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Additional file 1: Table S1. Echocardiographic findings in male rats at 7 weeks of age (baseline). Table S2. Basic data of male rats evaluated at 3 weeks after MCT or saline administration. Table S3. Basic data of female rats evaluated at 3 weeks after MCT or saline administration. Table S4. Basic data of male rats evaluated at 6 months of age. Table S5. Basic data of male rats evaluated after exposure to chronic hypoxia for 3 weeks. Table S6. Basic data of male rats evaluated at 4 weeks after MCT injection. Table S7. Basic data of male rats evaluated at 4 weeks after MCT injection and treated with tadalafil. Table S8. Basic data of male rats evaluated at 6 weeks after MCT injection and treated with tadalafil. Figure S1. Reduction of phosphorylated AKT (pAKT), a noncanonical downstream substrate proteins of BMPR2 signaling, in rats with Bmpr2 mutation (+/44insG). Figure S2. Macrophage infiltration into the lung and the representative images of muscularization of distal pulmonary artery in the monocrotaline-treated rats. Figure S3. Collagen deposition and number of vessels in the left and right ventricular myocardium after 3 weeks of monocrotaline injection. Figure S4. Pulmonary phenotype in female rats after 3 weeks of monocrotaline injection is similar between wild-type and Bmpr2 mutant rats. Figure S5. Pulmonary hemodynamics, right ventricular hypertrophy and histological assessment in male rats at 6 months of age. Figure S6. Pulmonary hemodynamics, right ventricular hypertrophy and histological assessment after 3 weeks of chronic hypoxic exposure in male rats. Figure S7. Systolic aortic pressure, right ventricular systolic pressure, hematocrit and right ventricular myocardial fibrosis at 4 weeks after monocrotaline injection in wild-type and +/44insG rats. Figure S8. Endothelin receptor A levels in lungs before and 3 and 4 weeks after monocrotaline injection. Figure S9. Expression of phosphodiesterase type 5 in lungs before, 3 and 4 weeks after monocrotaline injection. Figure S10. Tadalafil treatment improves survival of wild-type and Bmpr2 mutant rats 4 weeks after monocrotaline injection. Figure S11. Long course treatment with tadalafil from day 14 to day 42 of monocrotaline in male wild-type and +/44insG rats.

Supplemental material, sj-pdf-1-pul-10.1177_2045894020919355 for A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice by Taichi Kato, Yoshihide Mitani, Masahiro Masuya, Junko Maruyama, Hirofumi Sawada, Hiroyuki Ohashi, Yukiko Ikeyama, Shoichiro Otsuki, Noriko Yodoya, Tsutomu Shinohara, Eri Miyata, Erquan Zhang, Naoyuki Katayama, Hideto Shimpo, Kazuo Maruyama, Yoshihiro Komada and Masahiro Hirayama in Pulmonary Circulation

Supplemental material, sj-pdf-1-pul-10.1177_2045894020919355 for A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice by Taichi Kato, Yoshihide Mitani, Masahiro Masuya, Junko Maruyama, Hirofumi Sawada, Hiroyuki Ohashi, Yukiko Ikeyama, Shoichiro Otsuki, Noriko Yodoya, Tsutomu Shinohara, Eri Miyata, Erquan Zhang, Naoyuki Katayama, Hideto Shimpo, Kazuo Maruyama, Yoshihiro Komada and Masahiro Hirayama in Pulmonary Circulation