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356 results on '"Ostrovidov, A"'

1. Bionic artificial penile Tunica albuginea

Author

Muyuan Chai, Zhichen Zhai, Xuemin Liu, Kai Wu, Yingcong He, Serge Ostrovidov, Hongkai Wu, Liming Bian, and Xuetao Shi

Subjects
General Materials Science
Published
2023

2. Usluge tržišta rada

Author

Ostrovidov Jakšić, Ana and Rogić Lugarić, Tereza

Subjects
Sociology and Political Science, Political Science and International Relations, usluge tržišta rada, savjetovanje nezaposlenih, tržište rada, Hrvatska, labour market services, counseling the unemployed, labour market, Croatia
Abstract

Rad analizira usluge tržišta rada, kao jednu od intervencija politike tržišta rada. Ove usluge predstavljaju sve aktivnosti ureda za zapošljavanje i druge javno financirane usluge za tražitelje posla, što uključuje savjetovanje nezaposlenih, posredovanje između radnika i poslodavaca, informiranje, praćenje nezaposlenih i sankcioniranje u slučaju netraženja posla, a smatra se troškovno najučinkovitijom intervencijom tržišta rada. Iako je proteklih desetljeća glavni fokus politike tržišta rada bio na mjerama aktivne politike (poput usavršavanja ili subvencioniranog zapošljavanja), posljednjih godina, aktualiziranjem koncepta aktivacije, u prvi plan dolaze usluge tržišta rada. Ovaj rad prikazuje glavna obilježja, razvoj, prednosti i mane ove intervencije u Republici Hrvatskoj te mišljenje glavnih provoditelja ove intervencije, savjetnika za zapošljavanje Hrvatskoga zavoda za zapošljavanje., The paper analyzes labour market services, as one of the labor market interventions. Labour market services represent all activities of the public employment service and other publicly funded services for jobseekers, which include counseling the unemployed, mediation between workers and employers, informing, monitoring the unemployed and sanctioning in the case of non-compliance, and are considered to be the most cost-effective labour market intervention. Although in recent decades the main focus of labour market policy has been on measures of active labour market policy (such as training or employment incentives), in recent years, with the actualization of the activation concept, labour market services have taken their turn. This paper presents the main features, development, advantages and disadvantages of this intervention in the Republic of Croatia and the opinion of the main actors of this intervention, the Employment Advisors of the Croatian Employment Service.

Published
2022

3. Measurement of Spin-Density Matrix Elements in $ρ(770)$ Production with a Linearly Polarized Photon Beam at $E_γ= 8.2\,-\,8.8\,\text{GeV}$

Author

Adhikari, S., Afzal, F., Akondi, C. S., Albrecht, M., Amaryan, M., Arroyave, V., Asaturyan, A., Austregesilo, A., Baldwin, Z., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Byer, D., Chudakov, E., Cole, P. L., Cortes, O., Crede, V., Dalton, M. M., Darulis, D., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Ebersole, D., Edo, M., Egiyan, H., Erbora, T., Eugenio, P., Fabrizi, A., Fanelli, C., Fang, S., Fegan, S., Fitches, J., Foda, A. M., Furletov, S., Gan, L., Gao, H., Gardner, A., Gasparian, A., Gleason, C., Goetzen, K., Goryachev, V. S., Grube, B., Guo, J., Guo, L., Hague, T. J., Hakobyan, H., Hernandez, J., Hoffman, N. D., Hornidge, D., Hou, G., Huber, G. M., Hurck, P., Hurley, A., Imoehl, W., Ireland, D. G., Ito, M. M., Jaegle, I., Jarvis, N. S., Jeske, T., Jones, R. T., Kakoyan, V., Kalicy, G., Khachatryan, V., Khatchatryan, M., Kourkoumelis, C., LaDuke, A., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Liu, B., Livingston, K., Lolos, G. J., Lorenti, L., Lyubovitskij, V., Ma, R., Mack, D., Mahmood, A., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mizutani, K., Neelamana, V., Ng, L., Nissen, E., Orešić, S., Ostrovidov, A. I., Papandreou, Z., Paudel, C., Pedroni, R., Pentchev, L., Peters, K. J., Prather, E., Rakshit, S., Reinhold, J., Remington, A., Ritchie, B. G., Ritman, J., Rodriguez, G., Romanov, D., Saldana, K., Salgado, C., Schadmand, S., Schertz, A. M., Scheuer, K., Schick, A., Schmidt, A., Schumacher, R. A., Schwiening, J., Sharp, P., Shen, X., Shepherd, M. R., Smith, A., Smith, E. S., Sober, D. I., Somov, S., Somov, A., Stevens, J. R., Strakovsky, I. I., Sumner, B., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Viducic, T., Whitlatch, T., Wickramaarachchi, N., Williams, M., Wunderlich, Y., Yu, B., Zarling, J., Zhang, Z., Zhao, Z., Zhou, X., Zhou, J., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

The GlueX experiment at Jefferson Lab studies photoproduction of mesons using linearly polarized $8.5\,\text{GeV}$ photons impinging on a hydrogen target which is contained within a detector with near-complete coverage for charged and neutral particles. We present measurements of spin-density matrix elements for the photoproduction of the vector meson $ρ$(770). The statistical precision achieved exceeds that of previous experiments for polarized photoproduction in this energy range by orders of magnitude. We confirm a high degree of $s$-channel helicity conservation at small squared four-momentum transfer $t$ and are able to extract the $t$-dependence of natural and unnatural-parity exchange contributions to the production process in detail. We confirm the dominance of natural-parity exchange over the full $t$ range. We also find that helicity amplitudes in which the helicity of the incident photon and the photoproduced $ρ(770)$ differ by two units are negligible for $-t, 15 pages, 11 figures

Published
2023
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4. Measurement of the J/$ψ$ photoproduction cross section over the full near-threshold kinematic region

Author

Adhikari, S., Afzal, F., Akondi, C. S., Albrecht, M., Amaryan, M., Arroyave, V., Asaturyan, A., Austregesilo, A., Baldwin, Z., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Byer, D., Chudakov, E., Cole, P. L., Cortes, O., Crede, V., Dalton, M. M., Darulis, D., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Ebersole, D., Egiyan, H., Erbora, T., Eugenio, P., Fabrizi, A., Fanelli, C., Fang, S., Fegan, S., Fitches, J., Foda, A. M., Furletov, S., Gan, L., Gao, H., Gardner, A., Gasparian, A., Gleason, C., Goetzen, K., Goryachev, V. S., Grube, B., Guo, J., Guo, L., Hague, T. J., Hakobyan, H., Hernandez, J., Hoffman, N. D., Hornidge, D., Hou, G., Huber, G. M., Hurck, P., Hurley, A., Imoehl, W., Ireland, D. G., Ito, M. M., Jaegle, I., Jarvis, N. S., Jeske, T., Jones, R. T., Kakoyan, V., Kalicy, G., Khachatryan, V., Khatchatryan, M., Kourkoumelis, C., LaDuke, A., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W. B., Liu, B., Livingston, K., Lolos, G. J., Lorenti, L., Lyubovitskij, V., Mack, D., Mahmood, A., Martel, P. P., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mizutani, K., Neelamana, V., Ng, L., Nissen, E., Orei, S., Ostrovidov, A. I., Papandreou, Z., Paudel, C., Pedroni, R., Pentchev, L., Peters, K. J., Prather, E., Rakshit, S., Reinhold, J., Remington, A., Ritchie, B. G., Ritman, J., Rodriguez, G., Romanov, D., Saldana, K., Salgado, C., Schadmand, S., Schertz, A. M., Scheuer, K., Schick, A., Schmidt, A., Schumacher, R. A., Schwiening, J., Sharp, P., Shen, X., Shepherd, M. R., Smith, A., Smith, E. S., Sober, D. I., Somov, S., Somov, A., Stevens, J. R., Strakovsky, I. I., Sumner, B., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Viducic, T., Whitlatch, T., Wickramaarachchi, N., Williams, M., Wunderlich, Y., Yu, B., Zarling, J., Zhang, Z., Zhao, Z., Zhou, X., Zhou, J., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

We report the total and differential cross sections for $J/ψ$ photoproduction with the large acceptance GlueX spectrometer for photon beam energies from the threshold at 8.2~GeV up to 11.44~GeV and over the full kinematic range of momentum transfer squared, $t$. Such coverage facilitates the extrapolation of the differential cross sections to the forward ($t = 0$) point beyond the physical region. The forward cross section is used by many theoretical models and plays an important role in understanding $J/ψ$ photoproduction and its relation to the $J/ψ-$proton interaction. These measurements of $J/ψ$ photoproduction near threshold are also crucial inputs to theoretical models that are used to study important aspects of the gluon structure of the proton, such as the gluon Generalized Parton Distribution (GPD) of the proton, the mass radius of the proton, and the trace anomaly contribution to the proton mass. We observe possible structures in the total cross section energy dependence and find evidence for contributions beyond gluon exchange in the differential cross section close to threshold, both of which are consistent with contributions from open-charm intermediate states., 15 pages 18 figures

Published
2023
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5. 3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives

Author

Lijia Cheng, Qiyang Feng, Gulden Camci-Unal, Murugan Ramalingam, Hongyan He, Sasirekha Krishnan, Ritu Singh Rajput, Yuzhuang Wang, S. Ramesh, Serge Ostrovidov, and Shoma Suresh K

Subjects
Engineering, Artificial bone, Stereolithography, Pharmaceutical Science, 3D printing, Biocompatible Materials, Review, 02 engineering and technology, Regenerative Medicine, 01 natural sciences, Bone tissue engineering, law.invention, law, Drug Discovery, Nanotechnology, bone tissue engineering, artificial bone, nanomaterials, Titanium, Fused deposition modeling, Pharmacology and Pharmaceutical Sciences, General Medicine, 021001 nanoscience & nanotechnology, Printing, Three-Dimensional, Printing, Development of treatments and therapeutic interventions, 0210 nano-technology, biomaterials, Biotechnology, Biophysics, Bioengineering, Bone healing, 010402 general chemistry, Bone and Bones, Biomaterials, Alloys, Animals, Humans, Regeneration, Nanoscience & Nanotechnology, 5.2 Cellular and gene therapies, Tissue Engineering, business.industry, Lasers, Regeneration (biology), Organic Chemistry, Nanostructures, 0104 chemical sciences, Selective laser sintering, Musculoskeletal, Three-Dimensional, Bone Substitutes, Biochemistry and Cell Biology, business
Abstract

Recent developments in three-dimensional (3D) printing technology offer immense potential in fabricating scaffolds and implants for various biomedical applications, especially for bone repair and regeneration. As the availability of autologous bone sources and commercial products is limited and surgical methods do not help in complete regeneration, it is necessary to develop alternative approaches for repairing large segmental bone defects. The 3D printing technology can effectively integrate different types of living cells within a 3D construct made up of conventional micro- or nanoscale biomaterials to create an artificial bone graft capable of regenerating the damaged tissues. This article reviews the developments and applications of 3D printing in bone tissue engineering and highlights the numerous conventional biomaterials and nanomaterials that have been used in the production of 3D-printed scaffolds. A comprehensive overview of the 3D printing methods such as stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), and ink-jet 3D printing, and their technical and clinical applications in bone repair and regeneration has been provided. The review is expected to be useful for readers to gain an insight into the state-of-the-art of 3D printing of bone substitutes and their translational perspectives., Graphical Abstract

Published
2021

8. Healthy and diseased in vitro models of vascular systems

Author

Serge Ostrovidov, Gorka Orive, Vahid Hosseini, Reihaneh Haghniaz, Mehmet R. Dokmeci, Samad Ahadian, Avijit Baidya, M. Mehdi Salek, Anna Mallone, Rohollah Nasiri, Ali Khademhosseini, Mohammad Ali Darabi, Fatemeh Nasrollahi, Amir Shamloo, and Mahboobeh Mahmoodi

Subjects
0303 health sciences, Pathology, medicine.medical_specialty, business.industry, Biomedical Engineering, Pulsatile flow, Hemodynamics, Bioengineering, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Biochemistry, Thrombosis, In vitro, In vitro model, Endothelial stem cell, 03 medical and health sciences, Smooth muscle, medicine, 0210 nano-technology, business, Vascular tissue, 030304 developmental biology
Abstract

Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the translation of such findings. Recent advances in vascular tissue engineering and the suitability of in vitro models for interim analysis have increased the use of in vitro human vascular tissue models. Although the effect of flow on endothelial cell (EC) pathophysiology and EC-flow interactions have been vastly studied in two-dimensional systems, they cannot be used to understand the effect of other micro- and macro-environmental parameters associated with vessel wall diseases. To generate an ideal in vitro model of the vascular system, essential criteria should be included: 1) the presence of smooth muscle cells or perivascular cells underneath an EC monolayer, 2) an elastic mechanical response of tissue to pulsatile flow pressure, 3) flow conditions that accurately mimic the hemodynamics of diseases, and 4) geometrical features required for pathophysiological flow. In this paper, we review currently available in vitro models that include flow dynamics and discuss studies that have tried to address the criteria mentioned above. Finally, we critically review in vitro fluidic models of atherosclerosis, aneurysm, and thrombosis.

Published
2021

9. First Measurement of $Λ$ Electroproduction off Nuclei in the Current and Target Fragmentation Regions

Author

Chetry, T., Fassi, L. El, Brooks, W. K., Dupré, R., Alaoui, A. El, Hafidi, K., Achenbach, P., Adhikari, K. P., Akbar, Z., Armstrong, W. R., Arratia, M., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossù, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Egiyan, H., Elouadrhiri, L., Eugenio, P., Fegan, S., Filippi, A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Griffioen, K. A., Guidal, M., Guo, L., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jenkins, D., Jo, H. S., Kabir, M. L., Khanal, A., Khandaker, M., Kim, A., Kim, W., Klein, F. J., Kripko, A., Kubarovsky, V., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I. J. D., Marchand, D., Mascagna, V., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rosner, G., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Wei, X., Weinstein, L. B., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

We report results of $Λ$ hyperon production in semi-inclusive deep-inelastic scattering off deuterium, carbon, iron, and lead targets obtained with the CLAS detector and the Continuous Electron Beam Accelerator Facility 5.014~GeV electron beam. These results represent the first measurements of the $Λ$ multiplicity ratio and transverse momentum broadening as a function of the energy fraction~($z$) in the current and target fragmentation regions. The multiplicity ratio exhibits a strong suppression at high~$z$~and~an enhancement at~low~$z$. The measured transverse momentum broadening is an order of magnitude greater than that seen for light mesons. This indicates that the propagating entity interacts very strongly with the nuclear medium, which suggests that propagation of diquark configurations in the nuclear medium takes place at least part of the time, even at high~$z$. The trends of these results are qualitatively described by the Giessen Boltzmann-Uehling-Uhlenbeck transport model, particularly for the multiplicity ratios. These observations will potentially open a new era of studies of the structure of the nucleon as well as of strange baryons., 14 pages, 6 figures

Published
2022
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10. Minimally Invasive Sub-Retinal Transplantation of RPE-J Cells on a Biodegradable Composite PCL/Collagen Nanosheet

Author

Kazuya Yamashita, Serge Ostrovidov, Bibek Raut, Takeshi Hori, Yuji Nashimoto, Nobuhiro Nagai, Toshiaki Abe, and Hirokazu Kaji

Subjects
Transplantation, Biomedical Engineering, Cell Biology
Abstract

Retinal cells are irreparably damaged by diseases such as age-related macular degeneration (AMD). A promising method to restore partial or whole vision is through cell-based transplantation to the damaged location. However, cell transplantation using conventional vitreous surgery is an invasive procedure that may induce infections and has a high failure rate of cell engraftment. In this study, we describe the fabrication of a biodegradable composite nanosheet used as a substrate to support retinal pigment epithelial (RPE-J) cells, which can be grafted to the sub-retinal space using a minimally invasive approach. The nanosheet was fabricated using polycaprolactone (PCL) and collagen in 80:20 weight ratio, and had size of 200 µm in diameter and 300 nm in thickness. These PCL/collagen nanosheets showed excellent biocompatibility and mechanical strength in vitro. Using a custom designed 27-gauge glass needle, we successfully transplanted an RPE-J cell loaded nanosheet into the sub-retinal space of a rat model with damaged photoreceptors. The cell loaded nanosheet did not trigger immunological reaction within 2 weeks of implantation and restored the retinal environment. Thus, this composite PCL/collagen nanosheet holds great promise for organized cell transplantation, and the treatment of retinal diseases.

