adaptation to normal life. We report on the HRQoL of patients treated in the randomised H8 trial of the European Organisation for Research and Treatment of Cancer (EORTC) Lymphoma Group and the Groupe dEtudes des Lymphomes de I'Adulte (GELA). We aimed to assess HRQoL and fatigue following treatment, to analyse relations with treatment, and to identify factors that predict persistent fatigue. Methods Patients received HRQoL questionnaires at the end of primary therapy and during follow-up. The EORTC QLQ-C30 was used to assess HRQoL, and the Muiltidimensional Fatigue Inventory (MFI-20) was used to assess fatigue. Changes of mean HRQoL scores over time were analysed with mixed models. Multiple polytomic: nominal logistic regression was done to identify independent baseline predictors of fatigue within MFI-20 dimensions. Analyses were done on an intention-to-treat basis. This study is registered with www.ClinicalTrials.gov, number NCT00379041. Findings 2666 assessments from 935 patients were analysed. Mean follow-up was 90 months (range 52-118). Age affected all functioning and symptom scores except emotional functioning, with younger age associated with higher functioning and lower severity of symptoms; improvement with time showed similar patterns between age groups. Women reported lower HRQoL and higher symptom scores than did men. Overall, 3.2% (14/439 for role functioning) to 9.7% (43/442 for social functioning) and 5.8% (29/498 for reduced motivation) to 9.9% (49/498 for general fatigue) of patients reported impairments of 10 points or more (on a 0-100 scale) in QLQ-C30 and MFI-20 scores, respectively, independent of age and sex. Emotional domains were more affected than physical ones. There was no relation between HRQoL outcome and type of treatment. Fatigue (MFI-20 scores) at the end of treatment was the only predictive variable for persistent fatigue, with odds ratios varying from 2.58 (95% CI 1.00-6.67) to 41.51 (12.02-143.33; p
Published: 2009
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48. Wirkungen des SGB II auf Personen mit Migrationshintergrund: Projekt IIa1 - 04/06 ; Jahresbericht zum 31.12.2008 - Hauptband

Author: Knuth, Matthias, Brussig, Martin, Neuffer, Stefanie, Dittmar, Vera, Mosler, Bettina, Sauer, Martina, Kaltenborn, Bruno, Wielage, Nina, Thomsen, Stephan, Boockmann, Bernhard, Walter, Thomas, Krieg, Oliver, Schneider-Haase, Torsten, Arens, Melanie, Bode, Heidrun, Frings, Dorothee, Rosemann, Martin, Dann, Sabine, Hamacher, Christine, Schneider, Anne, Bundesministerium für Arbeit und Soziales, Universität Duisburg-Essen Campus Duisburg, Fak. für Gesellschaftswissenschaften, Institut Arbeit und Qualifikation (IAQ), Zentrum für Europäische Wirtschaftsforschung (ZEW) GmbH, Otto-von-Guericke-Universität Magdeburg, Stiftung Zentrum für Türkeistudien und Integrationsforschung Institut an der Universität Duisburg-Essen, Dr. Bruno Kaltenborn - Wirtschaftsforschung und Politikberatung, and TNS Emnid Medien- und Sozialforschung GmbH
Subjects: Arbeitslosengeld II, Erwerbsbeteiligung, Economics, Arbeitsmarkt, Code of Social Law, level of education attained, Labor Market Policy, Federal Republic of Germany, Social Security, Sozialgesetzbuch, ddc:330, Bildungsabschluss, soziale Sicherung, Social sciences, sociology, anthropology, berufliche Integration, Arbeitsvermittlung, Chancengleichheit, equal opportunity, Förderungsmaßnahme, Sozialwissenschaften, Soziologie, Migrationshintergrund, employment service, Wirtschaft, Migrant, occupational integration, Arbeitsförderung, employment promotion, Arbeitsmarktpolitik, Bundesrepublik Deutschland, Aktivierung, migration background, Arbeitsuchender, basic income, labor force participation, promotional measure, job seeker, ddc:300, activation, labor market, Grundsicherung
Abstract: Auf Grundlage von Geschäftsdaten, von repräsentativen telefonischen Befragungen und von qualitativen Interviews mit Betroffenen und Fallmanagern wurden die Wirkungen der "Grundsicherung für Arbeitsuchende" auf Migrant/innen untersucht. Ihr Anteil an allen ALG-II Beziehenden beträgt im bundesweiten Durchschnitt 28 Prozent. Im Vergleich zu denjenigen ohne Migrationshintergrund sind sie im Durchschnitt jünger und haben häufiger keinen, aber auch häufiger höhere (Aus-)Bildungsabschlüsse. Die häufig fehlende Anerkennung ausländischer Abschlüsse wirkt sich auf die Arbeitsmarktchancen ebenso negativ aus wie das Fehlen jeglicher Ausbildung. Migrant/innen erhalten bei den Grundsicherungsstellen im Vergleich zu Deutschen ohne Migrationshintergrund mehr Beratungsgespräche, schließen jedoch seltener Eingliederungsvereinbarungen ab und nehmen seltener an Maßnahmen teil. Einige Herkunftsgruppen werden deutlich häufiger mit Sanktionen belegt, andere Herkunftsgruppen deutlich seltener.
Published: 2009

49. Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome

Author: Solange Pannetier, André Hanauer, Nicolas Foos, Katharina Braun, Michael Gruss, Patricia Marques Pereira, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Institute of Biology, Otto-von-Guericke University [Magdeburg] (OVGU), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), and Peney, Maité
Subjects: Male, MESH: Eukaryotic Initiation Factor-2, Small-Conductance Calcium-Activated Potassium Channels, Dopamine, Eukaryotic Initiation Factor-2, Gene Expression, MESH: Coffin-Lowry Syndrome, Dopamine beta-Hydroxylase, Biochemistry, MESH: Mice, Knockout, Mice, 0302 clinical medicine, MESH: Receptors, Dopamine D2, MESH: Animals, Tyrosine, Extracellular Signal-Regulated MAP Kinases, MESH: Extracellular Signal-Regulated MAP Kinases, MESH: Tyrosine 3-Monooxygenase, Chromatography, High Pressure Liquid, Mice, Knockout, 0303 health sciences, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Dopaminergic, Brain, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Dopamine receptor, MESH: Dopamine Plasma Membrane Transport Proteins, medicine.drug, medicine.medical_specialty, Dopamine and cAMP-Regulated Phosphoprotein 32, MESH: Gene Expression, Tyrosine 3-Monooxygenase, MESH: Dopamine, Biology, Models, Biological, MESH: Small-Conductance Calcium-Activated Potassium Channels, MESH: Dopamine and cAMP-Regulated Phosphoprotein 32, MESH: Dopamine beta-Hydroxylase, 03 medical and health sciences, Cellular and Molecular Neuroscience, MESH: Brain, Neurochemical, MESH: Mice, Inbred C57BL, Internal medicine, medicine, Coffin-Lowry Syndrome, Animals, MESH: Chromatography, High Pressure Liquid, MESH: Mice, 030304 developmental biology, Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, Tyrosine hydroxylase, Receptors, Dopamine D2, MESH: Models, Biological, MESH: Male, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, Catecholamine, biology.protein, MESH: Disease Models, Animal, 030217 neurology & neurosurgery
Abstract: International audience; The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-Lowry syndrome. The aim of the present study was to identify possible neurochemical dysregulation associated with the behavioral and morphological abnormalities exhibited by mrsk2_KO mice. A cortical dopamine level increase was found in mrsk2_KO mice that was accompanied by an over-expression of dopamine receptor of type 2 and the dopamine transporter. We also detected an increase of total and phosphorylated extracellular regulated kinase that may be responsible for the increased level of tyrosine hydroxylase phosphorylation also observed. By taking into consideration previously reported data, our results strongly suggest that the dopaminergic dysregulation in mrsk2_KO mice may be caused, at least in part, by tyrosine hydroxylase hyperactivity. This cortical hyperdopaminergia may explain some non-cognitive but also cognitive alterations exhibited by mrsk2_KO mice.
Published: 2008
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50. Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules

Author: Gaël Ménasché, Burkhart Schraven, Natalie A. Bezman, Stefanie Kliche, Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Otto-von-Guericke University [Magdeburg] (OVGU), Ménasché, Gaël, and Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)
Subjects: [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV]Life Sciences [q-bio], Immunology, Integrin, Receptors, Antigen, T-Cell, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 03 medical and health sciences, Adapter molecule crk, 0302 clinical medicine, Cytosol, Immunology and Allergy, Humans, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, 0303 health sciences, biology, Effector, Cell adhesion molecule, T-cell receptor, Signal transducing adaptor protein, rap1 GTP-Binding Proteins, Cell biology, [SDV] Life Sciences [q-bio], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Rap1, Signal transduction, 030215 immunology, Protein Binding, Signal Transduction
Abstract: International audience; Integrins are critical for the migration of T cells to lymphoid organs and to sites of inflammation and are also necessary for productive interactions between T cells and antigen-presenting cells. Integrin activation is enhanced following T-cell receptor (TCR) engagement, as signals initiated by the TCR increase affinity and avidity of integrins for their ligands. This process, known as inside-out signaling, has been shown to require several molecular components including the cytosolic adapter proteins adhesion and degranulation-promoting adapter protein and Src homology 2 domain-containing adapter protein of 55 kDa, the low molecular weight guanosine triphosphatase Rap1, and the Rap1 effector proteins Rap1 guanosine triphosphate-interacting adapter molecule, regulator of adhesion and cell polarization enriched in lymphoid tissues, and protein kinase D1. Herein, we review recent findings about how the TCR is linked to integrin activation through inside-out signaling.
Published: 2007
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