Published
2023

11. Improved Λp Elastic Scattering Cross Sections between 0.9 and 2.0 GeV/c as a Main Ingredient of the Neutron Star Equation of State

Author

Rowley, J., Compton, N., Djalali, C., Hicks, K., Price, J., Zachariou, N., Adhikari, K. P., Armstrong, W. R., Atac, H., Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clark, Louise, Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D’Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dupré, R., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fradi, A., Gavalian, G., Girod, F. X., Glazier, Derek I., Golubenko, A., Gothe, R. W., Griffioen, K., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, David G., Isupov, E. L., Jenkins, D., Jo, H. S., Joo, K., Keller, D., Khanal, A., Khandaker, M., Kim, A., Korover, I., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, Kenneth, MacGregor, I. J. Douglas, Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McCracken, M. E., McKinnon, Bryan, McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Neupane, K., Niccolai, S., Niculescu, G., O’Connell, T. R., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Pasyuk, E., Pogorelko, O., Prok, Y., Reed, T., Ripani, M., Ritman, J., Rizzo, A., Rosner, Guenther, Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shrestha, U., Sokhan, Daria, Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Tyson, Richard, Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D. P., Wei, K., Wei, X., Wishart, Robert, Wood, M. H., Yale, B., Yurov, M., Zhang, J., and Zhao, Z. W.

Subjects
Hyperons in neutron stars, Economica, PE2_2, PE2_1, Settore FIS/04, Nuclear Theory, Socio-culturale, Ambientale, ddc:530, Hyperons's Scattering, Nuclear Experiment, PE2_3
Abstract

Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state. Yet, compared to other elastic scattering processes, there is very little data on \ud Λ\ud −\ud N\ud scattering. This experiment utilized the CEBAF Large Acceptance Spectrometer (CLAS) detector to study the \ud Λ\ud p\ud →\ud Λ\ud p\ud elastic scattering cross section in the incident \ud Λ\ud momentum range \ud 0.9\ud –\ud 2.0\ud \ud \ud GeV\ud /\ud c\ud . These are the first data on this reaction since the 1970s. The new cross sections have significantly better accuracy and precision than the existing world data, and the techniques developed here can also be used in future experiments.

Published
2021

12. Measurement of the beam spin asymmetry of e→p→e′p′η in the deep-inelastic regime with CLAS

Author

M. Guidal, C. Djalali, J. A. Tan, A. I. Ostrovidov, K. Park, Z.W. Zhao, G. D. Smith, M. Holtrop, M. Hattawy, D. G. Ireland, Iu. Skorodumina, Volker D. Burkert, K. A. Griffioen, A. S. Biselli, Maxime Defurne, V. Mokeev, D. Marchand, X. Wei, M. Bashkanov, S. Adhikari, V. Crede, Rong Wang, B. McKinnon, P. Lenisa, L. Lanza, Taya Chetry, R. A. Montgomery, C. A. Meyer, N. A. Baltzell, Y. G. Sharabian, P. Chatagnon, M. Ehrhart, W. Kim, D. G. Jenkins, A. Kim, Y. Prok, M. Mirazita, Z. E. Meziani, A. Celentano, R. W. Gothe, R. De Vita, G. Niculescu, Sergey Kuleshov, F. Sabatié, N. Markov, F. X. Girod, V. Batourine, M. Ungaro, N. Dashyan, M. Khachatryan, V. P. Kubarovsky, H. S. Jo, R. Paremuzyan, K. Livingston, O. Pogorelko, L. Barion, G. Rosner, Nicholas M. Harrison, Gerard Gilfoyle, Friedrich Klein, M. Battaglieri, H. Avakian, K. Joo, S. Strauch, H. Hakobyan, D. Sokhan, I. Bedlinskiy, H. Voskanyan, Y. Ghandilyan, Laura Clark, B. S. Ishkhanov, H. Egiyan, Jie Zhang, S. Diehl, C. Salgado, M. Osipenko, K. Hicks, B. Zhao, G. Khachatryan, P. Nadel-Turonski, G. Ciullo, J. P. Ball, S. E. Kuhn, D. S. Carman, Dustin Keller, D. Heddle, Nikos Sparveris, E. De Sanctis, R. A. Schumacher, G. Angelini, P. Eugenio, S. Johnston, L. Guo, Alessandro Rizzo, S. Niccolai, Michael Wood, P. Rossi, C. Munoz Camacho, K. Hafidi, W. J. Briscoe, M. L. Kabir, E. Golovatch, R. Dupre, T. A. Forest, S. Stepanyan, A. Filippi, Avraham Klein, E. L. Isupov, G. Gavalian, I. J. D. MacGregor, M. Contalbrigo, M. Khandaker, I. I. Strakovsky, A. Deur, M. Ripani, S. Boiarinov, M. Taiuti, W. K. Brooks, B. A. Clary, Z. Akbar, Michael Paolone, J. W. Price, A. D'Angelo, D. Protopopescu, E. Voutier, L. El Fassi, A. El Alaoui, Y. Ilieva, Nicholas Zachariou, and P. L. Cole

Subjects
Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Scattering, media_common.quotation_subject, Hadron, Virtual particle, Parton, 01 natural sciences, Asymmetry, Nuclear physics, Pseudoscalar, 0103 physical sciences, Nuclear Experiment, 010306 general physics, Spin-½, media_common, Lepton
Abstract

The beam spin asymmetry of the exclusive pseudoscalar channel e → p → e ′ p ′ η was measured for the first time in the deep-inelastic regime ( W > 2 GeV / c 2 and Q 2 > 1 GeV 2 / c 2 ) using a longitudinally polarized 5.78 GeV electron beam at Jefferson Lab with the CEBAF Large Acceptance Spectrometer. The data were accumulated in 144 four-dimensional bins of Q 2 , x B , − t and ϕ over a wide kinematic range, where ϕ is the azimuthal angle between the lepton and hadron scattering planes, The measured azimuthal dependence with large amplitudes of the sin ⁡ ϕ moments is a clear indication of a substantial contribution to the polarized cross-section from transversely polarized virtual photons. In the framework of generalized parton distributions (GPDs) this contribution is expressed via longitudinal-transverse interference between chiral-even and chiral-odd GPDs. The experimental results are compared to the existing theoretical models demonstrating the sensitivity to the product of chiral-odd and chiral-even GPDs and provide new constraints to the existing GPD parameterizations.

Published
2019

13. Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers

Author

Serge Ostrovidov, Haiguang Zhang, Gulden Camci-Unal, Murugan Ramalingam, Kavitha Govarthanan, Qingxi Hu, Rama Shanker Verma, and S. Ramesh

Subjects
0301 basic medicine, Cardiac function curve, Mesenchymal stem cell, Myocardial Infarction, Cell Differentiation, Mesenchymal Stem Cells, Epigenome, Biology, Microvesicles, In vitro, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, microRNA, Humans, Myocytes, Cardiac, Epigenetics, Stem cell
Abstract

Cardiovascular disorders (CVDs) are the leading cause of global death, widely occurs due to irreparable loss of the functional cardiomyocytes. Stem cell-based therapeutic approaches, particularly the use of Mesenchymal Stem Cells (MSCs) is an emerging strategy to regenerate myocardium and thereby improving the cardiac function after myocardial infarction (MI). Most of the current approaches often employ the use of various biological and chemical factors as cues to trigger and modulate the differentiation of MSCs into the cardiac lineage. However, the recent advanced methods of using specific epigenetic modifiers and exosomes to manipulate the epigenome and molecular pathways of MSCs to modify the cardiac gene expression yield better profiled cardiomyocyte like cells in vitro. Hitherto, the role of cardiac specific inducers triggering cardiac differentiation at the cellular and molecular level is not well understood. Therefore, the current review highlights the impact and recent trends in employing biological and chemical inducers on cardiac differentiation of MSCs. Thereby, deciphering the interactions between the cellular microenvironment and the cardiac inducers will help us to understand cardiomyogenesis of MSCs. Additionally, the review also provides an insight on skeptical roles of the cell free biological factors and extracellular scaffold assisted mode for manipulation of native and transplanted stem cells towards translational cardiac research.

Published
2021

14. Photoproduction of the f2(1270) Meson Using the CLAS Detector

Author

V. Mokeev, P. Eugenio, Vincent Mathieu, D. Heddle, R. A. Schumacher, M. Battaglieri, K. A. Griffioen, R. Paremuzyan, Laura Clark, L. Marsicano, L. Lanza, M. J. Amaryan, M Carver, G. Angelini, D. P. Watts, Gerard Gilfoyle, M. Osipenko, N. Gevorgyan, P. Lenisa, M. Contalbrigo, H. Egiyan, K. Livingston, R. Tyson, D. Sokhan, S. Stepanyan, I. J. D. MacGregor, F. X. Girod, S. Adhikari, Dustin Keller, F. Sabatié, B. McKinnon, G. Niculescu, G. Rosner, B. A. Clary, D. G. Ireland, V. Crede, D. Bulumulla, William Brooks, E. Munevar, Jie Zhang, T. B. Hayward, K. Hafidi, A. Filippi, W. Phelps, Z. E. Meziani, B. Yale, Aditya R. Khanal, L. Venturelli, M. Ehrhart, M. Khandaker, E. L. Isupov, Friedrich Klein, Alessandro Rizzo, A. Kim, Michael Paolone, S. Boiarinov, Andrea Bianconi, G. Ciullo, A. Pilloni, C. W. Kim, A. Celentano, R. W. Gothe, Y. Prok, C. E. Hyde, I. Bedlinskiy, A. El Alaoui, N. A. Baltzell, F. Bossu, T. Chetry, D. S. Carman, Nicholas Zachariou, H. S. Jo, U. Shrestha, J. C. Carvajal, H. Voskanyan, Z. W. Zhao, Fatiha Benmokhtar, Nikos Sparveris, X. Wei, W. J. Briscoe, O. Soto, V. Mascagna, Maxime Defurne, M. Holtrop, S. Joosten, S. Niccolai, D. Protopopescu, E. Voutier, Luciano Pappalardo, A. Movsisyan, R. De Vita, H. Hakobyan, O. Pogorelko, S. Strauch, J. Ritman, J. Rowley, A. I. Ostrovidov, P. Chatagnon, K. Wei, S. Diehl, C. Salgado, S. Fegan, H. Atac, Volker D. Burkert, C. Munoz Camacho, Eugene Pasyuk, A. S. Biselli, G. Gavalian, V. P. Kubarovsky, Krishna Neupane, M. Ripani, M. Hattawy, K. Hicks, N. Dashyan, Michael Dugger, Yordanka Ilieva, L. Barion, Barry Ritchie, R. Dupre, D. Marchand, M. Ungaro, G. V. Fedotov, Q. Huang, K. P. Adhikari, K. Joo, D. G. Jenkins, M. Leali, Axel Schmidt, I. I. Strakovsky, P. Nadel-Turonski, A. Deur, Mark W. Bondi, M. E. McCracken, N. Tyler, C. Djalali, A. D'Angelo, L. El Fassi, A. Kripko, Y. G. Sharabian, and P. L. Cole

Subjects
Quark, Physics, Spectrometer, Meson, High Energy Physics::Lattice, Nuclear Theory, Quark model, Detector, General Physics and Astronomy, Quantum number, 01 natural sciences, 7. Clean energy, Resonance (particle physics), Nuclear physics, Pion, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics
Abstract

The quark structure of the f2(1270) meson has, for many years, been assumed to be a pure quark-antiquark (qq¯) resonance with quantum numbers JPC=2++. Recently, it was proposed that the f2(1270) is a molecular state made from the attractive interaction of two ρ mesons. Such a state would be expected to decay strongly to final states with charged pions due to the dominant decay ρ→π+π-, whereas decay to two neutral pions would likely be suppressed. Here, we measure for the first time the reaction γp→π0π0p, using the CEBAF Large Acceptance Spectrometer detector at Jefferson Lab for incident beam energies between 3.6 and 5.4 GeV. Differential cross sections, dσ/dt, for f2(1270) photoproduction are extracted with good precision due to low backgrounds and are compared to theoretical calculations.

Published
2021

15. Measurement of beam asymmetry for π−Δ++ photoproduction on the proton at Eγ=8.5GeV

Author

E. S. Smith, T. Erbora, Ilya Larin, V. V. Tarasov, J. Schwiening, K. Luckas, B. E. Cannon, A. Austregesilo, C. Fanelli, A. Hurley, H. Marukyan, J. Fitches, R.S. Pedroni, W. McGinley, C. A. Meyer, L. Guo, J. Reinhold, A. Ali, T. D. Beattie, S. Furletov, M. M. Dalton, A. Smith, Z. Zhao, M. M. Ito, G. Rodriguez, F. Barbosa, D. Romanov, W. J. Briscoe, V. A. Matveev, A. M. Schertz, D. G. Ireland, V. Crede, T. Daniels, L. Gan, H. Egiyan, B. C.L. Sumner, A. LaDuke, G. J. Lolos, C. S. Akondi, V. Lyubovitskij, S. Somov, S. Fegan, R. Barsotti, S. Adhikari, M. R. Shepherd, A. Gasparian, E. Pooser, T. Whitlatch, N. Wickramaarachchi, Xiang Zhou, T. Britton, Sergey Kuleshov, B. Liu, M. Khatchatryan, H. Hakobyan, A. I. Ostrovidov, D. I. Lersch, K. Suresh, H. Li, P. Eugenio, W. B. Li, J. Barlow, Stephen Taylor, W. Phelps, J. Ritman, J. R. Stevens, M. McCaughan, Haiyan Gao, Mark Richard James Williams, Michael Dugger, Q. Zhou, Barry Ritchie, G. M. Huber, D. I. Sober, C. Gleason, K. Livingston, A. Thiel, A. Hamdi, I. I. Strakovsky, A. Schick, E. Barriga, V. S. Goryachev, A. Deur, Carlos A. Salgado, P. Pauli, V. Neelamana, Z. Baldwin, Z. Papandreou, O. Soto, R. Dzhygadlo, S. Schadmand, I. Jaegle, V. Khachatryan, J. Zarling, R. Dotel, Krisztian Peters, K. Goetzen, M. J. Amaryan, A. Asaturyan, F. Nerling, R. A. Schumacher, X. Shen, Christine Kourkoumelis, R. E. Mitchell, R. A. Miskimen, B. Zihlmann, L. Ng, A. Ernst, Zhiyong Zhang, V. V. Berdnikov, G. Vasileiadis, W.U. Boeglin, V. Kakoyan, D. J. Mack, D. Lawrence, Sean A Dobbs, A. Somov, William Brooks, Lubomir Pentchev, C. Paudel, A. M. Foda, G. Kalicy, N. S. Jarvis, A. Dolgolenko, S. Cole, O. Cortes, C.P. Romero, T. C. Black, R. T. Jones, M. E. McCracken, J. Zhou, K. Mizutani, M. Kamel, A. Teymurazyan, Y. Yang, and E. Chudakov

Subjects
Physics, Range (particle radiation), GlueX, Proton, Meson, 010308 nuclear & particles physics, media_common.quotation_subject, Momentum transfer, 01 natural sciences, Asymmetry, Pseudoscalar, Nuclear physics, Pion, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, media_common
Abstract

We report a measurement of the π − photoproduction beam asymmetry for the reaction → γ p → π − Δ + + using data from the GlueX experiment in the photon beam energy range 8.2–8.8 GeV. The asymmetry Σ is measured as a function of four-momentum transfer t to the Δ + + and compared to phenomenological models. We find that Σ varies as a function of t : negative at smaller values and positive at higher values of | t | . The reaction can be described theoretically by t -channel particle exchange requiring pseudoscalar, vector, and tensor intermediaries. In particular, this reaction requires charge exchange, allowing us to probe pion exchange and the significance of higher-order corrections to one-pion exchange at low momentum transfer. Constraining production mechanisms of conventional mesons may aid in the search for and study of unconventional mesons. This is the first measurement of the process at this energy.

Published
2021

16. Healthy and diseased

Author

Vahid, Hosseini, Anna, Mallone, Fatemeh, Nasrollahi, Serge, Ostrovidov, Rohollah, Nasiri, Mahboobeh, Mahmoodi, Reihaneh, Haghniaz, Avijit, Baidya, M Mehdi, Salek, Mohammad Ali, Darabi, Gorka, Orive, Amir, Shamloo, Mehmet R, Dokmeci, Samad, Ahadian, and Ali, Khademhosseini

Subjects
Pulsatile Flow, Myocytes, Smooth Muscle, Hemodynamics, Models, Cardiovascular, Animals, Endothelial Cells, Humans, Atherosclerosis
Abstract

Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the translation of such findings. Recent advances in vascular tissue engineering and the suitability of in vitro models for interim analysis have increased the use of in vitro human vascular tissue models. Although the effect of flow on endothelial cell (EC) pathophysiology and EC-flow interactions have been vastly studied in two-dimensional systems, they cannot be used to understand the effect of other micro- and macro-environmental parameters associated with vessel wall diseases. To generate an ideal in vitro model of the vascular system, essential criteria should be included: 1) the presence of smooth muscle cells or perivascular cells underneath an EC monolayer, 2) an elastic mechanical response of tissue to pulsatile flow pressure, 3) flow conditions that accurately mimic the hemodynamics of diseases, and 4) geometrical features required for pathophysiological flow. In this paper, we review currently available in vitro models that include flow dynamics and discuss studies that have tried to address the criteria mentioned above. Finally, we critically review in vitro fluidic models of atherosclerosis, aneurysm, and thrombosis.

Published
2021

17. Development of Flexible Cell-Loaded Ultrathin Ribbons for Minimally Invasive Delivery of Skeletal Muscle Cells

Author

Toshinori Fujie, Serge Ostrovidov, Xiaobin Liang, Majid Ebrahimi, Hojae Bae, Ken Nakajima, Ramin Banan Sadeghian, Ali Khademhosseini, and Sahar Salehi

Subjects
Materials science, Cell, Biomedical Engineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, chemistry.chemical_compound, Tissue engineering, medicine, Viability assay, biology, fungi, Skeletal muscle, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Fibronectin, Transplantation, PLGA, medicine.anatomical_structure, chemistry, biology.protein, sense organs, 0210 nano-technology, C2C12, Biomedical engineering
Abstract

Cell transplantation therapy provides a potential solution for treating skeletal muscle disorders, but cell survival after transplantation is poor. This limitation could be addressed by grafting donor cells onto biomaterials to protect them against harsh environments and processing, consequently improving cell viability in situ. Thus, we present here the fabrication of poly(lactic-co-glycolic acid) (PLGA) ultrathin ribbons with “canal-like” structures using a microfabrication technique to generate ribbons of aligned murine skeletal myoblasts (C2C12). We found that the ribbons functionalized with a solution of 3,4-dihydroxy-l-phenylalanine (DOPA) and then coated with poly-l-lysine (PLL) and fibronectin (FN) improve cell attachment and support the growth of C2C12. The viability of cells on the ribbons is evaluated following the syringe-handling steps of injection with different needle sizes. C2C12 cells readily adhere to the ribbon surface, proliferate over time, align (over 74%), maintain high viability (o...

Published
2021

18. Improved $��p$ Elastic Scattering Cross Sections Between 0.9 and 2.0 GeV/c and Connections to the Neutron Star Equation of State

Author

CLAS Collaboration, Rowley, J., Compton, N., Djalali, C., Hicks, K., Price, J., Zachariou, N., Adhikari, K. P., Armstrong, W. R., Atac, H., Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Bossu, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clark, L., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fradi, A., Gavalian, G., Girod, F. X., Glazier, D. I., Golubenko, A., Gothe, R. W., Griffioen, K., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jenkins, D., Jo, H. S., Joo, K., Keller, D., Khanal, A., Khandaker, M., Kim, A., Korover, I., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McCracken, M. E., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munevar, E., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T. R., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Pasyuk, E., Pogorelko, O., Prok, Y., Reed, T., Ripani, M., Ritman, J., Rizzo, A., Rosner, G., Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D., Wei, K., Wei, X., Wishart, R., Wood, M. H., Yale, B., Yurov, M., Zhang, J., and Zhao, Z. W.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state (EOS). Yet, compared to other elastic scattering processes, there is very little data on $��$-$N$ scattering. This experiment utilized the CLAS detector to study the $��p \rightarrow ��p$ elastic scattering cross section in the incident $��$ momentum range 0.9-2.0 GeV/c. This is the first data on this reaction in several decades. The new cross sections have significantly better accuracy and precision than the existing world data, and the techniques developed here can also be used in future experiments., 6 pages, 5 figures

Published
2021
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19. Photoproduction of η mesons off the proton for 1.2<Eγ<4.7GeV using CLAS at Jefferson Laboratory

Author

I. Illari, R. A. Schumacher, U. Shrestha, M. Leali, S. Adhikari, B. McKinnon, C. A. Meyer, E. Munevar, P. Chatagnon, B. S. Ishkhanov, Aditya R. Khanal, G. V. Fedotov, P. Lenisa, J. Ritman, S. Stepanyan, N. Dashyan, D. P. Watts, Andrea Bianconi, M. Ungaro, K. P. Adhikari, A. El Alaoui, I. I. Strakovsky, G. Rosner, T. Chetry, A. Deur, C. W. Kim, Laura Clark, W. Phelps, M. Battaglieri, Nicholas Zachariou, J. C. Carvajal, Alexander Schmidt, M. J. Amaryan, William Brooks, Yordanka Ilieva, T. B. Hayward, V. Mascagna, B. A. Clary, E. L. Isupov, Y. G. Sharabian, H. Voskanyan, Friedrich Klein, W. J. Briscoe, P. Eugenio, S. Boiarinov, Brian Raue, G. Angelini, L. Barion, K. Joo, M. Guidal, Michael Paolone, Z. W. Zhao, F. X. Girod, F. Bossu, R. Cruz-Torres, E. Golovatch, M. Holtrop, R. Dupre, S. Strauch, Hovanes Egiyan, Maxime Defurne, K. A. Griffioen, Dustin Keller, C. Munoz Camacho, H. Hakobyan, Y. Prok, H. S. Jo, M. Hattawy, Michael Wood, K. Hafidi, D. G. Ireland, Luciano Pappalardo, V. Crede, A. Kim, D. I. Glazier, G. Ciullo, D. S. Carman, F. Sabatié, T. Hu, R. Paremuzyan, R. De Vita, D. Marchand, D. Protopopescu, Eugene Pasyuk, X. Wei, L. Venturelli, S. Diehl, Fatiha Benmokhtar, O. Soto, C. Salgado, E. Voutier, L. Lanza, Nicholas M. Harrison, Gerard Gilfoyle, A. Filippi, A. Movsisyan, J. W. Price, D. Sokhan, V. P. Kubarovsky, I. Bedlinskiy, M. Khandaker, M. Khachatryan, Nikolaos Sparveris, Z. E. Meziani, K. Wei, S. Niccolai, K. Livingston, N. Markov, Iu. Skorodumina, N. Tyler, C. Djalali, J. A. Tan, V. I. Mokeev, D. Heddle, Jie Zhang, G. Gavalian, D. G. Jenkins, R. Fersch, M. Ehrhart, M. Ripani, O. Pogorelko, P. L. Cole, J. Rowley, Tim O'Connell, A. I. Ostrovidov, Michael Dugger, T. Mineeva, P. Nadel-Turonski, H. Atac, A. S. Biselli, A. D'Angelo, L. Guo, Sylvester Joosten, Alessandro Rizzo, G. Asryan, L. El Fassi, C. Ayerbe Gayoso, M. E. McCracken, A. Hobart, C. Hanretty, W. Kim, G. Niculescu, P. Stoler, M. Osipenko, I. J. D. MacGregor, K. Hicks, M. Contalbrigo, J. Poudel, Z. Akbar, A. Celentano, and R. W. Gothe

Subjects
Physics, Particle physics, Range (particle radiation), Photon, Proton, Meson, 010308 nuclear & particles physics, Sigma, Photon energy, 01 natural sciences, 7. Clean energy, Resonance (particle physics), 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Nucleon
Abstract

Photoproduction cross sections are reported for the reaction $\gamma p\to p\eta$ using energy-tagged photons and the CLAS spectrometer at Jefferson Laboratory. The $\eta$ mesons are detected in their dominant charged decay mode, $\eta\to \pi^+\pi^-\pi^0$, and results on differential cross sections are presented for incident photon energies between 1.2 and 4.7 GeV. These new $\eta$ photoproduction data are consistent with earlier CLAS results but extend the energy range beyond the nucleon resonance region into the Regge regime. The normalized angular distributions are compared with the experimental results from several other experiments, and with predictions of $\eta$ MAID\,2018 and the latest solution of the Bonn-Gatchina coupled-channel analysis. Differential cross sections $d\sigma/dt$ are presented for incident photon energies $E_\gamma > 2.9$ GeV ($W > 2.5$ GeV), and compared with predictions which are based on Regge trajectories exchange in the $t$-channel (Regge models). The data confirm the expected dominance of $\rho$, $\omega$ vector-meson exchange in an analysis by the Joint Physics Analysis Center.

Published
2020

20. Beam-spin asymmetry Σ for Σ− hyperon photoproduction off the neutron

Author

Zachariou, N., Munevar, E., Berman, B.L., Bydžovský, P., Cieplý, A., Feldman, G., Ilieva, Y., Nadel-Turonski, P., Skoupil, D., Sarantsev, A.V., Watts, D.P., Amaryan, M.J., Angelini, G., Armstrong, W.R., Atac, H., Avakian, H., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A.S., Bondi, M., Bossù, F., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Bulumulla, D., Burkert, V.D., Carman, D.S., Carvajal, J.C., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, Louise, Cole, P.L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Dugger, M., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Filippi, A., Fradi, A., Gavalian, G., Gilfoyle, G.P., Girod, F.X., Gleason, C., Golubenko, A.A., Gothe, R.W., Griffioen, K.A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T.B., Heddle, D., Hicks, K., Hobart, A., Holtrop, M., Ireland, D.G., Isupov, E.L., Jenkins, D., Jo, H.S., Joo, K., Keller, D., Khanal, A., Khandaker, M., Kim, A., Klein, F.J., Kripko, A., Kubarovsky, V., Lanza, L., Leali, M., Livingston, K., MacGregor, I.D.G., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McKinnon, B., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munoz Camacho, C., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T.R., Osipenko, M., Ostrovidov, A.I., Pandey, P., Paolone, M., Pappalardo, L.L., Paremuzyan, R., Pasyuk, E., Phelps, W., Pogorelko, O., Price, J.W., Prok, Y., Raue, B.A., Ripani, M., Ritman, J., Rizzo, A., Rosner, G., Rowley, J., Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R.A., Sharabian, Y.G., Shirokov, E.V., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Stepanyan, S., Stoler, P., Strakovsky, I.I., Strauch, S., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Wei, K., Wei, X., Wishart, R., Wood, M.H., Yale, B., Zhang, J., and Zhao, Z.W.

Subjects
Nuclear and High Energy Physics, ddc:530
Abstract

Physics letters / B 827, 136985 (2022). doi:10.1016/j.physletb.2022.136985, Published by North-Holland Publ., Amsterdam

Published
2022

21. First measurement of direct photoproduction of the a2(1320)0 meson on the proton

Author

J. Rowley, A. I. Ostrovidov, Volker D. Burkert, A. S. Biselli, W. Phelps, K. A. Griffioen, V. Mascagna, N. Markov, M. E. McCracken, A. Hobart, Carlos A. Salgado, A. Filippi, A. Pilloni, Frank Klein, Dustin Keller, P. Eugenio, L. Marsicano, Sylvester Joosten, Maxime Defurne, M. Khandaker, M. Khachatryan, M. Osipenko, Pawel Nadel-Turonski, Michael Paolone, Alexander Schmidt, D. I. Glazier, D. Bulumulla, E. Munevar, B. S. Ishkhanov, Aditya R. Khanal, Nikolaos Sparveris, M. Ungaro, K. Hafidi, F. Bossu, M. Guidal, G. Niculescu, L. Lanza, D. G. Jenkins, I. J. D. MacGregor, R. De Vita, M. Leali, Laura Clark, M. J. Amaryan, Andrea Bianconi, C. W. Kim, W. Kim, W. Gohn, F. X. Girod, N. Tyler, C. Djalali, J. A. Tan, P. Chatagnon, G. V. Fedotov, H. Voskanyan, A. D'Angelo, T. Chetry, I. Bedlinskiy, L. Elouadrhiri, M. Holtrop, F. Hauenstein, W. J. Briscoe, E. Pasyuk, S. Strauch, K. Joo, H. Atac, D. P. Watts, H. Egiyan, G. Angelini, L. El Fassi, I. I. Strakovsky, R. Dupre, M. Battaglieri, F. Sabatié, Luciano Pappalardo, D. Heddle, A. Deur, M. Ripani, G. Gavalian, V. Mokeev, D. Marchand, V. Lucherini, V. P. Kubarovsky, Michael Dugger, Fatiha Benmokhtar, Krishna Neupane, R. G. Fersch, O. Pogorelko, O. Soto, S. Niccolai, Vincent Mathieu, P. L. Cole, Z. W. Zhao, Alessandro Rizzo, E. Golovatch, P. Lenisa, K. Hicks, M. Ehrhart, S. Adhikari, T. B. Hayward, J. Zhang, M. Hattawy, J. W. Price, N. Dashyan, Yordanka Ilieva, L. Barion, G. Rosner, William Brooks, G. Ciullo, Y. Prok, L. Venturelli, D. S. Carman, R. A. Schumacher, A. El Alaoui, X. Wei, Nicholas Zachariou, J. C. Carvajal, S. Stepanyan, E. Voutier, A. Movsisyan, Adam P. Szczepaniak, D. Sokan, Z. E. Meziani, K. Livingston, K. P. Adhikari, H. Hakobyan, H. S. Jo, A. Kim, J. Ritman, S. Diehl, D. G. Ireland, V. Crede, O. Cortes, E. L. Isupov, R. Paremuzyan, S. Boiarinov, R. Cruz-Torres, Nicholas M. Harrison, U. Shrestha, M. Contalbrigo, C. Munoz Camacho, M. H. Wood, B. McKinnon, A. Celentano, R. W. Gothe, M. Mirazita, and N. Gevorgyan

Subjects
Physics, Meson, 010308 nuclear & particles physics, Partial wave analysis, Hadron, Sigma, Photon energy, 01 natural sciences, Nuclear physics, Amplitude, 0103 physical sciences, Invariant mass, Nuclear Experiment, 010306 general physics, Phenomenology (particle physics)
Abstract

We present the first measurement of the exclusive reaction $\gamma p \rightarrow a_2(1320)^0 \, p$ in the photon energy range $3.5$-$5.5$ GeV and four-momentum transfer squared $0.2

Published
2020

22. Measurement of the photon beam asymmetry in γ⃗p→K+Σ0 at Eγ=8.5 GeV

Author

T. D. Beattie, K. Goetzen, W. J. Briscoe, P. Pauli, G. M. Huber, D. I. Sober, M. J. Amaryan, V. Crede, M. M. Dalton, V. S. Goryachev, Christine Kourkoumelis, A. Hurley, R. E. Mitchell, G. Kalicy, N. S. Jarvis, C. A. Meyer, L. Ng, D. Lawrence, A. Ernst, H. Hakobyan, V. Lyubovitskij, G. J. Lolos, I. Larin, C. Salgado, R. Barsotti, S. Adhikari, O. Cortes, Sean A Dobbs, T. Britton, A. Somov, A. Ali, Sergey Kuleshov, C.P. Romero, P. Eugenio, R. A. Schumacher, D. I. Lersch, K. Livingston, M. M. Ito, Barry Ritchie, N. Cao, Ashot Gasparian, A. Hamdi, Krisztian Peters, Michael Dugger, T. C. Black, I. I. Strakovsky, J. Barlow, Joerg Reinhold, S. Fegan, A. Deur, S. Cole, J. Frye, E. Pooser, V. A. Matveev, N. Qin, J. Schwiening, O. Soto, A. M. Schertz, T. Whitlatch, L. Robison, T. Daniels, B. E. Cannon, T. Erbora, H. Ni, Z. Papandreou, Ting Xiao, V. V. Berdnikov, William Brooks, J. R. Stevens, M. McCaughan, Mark Richard James Williams, Lubomir Pentchev, C. Gleason, S. Furletov, Q. Zhou, A. M. Foda, Dmitri Romanov, H. Marukyan, R.S. Pedroni, W. U. Boeglin, W. McGinley, E. Chudakov, N. Wickramaarachchi, A. Thiel, K. K. Seth, C. Fanelli, M. Kamel, W. Phelps, F. Nerling, Elton Smith, B. Liu, G. Vasileiadis, A. Austregesilo, Zhiyong Zhang, M. R. Shepherd, A. Teymurazyan, R. T. Jones, Y. Yang, M. E. McCracken, Xiang Zhou, S. Taylor, L. Gan, S. Somov, L. Guo, J. Zarling, C. Paudel, A. Dolgolenko, V. V. Tarasov, E. Barriga, M. Patsyuk, J. Foote, X. Shen, K. Suresh, Hovanes Egiyan, R. A. Miskimen, R. Dzhygadlo, F. Barbosa, V. Kakoyan, D. J. Mack, A. Goncalves, R. Dotel, B. Zihlmann, A. I. Ostrovidov, H. Li, D. G. Ireland, and W. B. Li

Subjects
Physics, Range (particle radiation), GlueX, Spectrometer, 010308 nuclear & particles physics, Linear polarization, media_common.quotation_subject, Theoretical models, 01 natural sciences, Asymmetry, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Photon beam, Nuclear Experiment, 010306 general physics, Beam (structure), media_common
Abstract

We report measurements of the photon beam asymmetry Σ for the reaction γp→K+Σ0 (1193) using the GlueX spectrometer in Hall D at Jefferson Lab. Data were collected by using a linearly polarized photon beam in the energy range of 8.2–8.8 GeV incident on a liquid hydrogen target. The beam asymmetry Σ was measured as a function of the Mandelstam variable t , and a single value of Σ was extracted for events produced in the u channel. These are the first exclusive measurements of the photon beam asymmetry Σ for the reaction in this energy range. For the t channel, the measured beam asymmetry is close to unity over the t range studied, − t = ( 0.1 – 1.4 ) ( GeV / c ) 2 , with an average value of Σ = 1.00 ± 0.05 . This agrees with theoretical models that describe the reaction via the natural-parity exchange of the K ∗ (892) Regge trajectory. A value of Σ = 0.41 ± 0.09 is obtained for the u channel integrated up to − u = 2.0 ( GeV / c ) 2 .

Published
2020

23. The CLAS12 Backward Angle Neutron Detector (BAND)

Author

A. I. Ostrovidov, A. Denniston, A. Nambrath, Eliahu Cohen, A. Hrnjic, P. Eugenio, I. Vega, I. Korover, Alexander Schmidt, M. Ungerer, H. Hakobyan, R. Cruz-Torres, T. Hartlove, F. Hauenstein, Larry Weinstein, J.R. Pybus, E.P. Segarra, M. Duer, Or Hen, T. Kutz, C. Fogler, A. Beck, J. Barlow, William Brooks, K. Price, E. Piasetzky, E. Barriga, S. May-Tal Beck, and Massachusetts Institute of Technology. Laboratory for Nuclear Science

Subjects
Physics, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, business.industry, Detector, FOS: Physical sciences, Cosmic ray, Instrumentation and Detectors (physics.ins-det), Scintillator, Charged particle, Momentum, Time of flight, Optics, Neutron detection, Neutron, Nuclear Experiment (nucl-ex), business, Instrumentation, Nuclear Experiment
Abstract

The Backward Angle Neutron Detector (BAND) of CLAS12 detects neutrons emitted at backward angles of $155^\circ$ to $175^\circ$, with momenta between $200$ and $600$ MeV/c. It is positioned 3 meters upstream of the target, consists of $18$ rows and $5$ layers of $7.2$ cm by $7.2$ cm scintillator bars, and read out on both ends by PMTs to measure time and energy deposition in the scintillator layers. Between the target and BAND there is a 2 cm thick lead wall followed by a 2 cm veto layer to suppress gammas and reject charged particles. This paper discusses the component-selection tests and the detector assembly. Timing calibrations (including offsets and time-walk) were performed using a novel pulsed-laser calibration system, resulting in time resolutions better than $250$ ps (150 ps) for energy depositions above 2 MeVee (5 MeVee). Cosmic rays and a variety of radioactive sources were used to calibration the energy response of the detector. Scintillator bar attenuation lengths were measured. The time resolution results in a neutron momentum reconstruction resolution, $\delta p/p < 1.5$\% for neutron momentum $200\le p\le 600$ MeV/c. Final performance of the BAND with CLAS12 is shown, including electron-neutral particle timing spectra and a discussion of the off-time neutral contamination as a function of energy deposition threshold., Comment: 17 pages, 25 figures, 3 tables. Accepted for publication in NIM-A

Published
2020
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24. Probing the core of the strong nuclear interaction

Author

Schmidt, A, Pybus, J, Weiss, R, Segarra, E, Hrnjic, A, Denniston, A, Hen, O, Piasetzky, E, Weinstein, L, Barnea, N, Strikman, M, Larionov, A, Higinbotham, D, Adhikari, S, Amaryan, M, Angelini, G, Asryan, G, Atac, H, Avakian, H, Gayoso, C, Baashen, L, Barion, L, Bashkanov, M, Battaglieri, M, Beck, A, Bedlinskiy, I, Benmokhtar, F, Bianconi, A, Biselli, A, Bossu, F, Boiarinov, S, Brahim, M, Briscoe, W, Brooks, W, Burkert, V, Cao, F, Carman, D, Carvajal, J, Celentano, A, Chatagnon, P, Chetry, T, Ciullo, G, Clark, L, Cohen, E, Cole, P, Contalbrigo, M, Crede, V, Cruz-Torres, R, D'Angelo, A, Dashyan, N, De Vita, R, De Sanctis, E, Defurne, M, Deur, A, Diehl, S, Djalali, C, Duer, M, Dugger, M, Dupre, R, Egiyan, H, Ehrhart, M, El Alaoui, A, El Fassi, L, Eugenio, P, Filippi, A, Forest, T, Gavalian, G, Gilad, S, Gilfoyle, G, Giovanetti, K, Girod, F, Giuseppe, C, Glazier, D, Golovatch, E, Gothe, R, Griffioen, K, Guo, L, Hafidi, K, Hakobyan, H, Hanretty, C, Harrison, N, Hattawy, M, Hauenstein, F, Hayward, T, Hicks, K, Holtrop, M, Ilieva, Y, Illari, I, Ireland, D, Ishkanov, B, Isupov, E, Jenkins, D, Hs, J, Joo, K, Keller, D, Khachatryan, M, Khanal, A, Khandaker, M, Kim, C, Kim, W, Klein, F, Korover, I, Kubarovsky, V, Lanza, L, Leali, M, Lenisa, P, Macgregor, I, Marchand, D, Markov, N, Marsicano, L, Mascagna, V, Beck, S, Mckinnon, B, Mirazita, M, Mokeev, V, Camacho, C, Mustafa, B, Nadel-Turonski, P, Nanda, S, Niccolai, S, Niculescu, G, Osipenko, M, Ostrovidov, A, Paolone, M, Pappalardo, L, Paremuzyan, R, Park, K, Pasyuk, E, Patsyuk, M, Phelps, W, Pogorelko, O, Price, J, Prok, Y, Protopopescu, D, Ripani, M, Riser, D, Rizzo, A, Rosner, G, Rossi, P, Sabatie, F, Salgado, C, Schmookler, B, Schumacher, R, Sharabian, Y, Shrestha, U, Skorodumina, I, Sokhan, D, Soto, O, Sparveris, N, Stepanyan, S, Strakovsky, I, Strauch, S, Tan, J, Tyler, N, Ungaro, M, Venturelli, L, Voskanyan, H, Voutier, E, Wang, R, Watts, D, Wei, X, Wood, M, Zachariou, N, Zhang, J, Zhao, Z, Zheng, X, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CLAS, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Nuclear Theory, nucleon: pair, Socio-culturale, Nuclear Interactions, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Structure, spin: dependence, 01 natural sciences, 7. Clean energy, Nuclear physics, Nuclear Theory (nucl-th), PE2_1, CLAS, 0103 physical sciences, quantum chromodynamics, Neutron, density: high, Nuclear Models, Quarks and Gluons, Electron Scattering, Spin Dependent Cross Sections, Nuclear Experiment (nucl-ex), 010306 general physics, neutron star, Nuclear Experiment, PE2_3, nucleus: interaction, Physics, Quantum chromodynamics, Multidisciplinary, 010308 nuclear & particles physics, Settore FIS/04, Nuclear matter, Fundamental interaction, quark gluon: interaction, Neutron star, electron: scattering, kinematics, nuclear matter, Atomic nucleus, Quark–gluon plasma, Nucleon, experimental results
Abstract

The strong nuclear interaction between nucleons (protons and neutrons) is the effective force that holds the atomic nucleus together. This force stems from fundamental interactions between quarks and gluons (the constituents of nucleons) that are described by the equations of Quantum Chromodynamics (QCD). However, as these equations cannot be solved directly, physicists resort to describing nuclear interactions using effective models that are well constrained at typical inter-nucleon distances in nuclei but not at shorter distances. This limits our ability to describe high-density nuclear matter such as in the cores of neutron stars. Here we use high-energy electron scattering measurements that isolate nucleon pairs in short-distance, high-momentum configurations thereby accessing a kinematical regime that has not been previously explored by experiments, corresponding to relative momenta above 400 MeV/c. As the relative momentum between two nucleons increases and their separation thereby decreases, we observe a transition from a spin-dependent tensor-force to a predominantly spin-independent scalar-force. These results demonstrate the power of using such measurements to study the nuclear interaction at short-distances and also support the use of point-like nucleons with two- and three-body effective interactions to describe nuclear systems up to densities several times higher than the central density of atomic nuclei., Comment: Total 26 pages, 13 figures. Main text: 8 pages, 3 figures. Methods section: 6 pages. Extended Data: 8 figures, 1 table. Supplementary Materials: 8 pages, 2 figures

Published
2020
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25. Measurement of beam asymmetry for $��^-��^{++}$ photoproduction on the proton at $E_��$=8.5 GeV

Author

GlueX Collaboration, Adhikari, S., Akondi, C. S., Ali, A., Amaryan, M., Asaturyan, A., Austregesilo, A., Baldwin, Z., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Erbora, T., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Fitches, J., Foda, A. M., Furletov, S., Gan, L., Gao, H., Gasparian, A., Gleason, C., Goetzen, K., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jaegle, I., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Khachatryan, V., Khatchatryan, M., Kourkoumelis, C., Kuleshov, S., LaDuke, A., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W. B., Liu, B., Livingston, K., Lolos, G. J., Luckas, K., Lyubovitskij, V., Mack, D., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mizutani, K., Neelamana, V., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Paudel, C., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Reinhold, J., Ritchie, B. G., Ritman, J., Rodriguez, G., Romanov, D., Romero, C., Salgado, C., Schadmand, S., Schertz, A. M., Schick, A., Schumacher, R. A., Schwiening, J., Shen, X., Shepherd, M. R., Smith, A., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Stevens, J. R., Strakovsky, I. I., Sumner, B., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Whitlatch, T., Wickramaarachchi, N., Williams, M., Yang, Y., Zarling, J., Zhang, Z., Zhao, Z., Zhou, J., Zhou, Q., Zhou, X., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report a measurement of the $��^-$ photoproduction beam asymmetry for the reaction $\vec�� p \rightarrow ��^- ��^{++}$ using data from the GlueX experiment in the photon beam energy range 8.2--8.8 GeV. The asymmetry $��$ is measured as a function of four-momentum transfer $t$ to the $��^{++}$ and compared to phenomenological models. We find that $��$ varies as a function of $t$: negative at smaller values and positive at higher values of $|t|$. The reaction can be described theoretically by $t$-channel particle exchange requiring pseudoscalar, vector, and tensor intermediaries. In particular, this reaction requires charge exchange, allowing us to probe pion exchange and the significance of higher-order corrections to one-pion exchange at low momentum transfer. Constraining production mechanisms of conventional mesons may aid in the search for and study of unconventional mesons. This is the first measurement of the process at this energy., 7 pages, 5 figures

Published
2020
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26. Cell-laden alginate hydrogels for the treatment of diabetes

Author

Nicholas A. Peppas, Giovanna Paolone, Dwaine F. Emerich, Paul de Vos, Gorka Orive, Tatiane Eufrasio-da-Silva, Lukin Izeia, Alireza Dolatshahi-Pirouz, Serge Ostrovidov, Translational Immunology Groningen (TRIGR), and Man, Biomaterials and Microbes (MBM)

Subjects
Alginates, medicine.medical_treatment, Cell, Pharmaceutical Science, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, cell encapsulation, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, SDG 3 - Good Health and Well-being, medicine, Diabetes Mellitus, alginate, Humans, Insulin, Cell encapsulation, cell-laden hydrogels, drug delivery, business.industry, Alginate, Hydrogels, 021001 nanoscience & nanotechnology, medicine.disease, Cell-laden hydrogels, medicine.anatomical_structure, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Drug delivery, Self-healing hydrogels, Alginate hydrogel, 0210 nano-technology, business
Abstract

Contains fulltext : 225369.pdf (Publisher’s version ) (Closed access) INTRODUCTION: Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry. AREA COVERED: The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed. EXPERT OPINION: Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.

Published
2020

27. Measurement of the Photon Beam Asymmetry in $\vec�� p\to K^+��^0$ at $E_�� = 8.5$ GeV

Author

The GlueX Collaboration, Adhikari, S., Ali, A., Amaryan, M., Austregesilo, A., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Erbora, T., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., Meyer, C. A., Miskimen, R., Mitchell, R. E., Nerling, F., Ng, L., Ni, H., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Paudel, C., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhou, Q., Zhou, X., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report measurements of the photon beam asymmetry $��$ for the reaction $\vec�� p\to K^+��^0$(1193) using the GlueX spectrometer in Hall D at Jefferson Lab. Data were collected using a linearly polarized photon beam in the energy range of 8.2-8.8 GeV incident on a liquid hydrogen target. The beam asymmetry $��$ was measured as a function of the Mandelstam variable $t$, and a single value of $��$ was extracted for events produced in the $u$-channel. These are the first exclusive measurements of the photon beam asymmetry $��$ for the reaction in this energy range. For the $t$-channel, the measured beam asymmetry is close to unity over the $t$-range studied, $-t=(0.1-1.4)~$(GeV/$c$)$^{2}$, with an average value of $��= 1.00\pm 0.05$. This agrees with theoretical models that describe the reaction via the natural-parity exchange of the $K^{*}$(892) Regge trajectory. A value of $��= 0.41 \pm 0.09$ is obtained for the $u$-channel integrated up to $-u=2.0$~(GeV/$c$)$^{2}$.

Published
2020
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28. Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Author

Serge Ostrovidov, Sahar Salehi, Ali Khademhosseini, Majid Ebrahimi, Hojae Bae, and Sang Bok Kim

Subjects
0301 basic medicine, Muscle tissue, Myoblasts, Skeletal, Muscle Fibers, Skeletal, Cell Culture Techniques, Biomedical Engineering, Muscle Proteins, Medicine (miscellaneous), 02 engineering and technology, Muscle Development, Regenerative medicine, Cell Line, Biomaterials, Mice, 03 medical and health sciences, Polymethacrylic Acids, Tissue engineering, medicine, Animals, Myocyte, Agrin, Tissue Engineering, Myogenesis, Chemistry, Skeletal muscle, Cell Differentiation, Hydrogels, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Gelatin, 0210 nano-technology, C2C12
Abstract

Bioengineered functional muscle tissues are beneficial for regenerative medicine due to their treatment potential for various debilitating disorders, including myopathy and traumatic injuries. However, the contractile properties of engineered muscle constructs are lacking compared with their native counterparts. Here, we used microfluidic spinning to fabricate photocrosslinkable gelatin methacryloyl (GelMA) hydrogel fibres with well-defined surface morphologies for engineering muscle tissues. We examined whether the combination of topographical cues from surface micropatterning and biochemical stimulation with recombinant agrin can improve the generation of bioengineered muscle tissue. Topographical cues on micropatterned fibres promoted alignment of C2C12 myoblasts and augmented myotube formation during differentiation, as assessed by increased myotube length, aspect ratio, and the elevated mRNA expression of myogenic genes. Moreover, agrin treatment significantly increased acetylcholine receptor expression/clustering and myotube formation and upregulated dystrophin expression in differentiated C2C12 myotubes. Interestingly, the combination of topographical cues with agrin treatment further enhanced myotube maturation and functionality as shown by improved contractility under electrical stimulation. Thus, combining topographical cues and agrin treatment improved functions of engineered muscle tissue, which has potential in biorobotics, drug screening, tissue engineering, and regenerative medicine.

Published
2018

30. Gelatin–Polyaniline Composite Nanofibers Enhanced Excitation–Contraction Coupling System Maturation in Myotubes

Author

Makoto Osanai, Tomokazu Matsue, Ken Nakajima, Akichika Kumatani, Serge Ostrovidov, Majid Ebrahimi, Xuetao Shi, Sang Bok Kim, Sahar Salehi, Shizu Hidema, Hojae Bae, Ali Khademhosseini, and Hung K. Nguyen

Subjects
0301 basic medicine, Materials science, food.ingredient, Muscle Fibers, Skeletal, Nanofibers, Nanotechnology, 02 engineering and technology, Gelatin, 03 medical and health sciences, food, Myocyte, General Materials Science, Aniline Compounds, Ryanodine receptor, Myogenesis, musculoskeletal system, 021001 nanoscience & nanotechnology, Electrospinning, Coupling (electronics), 030104 developmental biology, Nanofiber, Biophysics, Calcium, 0210 nano-technology, C2C12
Abstract

In this study, composite gelatin-polyaniline (PANI) nanofibers doped with camphorsulfonic acid (CSA) were fabricated by electrospinning and used as substrates to culture C2C12 myoblast cells. We observed enhanced myotube formation on composite gelatin-PANI nanofibers compared to gelatin nanofibers, concomitantly with enhanced myotube maturation. Thus, in myotubes, intracellular organization, colocalization of the dihydropyridine receptor (DHPR) and ryanodine receptor (RyR), expression of genes correlated to the excitation-contraction (E-C) coupling apparatus, calcium transients, and myotube contractibility were increased. Such composite material scaffolds combining topographical and electrically conductive cues may be useful to direct skeletal muscle cell organization and to improve cellular maturation, functionality, and tissue formation.

Published
2017

31. 12C(e,e'pN) measurements of short range correlations in the tensor-to-scalar interaction transition region

Author

M. J. Amaryan, P. Lenisa, Jie Zhang, A. Beck, L. Marsicano, T. B. Hayward, U. Shrestha, Larry Weinstein, S. Strauch, Maxime Defurne, K. A. Griffioen, D. P. Watts, Friedrich Klein, R. Paremuzyan, Brian Raue, O. Pogorelko, J. Rowley, A. I. Ostrovidov, R. A. Schumacher, F. X. Girod, M. Duer, A. Denniston, E. Golovatch, R. Dupre, Nicholas M. Harrison, R. De Vita, I. I. Strakovsky, P. Eugenio, A. Deur, W. K. Brooks, A. Filippi, D. Sokhan, B. A. Clary, D. Protopopescu, Volker D. Burkert, A. S. Biselli, L. Lanza, M. Khandaker, N. Tyler, C. Djalali, E. Voutier, Michael Paolone, Y. G. Sharabian, X. Zheng, H. Atac, J. A. Tan, Y. Prok, D. S. Carman, I. Bedlinskiy, W. Phelps, V. Lucherini, M. Battaglieri, A. El Alaoui, Y. Ilieva, E. L. Isupov, Nicholas Zachariou, X. Wei, S. Mey-Tal Beck, S. Boiarinov, Hovanes Egiyan, F. Hauenstein, C. Munoz Camacho, J. W. Price, Taofeng Wang, Fatiha Benmokhtar, M. Khachatryan, Nikolaos Sparveris, N. Markov, A. Movsisyan, R. Cruz-Torres, T. A. Forest, O. Soto, D. Heddle, M. Ungaro, K. P. Adhikari, Douglas Higinbotham, Latifa Elouadrhiri, D. Marchand, P. Nadel-Turonski, S. Adhikari, B. McKinnon, M. Ripani, A. Kim, S. Stepanyan, I. Korover, M. Hattawy, M. Guidal, B. Mustapha, Z. W. Zhao, T. Mineeva, Or Hen, H. Hakobyan, M. Mirazita, J. Ritman, L. Barion, J.R. Pybus, M. Holtrop, S. Diehl, R. G. Fersch, C. Salgado, K. Joo, Luciano Pappalardo, T. Chetry, E.P. Segarra, H. S. Jo, D. G. Jenkins, M. Leali, Eugene Pasyuk, P. L. Cole, M. Ehrhart, G. Rosner, P. Chatagnon, A. D'Angelo, L. El Fassi, V. P. Kubarovsky, L. Venturelli, Krishna Neupane, C. W. Kim, H. Voskanyan, W. J. Briscoe, Dustin Keller, E. Piasetzky, D. Bulumulla, Michael Wood, K. Hafidi, Aditya R. Khanal, Andrea Bianconi, G. Niculescu, Alexander Schmidt, G. Gavalian, M. Osipenko, I. J. D. MacGregor, F. Sabatié, D. G. Ireland, V. Crede, M. Contalbrigo, Laura Clark, G. Angelini, K. Hicks, A. Celentano, R. W. Gothe, Alessandro Rizzo, V. Mascagna, S. Joosten, K. Livingston, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and The Clas Collaboration

Subjects
Nuclear and High Energy Physics, Nuclear Theory, dependence, CLAS, dynamics, isospin, energy, system, Astronomy & Astrophysics, Physics, QC1-999, Scalar (mathematics), FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Astrophysics, 01 natural sciences, Nuclear Theory (nucl-th), Momentum, High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, ddc:530, Tensor, Nuclear Experiment (nucl-ex), Nuclear Experiment, 010306 general physics, Nuclear theory, [PHYS]Physics [physics], Range (particle radiation), 010308 nuclear & particles physics, Settore FIS/04, Nuclear interaction, High Energy Physics - Phenomenology, Astronomy &amp, Atomic physics, Nucleon
Abstract

High-momentum configurations of nucleon pairs at short-distance are probed using measurements of the $^{12}$C$(e,e'p)$ and $^{12}$C$(e,e'pN)$ reactions (where $N$ is either $n$ or $p$), at high-$Q^2$ and $x_B>1.1$. The data span a missing-momentum range of 300--1000 MeV/c and are predominantly sensitive to the transition region of the strong nuclear interaction from a Tensor to Scalar interaction. The data are well reproduced by theoretical calculations using the Generalized Contact Formalism with both chiral and phenomenological nucleon-nucleon ($NN$) interaction models. This agreement suggests that the measured high missing-momentum protons up to $1000$ MeV/c predominantly belong to short-ranged correlated (SRC) pairs. The measured $^{12}$C$(e,e'pN)$ / $^{12}$C$(e,e'p)$ and $^{12}$C$(e,e'pp)$ / $^{12}$C$(e,e'pn)$ cross-section ratios are consistent with a decrease in the fraction of proton-neutron SRC pairs and increase in the fraction of proton-proton SRC pairs with increasing missing momentum. This confirms the transition from an isospin-dependent tensor $NN$ interaction at $\sim 400$ MeV/c to an isospin-independent scalar interaction at high-momentum around $\sim 800$ MeV/c as predicted by theoretical calculation., Accepted for publication in Physics Letters B. 7 pages, 3 figures, and online supplementary materials

Published
2021

32. Biodegradable Implantable Sensors: Materials Design, Fabrication, and Applications

Author

Ana L. Hernandez, Natan Roberto de Barros, Bige D. Unluturk, Antoinette S. Gomes, Nureddin Ashammakhi, Jinxing Li, Miguel Holgado, Sergio Quintero, Ehsanul Hoque Apu, Abdullah Bin Shams, Christopher H. Contag, and Serge Ostrovidov

Subjects
Biomaterials, Materials science, Fabrication, Electrochemistry, Nanotechnology, Materials design, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Published
2021

33. Photon beam asymmetry Σ in the reaction γ→p→pω for E= 1.152 to 1.876 GeV

Author

G. Khachatryan, W. Kim, M. Battaglieri, N. K. Walford, G. Niculescu, L. Lanza, Michael Paolone, M. Bashkanov, S. Adhikari, H. Avakian, F. X. Girod, W. J. Briscoe, Laura Clark, B. McKinnon, P. Lenisa, T. Cao, M. Ungaro, I. J. D. MacGregor, F. Sabatié, I. I. Strakovsky, H. Voskanyan, A. Kim, E. De Sanctis, V. A. Nikonov, A. Deur, E. Pasyuk, J. W. Price, N. Dashyan, C. Gleason, G. Rosner, K. Hicks, V. Mokeev, P. Nadel-Turonski, V. Batourine, I. Bedlinskiy, D. I. Sober, S. Strauch, V. Crede, William Brooks, Dustin Keller, M. Defurne, Y. Ghandilyan, D. P. Watts, Barry Ritchie, Brian Raue, Alessandro Rizzo, C. Hanretty, H. Egiyan, E. Golovatch, R. Dupre, R. A. Montgomery, A. Celentano, R. W. Gothe, M. Khachatryan, Sylvester Joosten, B. S. Ishkhanov, G. Charles, Michael Wood, J. Ball, K. Hafidi, W. Phelps, H. S. Jo, A. V. Sarantsev, G. Ciullo, Y. Prok, D. I. Glazier, D. S. Carman, A. Simonyan, O. Cortes, N. A. Baltzell, C. Munoz Camacho, Nikos Sparveris, F. J. Klein, M. Ripani, M. Contalbrigo, Z. E. Meziani, E. L. Isupov, S. Niccolai, D. G. Jenkins, M. Osipenko, K. A. Griffioen, R. Paremuzyan, Eberhard Klempt, S. Boiarinov, N. Markov, V. P. Kubarovsky, A. Movsisyan, R. De Vita, Nicholas M. Harrison, O. Pogorelko, Gerard Gilfoyle, J. Zhang, S. M. Hughes, X. Wei, S. Pisano, D. Sokhan, I. Stankovic, A. V. Anisovich, C. A. Meyer, Z. Akbar, G. V. Fedotov, I. Niculescu, C. Salgado, P. L. Cole, A. I. Ostrovidov, K. Park, R. A. Schumacher, D. G. Ireland, H. Jiang, H. Hakobyan, S. Anefalos Pereira, Volker D. Burkert, A. S. Biselli, L. El Fassi, K. P. Adhikari, S. Stepanyan, E. Munevar, L. A. Net, Avraham Klein, Y. G. Sharabian, J. A. Fleming, Iu. Skorodumina, D. Heddle, G. Hollis, P. Eugenio, M. Taiuti, P. Collins, S. Procureur, K. L. Giovanetti, A. El Alaoui, Y. Ilieva, Nicholas Zachariou, A. Filippi, M. Khandaker, K. Livingston, M. Hattawy, D. Protopopescu, Z. W. Zhao, E. Voutier, Chaden Djalali, Michael Dugger, T. Mineeva, F. Cao, D. Adikaram, M. Guidal, G. D. Smith, M. Holtrop, Taya Chetry, and Sergey Kuleshov

Subjects
Physics, Nuclear and High Energy Physics, Photon, Meson, Proton, 010308 nuclear & particles physics, Partial wave analysis, Bremsstrahlung, Photon energy, 01 natural sciences, Nuclear physics, Pomeron, 0103 physical sciences, Nuclear Experiment, 010306 general physics, Nucleon
Abstract

Photon beam asymmetry Σ measurements for ω photoproduction in the reaction γ → p → ω p are reported for photon energies from 1.152 to 1.876 GeV. Data were taken using a linearly-polarized tagged photon beam, a cryogenic hydrogen target, and the CLAS spectrometer in Hall B at Jefferson Lab. The measurements obtained markedly increase the size of the database for this observable, extend coverage to higher energies, and resolve discrepancies in previously published data. Comparisons of these new results with predictions from a chiral-quark-based model and from a dynamical coupled-channels model indicate the importance of interferences between t-channel meson exchange and s- and u-channel contributions, underscoring sensitivity to the nucleon resonances included in those descriptions. Comparisons with the Bonn–Gatchina partial-wave analysis indicate the Σ data reported here help to fix the magnitudes of the interference terms between the leading amplitudes in that calculation (Pomeron exchange and the resonant portion of the J P = 3 / 2 + partial wave), as well as the resonant portions of the smaller partial waves with J P = 1 / 2 − , 3 / 2 − , and 5 / 2 + .

Published
2017

34. Macroporous mesh of nanoporous gold in electrochemical monitoring of superoxide release from skeletal muscle cells

Author

Ali Khademhosseini, Jiuhui Han, Mingwei Chen, Serge Ostrovidov, Sahar Salehi, Behzad Bahraminejad, Ramin Banan Sadeghian, and Samad Ahadian

Subjects
Analyte, Working electrode, Diffusion, Biomedical Engineering, Biophysics, Nanotechnology, Biosensing Techniques, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 01 natural sciences, Cell Line, Myoblasts, Mice, chemistry.chemical_compound, Superoxides, Monolayer, Animals, Electrodes, chemistry.chemical_classification, Reactive oxygen species, Nanoporous, Chemistry, Superoxide, Cytochromes c, Electrochemical Techniques, General Medicine, Enzymes, Immobilized, 021001 nanoscience & nanotechnology, Nanostructures, 0104 chemical sciences, Chemical engineering, Gold, 0210 nano-technology, Porosity, Biotechnology
Abstract

Real-time monitoring of metabolically relevant biochemicals released in minuscule amounts is of utmost diagnostic importance. Superoxide anion as a primary member of reactive oxygen species, has physiological and pathological effects that depend on its concentration and release rate. Here we present fabrication and successfully testing of a highly sensitive electrochemical biosensor featuring a three-dimensional macroporous mesh of nanoporous gold tailored to measure the dynamics of extracellular superoxide concentration. Wide and accessible surface of the mesh combined with high porosity of the thin nanoporous gold coating enables capturing the analyte in pico- to nano-molar ranges. The mesh is functionalized with cytochrome- c (cyt- c ) and incorporated as a working electrode to measure the release rate of drug-induced superoxides from C2C12 cells through a porous membrane. The device displays a considerably improved superoxide sensitivity of 7.29 nA nM − 1 cm − 2 and a low level of detection of 70 pM. Such sensitivity is orders of magnitude higher than any similar enzyme-based electrochemical superoxide sensor and is attributed to the facile diffusion of the analyte through the well-spread nanofeatured gold skin. Superoxide generation rates captured from monolayer myoblast cultures containing about 4×10 4 cells, varied from 1.0 to 9.0 nM min − 1 in a quasi-linear fashion as a function of drug concentration. This work provides a platform for the development of highly sensitive molecular electrochemical biosensors.

Published
2017

35. Beam asymmetry Σ for the photoproduction of η and η′ mesons at Eγ=8.8GeV

Author

A. Hurley, L. Gan, C. A. Meyer, J. Frye, C. Paudel, V. V. Tarasov, A. Dolgolenko, H. Hakobyan, C. Salgado, A. M. Schertz, E. Barriga, T. Daniels, C. Fanelli, R. T. Jones, W. Phelps, F. Nerling, M. E. McCracken, Krisztian Peters, Michael Dugger, V. Kakoyan, M. J. Staib, B. E. Cannon, T. Erbora, E. Pooser, I. A. Semenova, Z. Zhang, V. A. Matveev, A. Barnes, Dmitri Romanov, Sean A Dobbs, V. V. Berdnikov, A. Hamdi, J. Barlow, I. I. Strakovsky, Mark Richard James Williams, K. Suresh, T. Whitlatch, A. Somov, T. C. Black, D. Lawrence, A. Thiel, M. M. Dalton, H. Marukyan, Hovanes Egiyan, L. Ng, A. Ernst, M. McCaughan, R.S. Pedroni, W. McGinley, G. M. Huber, D. I. Sober, L. Robison, K. Livingston, V. Lyubovitskij, A. Deur, Ting Xiao, Q. Zhou, R. A. Miskimen, William Brooks, X. Zhou, P. Eugenio, G. Zhao, N. Wickramaarachchi, O. Cortes, N. Qin, L. Guo, E. Chudakov, R. Barsotti, Lubomir Pentchev, N. Cao, O. Soto, K. K. Seth, R. Dzhygadlo, F. Barbosa, B. Zihlmann, S. Fegan, M. Kamel, A. M. Foda, D. J. Mack, R. A. Schumacher, N. Gevorgyan, T. Britton, A. I. Ostrovidov, B. Liu, V. Crede, C.P. Romero, G. J. Lolos, I. Larin, G. Vasileiadis, H. Li, Ashot Gasparian, Sergey Kuleshov, D. I. Lersch, D. G. Ireland, A. Goncalves, Z. Papandreou, V. S. Goryachev, M. J. Amaryan, P. Mattione, S. Adhikari, M. Patsyuk, W. B. Li, A. Yu. Semenov, R. Dotel, Elton Smith, J. Schwiening, Barry Ritchie, J. R. Stevens, S. Somov, M. Boer, J. Foote, J. Zarling, M. R. Shepherd, A. Teymurazyan, C. Gleason, G. Kalicy, N. S. Jarvis, X. Shen, A. Austregesilo, S. Cole, Christine Kourkoumelis, Joerg Reinhold, A. Ali, R. E. Mitchell, W. U. Boeglin, Y. Yang, M. M. Ito, P. Pauli, S. Furletov, W. J. Briscoe, T. D. Beattie, and K. Goetzen

Subjects
Physics, GlueX, Meson, 010308 nuclear & particles physics, Linear polarization, media_common.quotation_subject, Momentum transfer, Parity (physics), 01 natural sciences, 7. Clean energy, Asymmetry, 0103 physical sciences, Quasiparticle, Atomic physics, Photon beam, 010306 general physics, media_common
Abstract

We report on the measurement of the beam asymmetry Σ for the reactions → γ p → p η and → γ p → p η ′ from the GlueX experiment using an 8.2–8.8-GeV linearly polarized tagged photon beam incident on a liquid hydrogen target in Hall D at Jefferson Laboratory. These measurements are made as a function of momentum transfer − t with significantly higher statistical precision than our earlier η measurements and are the first measurements of η ′ in this energy range. We compare the results to theoretical predictions based on t -channel quasiparticle exchange. We also compare the ratio of Σ η to Σ η ′ to these models as this ratio is predicted to be sensitive to the amount of s ¯ s exchange in the production. We find that photoproduction of both η and η ′ is dominated by natural parity exchange with little dependence on − t .

Published
2019

36. First Measurement of Near-Threshold J/ψ Exclusive Photoproduction off the Proton

Author

The GlueX Collaboration, Ali, A., Amaryan, M., Anassontzis, E. G., Austregesilo, A., Baalouch, M., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Boer, M., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gauzshtein, V., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Han, S., Hardin, J., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Kuznetsov, I., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., McIntyre, J., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mokaya, F., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Werthmueller, D., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhao, G., Zhou, Q., Zhou, X., and Zihlmann, B.

Subjects
Physics, Scattering cross-section, GlueX, General Physics and Astronomy, Exotic hadron, 01 natural sciences, 7. Clean energy, Pentaquark, Model exchange, Nuclear physics, Near threshold, 0103 physical sciences, High Energy Physics::Experiment, Photon beam, 010306 general physics, Nuclear Experiment
Abstract

We report on the measurement of the $\gamma p \rightarrow J/\psi p$ cross section from $E_\gamma = 11.8$ GeV down to the threshold at $8.2$ GeV using a tagged photon beam with the GlueX experiment. We find the total cross section falls toward the threshold less steeply than expected from two-gluon exchange models. The differential cross section $d\sigma /dt$ has an exponential slope of $1.67 \pm 0.39$ GeV$^{-2}$ at $10.7$ GeV average energy. The LHCb pentaquark candidates $P_c^+$ can be produced in the $s$-channel of this reaction. We see no evidence for them and set model-dependent upper limits on their branching fractions $\mathcal{B}(P_c^+ \rightarrow J/\psi p)$ and cross sections $\sigma(\gamma p \to P_c^+)\times\mathcal{B}(P_c^+ \to J/\psi p) $., Comment: 12 pages, 7 figures

Published
2019

37. First Measurements of the Double-Polarization Observables F , P , and H in ω Photoproduction off Transversely Polarized Protons in the N* Resonance Region

Author

Eberhard Klempt, O. Cortes, C. Hanretty, K. A. Griffioen, M. Ungaro, V. A. Nikonov, X. Wei, B. S. Ishkhanov, O. Soto, C. D. Keith, S. Strauch, G. Khachatryan, F. X. Girod, M. Osipenko, A. D'Angelo, Eugene Pasyuk, H. S. Jo, A. El Alaoui, W. J. Briscoe, Y. Ilieva, Aditya R. Khanal, Dustin Keller, L. Barion, F. Sabatié, I. I. Strakovsky, L. Guo, Alessandro Rizzo, A. V. Anisovich, L. Lanza, J. Brock, V. Mokeev, E. L. Isupov, Nicholas Zachariou, K Nakayama, M. C. Kunkel, P. Nadel-Turonski, Rong Wang, R. De Vita, A. Deur, R. A. Schumacher, Michael Wood, P. Lenisa, W. Phelps, Barry Ritchie, S. Boiarinov, K. Hafidi, G. Ciullo, Y. Prok, Iu. Skorodumina, S Niccolai, P. Eugenio, W. Kim, G. Niculescu, D. S. Carman, W. K. Brooks, I. Bedlinskiy, C. A. Meyer, D. Payette, K. Livingston, Sylvester Joosten, G. Rosner, H. Egiyan, Andrea Celentano, T. B. Hayward, J. Pierce, Jie Zhang, S. Adhikari, Friedrich Klein, D. G. Jenkins, M. Taiuti, K. P. Adhikari, Brian Raue, D. P. Watts, D. Marchand, Y. G. Sharabian, A. Movsisyan, S. Diehl, M. Ripani, C. Salgado, C. Carlin, S. Fegan, M. L. Kabir, A. V. Sarantsev, M. Battaglieri, N. Tyler, B. Duran, V. P. Kubarovsky, E. Voutier, J. A. Tan, U. Shrestha, V. Crede, D. Riser, Chaden Djalali, O. Pogorelko, M. Khachatryan, Michael Dugger, T. Mineeva, H. Avakian, E. Golovatch, A Fradi, R. Dupre, H. Voskanyan, Nikolaos Sparveris, F. Cao, P. Roy, N C Wei, N. K. Walford, R. A. Montgomery, M. Guidal, E. De Sanctis, N. Dashyan, A. Kim, P. Chatagnon, I. J. D. MacGregor, Michael Paolone, M. Holtrop, M. Hattawy, R. W. Gothe, M Ehrhart, K. Hicks, Luciano Pappalardo, S. Park, Taya Chetry, M. Contalbrigo, G. Angelini, Sergey Kuleshov, D. G. Meekins, L. El Fassi, A. I. Ostrovidov, D. G. Ireland, Volker D. Burkert, A. S. Biselli, M. Khandaker, B. McKinnon, D. Heddle, P. L. Cole, M. L. Seely, B. Torayev, Feng Huang, R. Paremuzyan, Sandra K. Johnston, D. Protopopescu, Z. W. Zhao, Nicholas M. Harrison, Gerard Gilfoyle, D. Sokhan, A. Filippi, and C. Munoz Camacho

Subjects
Physics, Photon, Spectrometer, Proton, Linear polarization, media_common.quotation_subject, Nuclear Theory, General Physics and Astronomy, Resonance, Polarization (waves), 01 natural sciences, Asymmetry, Nuclear physics, 0103 physical sciences, Physics::Accelerator Physics, Nuclear Experiment, 010306 general physics, Nucleon, media_common
Abstract

First measurements of double-polarization observables in ω photoproduction off the proton are presented using transverse target polarization and data from the CEBAF Large Acceptance Spectrometer (CLAS) FROST experiment at Jefferson Lab. The beam-target asymmetry F has been measured using circularly polarized, tagged photons in the energy range 1200-2700 MeV, and the beam-target asymmetries H and P have been measured using linearly polarized, tagged photons in the energy range 1200-2000 MeV. These measurements significantly increase the database on polarization observables. The results are included in two partial-wave analyses and reveal significant contributions from several nucleon (N^{*}) resonances. In particular, contributions from new N^{*} resonances listed in the Review of Particle Properties are observed, which aid in reaching the goal of mapping out the nucleon resonance spectrum.

Published
2019

38. In situ three-dimensional printing for reparative and regenerative therapy

Author

Samad Ahadian, Ippokratis Pountos, Mehmet R. Dokmeci, Nazzar Tellisi, Shu-Kai Hu, Praveen Bandaru, Ali Khademhosseini, Nureddin Ashammakhi, and Serge Ostrovidov

Subjects
In situ, 3D bioprinting, Computer science, Regeneration (biology), 010401 analytical chemistry, Bioprinting, Biomedical Engineering, Structural integrity, Equipment Design, 02 engineering and technology, Regenerative Medicine, 021001 nanoscience & nanotechnology, 01 natural sciences, Regenerative medicine, 0104 chemical sciences, law.invention, law, Three dimensional printing, Printing, Three-Dimensional, 0210 nano-technology, Molecular Biology, Ex vivo, Biomedical engineering, Biofabrication
Abstract

Three-dimensional (3D) bioprinting is an emerging biofabrication technology, driving many innovations and opening new avenues in regenerative therapeutics. The aim of 3D bioprinting is to fabricate grafts in vitro, which can then be implanted in vivo. However, the tissue culture ex vivo carries safety risks and thereby complicated manufacturing equipment and practice are required for tissues to be implanted in the humans. The implantation of printed tissues also adds complexities due to the difficulty in maintaining the structural integrity of fabricated constructs. To tackle this challenge, the concept of in situ 3D bioprinting has been suggested in which tissues are directly printed at the site of injury or defect. Such approach could be combined with cells freshly isolated from patients to produce custom-made grafts that resemble target tissue and fit precisely to target defects. Moreover, the natural cellular microenvironment in the body can be harnessed for tissue maturation resulting in the tissue regeneration and repair. Here, we discuss literature reports on in situ 3D printing and we describe future directions and challenges for in situ 3D bioprinting. We expect that this novel technology would find great attention in different biomedical fields in near future.

Published
2019

39. Engineering Hydrogels beyond a Hydrated Network

Author

Robert Wieduwild, Gorka Orive, Yong Xu, Serge Ostrovidov, Ali Khademhosseini, and Yixin Zhang

Subjects
Polymer network, Tissue Engineering, Computer science, High-throughput screening, Stem Cells, Biomedical Engineering, Pharmaceutical Science, Biocompatible Materials, Hydrogels, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Ligands, 01 natural sciences, Regenerative medicine, 0104 chemical sciences, Biomaterials, Self-healing hydrogels, Animals, Humans, Biochemical engineering, 0210 nano-technology
Abstract

In recent years, many mechanical, physical, chemical, and biochemical features of biomatrices have emerged as important properties to dictate the fates of cells. To construct chemically defined biomaterials to recapitulate various biological niches for both cell biology research and therapeutic utilities, it has become increasingly clear that a simple hydrated polymer network would not be able to provide the complex cues and signaling required for many types of cells. The researchers are facing a growing list of mechanophysical and biochemical properties, while each of them could be an important cellular trigger. To include all these design parameters in screening and synthesis is practically difficult, if not impossible. Developing novel high throughput screening technology by combining assay miniaturization, computer simulations, and modeling can help researchers to tackle the challenge to identify the most relevant parameters to tailor materials for specific applications.

Published
2019

40. First measurement of near-threshold J/$��$ exclusive photoproduction off the proton

Author

The GlueX Collaboration, Ali, A., Amaryan, M., Anassontzis, E. G., Austregesilo, A., Baalouch, M., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Boer, M., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gauzshtein, V., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Han, S., Hardin, J., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Kuznetsov, I., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., McIntyre, J., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mokaya, F., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Werthmueller, D., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhao, G., Zhou, Q., Zhou, X., and Zihlmann, B.

Subjects
FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report on the measurement of the $��p \rightarrow J/��p$ cross section from $E_��= 11.8$ GeV down to the threshold at $8.2$ GeV using a tagged photon beam with the GlueX experiment. We find the total cross section falls toward the threshold less steeply than expected from two-gluon exchange models. The differential cross section $d��/dt$ has an exponential slope of $1.67 \pm 0.39$ GeV$^{-2}$ at $10.7$ GeV average energy. The LHCb pentaquark candidates $P_c^+$ can be produced in the $s$-channel of this reaction. We see no evidence for them and set model-dependent upper limits on their branching fractions $\mathcal{B}(P_c^+ \rightarrow J/��p)$ and cross sections $��(��p \to P_c^+)\times\mathcal{B}(P_c^+ \to J/��p) $., 12 pages, 7 figures

Published
2019
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41. Beam Asymmetry $\mathbf��$ for the Photoproduction of $\mathbf��$ and $\mathbf{��^{\prime}}$ Mesons at $\mathbf{E_��=8.8}$GeV

Author

The GlueX Collaboration, Adhikari, S., Ali, A., Amaryan, M., Austregesilo, A., Barbosa, F., Barlow, J., Barnes, A., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Boer, M., Briscoe, W. J., Britton, T., Brooks, W. K., Cannon, B. E., Cao, N., Chudakov, E., Cole, S., Cortes, O., Crede, V., Dalton, M. M., Daniels, T., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Egiyan, H., Erbora, T., Ernst, A., Eugenio, P., Fanelli, C., Fegan, S., Foda, A. M., Foote, J., Frye, J., Furletov, S., Gan, L., Gasparian, A., Gevorgyan, N., Gleason, C., Goetzen, K., Goncalves, A., Goryachev, V. S., Guo, L., Hakobyan, H., Hamdi, A., Huber, G. M., Hurley, A., Ireland, D. G., Ito, M. M., Jarvis, N. S., Jones, R. T., Kakoyan, V., Kalicy, G., Kamel, M., Kourkoumelis, C., Kuleshov, S., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W., Liu, B., Livingston, K., Lolos, G. J., Lyubovitskij, V., Mack, D., Marukyan, H., Mattione, P., Matveev, V., McCaughan, M., McCracken, M., McGinley, W., Meyer, C. A., Miskimen, R., Mitchell, R. E., Nerling, F., Ng, L., Ostrovidov, A. I., Papandreou, Z., Patsyuk, M., Paudel, C., Pauli, P., Pedroni, R., Pentchev, L., Peters, K. J., Phelps, W., Pooser, E., Qin, N., Reinhold, J., Ritchie, B. G., Robison, L., Romanov, D., Romero, C., Salgado, C., Schertz, A. M., Schumacher, R. A., Schwiening, J., Semenov, A. Yu., Semenova, I. A., Seth, K. K., Shen, X., Shepherd, M. R., Smith, E. S., Sober, D. I., Somov, A., Somov, S., Soto, O., Staib, M., Stevens, J. R., Strakovsky, I. I., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Vasileiadis, G., Whitlatch, T., Wickramaarachchi, N., Williams, M., Xiao, T., Yang, Y., Zarling, J., Zhang, Z., Zhao, G., Zhou, Q., Zhou, X., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report on the measurement of the beam asymmetry $��$ for the reactions $\vec��p\rightarrow p��$ and $\vec��p \rightarrow p��^{\prime}$ from the GlueX experiment, using an 8.2--8.8 GeV linearly polarized tagged photon beam incident on a liquid hydrogen target in Hall D at Jefferson Lab. These measurements are made as a function of momentum transfer $-t$, with significantly higher statistical precision than our earlier $��$ measurements, and are the first measurements of $��^{\prime}$ in this energy range. We compare the results to theoretical predictions based on $t$--channel quasi-particle exchange. We also compare the ratio of $��_��$ to $��_{��^{\prime}}$ to these models, as this ratio is predicted to be sensitive to the amount of $s\bar{s}$ exchange in the production. We find that photoproduction of both $��$ and $��^{\prime}$ is dominated by natural parity exchange with little dependence on $-t$., 18 pages, 7 figures

Published
2019
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42. Ξ* photoproduction from threshold to W=3.3GeV

Author

Frank Klein, Dustin Keller, K. Hafidi, E. Golovatch, Y. G. Sharabian, K. Hicks, M. Ripani, C. Bookwalter, K. A. Griffioen, L. Lanza, H. Egiyan, V. Crede, I. J. D. MacGregor, M. Contalbrigo, S. Adhikari, M. Hattawy, C. Munoz Camacho, M. H. Wood, B. McKinnon, I. Bedlinskiy, D. Protopopescu, Michael Dugger, M. Osipenko, L. Elouadrhiri, M. Khachatryan, M. S. Saini, G. Ciullo, P. Eugenio, M. Taiuti, A. El Alaoui, Carlos A. Salgado, F. Cao, W. Kim, I. I. Strakovsky, Maxime Defurne, A. Deur, J. T. Goetz, Y. Prok, D. S. Carman, M. Mirazita, Nikos Sparveris, B. S. Ishkhanov, Nicholas Zachariou, M. L. Kabir, Diane Schott, Michael Paolone, C. A. Meyer, A. I. Ostrovidov, K. Park, X. Wei, N. Gevorgyan, D. I. Glazier, P. Chatagnon, G. V. Fedotov, D. G. Ireland, R. De Vita, M. Guidal, E. Voutier, A. Movsisyan, J. Zhang, F. Sabatié, G. Niculescu, S. Chandavar, V. P. Kubarovsky, Volker D. Burkert, A. S. Biselli, K. Livingston, J. W. Price, A. Celentano, R. W. Gothe, S. Anefalos Pereira, R. Paremuzyan, D. Riser, V. Mokeev, D. P. Weygand, A. Filippi, M. C. Kunkel, Brian Raue, O. Pogorelko, Nicholas M. Harrison, Rong Wang, M. Holtrop, S. Niccolai, R. Dupre, M. Battaglieri, M. Khandaker, Alessandro Rizzo, D. Sokhan, D. I. Sober, L. Guo, M. Ehrhart, M. Ungaro, Pawel Nadel-Turonski, H. Voskanyan, W. J. Briscoe, E. Pasyuk, Iu. Skorodumina, D. Heddle, Taya Chetry, William Brooks, P. L. Cole, Z. W. Zhao, R. A. Schumacher, A. D'Angelo, F. X. Girod, L. El Fassi, S. Strauch, E. L. Isupov, S. Boiarinov, H. Hakobyan, H. S. Jo, S. Diehl, Sylvester Joosten, C. Djalali, J. A. Tan, G. Khachatryan, N. Dashyan, A. Kim, G. Rosner, and Y. Ghandilyan

Subjects
Quark, Physics, Particle physics, 010308 nuclear & particles physics, Nuclear Theory, Quark model, Lattice field theory, 01 natural sciences, Xi baryon, Baryon, Lattice (order), Excited state, 0103 physical sciences, High Energy Physics::Experiment, Gauge theory, Nuclear Experiment, 010306 general physics
Abstract

The doubly strange Xi baryons provide an effective way to study a puzzle called the missing-baryons problem where both quark models and lattice guage theory predict more baryon excited states than are seen experimentally. However, few of these excited states have been observed with any certainty. Here, high-mass Xi* states have been searched for in photoproduction with the detector of the CLAS collaboration, and upper limits for the total cross sections have been established from threshold to W = 3.3 GeV. In addition, the total cross sections of the ground-state Xi(-)(1320) and first excited state Xi(-)(1530) are presented, extending significantly the centre-of-mass energy range of previous data.

Published
2018

43. 3D Bioprinting in Skeletal Muscle Tissue Engineering

Author

Cesare Gargioli, Gorka Orive, Marco Costantini, Wojciech Swieszkowski, Toshinori Fujie, Sahar Salehi, Kasinan Suthiwanich, Stefano Cannata, Serge Ostrovidov, Ali Khademhosseini, Xuetao Shi, Majid Ebrahimi, Ali Tamayol, Ramin Banan Sadeghian, and Mehmet R. Dokmeci

Subjects
Engineering, Settore BIO/06, bioinks, Cell Culture Techniques, 02 engineering and technology, 010402 general chemistry, Regenerative Medicine, 01 natural sciences, Article, law.invention, Biomaterials, law, Skeletal Muscle Tissue, Humans, General Materials Science, skeletal muscle, Muscle, Skeletal, hydrogels, Cells, Cultured, 3D bioprinting, Tissue Engineering, Tissue Scaffolds, business.industry, Settore BIO/13, Bioprinting, General Chemistry, 3D printing, 021001 nanoscience & nanotechnology, 0104 chemical sciences, bioprinting, tissue engineering, Printing, Three-Dimensional, 0210 nano-technology, business, Biotechnology, Biomedical engineering
Abstract

Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments have been done in SMTE, however it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. In this review, after a brief description of the anatomy of skeletal muscle, and a short state-of-the-art on developments made in SMTE with “conventional methods”, we focus on the use of three dimensional (3D) bioprinting as a new tool for SMTE. We discuss on the current bioprinting methods, and provide an overview on the bioink formulations and properties used in 3D bioprinting. Finally, we highlight different advances made in SMTE by 3D bioprinting, and describe future needs and provide a short perspective.

Published
2018

45. Online Monitoring of Superoxide Anions Released from Skeletal Muscle Cells Using an Electrochemical Biosensor Based on Thick-Film Nanoporous Gold

Author

Hojae Bae, Jiuhui Han, Serge Ostrovidov, Sahar Salehi, Mingwei Chen, Ali Khademhosseini, Behzad Bahraminejad, and Ramin Banan Sadeghian

Subjects
Materials science, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, medicine, Myocyte, Instrumentation, Fluid Flow and Transfer Processes, chemistry.chemical_classification, Detection limit, Reactive oxygen species, Nanoporous, Superoxide, Process Chemistry and Technology, Skeletal muscle, 021001 nanoscience & nanotechnology, 0104 chemical sciences, medicine.anatomical_structure, chemistry, Biochemistry, Biophysics, 0210 nano-technology, C2C12, Biosensor
Abstract

Online detection and accurate quantification of superoxide anions released from skeletal muscle tissue is important in both physiological and pathological contexts. Above certain physiologically redundant levels, superoxides may exert toxic effects. Here we present design, fabrication, and successful testing of a highly sensitive electrochemical superoxide biosensor based on nanoporous gold (NPG) immobilized with cytochrome-c (cyt-c). A significant 14-fold enhancement in the biosensor sensitivity was achieved using NPG instead of nonporous gold, enabling the device to quantify minuscule levels of superoxides. Such improvement was attributed to the very large surface-to-volume ratio of the NPG network. The average values of superoxide sensitivity and analytical limit of detection (LOD) were 1.90 ± 0.492 nA nM–1 cm–2 and 3.7 nM, respectively. The sensor was employed to measure the rates of superoxide release from C2C12 myoblasts and differentiated myotubes upon stimulation with an endogenous superoxide-prod...

Published
2016

46. Biodegradable Polymers: A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy (Adv. Funct. Mater. 23/2020)

Author

KangJu Lee, Shiming Zhang, Samad Ahadian, Nureddin Ashammakhi, Peyton Tebon, Serge Ostrovidov, Wujin Sun, Ali Khademhosseini, Yumeng Xue, Han-Jun Kim, Xingwu Zhou, Reihaneh Haghniaz, Einollah Sarikhani, Mehmet R. Dokmeci, Yaowen Liu, Junmin Lee, and Betül Çelebi-Saltik

Subjects
Biomaterials, Materials science, Depot, Regeneration (biology), Mesenchymal stem cell, Electrochemistry, Condensed Matter Physics, Regenerative medicine, Biodegradable polymer, Electronic, Optical and Magnetic Materials, Biomedical engineering
Published
2020

47. A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy

Author

Shiming Zhang, Peyton Tebon, Samad Ahadian, Ali Khademhosseini, Wujin Sun, Betül Çelebi-Saltik, Xingwu Zhou, Han-Jun Kim, Yaowen Liu, Serge Ostrovidov, Nureddin Ashammakhi, KangJu Lee, Junmin Lee, Yumeng Xue, Einollah Sarikhani, Mehmet R. Dokmeci, and Reihaneh Haghniaz

Subjects
Materials science, food.ingredient, Mesenchymal stem cell, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Biodegradable polymer, Regenerative medicine, Gelatin, Article, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Biomaterials, PLGA, chemistry.chemical_compound, food, chemistry, In vivo, Electrochemistry, Viability assay, Stem cell, 0210 nano-technology, Biomedical engineering
Abstract

Mesenchymal stem cells (MSCs) have been widely used for regenerative therapy. In most current clinical applications, MSCs are delivered by injection but face significant issues with cell viability and penetration into the target tissue due to a limited migration capacity. Some therapies have attempted to improve MSC stability by their encapsulation within biomaterials; however, these treatments still require an enormous number of cells to achieve therapeutic efficacy due to low efficiency. Additionally, while local injection allows for targeted delivery, injections with conventional syringes are highly invasive. Due to the challenges associated with stem cell delivery, a local and minimally invasive approach with high efficiency and improved cell viability is highly desired. In this study, we present a detachable hybrid microneedle depot (d-HMND) for cell delivery. Our system consists of an array of microneedles with an outer poly(lactic-co-glycolic) acid (PLGA) shell and an internal gelatin methacryloyl (GelMA)-MSC mixture (GMM). The GMM was characterized and optimized for cell viability and mechanical strength of the d-HMND required to penetrate mouse skin tissue was also determined. MSC viability and function within the d-HMND was characterized in vitro and the regenerative efficacy of the d-HMND was demonstrated in vivo using a mouse skin wound model.

Published
2020

48. Beam-target helicity asymmetry E in K0Λ and K0Σ0 photoproduction on the neutron

Author

P. Lenisa, M. Ungaro, D. G. Ireland, C. A. Meyer, R. Dupre, V. Crede, C.D. Bass, V. A. Nikonov, M. Battaglieri, P. Chatagnon, G. V. Fedotov, R. A. Montgomery, Ron L. Workman, R. Paremuzyan, R. A. Schumacher, C. S. Whisnant, K. P. Adhikari, A. Fradi, M. Osipenko, D. G. Jenkins, Nicholas M. Harrison, N. Markov, Martin K. Mayer, K. A. Griffioen, I. Zonta, I. J. D. MacGregor, A. Kim, H. Hakobyan, M. Khachatryan, D. Sokhan, H. S. Jo, Tim O'Connell, D. Marchand, S. Diehl, M. Bashkanov, B. McKinnon, A. I. Ostrovidov, K. Park, V. Mokeev, G. Khachatryan, L. Lanza, Eberhard Klempt, P. Collins, S. Niccolai, F. X. Girod, M. Contalbrigo, Sandra K. Johnston, P. Eugenio, T. Chetry, Volker D. Burkert, A. S. Biselli, Pawel Nadel-Turonski, M. Mirazita, J. Zhang, Rong Wang, J. W. Price, Alessandro Rizzo, S. Strauch, Iu. Skorodumina, C. Hanretty, George Davey Smith, M. Taiuti, C. Djalali, J. A. Tan, E. Golovatch, Y. G. Sharabian, M. Lowry, G. Charles, K. L. Giovanetti, I. Bedlinskiy, M. Rehfuss, K. Hicks, S. Adhikari, M. L. Kabir, M. Ehrhart, F. Sabatié, Andreas Klein, V. Laine, F. Cao, D. Adikaram, M. Guidal, W. Kim, Larry Weinstein, Z. Akbar, G. Rosner, P. Peng, C. Munoz Camacho, M. H. Wood, M. Hattawy, G. Niculescu, J. A. Fleming, I. I. Strakovsky, M. Holtrop, A. Filippi, A. D'Angelo, M. Ripani, Y. Ghandilyan, Carlos A. Salgado, B. A. Clary, A. M. Sandorfi, B. S. Ishkhanov, M. Khandaker, D. I. Sober, A. Deur, Hong Lu, Michael Paolone, D. Ho, S. Fegan, A. Celentano, R. W. Gothe, D. Heddle, Maxime Defurne, E. L. Isupov, W. Gohn, S. Boiarinov, R. De Vita, T. Kageya, L. El Fassi, N. K. Walford, R. G. Fersch, Frank Klein, P. L. Cole, Z. W. Zhao, Dustin Keller, G. Ciullo, J. P. Ball, Y. Prok, D. S. Carman, Nikos Sparveris, X. Wei, K. Hafidi, E. Voutier, A. Movsisyan, Yordanka Ilieva, L. Barion, V. P. Kubarovsky, D. Riser, A. El Alaoui, Nicholas Zachariou, O. Pogorelko, K. Livingston, H. Voskanyan, D. Protopopescu, W. J. Briscoe, E. Pasyuk, D. P. Watts, H. Egiyan, A. V. Sarantsev, and S. Chandavar

Subjects
Physics, Strange quark, 010308 nuclear & particles physics, media_common.quotation_subject, Nuclear Theory, Quark model, Hyperon, 01 natural sciences, Helicity, Asymmetry, Pseudoscalar meson, Nuclear physics, 13. Climate action, Isospin, 0103 physical sciences, Neutron, Nuclear Experiment, 010306 general physics, media_common
Abstract

We report the first measurements of the E beam-target helicity asymmetry for the γn→K0Λ and K0Σ0 channels in the energy range 1.70≤W≤2.34 GeV. The CLAS system at Jefferson Lab uses a circularly polarized photon beam and a target consisting of longitudinally polarized solid molecular hydrogen deuteride with low background contamination for the measurements. The multivariate analysis method boosted decision trees is used to isolate the reactions of interest. Comparisons with predictions from the KaonMAID, SAID, and Bonn-Gatchina models are presented. These results will help separate the isospin I=0 and I=1 photocoupling transition amplitudes in pseudoscalar meson photoproduction.

Published
2018

49. Photoproduction of K+K− meson pairs on the proton

Author

G. Ricco, R. A. Schumacher, K. Mikhailov, L. Bibrzycki, P. Stoler, A. D'Angelo, K. Hicks, H. Hakobyan, Ashot Gasparian, L. Gan, V. Mokeev, A.V. Stavinsky, K. Livingston, D. S. Dale, S. Anefalos Pereira, A. V. Vlassov, D. J. Tedeschi, V. V. Mochalov, K. A. Griffioen, S. Fegan, E. Clinton, Michael Wood, N. Hassall, M. Bellis, K. Hafidi, Michael Vineyard, R. De Vita, S. Stepanyan, C. Bookwalter, P. Nadel-Turonski, M. Kossov, Avraham Klein, T. Mineeva, V. Drozdov, S. Strauch, V. Kuznetsov, Friedrich Klein, D. P. Watts, E. L. Isupov, E. Munevar, H. Egiyan, I. Nakagawa, I. Bedlinskiy, Brian Raue, W. J. Briscoe, Michael L. Williams, A. Kubarovsky, W. Gohn, E. Wolin, Lorenzo Zana, M. Y. Gabrielyan, C. E. Hyde, O. Glamazdin, M. R. Niroula, Z. W. Zhao, S. Niccolai, Y. Prok, D. S. Carman, M. Battaglieri, Barry Ritchie, N. Pivnyuk, I. I. Strakovsky, D. Protopopescu, C. Salgado, E. De Sanctis, M. Garçon, S. Pozdniakov, A. Deur, G. E. Dodge, Martin K. Mayer, G. Rosner, H. Y. Lu, Kei Moriya, C. A. Meyer, M. Osipenko, N. Dashyan, D. I. Sober, F. X. Girod, E. Pasyuk, G. V. Fedotov, S. Tkachenko, Adam P. Szczepaniak, M. S. Saini, I. Niculescu, P. Eugenio, H. Baghdasaryan, K. P. Adhikari, D. P. Weygand, E. Golovatch, M. Taiuti, J. T. Goetz, D. Schott, J. W. Price, C. Djalali, F. Sabatié, V. P. Kubarovsky, O. Pogorelko, W. Kim, P. Collins, M. Anghinolfi, Leonard Lesniak, H. Seraydaryan, J. Zhang, P. Khetarpal, Y. G. Sharabian, C. S. Nepali, M. Ripani, V. Crede, C. Hanretty, J. R. Johnstone, L. Guo, M. Ungaro, S. Park, P. Rossi, K. Joo, M. Guidal, M. Holtrop, A. Daniel, A. I. Ostrovidov, K. Park, Sergey Kuleshov, D. G. Ireland, S. S. Stepanyan, Mark W. Paris, B. Zhao, Volker D. Burkert, A. S. Biselli, S. Dhamija, R. W. Gothe, A. Fradi, M. J. Amaryan, J. Goett, B. McKinnon, D. Branford, S. Pisano, M. Mirazita, S. L. Careccia, J. M. Laget, K. L. Giovanetti, Larry Weinstein, D. Keller, Gerard Gilfoyle, M. Khandaker, M. E. McCracken, Y. Ilieva, D. Sokhan, D. Doughty, A. Teymurazyan, and P. L. Cole

Subjects
Physics, Particle physics, Meson, 010308 nuclear & particles physics, Partial wave analysis, Hadron, Elementary particle, 01 natural sciences, 7. Clean energy, Particle decay, Pion, 0103 physical sciences, High Energy Physics::Experiment, Production (computer science), Nuclear Experiment, 010306 general physics, Nucleon
Abstract

The exclusive reaction $\ensuremath{\gamma}p\ensuremath{\rightarrow}p{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ was studied in the photon energy range 3.0--3.8 GeV and the momentum transfer range $0.4l\ensuremath{-}tl1.0\text{ }\text{ }{\mathrm{GeV}}^{2}$. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility. In this kinematic range, the integrated luminosity was about $20\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$. The reaction was isolated by detecting the ${\ensuremath{\pi}}^{+}$ and proton in CLAS, and reconstructing the ${\ensuremath{\pi}}^{\ensuremath{-}}$ via the missing-mass technique. Moments of the di-pion decay angular distributions were derived from the experimental data. Differential cross sections for the $S$, $P$, and $D$-waves, in the ${M}_{{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}}$ mass range 0.4--1.4 GeV, were derived performing a partial wave expansion of the extracted moments. Beside the dominant contribution of the $\ensuremath{\rho}(770)$ meson in the $P$-wave, evidence for the ${f}_{0}(980)$ and the ${f}_{2}(1270)$ mesons was found in the $S$ and $D$-waves, respectively. The differential production cross sections $d\ensuremath{\sigma}/dt$ for individual waves in the mass range of the above-mentioned mesons were extracted. This is the first time the ${f}_{0}(980)$ has been measured in a photoproduction experiment.

Published
2018

50. Center of Mass Motion of Short-Range Correlated Nucleon Pairs studied via the A(e,e′pp) Reaction

Author

D. Protopopescu, Z. W. Zhao, E. Voutier, M. Duer, D. Marchand, X. Wei, Dustin Keller, P. Eugenio, I. J. D. MacGregor, G. Ciullo, M. Taiuti, C. Djalali, J. A. Tan, W. Kim, Y. Prok, F. Sabatié, L. Lanza, J. P. Ball, D. S. Carman, G. Niculescu, M. L. Kabir, P. Lenisa, S. Strauch, Michael Wood, K. Hafidi, B. A. Clary, K. Livingston, D. G. Jenkins, S. Niccolai, A. Movsisyan, Jie Zhang, Michael Paolone, D. Heddle, A. Celentano, R. W. Gothe, N. Dashyan, Maxime Defurne, H. Avakian, S. E. Kuhn, Friedrich Klein, M. Contalbrigo, A. Beck, Hovanes Egiyan, C. Munoz Camacho, M. Osipenko, M. Ungaro, Eli Piasetzky, H. Voskanyan, R. Fersch, Or Hen, Z. Akbar, L. Barion, R. De Vita, P. Nadel-Turonski, V. Crede, Alessandro Rizzo, Eliahu Cohen, E. Golovatch, R. Dupre, W. J. Briscoe, E. Pasyuk, A. El Alaoui, R. A. Montgomery, R. Paremuzyan, V. Mokeev, M. Battaglieri, M. Ripani, F. Hauenstein, B. S. Ishkhanov, Nicholas M. Harrison, Nicholas Zachariou, Rong Wang, D. Sokhan, Alexander Schmidt, D. P. Watts, S. Adhikari, K. Hicks, B. McKinnon, E. De Sanctis, S. Mey-Tal Beck, A. Kim, V. P. Kubarovsky, Y. G. Sharabian, D. Riser, A. I. Ostrovidov, A. Filippi, P. Rossi, X. Zheng, M. Ehrhart, O. Pogorelko, M. Mirazita, A. Deur, D. G. Ireland, I. Bedlinskiy, M. Khachatryan, M. Khandaker, Nikolaos Sparveris, Volker D. Burkert, A. S. Biselli, M. J. Amaryan, Sandra K. Johnston, K. L. Giovanetti, Larry Weinstein, B. Schmookler, C. A. Meyer, P. Chatagnon, G. V. Fedotov, F. Cao, I. Korover, B. Mustapha, M. Holtrop, Taya Chetry, G. Charles, E. L. Isupov, S. Boiarinov, R. Cruz Torres, H. Hakobyan, S. Diehl, F. X. Girod, J. W. Price, R. A. Schumacher, S. Stepanyan, Avraham Klein, H. S. Jo, A. D'Angelo, L. El Fassi, G. Khachatryan, G. Rosner, Y. Ghandilyan, and K. A. Griffioen

Subjects
Physics, Range (particle radiation), 010308 nuclear & particles physics, Nuclear Theory, General Physics and Astronomy, 01 natural sciences, 7. Clean energy, Momentum, medicine.anatomical_structure, Quantum state, 0103 physical sciences, medicine, Nuclear force, Center of mass, Atomic physics, Nuclear Experiment, 010306 general physics, Nucleon, Nucleus, Fermi Gamma-ray Space Telescope
Abstract

Short-range correlated (SRC) nucleon pairs are a vital part of the nucleus, accounting for almost all nucleons with momentum greater than the Fermi momentum (k_{F}). A fundamental characteristic of SRC pairs is having large relative momenta as compared to k_{F}, and smaller center of mass (c.m.) which indicates a small separation distance between the nucleons in the pair. Determining the c.m. momentum distribution of SRC pairs is essential for understanding their formation process. We report here on the extraction of the c.m. motion of proton-proton (pp) SRC pairs in carbon and, for the first time in heavier and ansymetric nuclei: aluminum, iron, and lead, from measurements of the A(e,e^{'}pp) reaction. We find that the pair c.m. motion for these nuclei can be described by a three-dimensional Gaussian with a narrow width ranging from 140 to 170 MeV/c, approximately consistent with the sum of two mean-field nucleon momenta. Comparison with calculations appears to show that the SRC pairs are formed from mean-field nucleons in specific quantum states.

Published
2018

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